| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Järhult, L O Farnebo, H Graffner, J Hols. Effects of physiological increases in plasma noradrenaline on the human endocrine pancreas. Journal of endocrinological investigation. vol 12. issue 6. 1989-10-03. PMID:2570094. |
noradrenaline significantly inhibited plasma insulin levels but did not change plasma glucagon and somatostatin concentrations. |
1989-10-03 |
2023-08-11 |
human |
| D A D'Alessio, C Sieber, C Beglinger, J W Ensinc. A physiologic role for somatostatin 28 as a regulator of insulin secretion. The Journal of clinical investigation. vol 84. issue 3. 1989-09-21. PMID:2569481. |
a physiologic role for somatostatin 28 as a regulator of insulin secretion. |
1989-09-21 |
2023-08-11 |
human |
| C K Reynolds, G B Huntington, T H Elsasser, H F Tyrrell, P J Reynold. Net metabolism of hormones by portal-drained viscera and liver of lactating holstein cows. Journal of dairy science. vol 72. issue 6. 1989-09-18. PMID:2668359. |
net flux of insulin, glucagon, somatotropin, somatomedin-c, and somatostatin across the portal-drained viscera and liver of four lactating holstein cows was measured at 4 and 8 wk postpartum. |
1989-09-18 |
2023-08-11 |
cattle |
| C K Reynolds, G B Huntington, T H Elsasser, H F Tyrrell, P J Reynold. Net metabolism of hormones by portal-drained viscera and liver of lactating holstein cows. Journal of dairy science. vol 72. issue 6. 1989-09-18. PMID:2668359. |
twenty-four consecutive measurements of insulin, glucagon, and somatotropin net flux were obtained at 30-min intervals; 12 hourly measurements were obtained for somatomedin-c and somatostatin. |
1989-09-18 |
2023-08-11 |
cattle |
| M A Staten, D E Matthews, P E Cryer, D M Bie. Epinephrine's effect on metabolic rate is independent of changes in plasma insulin or glucagon. The American journal of physiology. vol 257. issue 2 Pt 1. 1989-09-15. PMID:2569829. |
to determine if the epinephrine-induced increase in metabolic rate is secondary to changes in glucagon or insulin or to changes in the fuels modulated by these hormones, metabolic rate was measured by indirect calorimetry in five normal weight post-absorptive young men on three occasions: study a, an intravenous epinephrine infusion alone; study b, a 4-h "islet clamp" consisting of somatostatin infusion with basal insulin and glucagon replacement; and study c, an intravenous epinephrine infusion combined with the islet clamp. |
1989-09-15 |
2023-08-11 |
Not clear |
| L Luzi, R A DeFronz. Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans. The American journal of physiology. vol 257. issue 2 Pt 1. 1989-09-15. PMID:2669517. |
to examine the importance of first-phase insulin secretion on total body glucose homeostasis, six normal subjects (age, 24 +/- 1 yr; ideal body wt, 100 +/- 1%) received three hyperglycemic (+75 mg/100 ml) clamp studies in combination with [3-3h]glucose: study i, 150 min hyperglycemic clamp; study ii, hyperglycemic clamp plus somatostatin (6 micrograms/min) plus basal glucagon replacement (0.4 ng.kg-1.min-1) plus an insulin infusion designed to mimic only the second phase of insulin secretion; and study iii, hyperglycemic clamp plus somatostatin plus basal glucagon plus an insulin infusion designed to mimic both the first and second phase of insulin secretion. |
1989-09-15 |
2023-08-11 |
human |
| H Bergne. [Nitrogen metabolism and its control mechanisms]. Archiv fur Tierernahrung. vol 39. issue 4-5. 1989-09-15. PMID:2669679. |
inhibition: 1) somatostatin inhibits sth, tsh and insulin; 2) cortisol directly inhibits protein synthesis and stimulates protein degradation. |
1989-09-15 |
2023-08-11 |
human |
| A L Swislocki, B B Hoffman, G M Reave. Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension. American journal of hypertension. vol 2. issue 6 Pt 1. 1989-09-13. PMID:2667570. |
in separate studies, insulin-stimulated glucose uptake was estimated by measuring the steady-state plasma glucose (sspg) and insulin (sspi) concentrations achieved during the last 30 minutes of a 180-minute continuous infusion of somatostatin, insulin, and glucose (insulin suppression test). |
1989-09-13 |
2023-08-11 |
human |
| G M Reaven, H Ho, B B Hoffman. Somatostatin inhibition of fructose-induced hypertension. Hypertension (Dallas, Tex. : 1979). vol 14. issue 2. 1989-09-08. PMID:2569446. |
at the end of this period, rats receiving the somatostatin analogue had a lower plasma insulin concentration (52 +/- 4 vs. 70 +/- 6 microunits/ml, p less than 0.01) and a lower blood pressure (133 +/- 2 vs. 150 +/- 2 mm hg) than did the rats infused with the control solution. |
1989-09-08 |
2023-08-11 |
rat |
