| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Jye Lin, Cheng Jiang, Masato Sadahiro, Ozlem Bozdagi, Lucy Vulchanova, Cristina M Alberini, Stephen R Salto. VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent Mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 28. 2015-09-24. PMID:26180209. |
reduced vgf expression was found to impair learning-evoked rac1 induction and phosphorylation of the synaptic plasticity markers cofilin and synapsin in the adult mouse hippocampus. |
2015-09-24 |
2023-08-13 |
mouse |
| Stefan J Kempf, Sonja Buratovic, Christine von Toerne, Simone Moertl, Bo Stenerlöw, Stefanie M Hauck, Michael J Atkinson, Per Eriksson, Soile Tapi. Ionising radiation immediately impairs synaptic plasticity-associated cytoskeletal signalling pathways in HT22 cells and in mouse brain: an in vitro/in vivo comparison study. PloS one. vol 9. issue 10. 2015-06-29. PMID:25329592. |
the decreased expression of mir-132 and rac1 was associated with an increase in hippocampal cofilin and phospho-cofilin. |
2015-06-29 |
2023-08-13 |
mouse |
| Elena Blanco-Suárez, Maria Fiuza, Xun Liu, Elavazhagan Chakkarapani, Jonathan G Hanle. Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 12. 2015-02-04. PMID:25248834. |
we show that rac1 and the rac guanine nucleotide exchange factor (gef) tiam1 are differentially activated by ogd in hippocampal and cortical neurons. |
2015-02-04 |
2023-08-13 |
Not clear |
| Valentina Vaghi, Roberta Pennucci, Francesca Talpo, Sara Corbetta, Valentina Montinaro, Cinzia Barone, Laura Croci, Paolo Spaiardi, G Giacomo Consalez, Gerardo Biella, Ivan de Curti. Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 5. 2014-11-28. PMID:23258346. |
rac1 and rac3 gtpases control synergistically the development of cortical and hippocampal gabaergic interneurons. |
2014-11-28 |
2023-08-12 |
mouse |
| Ivan de Curti. Roles of Rac1 and Rac3 GTPases during the development of cortical and hippocampal GABAergic interneurons. Frontiers in cellular neuroscience. vol 8. 2014-10-13. PMID:25309333. |
roles of rac1 and rac3 gtpases during the development of cortical and hippocampal gabaergic interneurons. |
2014-10-13 |
2023-08-13 |
Not clear |
| Dai Han, Li Xu, Honglei Xiao, Georgia C Prado Schmidt, Shenxun Sh. Dizocilpine reduces head diameter of dendritic spines in the hippocampus of adolescent rats. Psychiatry research. vol 210. issue 1. 2014-05-30. PMID:23747234. |
then spatial memory, spine morphological changes and rhoa, rac1, cdc42 mrna levels in hippocampus were measured. |
2014-05-30 |
2023-08-12 |
rat |
| Dai Han, Li Xu, Honglei Xiao, Georgia C Prado Schmidt, Shenxun Sh. Dizocilpine reduces head diameter of dendritic spines in the hippocampus of adolescent rats. Psychiatry research. vol 210. issue 1. 2014-05-30. PMID:23747234. |
mk-801 also reduced the expression levels of rac1 and cdc42 mrna and upregulated rhoa mrna in hippocampus. |
2014-05-30 |
2023-08-12 |
rat |
| Dai Han, Li Xu, Honglei Xiao, Georgia C Prado Schmidt, Shenxun Sh. Dizocilpine reduces head diameter of dendritic spines in the hippocampus of adolescent rats. Psychiatry research. vol 210. issue 1. 2014-05-30. PMID:23747234. |
these results imply that subchronic mk-801 administration during adolescence might disturb the expression of rhoa, rac1 and cdc42 mrna, and then lead to the decay of the spines in hippocampus, which could be involved in cognitive impairments in schizophrenia. |
2014-05-30 |
2023-08-12 |
rat |
| Jun Wang, Yu-hua Wang, Yuan-yuan Hou, Tao Xi, Yao Liu, Jing-gen Li. The small GTPase RhoA, but not Rac1, is essential for conditioned aversive memory formation through regulation of actin rearrangements in rat dorsal hippocampus. Acta pharmacologica Sinica. vol 34. issue 6. 2014-01-06. PMID:23564082. |
the small gtpase rhoa, but not rac1, is essential for conditioned aversive memory formation through regulation of actin rearrangements in rat dorsal hippocampus. |
2014-01-06 |
2023-08-12 |
rat |
| Yasuhiro Funahashi, Takashi Namba, Shin Fujisue, Norimichi Itoh, Shinichi Nakamuta, Katsuhiro Kato, Akiko Shimada, Chundi Xu, Wei Shan, Tomoki Nishioka, Kozo Kaibuch. ERK2-mediated phosphorylation of Par3 regulates neuronal polarization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 33. 2013-10-23. PMID:23946386. |
par3 interacts with the rac-specific guanine nucleotide-exchange factors (gefs) tiam1/2, which activate rac1, and participates in axon formation in cultured hippocampal neurons. |
2013-10-23 |
2023-08-12 |
mouse |
| Chengbo Meng, Zhiyong He, Da Xin. Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 33. 2013-10-23. PMID:23946409. |
