| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luis A Martinez, Maria V Tejada-Simo. Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21569781. |
pharmacological inactivation of the small gtpase rac1 impairs long-term plasticity in the mouse hippocampus. |
2012-04-17 |
2023-08-12 |
mouse |
| Luis A Martinez, Maria V Tejada-Simo. Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21569781. |
we have previously reported that rac1 is highly expressed in mouse hippocampus, where nmda receptor activation causes rac1 to translocate to the membrane in a manner similar to that observed in other non-neuronal cells. |
2012-04-17 |
2023-08-12 |
mouse |
| Luis A Martinez, Maria V Tejada-Simo. Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21569781. |
additionally rac1 has been seen to play a role in activation of signal transduction pathways associated with hippocampal learning and memory. |
2012-04-17 |
2023-08-12 |
mouse |
| Fumiko Kawakami-Mori, Tatsuo Shimosawa, Shengyu Mu, Hong Wang, Sayoko Ogura, Yutaka Yatomi, Toshiro Fujit. NADPH oxidase-mediated Rac1 GTP activity is necessary for nongenomic actions of the mineralocorticoid receptor in the CA1 region of the rat hippocampus. American journal of physiology. Endocrinology and metabolism. vol 302. issue 4. 2012-03-30. PMID:22114025. |
nadph oxidase-mediated rac1 gtp activity is necessary for nongenomic actions of the mineralocorticoid receptor in the ca1 region of the rat hippocampus. |
2012-03-30 |
2023-08-12 |
rat |
| Roberta Pennucci, Stefania Tavano, Diletta Tonoli, Sara Gualdoni, Ivan de Curti. Rac1 and Rac3 GTPases regulate the development of hilar mossy cells by affecting the migration of their precursors to the hilus. PloS one. vol 6. issue 9. 2012-01-30. PMID:21949760. |
we have previously shown that double deletion of the genes for rac1 and rac3 gtpases during neuronal development affects late developmental events that perturb the circuitry of the hippocampus, with ensuing epileptic phenotype. |
2012-01-30 |
2023-08-12 |
mouse |
| Gutiérrez-Vargas Johanna, Castro-Alvarez John Fredy, Velásquez-Carvajal David, Montañez-Velásquez Maria Natalia, Céspedes-Rubio Angel, Cardona-Gómez Gloria Patrici. Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemia. Neurochemistry international. vol 57. issue 7. 2011-09-07. PMID:20817060. |
our findings showed that during the acute phase (24h) after global cerebral ischemia, a decrease of the active state of rac1 was detected in the hippocampus, together with a down-regulation of survival signaling. |
2011-09-07 |
2023-08-12 |
rat |
| Lulu Y Chen, Christopher S Rex, Alex H Babayan, Eniko A Kramár, Gary Lynch, Christine M Gall, Julie C Lauterbor. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 33. 2010-09-03. PMID:20720104. |
we report here that physiological activation of the small gtpase rac1 and its effector p-21 activated kinase (pak), two enzymes critically involved in actin management and functional synaptic plasticity, is impaired at hippocampal synapses in the fmr1-knock-out (ko) mouse model of fxs. |
2010-09-03 |
2023-08-12 |
mouse |
| Ursula Haditsch, Dino P Leone, Mélissa Farinelli, Anna Chrostek-Grashoff, Cord Brakebusch, Isabelle M Mansuy, Susan K McConnell, Theo D Palme. A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Molecular and cellular neurosciences. vol 41. issue 4. 2009-09-07. PMID:19394428. |
a central role for the small gtpase rac1 in hippocampal plasticity and spatial learning and memory. |
2009-09-07 |
2023-08-12 |
Not clear |
| Ursula Haditsch, Dino P Leone, Mélissa Farinelli, Anna Chrostek-Grashoff, Cord Brakebusch, Isabelle M Mansuy, Susan K McConnell, Theo D Palme. A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Molecular and cellular neurosciences. vol 41. issue 4. 2009-09-07. PMID:19394428. |
here we demonstrate that selective elimination of rac1 in excitatory neurons in the forebrain in vivo not only affects spine structure, but also impairs synaptic plasticity in the hippocampus with consequent defects in hippocampus-dependent spatial learning. |
2009-09-07 |
2023-08-12 |
Not clear |
| Michael E Cahill, Zhong Xie, Michelle Day, Huzefa Photowala, Maria V Barbolina, Courtney A Miller, Craig Weiss, Jelena Radulovic, J David Sweatt, John F Disterhoft, D James Surmeier, Peter Penze. Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 31. 2009-08-26. PMID:19625617. |
here, we show that kalrn-knockout mice have specific reductions in cortical, but not hippocampal, rac1 signaling and spine density, and exhibit reduced cortical glutamatergic transmission. |
