| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C M Gronda, J P Rossi, J J Gagliardin. Effect of different stimulators and a blocker of insulin release on islet Na+, K+-ATPase activity. Methods and findings in experimental and clinical pharmacology. vol 11. issue 5. 1989-09-05. PMID:2547128. |
these results suggest that na+, k+-atpase activity would not be a main common step involved in the mechanism by which glucose, kic, glucagon + theophylline and somatostatin exert their effect on insulin secretion. |
1989-09-05 |
2023-08-11 |
rat |
| P S Norman, Y Habara, G E Man. Paradoxical effects of endogenous and exogenous insulin on amino acid transport activity in the isolated rat pancreas: somatostatin-14 inhibits insulin action. Diabetologia. vol 32. issue 3. 1989-09-01. PMID:2568959. |
regulatory effects of insulin, somatostatin and cholecystokinin on amino acid transport in the isolated perfused rat pancreas have been studied using a rapid dual isotope dilution technique. |
1989-09-01 |
2023-08-11 |
rat |
| P S Norman, Y Habara, G E Man. Paradoxical effects of endogenous and exogenous insulin on amino acid transport activity in the isolated rat pancreas: somatostatin-14 inhibits insulin action. Diabetologia. vol 32. issue 3. 1989-09-01. PMID:2568959. |
if endogenous insulin and somatostatin, released concurrently in response to 16.8 mmol/l d-glucose, were conveyed to the exocrine epithelium via an islet-acinar portal axis, it is conceivable that somatostatin modulates the stimulatory action of insulin on basolateral amino acid transport in the exocrine pancreas. |
1989-09-01 |
2023-08-11 |
rat |
| J I Stagner, E Samols, V Mark. The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat islet. Diabetologia. vol 32. issue 3. 1989-09-01. PMID:2568960. |
anterograde infusion of glucagon antibody did not affect insulin secretion, but rapidly decreased somatostatin secretion -46 +/- 8%, (p less than 0.005). |
1989-09-01 |
2023-08-11 |
rat |
| J I Stagner, E Samols, V Mark. The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat islet. Diabetologia. vol 32. issue 3. 1989-09-01. PMID:2568960. |
retrograde infusion of glucagon antibody decreased insulin secretion (-27 +/- 8%, p less than 0.005) but had no effect upon somatostatin secretion. |
1989-09-01 |
2023-08-11 |
rat |
| J I Stagner, E Samols, V Mark. The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat islet. Diabetologia. vol 32. issue 3. 1989-09-01. PMID:2568960. |
thus within the islet, vascular borne insulin regulates the release of glucagon, which in turn, regulates the release of somatostatin. |
1989-09-01 |
2023-08-11 |
rat |
| D G Lambert, T W Atkin. Effects of islet hormones on insulin secretion from cloned B cell lines, HIT-T15 and RINm5F. The Journal of endocrinology. vol 121. issue 3. 1989-09-01. PMID:2569024. |
this study supports the hypothesis that insulin release from normal b cells may be modified by the paracrine activity of islet hormones, glucagon, somatostatin and pancreatic polypeptide and probably occurs before any fine tuning imposed by subsequently released insulin. |
1989-09-01 |
2023-08-11 |
Not clear |
| W Waldhäus. Circadian rhythms of insulin needs and actions. Diabetes research and clinical practice. vol 6. issue 4. 1989-08-29. PMID:2666058. |
this basal mode of insulin secretion is subject to a multitude of endogenous control systems that act on the b-cell both in a stimulatory (e.g., beta-agonists, glucagon as well as glucose and amino acids) and an inhibitory fashion (e.g., alpha-agonists, somatostatin). |
1989-08-29 |
2023-08-11 |
human |
| F E Bauer, A Zintel, M J Kenny, D Calder, M A Ghatei, S R Bloo. Inhibitory effect of galanin on postprandial gastrointestinal motility and gut hormone release in humans. Gastroenterology. vol 97. issue 2. 1989-08-18. PMID:2472997. |
galanin potently suppressed the initial postprandial rise in plasma concentrations of glucose, insulin, peptide tyrosine tyrosine, neurotensin, enteroglucagon, pancreatic glucagon, somatostatin, and pancreatic polypeptide, but did not change gastric inhibitory polypeptide, motilin, peptide histidine methionine, and gastrin concentrations compared with control. |
1989-08-18 |
2023-08-11 |
human |
| K Nod. [Studies on developmental changes in rat pancreatic endocrine system during perinatal period]. Nihon Sanka Fujinka Gakkai zasshi. vol 41. issue 4. 1989-08-15. PMID:2568384. |
during the perinatal development of rats, pancreatic endocrine cells (b, a and d cells) were quantitated morphometrically and plasma insulin, glucagon and somatostatin were measured. |
1989-08-15 |
2023-08-11 |
rat |
| W J Krause, J H Cutts, J H Cutts, J Yamad. Immunohistochemical study of the developing endocrine pancreas of the opossum (Didelphis virginiana). Acta anatomica. vol 135. issue 1. 1989-08-14. PMID:2665414. |
