| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petra Hillmann, Doriano Fabbr. PI3K/mTOR Pathway Inhibition: Opportunities in Oncology and Rare Genetic Diseases. International journal of molecular sciences. vol 20. issue 22. 2020-04-08. PMID:31752127. |
in particular, genetically induced pi3k/mtor pathway activation causes rare disorders, known as overgrowth syndromes, like pten (phosphatase and tensin homolog) hamartomas, tuberous sclerosis complex (tsc), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca)-related overgrowth spectrum (pros), and activated pi3-kinase delta syndrome (pi3kcd, apds). |
2020-04-08 |
2023-08-13 |
Not clear |
| Zelin Tian, Jianing Tang, Qian Yang, Xin Li, Jian Zhu, Gaosong W. Atypical ubiquitin-binding protein SHARPIN promotes breast cancer progression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 119. 2020-02-25. PMID:31518875. |
abnormal oncogenic signaling has important effects on the development of breast cancer, such as erα/ esr1 (estrogen receptor alpha), pten (gene of phosphate and tension homology deleted on chromsome ten), nfκb(nuclear factor κb), and tumor protein p53 (p53 / tp53). |
2020-02-25 |
2023-08-13 |
Not clear |
| Nabil Hadi Alowiri, Shaden Muawia Hanafy, Reham Abdel Haleem, Ahmed Abdellati. PIK3CA and PTEN Genes Expressions in Breast Cancer. Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 9. 2020-02-14. PMID:31554385. |
the current study aimed to evaluate the expressions of two main regulators of pi3k pathway;phosphatidylinositol-3- kinase catalytic subunit alpha as activator (pik3ca), and phosphatase and tensin-homologas inhibitor (pten), in breast carcinoma tissue, and compare with their expressions in adjacent normal breast tissue.methods: a total of fifty female patients with breast carcinoma from surgical oncology unit of alexandria-mainuniversity hospital were included in this study. |
2020-02-14 |
2023-08-13 |
Not clear |
| Christopher A Waker, Robert M Lobe. Brain Tumors of Glial Origin. Advances in experimental medicine and biology. vol 1190. 2019-12-06. PMID:31760651. |
glioblastoma may evolve from lower-grade lesions with idh mutations, or arise independently from copy number changes in platelet-derived growth factor receptor alpha (pdgfra) and phosphatase and tensin homolog (pten). |
2019-12-06 |
2023-08-13 |
Not clear |
| Judit Olasz, Zoltán Doleschall, Zsuzsanna Dunai, András Pazsitka, Orsolya Csuk. [PI3K/AKT pathway activation and therapeutic consequences in breast cancer]. Magyar onkologia. vol 59. issue 4. 2019-11-20. PMID:26665196. |
the phosphatidylinositol-3-kinase/akt (pi3k/akt) pathway is commonly deregulated in breast cancer through several mechanisms, including pi3k catalytic subunit alpha (pik3ca) mutations and loss of phosphatase and tensin homolog (pten). |
2019-11-20 |
2023-08-13 |
Not clear |
| Sarah Minner, Jannes Lutz, Claudia Hube-Magg, Martina Kluth, Ronald Simon, Doris Höflmayer, Eike Burandt, Maria Christina Tsourlakis, Guido Sauter, Franziska Büscheck, Waldemar Wilczak, Stefan Steurer, Thorsten Schlomm, Hartwig Huland, Markus Graefen, Alexander Haese, Hans Heinzer, Frank Jacobsen, Andrea Hinsch, Alexandra Poos, Marcus Oswald, Karsten Rippe, Rainer König, Cornelia Schroede. Loss of CCAAT-enhancer-binding protein alpha (CEBPA) is linked to poor prognosis in PTEN deleted and TMPRSS2:ERG fusion type prostate cancers. The Prostate. vol 79. issue 3. 2019-11-15. PMID:30430607. |
loss of ccaat-enhancer-binding protein alpha (cebpa) is linked to poor prognosis in pten deleted and tmprss2:erg fusion type prostate cancers. |
2019-11-15 |
2023-08-13 |
Not clear |
| Zuoqing Li, Juntao Xie, Yingchun Fei, Pengfei Gao, Qigen Xie, Wenzong Gao, Zhe X. GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN. Biochemical and biophysical research communications. vol 510. issue 3. 2019-11-04. PMID:30722993. |
gdnf family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with pten. |
2019-11-04 |
2023-08-13 |
Not clear |
