| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xianlin Zhu, Fan Zhang, Yufeng You, Hongbai Wang, Su Yuan, Banglin Wu, Rongyu Zhu, Dawei Liu, Fuxia Yan, Zaiping Wan. S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats. Cellular and molecular neurobiology. 2022-01-27. PMID:35083636. |
the protein expression of rac1, glua1, synapsin1, and psd95 in the hippocampus was detected by western blot. |
2022-01-27 |
2023-08-13 |
rat |
| Xianlin Zhu, Fan Zhang, Yufeng You, Hongbai Wang, Su Yuan, Banglin Wu, Rongyu Zhu, Dawei Liu, Fuxia Yan, Zaiping Wan. S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats. Cellular and molecular neurobiology. 2022-01-27. PMID:35083636. |
our results showed that ketamine can up-regulate the expression and activity of rac1; increase the spine density and the expression of synaptic-related proteins such as glua1, synapsin1, and psd95 in the hippocampus of stressed rats; reduce the cums-induced ltp impairments; and consequently improve depression-like behavior. |
2022-01-27 |
2023-08-13 |
rat |
| Xianlin Zhu, Fan Zhang, Yufeng You, Hongbai Wang, Su Yuan, Banglin Wu, Rongyu Zhu, Dawei Liu, Fuxia Yan, Zaiping Wan. S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats. Cellular and molecular neurobiology. 2022-01-27. PMID:35083636. |
however, rac1 inhibitor nsc23766 could have effectively reversed ketamine-mediated changes in the hippocampus of rats and counteracted its antidepressant effects. |
2022-01-27 |
2023-08-13 |
rat |
| Xianlin Zhu, Fan Zhang, Yufeng You, Hongbai Wang, Su Yuan, Banglin Wu, Rongyu Zhu, Dawei Liu, Fuxia Yan, Zaiping Wan. S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats. Cellular and molecular neurobiology. 2022-01-27. PMID:35083636. |
the specific mechanism of s-ketamine's antidepressant effect may be related to the up-regulation of the expression and activity of rac1 in the hippocampus of stressed rats, thus enhancing synaptic plasticity. |
2022-01-27 |
2023-08-13 |
rat |
| Anna Longatti, Luisa Ponzoni, Edoardo Moretto, Giorgia Giansante, Norma Lattuada, Maria Nicol Colombo, Maura Francolini, Mariaelvina Sala, Luca Murru, Maria Passafar. Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice. Molecular neurobiology. vol 58. issue 12. 2021-12-04. PMID:34455539. |
arhgap22 disruption leads to rac1 hyperactivity affecting hippocampal glutamatergic synapses and cognition in mice. |
2021-12-04 |
2023-08-13 |
mouse |
| Dongyang Cui, Xiaodong Jiang, Ming Chen, Huan Sheng, Da Shao, Li Yang, Xinli Guo, Yingqi Wang, Bin Lai, Ping Zhen. Activation of Rac1 Has an Opposing Effect on Induction and Maintenance of Long-Term Potentiation in Hippocampus by Acting on Different Kinases. Frontiers in molecular neuroscience. vol 14. 2021-09-18. PMID:34531724. |
activation of rac1 has an opposing effect on induction and maintenance of long-term potentiation in hippocampus by acting on different kinases. |
2021-09-18 |
2023-08-13 |
Not clear |
| Dongyang Cui, Xiaodong Jiang, Ming Chen, Huan Sheng, Da Shao, Li Yang, Xinli Guo, Yingqi Wang, Bin Lai, Ping Zhen. Activation of Rac1 Has an Opposing Effect on Induction and Maintenance of Long-Term Potentiation in Hippocampus by Acting on Different Kinases. Frontiers in molecular neuroscience. vol 14. 2021-09-18. PMID:34531724. |
a previous study showed that the activation of rac1 had an opposing effect on induction and maintenance of long-term potentiation (ltp) in the hippocampus. |
2021-09-18 |
2023-08-13 |
Not clear |
| Dongyang Cui, Xiaodong Jiang, Ming Chen, Huan Sheng, Da Shao, Li Yang, Xinli Guo, Yingqi Wang, Bin Lai, Ping Zhen. Activation of Rac1 Has an Opposing Effect on Induction and Maintenance of Long-Term Potentiation in Hippocampus by Acting on Different Kinases. Frontiers in molecular neuroscience. vol 14. 2021-09-18. PMID:34531724. |
in the present work, we find that the activation of rac1 during the induction of ltp leads to an activation of pkcι/λ by phosphatidylinositol-3-kinase (pi3k), whereas the activation of rac1 during the maintenance of ltp leads to the inhibition of pkmζ by lim_kinase (limk) in the hippocampus. |
2021-09-18 |
2023-08-13 |
Not clear |
| Dongyang Cui, Xiaodong Jiang, Ming Chen, Huan Sheng, Da Shao, Li Yang, Xinli Guo, Yingqi Wang, Bin Lai, Ping Zhen. Activation of Rac1 Has an Opposing Effect on Induction and Maintenance of Long-Term Potentiation in Hippocampus by Acting on Different Kinases. Frontiers in molecular neuroscience. vol 14. 2021-09-18. PMID:34531724. |
this result suggests that during different stages of ltp, the activation of rac1 can modulate different signaling pathways, which leads to an opposing effect on the induction and maintenance of ltp in the hippocampus. |
2021-09-18 |
2023-08-13 |
Not clear |
