| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Gan, Ze-Yang Ding, Cheng Gan, Rong-Rong Mao, Heng Zhou, Lin Xu, Qi-Xin Zho. Corticosterone regulates fear memory via Rac1 activity in the hippocampus. Psychoneuroendocrinology. vol 71. 2017-09-18. PMID:27249795. |
corticosterone regulates fear memory via rac1 activity in the hippocampus. |
2017-09-18 |
2023-08-13 |
Not clear |
| Beata Fuchsova, Anabel Alvarez Juliá, Hooriyah S Rizavi, Alberto Carlos Frasch, Ghanshyam N Pande. Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression. Neuroscience. vol 333. 2017-09-06. PMID:27474226. |
using quantitative polymerase chain reaction (qpcr), mrna levels and coexpression of the group i paks: pak1, pak2, and pak3 as well as of their activators: rac1, cdc42 and arhgef7 were examined in postmortem samples from the pfc (n=25) and the hippocampus (n=23) of subjects with depression and compared to control subjects (pfc n=24; hippocampus n=21). |
2017-09-06 |
2023-08-13 |
human |
| Sandra Oliveira Braz, Andrea Cruz, Andrea Lobo, Joana Bravo, Joana Moreira-Ribeiro, Isabel Pereira-Castro, Jaime Freitas, Joao B Relvas, Teresa Summavielle, Alexandra Moreir. Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1860. issue 6. 2017-08-14. PMID:28274785. |
in particular, we show that rac1 originate mrna isoforms with longer 3' utrs specifically during neurite growth of cortical, but not hippocampal neurons. |
2017-08-14 |
2023-08-13 |
Not clear |
| Emi Nakamura, Hiroyuki Kinoshita, Guo-Gang Feng, Hisaki Hayashi, Maiko Satomoto, Motohiko Sato, Yoshihiro Fujiwar. Sevoflurane Inhalation Accelerates the Long-Term Memory Consolidation via Small GTPase Overexpression in the Hippocampus of Mice in Adolescence. PloS one. vol 11. issue 9. 2017-08-02. PMID:27632208. |
the current study was designed to examine whether sevoflurane exposure to mice in early adolescence modifies the long-term learning ability concomitantly with the changes in f-actin constitution as well as superoxide production in the hippocampus according to the levels of rac1 protein expression. |
2017-08-02 |
2023-08-13 |
mouse |
| Emi Nakamura, Hiroyuki Kinoshita, Guo-Gang Feng, Hisaki Hayashi, Maiko Satomoto, Motohiko Sato, Yoshihiro Fujiwar. Sevoflurane Inhalation Accelerates the Long-Term Memory Consolidation via Small GTPase Overexpression in the Hippocampus of Mice in Adolescence. PloS one. vol 11. issue 9. 2017-08-02. PMID:27632208. |
sevoflurane inhalation augmented f-actin constitution coexisting with the rac1 protein overexpression in the hippocampus whereas it did not alter the levels of superoxide. |
2017-08-02 |
2023-08-13 |
mouse |
| Emi Nakamura, Hiroyuki Kinoshita, Guo-Gang Feng, Hisaki Hayashi, Maiko Satomoto, Motohiko Sato, Yoshihiro Fujiwar. Sevoflurane Inhalation Accelerates the Long-Term Memory Consolidation via Small GTPase Overexpression in the Hippocampus of Mice in Adolescence. PloS one. vol 11. issue 9. 2017-08-02. PMID:27632208. |
sevoflurane exposure to 4-week-old mice accelerates the long-term memory concomitantly with the enhanced f-actin constitution coexisting with the small gtpase rac1 overexpression in the hippocampus. |
2017-08-02 |
2023-08-13 |
mouse |
| Lizhu Jiang, Rongrong Mao, Jianbin Tong, Jinnan Li, Anping Chai, Qixin Zhou, Yuexiong Yang, Liping Wang, Lingjiang Li, Lin X. Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear. Neuropharmacology. vol 109. 2017-06-19. PMID:27329554. |
inhibition of rac1 activity in the hippocampus impaired extinction of contextual fear. |
2017-06-19 |
2023-08-13 |
rat |
| Lizhu Jiang, Rongrong Mao, Jianbin Tong, Jinnan Li, Anping Chai, Qixin Zhou, Yuexiong Yang, Liping Wang, Lingjiang Li, Lin X. Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear. Neuropharmacology. vol 109. 2017-06-19. PMID:27329554. |
our previous study had shown that rac1 activity in hippocampus plays a crucial role in the learning of contextual fear memory in rats. |
2017-06-19 |
2023-08-13 |
rat |
| Lizhu Jiang, Rongrong Mao, Jianbin Tong, Jinnan Li, Anping Chai, Qixin Zhou, Yuexiong Yang, Liping Wang, Lingjiang Li, Lin X. Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear. Neuropharmacology. vol 109. 2017-06-19. PMID:27329554. |
we found that massed extinction obviously upregulated hippocampal rac1 activity and induced long-term extinction of contextual fear in rats. |
2017-06-19 |
2023-08-13 |
rat |
| Lizhu Jiang, Rongrong Mao, Jianbin Tong, Jinnan Li, Anping Chai, Qixin Zhou, Yuexiong Yang, Liping Wang, Lingjiang Li, Lin X. Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear. Neuropharmacology. vol 109. 2017-06-19. PMID:27329554. |
our study demonstrates that inhibition of rac1 activity in the hippocampus impaired extinction of contextual fear, suggesting that modulating rac1 activity of the hippocampus may be promising therapy of fear disorders. |