| Zuoqing Li, Juntao Xie, Yingchun Fei, Pengfei Gao, Qigen Xie, Wenzong Gao, Zhe X. GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN. Biochemical and biophysical research communications. vol 510. issue 3. 2019-11-04. PMID:30722993. |
in present study, we found that gdnf family receptor alpha 2 (gfra2) was upregulated in neuroblastoma cells and tissues, and its overexpression promoted neuroblastoma cell proliferation, as revealed using colony formation, soft agar growth, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assays tumor suppressor phosphatase and tensin homolog (pten) is an inhibitor of the phosphatidylinositol-4,5-bisphosphate 3-kinase (pi3k)/akt serine/threonine kinase (akt) pathway that interacts with gfra2. |
2019-11-04 |
2023-08-13 |
Not clear |
| Anna Onnis, Valentina Cianfanelli, Chiara Cassioli, Dijana Samardzic, Pier Giuseppe Pelicci, Francesco Cecconi, Cosima T Baldar. The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II. Autophagy. vol 14. issue 12. 2019-10-22. PMID:30109811. |
abbreviations: actb: actin beta; ampk: amp-activated protein kinase; atp: adenosine triphosphate; atg: autophagy-related; cycs: cytochrome c, somatic; clq: chloroquine; cox: cyclooxygenase; ctr: control; gfp: green fluorescent protein; hifia/hif alpha: hypoxia inducible factor 1 subunit alpha; ims: intermembrane space; lir: lc3 interacting region; map1lc3b/lc3b: microtubule associated protein 1 light chain 3 beta; mtor/mtor: mechanistic target of rapamycin kinase; oa: oligomycin and antimycin a; omm: outer mitochondrial membrane; phb: prohibitin; pbs: phosphate-buffered saline; pink1: pten induced putative kinase 1; rfp: red fluorescent protein; ros: reactive oxygen species; shc: src homology 2 domain-containing transforming protein; tmrm: tetramethylrhodamine, methyl ester; tomm: translocase of outer mitochondrial membrane; ulk1: unc-51 like autophagy activating kinase 1; wt: wild-type. |
2019-10-22 |
2023-08-13 |
Not clear |
| Steven Lehrer, Sheryl Green, Francine R Dembitzer, Peter H Rheinstein, Kenneth E Rosenzwei. Increased RNA Expression of von Willebrand Factor Gene Is Associated With Infiltrating Lobular Breast Cancer and Normal PAM50 Subtype. Cancer genomics & proteomics. vol 16. issue 3. 2019-09-06. PMID:31018945. |
ilc shows a high frequency of cadherin 1 (cdh1) mutations, along with loss of phosphatase and tensin homolog (pten), activation of alpha serine/threonine kinase (akt), and mutations in t-box transcription factor (tbx3) and forkhead box protein a1 (foxa1). |
2019-09-06 |
2023-08-13 |
Not clear |
| Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M Pascale, Diego F Calvisi, Xin Che. Functional role of SGK3 in PI3K/Pten driven liver tumor development. BMC cancer. vol 19. issue 1. 2019-08-13. PMID:30975125. |
activating mutations of pi3k catalytic subunit alpha (pik3ca) and/or loss of pten often occur in human hccs. |
2019-08-13 |
2023-08-13 |
human |
| Taranga Jyoti Baruah, Lakhon Km. Vicenin-2 acts as a radiosensitizer of the non-small cell lung cancer by lowering Akt expression. BioFactors (Oxford, England). vol 45. issue 2. 2019-07-22. PMID:30496626. |
we have conducted this study to check the effect of vcn-2 on the cell viability and the effect on pten (phosphatase and tensin homolog), pi3kca (phosphatidylinositol 4, 5-biphosphate 3-kinase catalytic subunit alpha isoform/pi3k 110α subunit), and akt1 when vcn-2 was used alone and in combination with radiation in the nsclc cell line nci-h23 (h23). |
2019-07-22 |
2023-08-13 |
Not clear |
| Xin Yang, Min Zhong, Jie Chen, Tingyu Li, Qian Cheng, Ying Da. HIF-1 Repression of PTEN Transcription Mediates Protective Effects of BMSCs on Neurons During Hypoxia. Neuroscience. vol 392. 2019-03-06. PMID:30267829. |
hif-1<alpha> repression of pten transcription mediates protective effects of bmscs on neurons during hypoxia. |
2019-03-06 |
2023-08-13 |
Not clear |
| Xin Yang, Min Zhong, Jie Chen, Tingyu Li, Qian Cheng, Ying Da. HIF-1 Repression of PTEN Transcription Mediates Protective Effects of BMSCs on Neurons During Hypoxia. Neuroscience. vol 392. 2019-03-06. PMID:30267829. |
