| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shigeo Fukuda, Sadao Onoe, Satoshi Nikaido, Kei Fujii, Soichi Kageyama, Yoshifumi Iwamaru, Morikazu Imamura, Kentaro Masujin, Yuichi Matsuura, Yoshihisa Shimizu, Kazuo Kasai, Miyako Yoshioka, Yuichi Murayama, Shirou Mohri, Takashi Yokoyama, Hiroyuki Okad. Neuroanatomical distribution of disease-associated prion protein in experimental bovine spongiform encephalopathy in cattle after intracerebral inoculation. Japanese journal of infectious diseases. vol 65. issue 1. 2012-05-17. PMID:22274156. |
animals euthanized at 10 months post-inoculation (mpi) showed prp(sc) deposits in the brainstem and thalamus, but no vacuolation; this suggested that the bse agent might exhibit area-dependent tropism in the brain. |
2012-05-17 |
2023-08-12 |
cattle |
| R F van der Willigen, H H L M Goossens, A J van Opsta. Linear visuomotor transformations in midbrain superior colliculus control saccadic eye-movements. Journal of integrative neuroscience. vol 10. issue 3. 2012-01-19. PMID:21960304. |
however, there is controversy as to how the brainstem saccade burst generators decode the sc activity. |
2012-01-19 |
2023-08-12 |
Not clear |
| S Fukuda, H Okada, S Arai, T Yokoyama, S Mohr. Neuropathological changes in auditory brainstem nuclei in cattle with experimentally induced bovine spongiform encephalopathy. Journal of comparative pathology. vol 145. issue 2-3. 2011-11-22. PMID:21333306. |
the neuropathological changes in the auditory brainstem nuclei were assessed by determining the severity of vacuolation and the presence of disease-associated prion protein (prp(sc)). |
2011-11-22 |
2023-08-12 |
cattle |
| S Fukuda, H Okada, S Arai, T Yokoyama, S Mohr. Neuropathological changes in auditory brainstem nuclei in cattle with experimentally induced bovine spongiform encephalopathy. Journal of comparative pathology. vol 145. issue 2-3. 2011-11-22. PMID:21333306. |
at 3, 10, 12 and 16 mpi), vacuolar change was absent or mild and prp(sc) deposition was minimal in the auditory brainstem nuclei. |
2011-11-22 |
2023-08-12 |
cattle |
| S Fukuda, H Okada, S Arai, T Yokoyama, S Mohr. Neuropathological changes in auditory brainstem nuclei in cattle with experimentally induced bovine spongiform encephalopathy. Journal of comparative pathology. vol 145. issue 2-3. 2011-11-22. PMID:21333306. |
the two cattle sacrificed at 18 and 19 mpi had no clinical signs and showed mild vacuolar degeneration and moderate amounts of prp(sc) accumulation in the auditory brainstem pathway. |
2011-11-22 |
2023-08-12 |
cattle |
| S Fukuda, H Okada, S Arai, T Yokoyama, S Mohr. Neuropathological changes in auditory brainstem nuclei in cattle with experimentally induced bovine spongiform encephalopathy. Journal of comparative pathology. vol 145. issue 2-3. 2011-11-22. PMID:21333306. |
neuropathological changes characterized by spongy lesions accompanied by prp(sc) accumulation in the auditory brainstem nuclei of bse-infected cattle may be associated with hyperacusia. |
2011-11-22 |
2023-08-12 |
cattle |
| M J Stack, S J Moore, A Vidal-Diez, M E Arnold, E M Jones, Y I Spencer, P Webb, J Spiropoulos, L Powell, P Bellerby, L Thurston, J Cooper, M J Chaplin, L A Davis, S Everitt, R Focosi-Snyman, S A C Hawkins, M M Simmons, G A H Well. Experimental bovine spongiform encephalopathy: detection of PrP(Sc) in the small intestine relative to exposure dose and age. Journal of comparative pathology. vol 145. issue 2-3. 2011-11-22. PMID:21388635. |
this study applies immunohistochemical and biochemical approaches to investigate the occurrence and distribution of disease-associated prion protein (prp(sc)) in the duodenum, jejunum and ileum of cattle orally exposed to a 1 g or 100 g dose of a titrated bse brainstem homogenate. |
