| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Candelaria Gomez-Manzano, Juan Fueyo, Hong Jiang, Tricia L Glass, Ho-Young Lee, Min Hu, Juinn-Lin Liu, Sushma L Jasti, Ta-Jen Liu, Charles A Conrad, W K Alfred Yun. Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Annals of neurology. vol 53. issue 1. 2004-01-16. PMID:12509854. |
western blot assays demonstrated that, in a normoxic environment, pten downregulates hif-1 alpha. |
2004-01-16 |
2023-08-12 |
human |
| Guizhu Hong, Bill Davis, Nachima Khatoon, Sharon F Baker, John Brow. PPAR gamma-dependent anti-inflammatory action of rosiglitazone in human monocytes: suppression of TNF alpha secretion is not mediated by PTEN regulation. Biochemical and biophysical research communications. vol 303. issue 3. 2003-05-29. PMID:12670479. |
ppar gamma-dependent anti-inflammatory action of rosiglitazone in human monocytes: suppression of tnf alpha secretion is not mediated by pten regulation. |
2003-05-29 |
2023-08-12 |
human |
| Ying-An Jiang, Li-Fang Fan, Chong-Qing Jiang, You-Yuan Zhang, He-Sheng Luo, Zhi-Jiao Tang, Dong Xia, Ming Wan. Expression and significance of PTEN, hypoxia-inducible factor-1 alpha in colorectal adenoma and adenocarcinoma. World journal of gastroenterology. vol 9. issue 3. 2003-04-22. PMID:12632503. |
expression and significance of pten, hypoxia-inducible factor-1 alpha in colorectal adenoma and adenocarcinoma. |
2003-04-22 |
2023-08-12 |
Not clear |
| Ying-An Jiang, Li-Fang Fan, Chong-Qing Jiang, You-Yuan Zhang, He-Sheng Luo, Zhi-Jiao Tang, Dong Xia, Ming Wan. Expression and significance of PTEN, hypoxia-inducible factor-1 alpha in colorectal adenoma and adenocarcinoma. World journal of gastroenterology. vol 9. issue 3. 2003-04-22. PMID:12632503. |
to investigate the expression and significance of pten, hypoxia-inducible factor-1 alpha (hif-1alpha), and targeting gene vegf during colorectal carciogenesis. |
2003-04-22 |
2023-08-12 |
Not clear |
| J Trojan, G Plotz, A Brieger, J Raedle, S J Meltzer, M Wolter, S Zeuze. Activation of a cryptic splice site of PTEN and loss of heterozygosity in benign skin lesions in Cowden disease. The Journal of investigative dermatology. vol 117. issue 6. 2002-04-05. PMID:11886535. |
we found a pten ivs2 + 1g > alpha 5'-splicing acceptor mutation resulting in activation of a cryptic splice site. |
2002-04-05 |
2023-08-12 |
Not clear |
| Tine Van de Sande, Ellen De Schrijver, Walter Heyns, Guido Verhoeven, Johannes V Swinne. Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. Cancer research. vol 62. issue 3. 2002-03-05. PMID:11830512. |
in support of a role for akt/protein kinase b as a downstream effector, cotransfection of constitutively active akt1/protein kinase b alpha abrogates the inhibitory effects of pten expression and restores fas promoter activity. |
2002-03-05 |
2023-08-12 |
Not clear |
| S M Walker, C P Downes, N R Lesli. TPIP: a novel phosphoinositide 3-phosphatase. The Biochemical journal. vol 360. issue Pt 2. 2002-01-10. PMID:11716755. |
tpip (tpte and pten homologous inositol lipid phosphatase) is a novel phosphatase that occurs in several differentially spliced forms of which two, tpip alpha and tpip beta, appear to be functionally distinct. |
2002-01-10 |
2023-08-12 |
human |
| S M Walker, C P Downes, N R Lesli. TPIP: a novel phosphoinositide 3-phosphatase. The Biochemical journal. vol 360. issue Pt 2. 2002-01-10. PMID:11716755. |
tpip alpha displays similar phosphoinositide 3-phosphatase activity compared with pten against ptdins(3,4,5)p(3), ptdins(3,5)p(2), ptdins(3,4)p(2) and ptdins(3)p, has n-terminal transmembrane domains and appears to be localized on the endoplasmic reticulum. |
2002-01-10 |
2023-08-12 |
human |
| S M Walker, C P Downes, N R Lesli. TPIP: a novel phosphoinositide 3-phosphatase. The Biochemical journal. vol 360. issue Pt 2. 2002-01-10. PMID:11716755. |
we suggest that tpip alpha plays a role in regulating phosphoinositide signalling on the endoplasmic reticulum, and might also represent a tumour suppressor and functional homologue of pten in some tissues. |
2002-01-10 |
2023-08-12 |
human |
| J Snaddon, E K Parkinson, J A Craft, C Bartholomew, R Fulto. Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head and neck, despite loss of heterozygosity at this locus. British journal of cancer. vol 84. issue 12. 2001-07-26. PMID:11401316. |
pten is an important negative regulator of pi3kinase, of which subunit alpha is frequently amplified in scc-hn. |
2001-07-26 |
2023-08-12 |
human |
| T M Hong, P C Yang, K Peck, J J Chen, S C Yang, Y C Chen, C W W. Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray. American journal of respiratory cell and molecular biology. vol 23. issue 3. 2000-09-29. PMID:10970827. |
pten overexpression downregulated genes, including integrin alpha(6), laminin beta(3), heparin-binding epidermal growth factor-like growth factor, urokinase-type plasminogen activator, myb protein b, akt2, and some expressed sequence tag (est) clones. |
2000-09-29 |
2023-08-12 |
human |
| T M Hong, P C Yang, K Peck, J J Chen, S C Yang, Y C Chen, C W W. Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray. American journal of respiratory cell and molecular biology. vol 23. issue 3. 2000-09-29. PMID:10970827. |
northern hybridization and flow cytometry analysis also confirmed that pten overexpression results in the reduced expression of the integrin alpha(6) subunit. |
2000-09-29 |
2023-08-12 |
human |
| T M Hong, P C Yang, K Peck, J J Chen, S C Yang, Y C Chen, C W W. Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray. American journal of respiratory cell and molecular biology. vol 23. issue 3. 2000-09-29. PMID:10970827. |
the results of this study indicate that pten overexpression may inhibit lung cancer invasion by downregulation of a panel of genes including integrin alpha(6). |
2000-09-29 |
2023-08-12 |
human |
| T Minaguchi, T Mori, Y Kanamori, M Matsushima, H Yoshikawa, Y Taketani, Y Nakamur. Growth suppression of human ovarian cancer cells by adenovirus-mediated transfer of the PTEN gene. Cancer research. vol 59. issue 24. 2000-01-24. PMID:10626791. |
we also found that the level of transcription of integrin alpha(v) in ovarian cancer cells correlated with the efficiency of transduction (p = 0.014) and with the degree of growth inhibition after pten gene transfer (p = 0.009). |
2000-01-24 |
2023-08-12 |
human |
| Y Lu, Y Z Lin, R LaPushin, B Cuevas, X Fang, S X Yu, M A Davies, H Khan, T Furui, M Mao, R Zinner, M C Hung, P Steck, K Siminovitch, G B Mill. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597304. |
in the presence of low concentrations of serum, enforced pten expression results in a marked increase in cellular apoptosis, a finding which is consistent with the capacity of pten to alter the phosphorylation, and presumably function, of the akt, bad, p70s6 kinase and gsk3 alpha apoptosis regulators. |
2000-01-04 |
2023-08-12 |
Not clear |