in addition, dendrite growth was improved after lllt, characterized by upregulation of rac1 activity and psd-95 expression, and the increase in length, branching, and spine density of dendrites in hippocampal neurons. |
2013-10-23 |
2023-08-12 |
mouse |
| Ursula Haditsch, Matthew P Anderson, Julia Freewoman, Branden Cord, Harish Babu, Cord Brakebusch, Theo D Palme. Neuronal Rac1 is required for learning-evoked neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 30. 2013-10-17. PMID:23884931. |
we have previously shown that activity-induced intracellular signaling through the rho family small gtpase rac1 is necessary in forebrain projection neurons for normal synaptic plasticity in vivo, and here we show that selective loss of neuronal rac1 also impairs the learning-evoked increase in neurogenesis in the adult mouse hippocampus. |
2013-10-17 |
2023-08-12 |
mouse |
| Ursula Haditsch, Matthew P Anderson, Julia Freewoman, Branden Cord, Harish Babu, Cord Brakebusch, Theo D Palme. Neuronal Rac1 is required for learning-evoked neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 30. 2013-10-17. PMID:23884931. |
loss of rac1 in mature projection neurons did reduce learning-evoked neurogenesis but, contrary to our expectations, these effects were not mediated by altering the survival of young neurons in the hippocampus. |
2013-10-17 |
2023-08-12 |
mouse |
| Krishna C Vadodaria, Cord Brakebusch, Ueli Suter, Sebastian Jessberge. Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 3. 2013-04-01. PMID:23325254. |
stage-specific functions of the small rho gtpases cdc42 and rac1 for adult hippocampal neurogenesis. |
2013-04-01 |
2023-08-12 |
mouse |
| Krishna C Vadodaria, Cord Brakebusch, Ueli Suter, Sebastian Jessberge. Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 3. 2013-04-01. PMID:23325254. |
here we used conditional genetic deletion and virus-based loss-of-function approaches to identify temporally distinct functions for cdc42 and rac1 in adult hippocampal neurogenesis. |
2013-04-01 |
2023-08-12 |
mouse |
| Krishna C Vadodaria, Cord Brakebusch, Ueli Suter, Sebastian Jessberge. Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 3. 2013-04-01. PMID:23325254. |
these results establish cell-autonomous and stage-specific functions for the small rho gtpases cdc42 and rac1 in the course of adult hippocampal neurogenesis. |
2013-04-01 |
2023-08-12 |
mouse |
| Pritha Majumder, Yi-Ting Chen, Jayarama Krishnan Bose, Cheng-Chun Wu, Wei-Cheng Cheng, Sin-Jhong Cheng, Yen-Hsin Fang, Ying-Ling Chen, Kuen-Jer Tsai, Cheng-Chang Lien, Che-Kun James She. TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1. Acta neuropathologica. vol 124. issue 2. 2012-12-10. PMID:22760527. |
furthermore, use of an inhibitor of rac1 activation negatively regulated spinogenesis of control hippocampal neurons as well as tdp-43-depleted hippocampal neurons. |
2012-12-10 |
2023-08-12 |
mouse |
| Ariadna Mendoza-Naranjo, Erick Contreras-Vallejos, Daniel R Henriquez, Carola Otth, James R Bamburg, Ricardo B Maccioni, Christian Gonzalez-Billaul. Fibrillar amyloid-β1-42 modifies actin organization affecting the cofilin phosphorylation state: a role for Rac1/cdc42 effector proteins and the slingshot phosphatase. Journal of Alzheimer's disease : JAD. vol 29. issue 1. 2012-09-21. PMID:22204905. |
we previously reported that fibrillar aβ1-42 (faβ) treatment of hippocampal neurons induced an increase in rac1 and cdc42 activities linking faβ effects with changes in actin dynamics. |
2012-09-21 |
2023-08-12 |
Not clear |
| Cheng-Che Lee, Chiung-Chun Huang, Kuei-Sen Hs. Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21683721. |
taken together, these results reveal a novel role for ir signaling in the regulation of dendritic spine formation and excitatory synapse development in hippocampal neurons through activation of the pi3k/akt/mtor and rac1 signaling pathways. |
2012-05-25 |
2023-08-12 |
rat |
| Ger J A Ramakers, David Wolfer, Georg Rosenberger, Kerstin Kuchenbecker, Hans-Jürgen Kreienkamp, Janine Prange-Kiel, Gabriele Rune, Karin Richter, Kristina Langnaese, Sophie Masneuf, Michael R Bösl, Klaus-Dieter Fischer, Harm J Krugers, Hans-Peter Lipp, Elly van Galen, Kerstin Kutsch. Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits. Human molecular genetics. vol 21. issue 2. 2012-04-26. PMID:21989057. |
the structural and electrophysiological alterations in the hippocampus were accompanied by a significant reduction in active rac1 and cdc42, but not rhoa. |
2012-04-26 |
2023-08-12 |
mouse |