2011-11-22 |
2023-08-12 |
human |
| Fumiko Ono, Naomi Tase, Asuka Kurosawa, Akio Hiyaoka, Atsushi Ohyama, Yukio Tezuka, Naomi Wada, Yuko Sato, Minoru Tobiume, Ken'ichi Hagiwara, Yoshio Yamakawa, Keiji Terao, Tetsutaro Sat. Atypical L-type bovine spongiform encephalopathy (L-BSE) transmission to cynomolgus macaques, a non-human primate. Japanese journal of infectious diseases. vol 64. issue 1. 2011-05-12. PMID:21266763. |
prp(sc) staining in the cerebral cortex showed a diffuse synaptic pattern by immunohistochemistry, whereas it accumulated as fine and coarse granules and/or small plaques in the cerebellar cortex and brain stem. |
2011-05-12 |
2023-08-12 |
monkey |
| Jordan K Leitch, Chase R Figley, Patrick W Stroma. Applying functional MRI to the spinal cord and brainstem. Magnetic resonance imaging. vol 28. issue 8. 2011-01-12. PMID:20409662. |
functional magnetic resonance imaging of the spinal cord (spinal fmri) has facilitated the noninvasive visualization of neural activity in the spinal cord (sc) and brainstem of both animals and humans. |
2011-01-12 |
2023-08-12 |
Not clear |
| Elena Borra, Abdelouahed Belmalih, Marzio Gerbella, Stefano Rozzi, Giuseppe Luppin. Projections of the hand field of the macaque ventral premotor area F5 to the brainstem and spinal cord. The Journal of comparative neurology. vol 518. issue 13. 2010-09-28. PMID:20503428. |
in the brainstem the f5 hand motor field projects to the intermediate and deep layers of the superior colliculus (sc) and to sectors of the mesencephalic, pontine, and bulbar reticular formation, which are the sources of spinal projections. |
2010-09-28 |
2023-08-12 |
monkey |
| H H L M Goossens, A J Van Opsta. Differential effects of reflex blinks on saccade perturbations in humans. Journal of neurophysiology. vol 103. issue 3. 2010-06-11. PMID:20130041. |
we hypothesize that the reduction in mean eye velocity is not caused by a trigeminal reactivation of brain stem omnipause neurons but could instead arise from a trigeminal transient inhibition of saccade-related activity in the midbrain superior colliculus (sc). |
2010-06-11 |
2023-08-12 |
human |
| I C Furigo, W F de Oliveira, A R de Oliveira, E Comoli, M V C Baldo, S R Mota-Ortiz, N S Cantera. The role of the superior colliculus in predatory hunting. Neuroscience. vol 165. issue 1. 2010-03-11. PMID:19825395. |
in contrast to the lateral sc lesions, medial sc lesions produced a small deficit in predatory hunting, and compared to what we have seen for the lateral scig, the medial scig has a very limited set of projections to thalamic sites related to the control of motor planning or motor output, and provides conspicuous inputs to brainstem sites involved in organizing a wide range of anti-predatory defensive responses. |
2010-03-11 |
2023-08-12 |
Not clear |
| Nathalie Auvergnon, Sophie Reibel, Monique Touret, Jérôme Honnorat, Thierry Baron, Pascale Giraudon, Anna Bencsi. Altered expression of CRMPs in the brain of bovine spongiform encephalopathy-infected mice during disease progression. Brain research. vol 1261. 2010-01-14. PMID:19401179. |
at the terminal stage of the disease, gene expression of each crmp had decreased, while at the mid-stage of the disease only crmp4 (mrna and protein) expression had increased, concomitant to the start of prp(sc) accumulation in the brainstem. |
2010-01-14 |
2023-08-12 |
mouse |
| Gianluigi Zanusso, Sergio Ferrari, Diego Benedetti, Marco Sbriccoli, Nicola Rizzuto, Salvatore Monac. Different prion conformers target the olfactory pathway in sporadic Creutzfeldt-Jakob disease. Annals of the New York Academy of Sciences. vol 1170. 2009-09-25. PMID:19686205. |