it has been reported that hif-1<alpha> and pten are involved in the process of hypoxia-ischemia, but the specific roles that these proteins play remains to be understood. |
2019-03-06 |
2023-08-13 |
Not clear |
| Xiaofan Guo, Wei Qiu, Qinglin Liu, Mingyu Qian, Shaobo Wang, Zongpu Zhang, Xiao Gao, Zihang Chen, Hao Xue, Gang L. Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways. Oncogene. vol 37. issue 31. 2019-02-22. PMID:29713056. |
the hypoxia-inducible expression of mir-10a and mir-21 in gdes mediated gde-induced mdsc expansion and activation by targeting rar-related orphan receptor alpha (rora) and phosphatase and tensin homolog (pten). |
2019-02-22 |
2023-08-13 |
mouse |
| Sibylle Loibl, Silvia Darb-Esfahani, Jens Huober, Alexander Klimowicz, Jenny Furlanetto, Bianca Lederer, Arndt Hartmann, Holger Eidtmann, Berit Pfitzner, Peter A Fasching, Katharina Tiemann, Christian Jackisch, Keyur Mehta, Gunter von Minckwitz, Michael Untch, Carsten Denker. Integrated Analysis of PTEN and p4EBP1 Protein Expression as Predictors for pCR in HER2-Positive Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 22. issue 11. 2018-01-22. PMID:26758558. |
we investigated the correlation between phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), pten, p4ebp1 (phosphorylated e4 binding protein 1), and pathologic complete response (pcr) in patients receiving neoadjuvant therapy. |
2018-01-22 |
2023-08-13 |
Not clear |
| Siria A Lemma, Milla Kuusisto, Kirsi-Maria Haapasaari, Raija Sormunen, Tuula Lehtinen, Tuula Klaavuniemi, Mine Eray, Esa Jantunen, Ylermi Soini, Kaija Vasala, Jan Böhm, Niina Salokorpi, Petri Koivunen, Peeter Karihtala, Jussi Vuoristo, Taina Turpeenniemi-Hujanen, Outi Kuittine. Integrin alpha 10, CD44, PTEN, cadherin-11 and lactoferrin expressions are potential biomarkers for selecting patients in need of central nervous system prophylaxis in diffuse large B-cell lymphoma. Carcinogenesis. vol 38. issue 8. 2017-10-05. PMID:28854563. |
integrin alpha 10, cd44, pten, cadherin-11 and lactoferrin expressions are potential biomarkers for selecting patients in need of central nervous system prophylaxis in diffuse large b-cell lymphoma. |
2017-10-05 |
2023-08-13 |
Not clear |
| Matthias B Stope, Dominique Koensgen, Jörg Weimer, Madeleine Paditz, Martin Burchardt, Dirk Bauerschlag, Alexander Muste. The future therapy of endometrial cancer: microRNA's functionality, capability, and putative clinical application. Archives of gynecology and obstetrics. vol 294. issue 5. 2017-08-09. PMID:27637583. |
the available biomarkers, such as cellular tumor antigen p53 (tp53), phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (pten), and phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) genes alone might not be sufficient, and thus, new predictive and prognostic biomarkers are urgently required. |
2017-08-09 |
2023-08-13 |
Not clear |
| Oznur Yilmaz, Fusun Oztay, Ozgecan Kayala. Dasatinib attenuated bleomycin-induced pulmonary fibrosis in mice. Growth factors (Chur, Switzerland). vol 33. issue 5-6. 2016-10-19. PMID:26607773. |
blm treatment-induced cell proliferation and increased the levels of collagen-1, alpha smooth muscle actin, phospho (p)-pdgfr-alpha, p-src, p-extracellular signal-regulated kinases1/2 and p-cytoplasmic-abelson-kinase (c-abl) in lungs, and down-regulated pten expression. |
2016-10-19 |
2023-08-13 |
mouse |
| Yuzhi Liu, Wenyu Li, Mengyao Guo, Chengye Li, Changwei Qi. Protective Role of Selenium Compounds on the Proliferation, Apoptosis, and Angiogenesis of a Canine Breast Cancer Cell Line. Biological trace element research. vol 169. issue 1. 2016-09-26. PMID:26051789. |
the protein and mrna expression levels of vascular endothelial growth factor-alpha (vegf-alpha), angiopoietin-2 (ang-2), and hypoxia inducible factor-1 alpha (hif-1 alpha) were downregulated in each group, while that of phosphatase and tensin homolog (pten) were upregulated (p < 0.05). |
2016-09-26 |
2023-08-13 |
Not clear |