| M E Kraenzlin, U Keller, A Keller, A Thélin, M J Arnaud, W Stauffache. Elevation of plasma epinephrine concentrations inhibits proteolysis and leucine oxidation in man via beta-adrenergic mechanisms. The Journal of clinical investigation. vol 84. issue 2. 1989-09-08. PMID:2569473. |
constant plasma insulin and glucagon concentrations were maintained in all studies by infusing somatostatin combined with insulin and glucagon replacements. |
1989-09-08 |
2023-08-11 |
human |
| M Amherdt, Y C Patel, L Orc. Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells. The Journal of clinical investigation. vol 84. issue 2. 1989-09-08. PMID:2569474. |
binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells. |
1989-09-08 |
2023-08-11 |
rat |
| J Philipp. Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line. The Journal of clinical investigation. vol 84. issue 2. 1989-09-08. PMID:2668337. |
complex interrelationships exist between the four pancreatic islet cell types and their respective secretory products, insulin, glucagon, somatostatin, and pancreatic polypeptide. |
1989-09-08 |
2023-08-11 |
Not clear |
| A Zeidler, S Arbuckle, E Mahan, K Soejima, B G Slavin, G H Albrecht, J Goldma. Assessment of pancreatic islet-cell population in the hyperglycemic athymic nude mouse: immunohistochemical, ultrastructural, and hormonal studies. Pancreas. vol 4. issue 2. 1989-09-07. PMID:2569196. |
radioimmunoassays of the pancreatic content (micrograms/g fresh pancreas) of insulin, glucagon, and somatostatin in pancreata in 8-week-old normal balb/c and hyperglycemic athymic nude mice were similar; however, the somatostatin content was significantly increased in the 8-week-old hyperglycemic nu/nu mice compared with age and sex-matched controls. |
1989-09-07 |
2023-08-11 |
mouse |
| C M Gronda, J P Rossi, J J Gagliardin. Effect of different stimulators and a blocker of insulin release on islet Na+, K+-ATPase activity. Methods and findings in experimental and clinical pharmacology. vol 11. issue 5. 1989-09-05. PMID:2547128. |
these results suggest that na+, k+-atpase activity would not be a main common step involved in the mechanism by which glucose, kic, glucagon + theophylline and somatostatin exert their effect on insulin secretion. |
1989-09-05 |
2023-08-11 |
rat |
| P S Norman, Y Habara, G E Man. Paradoxical effects of endogenous and exogenous insulin on amino acid transport activity in the isolated rat pancreas: somatostatin-14 inhibits insulin action. Diabetologia. vol 32. issue 3. 1989-09-01. PMID:2568959. |
regulatory effects of insulin, somatostatin and cholecystokinin on amino acid transport in the isolated perfused rat pancreas have been studied using a rapid dual isotope dilution technique. |
1989-09-01 |
2023-08-11 |
rat |
| P S Norman, Y Habara, G E Man. Paradoxical effects of endogenous and exogenous insulin on amino acid transport activity in the isolated rat pancreas: somatostatin-14 inhibits insulin action. Diabetologia. vol 32. issue 3. 1989-09-01. PMID:2568959. |
if endogenous insulin and somatostatin, released concurrently in response to 16.8 mmol/l d-glucose, were conveyed to the exocrine epithelium via an islet-acinar portal axis, it is conceivable that somatostatin modulates the stimulatory action of insulin on basolateral amino acid transport in the exocrine pancreas. |
1989-09-01 |
2023-08-11 |
rat |
| J I Stagner, E Samols, V Mark. The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat islet. Diabetologia. vol 32. issue 3. 1989-09-01. PMID:2568960. |
anterograde infusion of glucagon antibody did not affect insulin secretion, but rapidly decreased somatostatin secretion -46 +/- 8%, (p less than 0.005). |
1989-09-01 |
2023-08-11 |
rat |
| J I Stagner, E Samols, V Mark. The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat islet. Diabetologia. vol 32. issue 3. 1989-09-01. PMID:2568960. |
retrograde infusion of glucagon antibody decreased insulin secretion (-27 +/- 8%, p less than 0.005) but had no effect upon somatostatin secretion. |
1989-09-01 |
2023-08-11 |
rat |
| J I Stagner, E Samols, V Mark. The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat islet. Diabetologia. vol 32. issue 3. 1989-09-01. PMID:2568960. |
thus within the islet, vascular borne insulin regulates the release of glucagon, which in turn, regulates the release of somatostatin. |
1989-09-01 |
2023-08-11 |
rat |
| D G Lambert, T W Atkin. Effects of islet hormones on insulin secretion from cloned B cell lines, HIT-T15 and RINm5F. The Journal of endocrinology. vol 121. issue 3. 1989-09-01. PMID:2569024. |
this study supports the hypothesis that insulin release from normal b cells may be modified by the paracrine activity of islet hormones, glucagon, somatostatin and pancreatic polypeptide and probably occurs before any fine tuning imposed by subsequently released insulin. |
1989-09-01 |
2023-08-11 |
Not clear |