| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jana Schulz, Stefan Schumache. Methods to Study the Roles of Rho GTPases in Dendritic Tree Complexity. Methods in molecular biology (Clifton, N.J.). vol 1821. 2019-03-20. PMID:30062421. |
methods to assess the complexity of dendritic arbors like the sholl analysis, and techniques to investigate rac1 activity in hippocampal cells, and specifically in neuronal dendrites, such as fluorescence resonance energy transfer (fret) imaging are presented. |
2019-03-20 |
2023-08-13 |
Not clear |
| L A Martinez, Maria Victoria Tejada-Simo. Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28688003. |
herein, we report that fmr1 ko mouse hippocampus exhibits increased levels of membrane-bound rac1, which may prevent proper learning-induced synaptic changes. |
2019-02-26 |
2023-08-13 |
mouse |
| L A Martinez, Maria Victoria Tejada-Simo. Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28688003. |
we also determine that increasing training intensity during fear conditioning (fc) training restores contextual memory in fmr1 ko mice and reduces membrane-bound rac1 in fmr1 ko hippocampus. |
2019-02-26 |
2023-08-13 |
mouse |
| Elena Alvarez-Periel, Mar Puigdellívol, Verónica Brito, Florian Plattner, James A Bibb, Jordi Alberch, Silvia Giné. Cdk5 Contributes to Huntington's Disease Learning and Memory Deficits via Modulation of Brain Region-Specific Substrates. Molecular neurobiology. vol 55. issue 8. 2019-02-26. PMID:29288339. |
while the corticostriatal learning deficits are attenuated through compensatory regulation of nr2b surface levels, the rescue of hippocampal-dependent memory was likely due to restoration of hippocampal dendritic spine density along with an increase in rac1 activity. |
2019-02-26 |
2023-08-13 |
mouse |
| Luis A Martinez, Maria Victoria Tejada-Simo. Pharmacological Rescue of Hippocampal Fear Learning Deficits in Fragile X Syndrome. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29128904. |
we have previously shown that fxs mouse models exhibit learning and memory deficits as well as hyperactive rac1 in the hippocampus. |
2019-02-04 |
2023-08-13 |
mouse |
| Luis A Martinez, Maria Victoria Tejada-Simo. Pharmacological Rescue of Hippocampal Fear Learning Deficits in Fragile X Syndrome. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29128904. |
furthermore, long-term potentiation in hippocampal slices from fxs mice was increased after incubation with the rac1 inhibitor. |
2019-02-04 |
2023-08-13 |
mouse |
| Xuze Li, Zhifang Zhao, Lining Huang, Rongtian Kang, Xuefang Liu, Zhenming Don. The anti-apoptotic effect of nerve growth factor on propofol-induced neurotoxicity in hippocampal neurons is Rac1 dependent. Die Pharmazie. vol 73. issue 12. 2019-01-31. PMID:30522553. |
the anti-apoptotic effect of nerve growth factor on propofol-induced neurotoxicity in hippocampal neurons is rac1 dependent. |
2019-01-31 |
2023-08-13 |
Not clear |
| Valentina Zamboni, Maria Armentano, Gabriella Sarò, Elisa Ciraolo, Alessandra Ghigo, Giulia Germena, Alessandro Umbach, Pamela Valnegri, Maria Passafaro, Valentina Carabelli, Daniela Gavello, Veronica Bianchi, Patrizia D'Adamo, Ivan de Curtis, Nadia El-Assawi, Alessandro Mauro, Lorenzo Priano, Nicola Ferri, Emilio Hirsch, Giorgio R Merl. Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits. Scientific reports. vol 6. 2018-08-20. PMID:27713499. |
disruption of arhgap15 results in hyperactive rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits. |
2018-08-20 |
2023-08-13 |
Not clear |
| Chih-Ming Chen, Lauren L Orefice, Shu-Ling Chiu, Tara A LeGates, Samer Hattar, Richard L Huganir, Haiqing Zhao, Baoji Xu, Rejji Kuruvill. Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 4. 2018-04-12. PMID:28069946. |
wnt5a expression in hippocampal neurons begins postnatally, and its deletion attenuated camkii and rac1 activity, reduced glun1 glutamate receptor expression, and impaired synaptic plasticity and spatial learning and memory in 3-mo-old mice. |
2018-04-12 |
2023-08-13 |
mouse |
| Chris M Valdez, Geoffrey G Murphy, Asim A Be. The Rac-GAP alpha2-chimaerin regulates hippocampal dendrite and spine morphogenesis. Molecular and cellular neurosciences. vol 75. 2018-01-12. PMID:27297944. |
we have identified the rac1-gtpase activating protein, α2-chimaerin, as a critical negative regulator of rac1 in hippocampal neurons. |
2018-01-12 |
2023-08-13 |
Not clear |
