| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Su, Xu-Chao Zhang, She-Juan An, Wen-Zhao Zhong, Ying Huang, Shi-Liang Chen, Hong-Hong Yan, Zhi-Hong Chen, Wei-Bang Guo, Xiao-Sui Huang, Yi-Long W. Detecting the spectrum of multigene mutations in non-small cell lung cancer by Snapshot assay. Chinese journal of cancer. vol 33. issue 7. 2015-06-15. PMID:24823994. |
using the snapshot assay, mutation statuses were detected for egfr, kirsten rate sarcoma viral oncogene homolog (kras), phosphoinositide-3-kinase catalytic alpha polypeptide (pik3ca), v-raf murine sarcoma viral oncogene homolog b1 (braf), v-ras neuroblastoma viral oncogene homolog (nras), dual specificity mitogen activated protein kinase kinase 1 (mek1), phosphatase and tensin homolog (pten), and human epidermal growth factor receptor 2 (her2) in patient specimens and cell line dna. |
2015-06-15 |
2023-08-13 |
human |
| Bianca Cheaib, Aurélie Auguste, Alexandra Lear. The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges. Chinese journal of cancer. vol 34. issue 1. 2015-06-04. PMID:25556614. |
although it is likely that inhibition of the pi3k/akt/mtor pathway may have little effect in unselected oc patients, certain histological types, such as clear cell or endometrioid oc with frequent phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit alpha (pik3ca) and/or phosphatase and tensin homolog (pten) alterations, may be particularly suited to this approach. |
2015-06-04 |
2023-08-13 |
Not clear |
| Wen Zhang, Shuxin Wen, Taoyuan Zhang, Binquan Wang, Wei Gao, Lijuan L. [Expression and significance of PTEN and HIF-1α proteins in sinonasal inverted papilloma]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. vol 49. issue 5. 2015-04-21. PMID:25017225. |
to investigate the expression and clinical significance of phosphatase and tensin homology deleted on chromosome ten (pten) and hypoxia-inducible factor 1 alpha (hif-1α) in sinonasal inverted papilloma (snip) of different pathological grades. |
2015-04-21 |
2023-08-13 |
Not clear |
| Yanan Li, Yunzhi Zhou, Hongwu Wan. [Research status on molecular targeted therapy for squamous-cell lung cancer]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. vol 17. issue 8. 2015-04-02. PMID:25130969. |
sqclc molecular targeted therapy mainly epidermal growth factor receptor (egfr), phosphoin-3-kinase catalytic alpha polypeptide (pik3ca), fibroblast growth factor receptor 1 (fgfr1), discoidin domain receptor 2 (ddr2), phosphatase and tensin homolog deleted on chromosome ten (pten), braf, met, insulin-like growth factor 1 receptor (igf-1r) and other as the target of the drug, some targeted drugs are being developed, and some targeted drugs have entered clinical trials. |
2015-04-02 |
2023-08-13 |
Not clear |
| Hsien-Neng Huang, Ming-Chieh Lin, Wen-Chih Huang, Ying-Cheng Chiang, Kuan-Ting Ku. Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations and ZNF217 amplification in ovarian clear cell carcinoma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 27. issue 7. 2015-02-21. PMID:24336158. |
a total of 68 ovarian clear cell carcinoma cases were collected and subjected to immunohistochemistry testing for arid1a, smarca2, smarca4, smarcb1 and phosphatase and tensin homolog (pten), mutation analysis for phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) gene and fluorescence in situ hybridization for znf217 amplification. |
2015-02-21 |
2023-08-12 |
Not clear |
| Katharina Grupp, Rebecca Boumesli, Maria Christina Tsourlakis, Christina Koop, Waldemar Wilczak, Meike Adam, Guido Sauter, Ronald Simon, Jakob Robert Izbicki, Markus Graefen, Hartwig Huland, Stefan Steurer, Thorsten Schlomm, Sarah Minner, Alexander Quaa. The prognostic impact of high Nijmegen breakage syndrome (NBS1) gene expression in ERG-negative prostate cancers lacking PTEN deletion is driven by KPNA2 expression. International journal of cancer. vol 135. issue 6. 2014-09-22. PMID:24510842. |
high nbs1 expression was linked to biochemical recurrence in erg-negative and pten non-deleted cancers (p<0.0001), which was largely driven by high kpna2 karyopherin alpha 2 expression. |
2014-09-22 |
2023-08-12 |
Not clear |
| Adriana Olar, Dandan He, Diego Florentin, Yi Ding, Gustavo Ayal. Biologic correlates and significance of axonogenesis in prostate cancer. Human pathology. vol 45. issue 7. 2014-08-21. PMID:24767770. |