2017-06-19 |
2023-08-13 |
rat |
| Jana Schulz, Kristin Franke, Manfred Frick, Stefan Schumache. Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity. Journal of neurochemistry. vol 139. issue 1. 2017-06-09. PMID:27412363. |
combining gain-of-function and loss-of-function analysis in primary hippocampal neurons, we find that rac1 is essential for caleb/ngc-mediated dendritic branching. |
2017-06-09 |
2023-08-13 |
Not clear |
| Lizhu Jiang, Rongrong Mao, Qixin Zhou, Yuexiong Yang, Jun Cao, Yuqiang Ding, Yuan Yang, Xia Zhang, Lingjiang Li, Lin X. Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25613020. |
inhibition of rac1 activity in the hippocampus impairs the forgetting of contextual fear memory. |
2016-12-13 |
2023-08-13 |
rat |
| Lizhu Jiang, Rongrong Mao, Qixin Zhou, Yuexiong Yang, Jun Cao, Yuqiang Ding, Yuan Yang, Xia Zhang, Lingjiang Li, Lin X. Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25613020. |
here, we investigated whether inhibition of rac1 activity in rat hippocampus could contribute to the hypermnesia of contextual fear. |
2016-12-13 |
2023-08-13 |
rat |
| Lizhu Jiang, Rongrong Mao, Qixin Zhou, Yuexiong Yang, Jun Cao, Yuqiang Ding, Yuan Yang, Xia Zhang, Lingjiang Li, Lin X. Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25613020. |
we found that spaced but not massed training of contextual fear conditioning caused inhibition of rac1 activity in the hippocampus and heightened contextual fear. |
2016-12-13 |
2023-08-13 |
rat |
| Lizhu Jiang, Rongrong Mao, Qixin Zhou, Yuexiong Yang, Jun Cao, Yuqiang Ding, Yuan Yang, Xia Zhang, Lingjiang Li, Lin X. Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25613020. |
our study firstly demonstrates that contextual fear memory in rats is actively regulated by rac1 activity in the hippocampus, which suggests that the forgetting impairment of traumatic events in posttraumatic stress disorder may be contributed to the pathological inhibition of rac1 activity in the hippocampus. |
2016-12-13 |
2023-08-13 |
rat |
| Roberta Pennucci, Francesca Talpo, Veronica Astro, Valentina Montinaro, Lorenzo Morè, Marco Cursi, Valerio Castoldi, Sara Chiaretti, Veronica Bianchi, Silvia Marenna, Marco Cambiaghi, Diletta Tonoli, Letizia Leocani, Gerardo Biella, Patrizia D'Adamo, Ivan de Curti. Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 2. 2016-10-11. PMID:26582364. |
we have addressed the function of rac1 and rac3 proteins during the late maturation of hippocampal interneurons. |
2016-10-11 |
2023-08-13 |
mouse |
| Kuangfu Hsiao, Hala Harony-Nicolas, Joseph D Buxbaum, Ozlem Bozdagi-Gunal, Deanna L Benso. Cyfip1 Regulates Presynaptic Activity during Development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 5. 2016-06-22. PMID:26843638. |
such dysregulation occurs downstream of rac1 as acute exposure to rac1 inhibitors rescues presynaptic responses in culture and in hippocampal slices. |
2016-06-22 |
2023-08-13 |
mouse |
| Hongwei Kan, Wen Hu, Yuchan Wang, Wangyang Wu, Yanyan Yin, Yan Liang, Chunyan Wang, Dake Huang, Weizu L. NADPH oxidase-derived production of reactive oxygen species is involved in learning and memory impairments in 16-month-old female rats. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26058943. |
furthermore, the activity of superoxide dismutase (sod), level of malondialdehyde (mda), production of ros and expression levels of nox2, p47phox, ras‑related c3 botulinum toxin substrate 1 (rac1) and protein kinase c α (pkcα) were investigated in the cortex and hippocampus of 3‑month and 16‑month old female rats. |
2016-05-17 |
2023-08-13 |
rat |
| Bin-Yin Li, Hui-Dong Tang, Yuan Qiao, Sheng-Di Che. Mental Training for Cognitive Improvement in Elderly People: What have We Learned from Clinical and Neurophysiologic Studies? Current Alzheimer research. vol 12. issue 6. 2016-05-02. PMID:26238812. |
rac1 and nmda receptors are thought to be involved in hippocampal neurogenesis, which is induced by learning. |
2016-05-02 |
2023-08-13 |
mouse |
| Bérengère Petit, Alain Boissy, Adroaldo Zanella, Elodie Chaillou, Stéphane Andanson, Sébastien Bes, Frédéric Lévy, Marjorie Coulo. Stress during pregnancy alters dendritic spine density and gene expression in the brain of new-born lambs. Behavioural brain research. vol 291. 2016-03-28. PMID:26005125. |
for each group, a newborn from each litter was sacrificed at birth to collect its brain and analyze its expression levels of genes involved in neuronal dendritic morphology (dlg4, rac1, rhoa, doc2b), synaptic transmission (nr1, grin2a, grin2b) and glucocorticoid receptor (nr3c1) in hippocampus (hpc), prefrontal cortex (pfc) and amygdala (amyg). |
2016-03-28 |
2023-08-13 |
Not clear |