| Katharine R Smith, Dipen Rajgor, Jonathan G Hanle. Differential regulation of the Rac1 GTPase-activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons. The Journal of biological chemistry. vol 292. issue 49. 2018-01-05. PMID:29046349. |
differential regulation of the rac1 gtpase-activating protein (gap) bcr during oxygen/glucose deprivation in hippocampal and cortical neurons. |
2018-01-05 |
2023-08-13 |
Not clear |
| Katharine R Smith, Dipen Rajgor, Jonathan G Hanle. Differential regulation of the Rac1 GTPase-activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons. The Journal of biological chemistry. vol 292. issue 49. 2018-01-05. PMID:29046349. |
increased rac1 activity caused by ogd/ischemia contributes to neuronal death in hippocampal neurons via diverse effects on nadph oxidase activity and dendritic spine morphology. |
2018-01-05 |
2023-08-13 |
Not clear |
| Katharine R Smith, Dipen Rajgor, Jonathan G Hanle. Differential regulation of the Rac1 GTPase-activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons. The Journal of biological chemistry. vol 292. issue 49. 2018-01-05. PMID:29046349. |
the rac1 guanine nucleotide exchange factor tiam1 mediates an ogd-induced increase in rac1 activity in hippocampal neurons; however, the identity of an antagonistic gap remains elusive. |
2018-01-05 |
2023-08-13 |
Not clear |
| Katharine R Smith, Dipen Rajgor, Jonathan G Hanle. Differential regulation of the Rac1 GTPase-activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons. The Journal of biological chemistry. vol 292. issue 49. 2018-01-05. PMID:29046349. |
here we show that the rac1 gap breakpoint cluster region (bcr) associates with nmda receptors (nmdars) along with tiam1 and that this protein complex is more abundant in hippocampal compared with cortical neurons. |
2018-01-05 |
2023-08-13 |
Not clear |
| Yunlong Liu, Shuwen Du, Li Lv, Bo Lei, Wei Shi, Yikai Tang, Lianzhang Wang, Yi Zhon. Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory. Current biology : CB. vol 26. issue 17. 2017-12-27. PMID:27593377. |
hippocampal activation of rac1 regulates the forgetting of object recognition memory. |
2017-12-27 |
2023-08-13 |
mouse |
| Yunlong Liu, Shuwen Du, Li Lv, Bo Lei, Wei Shi, Yikai Tang, Lianzhang Wang, Yi Zhon. Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory. Current biology : CB. vol 26. issue 17. 2017-12-27. PMID:27593377. |
the inhibition of rac1 activity in hippocampal neurons through targeted expression of a dominant-negative rac1 form extended object recognition memory from less than 72 hr to over 72 hr, whereas rac1 activation accelerated memory decay within 24 hr. |
2017-12-27 |
2023-08-13 |
mouse |
| Xiao-Mu Guo, Zhao-Hui Liao, Ye-Zheng Tao, Fei-Fei Wang, Lan M. [Optogenetic activation of dorsal hippocampal astrocytic Rac1 blocks the learning of associative memory]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 3. 2017-10-03. PMID:28638915. |
[optogenetic activation of dorsal hippocampal astrocytic rac1 blocks the learning of associative memory]. |
2017-10-03 |
2023-08-13 |
mouse |
| Xiao-Mu Guo, Zhao-Hui Liao, Ye-Zheng Tao, Fei-Fei Wang, Lan M. [Optogenetic activation of dorsal hippocampal astrocytic Rac1 blocks the learning of associative memory]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 3. 2017-10-03. PMID:28638915. |
we injected aav-pa-rac1 and aav-pa-rac1-c450a into dorsal hippocampus to investigate the role of the activation of rac1 in regulating the associative learning. |
2017-10-03 |
2023-08-13 |
mouse |
| Xiao-Mu Guo, Zhao-Hui Liao, Ye-Zheng Tao, Fei-Fei Wang, Lan M. [Optogenetic activation of dorsal hippocampal astrocytic Rac1 blocks the learning of associative memory]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 3. 2017-10-03. PMID:28638915. |
our data suggest that the activation of rac1 in dorsal hippocampal astrocyte plays an important role in the associative learning. |
2017-10-03 |
2023-08-13 |
mouse |
| Pritha Majumder, Jen-Fei Chu, Biswanath Chatterjee, Krishna B S Swamy, Che-Kun James She. Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP. Acta neuropathologica. vol 132. issue 5. 2017-09-20. PMID:27518042. |
using molecular, cellular and imaging approaches, we show that these two rna-binding proteins (rbp) co-repress the translation initiation of rac1, map1b and glur1 mrnas, and consequently the hippocampal spinogenesis. |
2017-09-20 |
2023-08-13 |
Not clear |