intriguingly, in the ataxic or cerebellar variant, mainly observed in patients with the met/val polymorphism (2) carrying prp(sc) type 2, olfactory involvement is accompanied by pathologic changes in the dorsal motor nucleus of the vagus and other brainstem nuclei. |
2009-09-25 |
2023-08-12 |
human |
| Yuki Kaku, Kaoru Yoshida, Yoshiki Iwamot. Learning signals from the superior colliculus for adaptation of saccadic eye movements in the monkey. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 16. 2009-05-22. PMID:19386923. |
we propose that the sc, a brainstem structure long known to be crucial for saccade execution, is involved in motor learning and sends signals that dictate the direction of adaptive shift in saccade endpoint. |
2009-05-22 |
2023-08-12 |
monkey |
| Gültekin Tamgüney, Michael W Miller, Kurt Giles, Azucena Lemus, David V Glidden, Stephen J DeArmond, Stanley B Prusine. Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein. The Journal of general virology. vol 90. issue Pt 4. 2009-05-11. PMID:19264659. |
ssbp/1 prions produced abundant deposits of the disease-causing prp isoform, denoted prp(sc), in the cerebellum and pons of tg(elkprp) mice, whereas prp(sc) accumulation in tg mice inoculated with sheep-passaged bse prions was confined to the deep cerebellar nuclei, habenula and the brainstem. |
2009-05-11 |
2023-08-12 |
mouse |
| Thongchai Sooksawate, Kaoru Isa, Tadashi Is. Cholinergic responses in crossed tecto-reticular neurons of rat superior colliculus. Journal of neurophysiology. vol 100. issue 5. 2009-04-20. PMID:18753319. |
neurons in the intermediate gray layer (sgi) of mammalian superior colliculus (sc) receive cholinergic innervation from the brain stem parabrachial region, which seems to modulate the signal processing in the sc. |
2009-04-20 |
2023-08-12 |
rat |
| Thongchai Sooksawate, Kaoru Isa, Tadashi Is. Cholinergic responses in crossed tecto-reticular neurons of rat superior colliculus. Journal of neurophysiology. vol 100. issue 5. 2009-04-20. PMID:18753319. |
to clarify its role particularly in orienting behaviors, we studied cholinergic effects on the major output neuron group of the sgi, crossed tecto-reticular neurons (ctrns), identified by retrograde labeling from the contralateral brain stem gaze center in sc slices obtained from rats (pnd 17-22) by whole cell patch-clamp techniques. |
2009-04-20 |
2023-08-12 |
rat |
| Y H Lee, M M Simmons, S A C Hawkins, Y I Spencer, P Webb, M J Stack, G A H Well. Detection of pathologic prion protein in the olfactory bulb of natural and experimental bovine spongiform encephalopathy affected cattle in Great Britain. Veterinary pathology. vol 46. issue 1. 2009-03-31. PMID:19112116. |
to investigate the relative involvement of the olfactory region in classical bovine spongiform encephalopathy (bse), immunohistochemical labeling of prion protein scrapie (prp(sc)) was scored in the brainstem, frontal cerebral cortex, and olfactory bulb of cattle with natural and experimental clinical cases of bse in great britain. |
2009-03-31 |
2023-08-12 |
cattle |
| Y H Lee, M M Simmons, S A C Hawkins, Y I Spencer, P Webb, M J Stack, G A H Well. Detection of pathologic prion protein in the olfactory bulb of natural and experimental bovine spongiform encephalopathy affected cattle in Great Britain. Veterinary pathology. vol 46. issue 1. 2009-03-31. PMID:19112116. |
the intensity of immunolabeling was greatest in the brainstem, but prp(sc) was also detected in the olfactory bulb and the cerebral cortex. |
2009-03-31 |
2023-08-12 |
cattle |