it also correlated with expression of proteins involved in survival pathways (phosphorylated alpha serine/threonine-protein kinase, nfκb, gsk-2, pim-2, c-myc, skp-2, srf, p27n, pten), with increased levels of hormonal regulation elements (androgen receptor, estrogen receptor α), and coregulators and repressors (src-1, src-2, aib-1, dax). |
2014-08-21 |
2023-08-13 |
Not clear |
| Thanyanan Reungwetwattana, Grace Kho D. Targeted therapies in development for non-small cell lung cancer. Journal of carcinogenesis. vol 12. 2014-06-24. PMID:24574860. |
in non-small cell lung cancer (nsclc), the erbb family of receptors (e.g., egfr [epidermal growth factor receptor], her2 [human epidermal growth factor receptor 2]), ras (rat sarcoma gene), braf (v-raf murine sarcoma viral oncogene homolog b1), mapk (mitogen-activated protein kinase) c-met (c-mesenchymal-epithelial transition), fgfr (fibroblast growth factor receptor), ddr2 (discoidin domain receptor 2), pik3ca (phosphatidylinositol-4,5-bisphosphate3-kinase, catalytic subunit alpha)), pten (phosphatase and tensin homolog), akt (protein kinase b), alk (anaplastic lym phoma kinase), ret (rearranged during transfection), ros1 (reactive oxygen species 1) and eph (erythropoietin-producing hepatoma) are key targets of various agents currently in clinical development. |
2014-06-24 |
2023-08-12 |
human |
| Meng Zhang, Man-Him Chan, Wen-Jian Tu, Li-Ran He, Chak-Man Lee, Miao H. Using the theory of coevolution to predict protein-protein interactions in non-small cell lung cancer. Chinese journal of cancer. vol 32. issue 2. 2013-11-14. PMID:23237220. |
fifteen key proteins were identified and categorized into a special protein family f(k), which included cyclin d1 (ccnd1), e-cadherin (cdh1), cyclin-dependent kinase inhibitor 2a (cdkn2a), chemokine (c-x-c motif) ligand 12 (cxcl12), epidermal growth factor (egf), epidermal growth factor receptor (egfr), tnf receptor superfamily, member 6(fas), fk506 binding protein 12-rapamycin associated protein 1 (frap1), o-6-methylguanine-dna methyltransferase (mgmt), parkinson protein 2, e3 ubiquitin protein ligase (park2), phosphatase and tensin homolog (pten), calcium channel voltage-dependent alpha 2/delta subunit 2 (cacna2d2), tubulin beta class i (tubb), swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 2 (smarca2), and wingless-type mmtv integration site family, member 7a (wnt7a). |
2013-11-14 |
2023-08-12 |
Not clear |
| Allison B Weisbrod, Lisa Zhang, Meenu Jain, Stephanie Barak, Martha M Quezado, Electron Kebebe. Altered PTEN, ATRX, CHGA, CHGB, and TP53 expression are associated with aggressive VHL-associated pancreatic neuroendocrine tumors. Hormones & cancer. vol 4. issue 3. 2013-11-01. PMID:23361940. |
subcellular distribution of phosphatase and tensin (pten), chromogranin a (chga), and alpha thalassemia/mental retardation syndrome x-linked (atrx) were significantly different by who classifications (p ≤ 0.05). |
2013-11-01 |
2023-08-12 |
Not clear |
| Irina Palimaru, Anja Brügmann, Marie Kim Wium-Andersen, Ebba Nexo, Boe Sandahl Sorense. Expression of PIK3CA, PTEN mRNA and PIK3CA mutations in primary breast cancer: association with lymph node metastases. SpringerPlus. vol 2. 2013-10-01. PMID:24083111. |
here, we explore differences in expression of important pi3k pathway regulators: the activator, phosphatidylinositol-3-kinase catalytic subunit alpha (pik3ca), and the tumour suppressor, phosphatase and tensin homolog (pten), in breast carcinoma tissue and normal breast tissue. |
2013-10-01 |
2023-08-12 |
Not clear |
| Chunhua Yang, Shujing Li, Miao Wang, Alan K Chang, Ying Liu, Feng Zhao, Liyun Xiao, Lin Han, Dao Wang, Shen Li, Huijian W. PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha. Molecular cancer. vol 12. 2013-06-18. PMID:23514585. |
pten suppresses the oncogenic function of aib1 through decreasing its protein stability via mechanism involving fbw7 alpha. |
2013-06-18 |
2023-08-12 |
human |
| Agnieszka Piwkowska, Dorota Rogacka, Stefan Angielski, Maciej Jankowsk. Hydrogen peroxide induces activation of insulin signaling pathway via AMP-dependent kinase in podocytes. Biochemical and biophysical research communications. vol 428. issue 1. 2013-03-26. PMID:23068094. |
furthermore, h(2)o(2) inhibited phosphorylation of the phosphatase and tensin homologue (pten; peak activity at 10 min; Δ -32%, p<0.05) and stimulated phosphorylation of the amp-dependent kinase alpha subunit (ampkα; 78% at 3 min and 244% at 10 min). |