2009-08-26 |
2023-08-12 |
mouse |
| Pi-Lin Wang, Tetsuhiro Niidome, Akinori Akaike, Takeshi Kihara, Hachiro Sugimot. Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene. Journal of neuroscience research. vol 87. issue 9. 2009-08-14. PMID:19267423. |
in primary hippocampal neurons, the rac1-specific inhibitor nsc23766 decreased both rac1 activity and app protein levels in a concentration-dependent manner. |
2009-08-14 |
2023-08-12 |
Not clear |
| Pi-Lin Wang, Tetsuhiro Niidome, Akinori Akaike, Takeshi Kihara, Hachiro Sugimot. Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene. Journal of neuroscience research. vol 87. issue 9. 2009-08-14. PMID:19267423. |
taken together, our results suggest that rac1 regulates transcription of the app gene in primary hippocampal neurons. |
2009-08-14 |
2023-08-12 |
Not clear |
| Sara Gualdoni, Chiara Albertinazzi, Sara Corbetta, Flavia Valtorta, Ivan de Curti. Normal levels of Rac1 are important for dendritic but not axonal development in hippocampal neurons. Biology of the cell. vol 99. issue 8. 2007-08-22. PMID:17428196. |
normal levels of rac1 are important for dendritic but not axonal development in hippocampal neurons. |
2007-08-22 |
2023-08-12 |
Not clear |
| Shujie Wang, Takashi Watanabe, Jun Noritake, Masaki Fukata, Takeshi Yoshimura, Norimichi Itoh, Takumi Harada, Masato Nakagawa, Yoshiharu Matsuura, Nariko Arimura, Kozo Kaibuch. IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. Journal of cell science. vol 120. issue Pt 4. 2007-05-08. PMID:17244649. |
we found that iqgap3, an effector of rac1 and cdc42, associates directly with actin filaments and accumulates asymmetrically at the distal region of axons in hippocampal neurons. |
2007-05-08 |
2023-08-12 |
Not clear |
| Ariadna Mendoza-Naranjo, Christian Gonzalez-Billault, Ricardo B Maccion. Abeta1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases. Journal of cell science. vol 120. issue Pt 2. 2007-04-11. PMID:17200137. |
abeta1-42 stimulates actin polymerization in hippocampal neurons through rac1 and cdc42 rho gtpases. |
2007-04-11 |
2023-08-12 |
Not clear |
| Katie M Wiens, Hang Lin, Dezhi Lia. Rac1 induces the clustering of AMPA receptors during spinogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 46. 2006-03-10. PMID:16291935. |
the overexpression of green fluorescence protein-tagged wild-type rac1 initiated the formation of dendritic spines in cultured dissociated hippocampal neurons younger than 11 d in vitro, indicating that rac1 is likely one of the missing pieces responsible for the lack of spines in immature neurons. |
2006-03-10 |
2023-08-12 |
Not clear |
| Sang-Ho Choi, Da Yong Lee, Seung Up Kim, Byung Kwan Ji. Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: role of microglial NADPH oxidase. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 16. 2006-02-14. PMID:15843610. |
additional studies demonstrated that thrombin induced the upregulation of membrane (gp91(phox)) and cytosolic (p47(phox) and p67(phox)) components, translocation of cytosolic proteins (p47(phox), p67(phox), and rac1) to the membrane, and p67(phox) expression of the nadph oxidase in microglia in the hippocampus in vivo, indicating the activation of nadph oxidase. |
2006-02-14 |
2023-08-12 |
Not clear |
| Masashi Fujitani, Akiko Honda, Katsuhiko Hata, Satoru Yamagishi, Masaya Tohyama, Toshihide Yamashit. Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts. Biochemical and biophysical research communications. vol 327. issue 1. 2005-03-11. PMID:15629443. |
here, we report that neurotrophin dependent cytoskeletal changes, characteristic of the phenotype of rac1, in the hippocampal neurons or pc12 cells are inhibited by the disruption of lipid raft integrity. |
2005-03-11 |
2023-08-12 |
Not clear |
| Jorge Santos Da Silva, Vanessa Schubert, Carlos G Dott. RhoA, Rac1, and cdc42 intracellular distribution shift during hippocampal neuron development. Molecular and cellular neurosciences. vol 27. issue 1. 2005-01-26. PMID:15345238. |
rhoa, rac1, and cdc42 intracellular distribution shift during hippocampal neuron development. |
2005-01-26 |
2023-08-12 |
Not clear |
| Jorge Santos Da Silva, Vanessa Schubert, Carlos G Dott. RhoA, Rac1, and cdc42 intracellular distribution shift during hippocampal neuron development. Molecular and cellular neurosciences. vol 27. issue 1. 2005-01-26. PMID:15345238. |
to address this issue, we analyzed the intracellular distribution of the rho gtpases, rhoa, rac1, and cdc42 in hippocampal neurons in culture. |
2005-01-26 |
2023-08-12 |
Not clear |