cells immunoreactive for insulin, glucagon, somatostatin, bovine pancreatic polypeptide and 5-hydroxytryptamine are found in the pancreas of the newborn opossum and of all later stages examined. |
1989-08-14 |
2023-08-11 |
cattle |
| D H Wasserman, J A Spalding, D B Lacy, C A Colburn, R E Goldstein, A D Cherringto. Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. The American journal of physiology. vol 257. issue 1 Pt 1. 1989-08-11. PMID:2665514. |
five dogs were studied during paired experiments in which pancreatic hormones were clamped at basal levels during a control period (using somatostatin and intraportal hormone replacement), then altered during exercise to stimulate the normal exercise-induced fall in insulin, while glucagon was 1) increased to mimic its normal exercise-induced rise (sg) and 2) maintained at a basal level (bg). |
1989-08-11 |
2023-08-11 |
dog |
| E Peiró, P Miralles, R A Silvestre, M L Villanueva, J Marc. Pancreastatin inhibits insulin secretion as induced by glucagon, vasoactive intestinal peptide, gastric inhibitory peptide, and 8-cholecystokinin in the perfused rat pancreas. Metabolism: clinical and experimental. vol 38. issue 7. 1989-08-10. PMID:2661967. |
to further explore the influence of pancreastatin on islet cell secretion, the effect of synthetic porcine pancreastatin (a 2-micrograms priming dose, followed by constant infusion at a concentration of 15.7 nmol/l) was studied on the insulin, glucagon, and somatostatin responses to 1 nmol/l vasoactive intestinal peptide (vip), 1 nmol/l gastric inhibitory peptide (gip), and 1 nmol/l 26 to 33 octapeptide form of cholecystokinin (8-cck). |
1989-08-10 |
2023-08-11 |
rat |
| E Peiró, P Miralles, R A Silvestre, M L Villanueva, J Marc. Pancreastatin inhibits insulin secretion as induced by glucagon, vasoactive intestinal peptide, gastric inhibitory peptide, and 8-cholecystokinin in the perfused rat pancreas. Metabolism: clinical and experimental. vol 38. issue 7. 1989-08-10. PMID:2661967. |
the effect of pancreastatin on the insulin and somatostatin secretion elicited by glucagon (20 nmol/l) was also examined. |
1989-08-10 |
2023-08-11 |
rat |
| E Peiró, P Miralles, R A Silvestre, M L Villanueva, J Marc. Pancreastatin inhibits insulin secretion as induced by glucagon, vasoactive intestinal peptide, gastric inhibitory peptide, and 8-cholecystokinin in the perfused rat pancreas. Metabolism: clinical and experimental. vol 38. issue 7. 1989-08-10. PMID:2661967. |
pancreastatin infusion consistently reduced the insulin responses to vip, gip, and 8-cck without modifying glucagon or somatostatin release. |
1989-08-10 |
2023-08-11 |
rat |
| E Peiró, P Miralles, R A Silvestre, M L Villanueva, J Marc. Pancreastatin inhibits insulin secretion as induced by glucagon, vasoactive intestinal peptide, gastric inhibitory peptide, and 8-cholecystokinin in the perfused rat pancreas. Metabolism: clinical and experimental. vol 38. issue 7. 1989-08-10. PMID:2661967. |
it also inhibited the insulin release but not the somatostatin output induced by glucagon. |
1989-08-10 |
2023-08-11 |
rat |
| H Ishii, K Miyazaki, A Funakoshi, H Nawata, K Konomi, A Jim. A case of multiple endocrine neoplasia (MEN) type 1; the immunohistochemical and ultrastructural studies of its tumors and the analysis of hormones in tumor extracts. Endocrinologia japonica. vol 36. issue 1. 1989-07-14. PMID:2567230. |
measurement of hormone contents and immunohistochemical studies of the pancreatic tumors showed that the tumors contained insulin, glucagon, somatostatin, and pancreatic polypeptide. |
1989-07-14 |
2023-08-11 |
Not clear |
| D Deville de Perière, D Hillaire-Buys, R Gross, R Puech, S Arancibi. Increases in concentrations of somatostatin- and insulin-like immunoreactivities in submandibular salivary gland of diabetic rats: effect of insulin treatment. Acta endocrinologica. vol 120. issue 6. 1989-07-11. PMID:2658456. |
chronic insulin treatment of diabetic rats reversed the increase in somatostatin, but had no effect on the increase in insulin-like immunoreactivity concentration. |
1989-07-11 |
2023-08-11 |
rat |
| D Deville de Perière, D Hillaire-Buys, R Gross, R Puech, S Arancibi. Increases in concentrations of somatostatin- and insulin-like immunoreactivities in submandibular salivary gland of diabetic rats: effect of insulin treatment. Acta endocrinologica. vol 120. issue 6. 1989-07-11. PMID:2658456. |
a negative correlation (r = 0.24, p less than 0.05) was found between the plasma insulin level and the somatostatin concentration of the submandibular glands. |
1989-07-11 |
2023-08-11 |
rat |
| J Verhaeghe, T L Peeters, M Vandeputte, W Rombauts, R Bouillon, F A Van Assch. Maternal and fetal endocrine pancreas in the spontaneously diabetic BB rat. Biology of the neonate. vol 55. issue 4-5. 1989-07-10. PMID:2566332. |
plasma insulin levels were decreased while plasma glucagon and somatostatin concentrations were normal. |
1989-07-10 |
2023-08-11 |
rat |