2013-03-26 |
2023-08-12 |
rat |
| Sho Isoyama, Hisashi Yoshimi, Shingo Dan, Mutsumi Okamura, Mariko Seki, Tatsuro Irimura, Takao Yamor. Development of an immunohistochemical protein quantification system in conjunction with tissue microarray technology for identifying predictive biomarkers for phosphatidylinositol 3-kinase inhibitors. Biological & pharmaceutical bulletin. vol 35. issue 9. 2013-01-24. PMID:22975517. |
the phosphatidylinositol 3-kinase (pi3k) pathway is frequently activated in human cancers by gain-of-function mutations of phosphoinositide-3-kinase, catalytic, alpha polypeptide (pik3ca) or dysfunction of phosphatase and tensin homolog deleted on chromosome 10 (pten). |
2013-01-24 |
2023-08-12 |
human |
| Aristea S Galanopoulou, Jan A Gorter, Carlos Ceped. Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. Epilepsia. vol 53. issue 7. 2012-09-14. PMID:22578218. |
these include tuberous sclerosis, which is due to mutations in tsc1 or tsc2 genes; mutations in phosphatase and tensin homolog (pten) as in cowden syndrome, polyhydramnios, megalencephaly, symptomatic epilepsy syndrome (pmse) due to mutations in the ste20-related kinase adaptor alpha (stradalpha); and neurofibromatosis type 1 attributed to neurofibromin 1 mutations. |
2012-09-14 |
2023-08-12 |
mouse |
| Christian D Simmons, John Mark P Pabona, Melissa E Heard, Theodore M Friedman, Michael T Spataro, Amy L Godley, Frank A Simmen, Alexander F Burnett, Rosalia C M Simme. Krüppel-like factor 9 loss-of-expression in human endometrial carcinoma links altered expression of growth-regulatory genes with aberrant proliferative response to estrogen. Biology of reproduction. vol 85. issue 2. 2012-07-31. PMID:21543766. |
expression of estrogen receptor alpha (esr1) and the tumor-suppressor phosphatase and tensin homolog deleted in chromosome 10 (pten) did not differ between tumor and normal tissue. |
2012-07-31 |
2023-08-12 |
human |
| Izumi Oinuma, Yuri Ito, Hironori Katoh, Manabu Negish. Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons. The Journal of biological chemistry. vol 285. issue 36. 2010-10-05. PMID:20610402. |
we also suggested that the sema4d-induced pten dephosphorylation and growth cone collapse were mediated by the inhibition of casein kinase 2 alpha activity. |
2010-10-05 |
2023-08-12 |
Not clear |
| N Burrows, J Resch, R L Cowen, R von Wasielewski, C Hoang-Vu, C M West, K J Williams, G Braban. Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas. Endocrine-related cancer. vol 17. issue 1. 2010-07-15. PMID:19808899. |
high basal and hypoxia-induced expression of hif-1 alpha in ftc-133 cells that harbour a phosphatase and tensin homologue (pten) mutation was reduced by introduction of wild-type pten. |
2010-07-15 |
2023-08-12 |
Not clear |
| Long Chen, Baoshan Xu, Lei Liu, Yan Luo, Jun Yin, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Shile Huan. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Laboratory investigation; a journal of technical methods and pathology. vol 90. issue 5. 2010-06-07. PMID:20142804. |
furthermore, we identified that h(2)o(2) induction of ros inhibited the upstream kinases, akt and phosphoinositide-dependent kinase 1 (pdk1), but not the type i insulin-like growth factor receptor (igfr), and activated the negative regulator, amp-activated protein kinase alpha (ampkalpha), but not the phosphatase and tensin homolog (pten) in the cells. |
2010-06-07 |
2023-08-12 |
Not clear |
| Federica Perrone, Luca Da Riva, Marta Orsenigo, Marco Losa, Genny Jocollè, Clara Millefanti, Elisa Pastore, Alessandro Gronchi, Marco Alessandro Pierotti, Silvana Pilott. PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor. Neuro-oncology. vol 11. issue 6. 2010-02-23. PMID:19246520. |
the activation of the downstream receptor pathways was also studied by means of v-akt murine thymoma viral oncogene homolog (akt), extracellular signal-regulated kinase (erk), and mammalian target of rapamycin (mtor) western blotting experiments, as well as rat sarcoma viral oncogene homolog (ras), v-raf murine sarcoma viral oncogene homolog b1 (braf), phosphoinositide-3-kinase, catalytic, alpha polypeptide (pi3kca), and phosphatase and tensin homolog deleted on chromosome ten (pten) mutational analysis and fluorescence in situ hybridization. |
2010-02-23 |
2023-08-12 |
rat |