| Ying Wang, Xiaomin Du, Dan Wang, Jun Wang, Juan D. Effects of Bisphenol A Exposure during Pregnancy and lactation on Hippocampal Function in Newborn Rats. International journal of medical sciences. vol 17. issue 12. 2021-06-01. PMID:32714078. |
in summary, our study indicated that bpa exposure during pregnancy and lactation could impair the hippocampal function of male offspring by affecting the growth and apoptosis of hippocampal neurons, which might be due to the abnormal regulation of rhoa and rac1. |
2021-06-01 |
2023-08-13 |
rat |
| Luis Solabre Valois, Vanilla Hua Shi, Paul Bishop, Bangfu Zhu, Yasuko Nakamura, Kevin A Wilkinson, Jeremy M Henle. Neurotrophic effects of Botulinum neurotoxin type A in hippocampal neurons involve activation of Rac1 by the non-catalytic heavy chain (HC IBRO neuroscience reports. vol 10. 2021-05-28. PMID:34041508. |
neurotrophic effects of botulinum neurotoxin type a in hippocampal neurons involve activation of rac1 by the non-catalytic heavy chain (hc botulinum neurotoxins (bonts) are extremely potent naturally occurring poisons that act by silencing neurotransmission. |
2021-05-28 |
2023-08-13 |
Not clear |
| Frank Adu-Nti, Xu Gao, Jia-Min Wu, Jing Li, Javed Iqbal, Riaz Ahmad, Xin-Ming M. Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice. Frontiers in pharmacology. vol 12. 2021-05-26. PMID:34025413. |
ost treatment improved cognitive deficit, alleviated anxiety- and depression-like behaviors induced by ovx, and reversed ovx-induced alterations in the levels of synaptic proteins and erα, bdnf, trkb, p-creb, p-akt and rac1 in the hippocampus. |
2021-05-26 |
2023-08-13 |
mouse |
| Biyao Lian, Mengying Liu, Zhen Lan, Tao Sun, Zhaoyou Meng, Qing Chang, Zhi Liu, Jiqiang Zhang, Chengjun Zha. Hippocampal overexpression of SGK1 ameliorates spatial memory, rescues Aβ pathology and actin cytoskeleton polymerization in middle-aged APP/PS1 mice. Behavioural brain research. vol 383. 2021-05-25. PMID:31981651. |
levels of hippocampal adam10 (α-secretase) and ide (aβ degradase), actin remodeling related proteins rictor, rac1, cdc42 and profilin-1 were significantly increased after osgk1 treatment while hippocampal bace1 (γ-secretase) and cofilin remained unchanged. |
2021-05-25 |
2023-08-13 |
mouse |
| Cheng-Yi Yang, Ting-Hsuan Yu, Wan-Ling Wen, Pin Ling, Kuei-Sen Hs. Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 25. 2020-06-18. PMID:30992372. |
conditional deletion of cc2d1a reduces hippocampal synaptic plasticity and impairs cognitive function through rac1 hyperactivation. |
2020-06-18 |
2023-08-13 |
human |
| Wenjuan Wu, Shuwen Du, Wei Shi, Yunlong Liu, Ying Hu, Zuolei Xie, Xinsheng Yao, Zhenyu Liu, Weiwei Ma, Lin Xu, Chao Ma, Yi Zhon. Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer's disease. Protein & cell. vol 10. issue 10. 2020-05-11. PMID:31321704. |
here, we showed that rac1 activity is aberrantly elevated in the hippocampal tissues of ad patients and ad animal models. |
2020-05-11 |
2023-08-13 |
mouse |
| Roberta Pennucci, Irene Gucciardi, Ivan de Curti. Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons. PloS one. vol 14. issue 8. 2020-03-09. PMID:31369617. |
rac1 and rac3 gtpases differently influence the morphological maturation of dendritic spines in hippocampal neurons. |
2020-03-09 |
2023-08-13 |
Not clear |
| Roberta Pennucci, Irene Gucciardi, Ivan de Curti. Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons. PloS one. vol 14. issue 8. 2020-03-09. PMID:31369617. |
here, we have addressed the role of each gtpase in the formation of dendritic spines by overexpressing either rac1 or rac3 in wildtype neurons, or by re-expressing either gtpase in double knockout hippocampal cultures. |
2020-03-09 |
2023-08-13 |
Not clear |
| Roberta Pennucci, Irene Gucciardi, Ivan de Curti. Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons. PloS one. vol 14. issue 8. 2020-03-09. PMID:31369617. |
we show that the rac3 protein is expressed with rac1 in developing hippocampal neurons. |
2020-03-09 |
2023-08-13 |
Not clear |
| Yunlong Liu, Li Lv, Lianzhang Wang, Yi Zhon. Social Isolation Induces Rac1-Dependent Forgetting of Social Memory. Cell reports. vol 25. issue 2. 2019-12-18. PMID:30304669. |
the impairment is caused by elevated rac1 activity in the hippocampus. |
2019-12-18 |
2023-08-13 |
mouse |
| Mirta Borin, Claudia Saraceno, Marcella Catania, Erika Lorenzetto, Valeria Pontelli, Anna Paterlini, Silvia Fostinelli, Anna Avesani, Giuseppe Di Fede, Gianluigi Zanusso, Luisa Benussi, Giuliano Binetti, Simone Zorzan, Roberta Ghidoni, Mario Buffelli, Silvia Bologni. Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:30005699. |
notably, rac1 was abnormally activated in the hippocampus of 6-week-old 3xtg-ad mice. |
2019-06-04 |
2023-08-13 |
mouse |