| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Barry Fine, Cindy Hodakoski, Susan Koujak, Tao Su, Lao H Saal, Matthew Maurer, Benjamin Hopkins, Megan Keniry, Maria Luisa Sulis, Sarah Mense, Hanina Hibshoosh, Ramon Parson. Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science (New York, N.Y.). vol 325. issue 5945. 2009-09-18. PMID:19729658. |
p-rex2a mrna was more abundant in human cancer cells and significantly increased in tumors with wild-type pten that expressed an activated mutant of pik3ca encoding the p110 subunit of phosphoinositide 3-kinase subunit alpha (pi3kalpha). |
2009-09-18 |
2023-08-12 |
human |
| Robert A Figlin, Paul de Souza, David McDermott, Janice P Dutcher, Anna Berkenblit, Alexandra Thiele, Mizue Krygowski, Andrew Strahs, Jay Feingold, Joseph Boni, Gary Hude. Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha. Cancer. vol 115. issue 16. 2009-09-17. PMID:19526589. |
exploratory subgroup analyses from the phase 3 global advanced renal cell carcinoma (arcc) trial were conducted to determine if baseline levels of the tumor molecular markers pten and hif1 alpha correlated with efficacy in patients treated with temsirolimus (torisel) versus interferon-alpha (ifn). |
2009-09-17 |
2023-08-12 |
Not clear |
| Nalinie S Wickramasinghe, Tissa T Manavalan, Susan M Dougherty, Krista A Riggs, Yong Li, Carolyn M Kling. Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic acids research. vol 37. issue 8. 2009-06-24. PMID:19264808. |
sirna knockdown of er alpha blocked the e(2)-induced increase in pdcd4, pten and bcl-2. |
2009-06-24 |
2023-08-12 |
human |
| Dong Yin, Seishi Ogawa, Norihiko Kawamata, Patrizia Tunici, Gaetano Finocchiaro, Marica Eoli, Christian Ruckert, Thien Huynh, Gentao Liu, Motohiro Kato, Masashi Sanada, Anna Jauch, Martin Dugas, Keith L Black, H Phillip Koeffle. High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray. Molecular cancer research : MCR. vol 7. issue 5. 2009-06-23. PMID:19435819. |
the phosphoinositide 3-kinase pathway was altered in 71% (39 of 55) gbms either by deletion of pten or amplification of epidermal growth factor receptor and/or vascular endothelial growth factor receptor/platelet-derived growth factor receptor alpha. |
2009-06-23 |
2023-08-12 |
Not clear |
| T L Yuan, L C Cantle. PI3K pathway alterations in cancer: variations on a theme. Oncogene. vol 27. issue 41. 2008-10-08. PMID:18794884. |
receptor tyrosine kinases upstream of pi3k, the p110 alpha catalytic subunit of pi3k, the downstream kinase, akt, and the negative regulator, pten, are all frequently altered in cancer. |
2008-10-08 |
2023-08-12 |
Not clear |
| C Garcia-Echeverria, W R Seller. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene. vol 27. issue 41. 2008-10-08. PMID:18794885. |
notable in this regard are the prevalent somatic genetic alterations leading to the inactivation of the tumor suppressor gene pten and gain-of-function mutations targeting pik3ca--the gene encoding the catalytic phosphosinositide-3 kinase subunit p110 alpha. |
2008-10-08 |
2023-08-12 |
human |
| Nandini Dey, Hal E Crosswell, Pradip De, Ramon Parsons, Qiong Peng, Jing Dong Su, Donald L Durde. The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer research. vol 68. issue 6. 2008-04-09. PMID:18339867. |
the results provide direct evidence that the downstream effect of the protein phosphatase activity of pten is to suppress sfk and fyn, and to regulate rac-gtpase activity after alpha(v) integrin stimulation. |
2008-04-09 |
2023-08-12 |
mouse |
| Nandini Dey, Hal E Crosswell, Pradip De, Ramon Parsons, Qiong Peng, Jing Dong Su, Donald L Durde. The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer research. vol 68. issue 6. 2008-04-09. PMID:18339867. |
furthermore, studying vitronectin-directed migration using (a) fyn small interfering rna and (b) astrocytes from fyn heterozygous (+/-) mice, pten heterozygous (+/-) mice, pten and fyn double heterozygous (+/-) mice, or fyn knockout (-/-) mice confirmed a role of fyn in alpha(v) integrin-mediated haptotaxis in glial cells. |
2008-04-09 |
2023-08-12 |
mouse |
| Semir Vranić, Nurija Bilalović, Lisa M J Lee, Bozo Kruslin, Stan L Lilleberg, Zoran Gatalic. PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney. Human pathology. vol 38. issue 9. 2007-10-29. PMID:17669465. |
a detailed molecular genetic analysis of the primary and metastatic tumors demonstrated somatic mutations in 2 well-known cancer genes associated with regulation of pi3k/akt signaling pathway: (1) pik3ca, which encodes the catalytic alpha subunit of the phosphoinositide-3-kinase, and (2) pten, which encodes phosphatase and tensin homolog. |
2007-10-29 |
2023-08-12 |
Not clear |
| Angela C Rutledge, Khosrow Adel. Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms. Nutrition reviews. vol 65. issue 6 Pt 2. 2007-08-01. PMID:17605309. |
in particular, the roles of cellular signaling molecules including nuclear factor kappa b (nfkb), tumor necrosis factor alpha (tnf-alpha), c-jun amino terminal kinase 1 (jnk-1), protein tyrosine phosphatase 1b (ptp-1b), phosphatase and tensin homolog deleted on chromosome ten (pten), liver x receptor (lxr), farnesoid x receptor (fxr), and sterol regulatory element-binding protein-1c (srebp-1c) will be addressed. |
2007-08-01 |
2023-08-12 |
Not clear |
| Mi-Sung Kim, Sang Min Lee, Won Dong Kim, Sung Hwan Ki, Aree Moon, Chang Ho Lee, Sang Geon Ki. G alpha 12/13 basally regulates p53 through Mdm4 expression. Molecular cancer research : MCR. vol 5. issue 5. 2007-06-29. PMID:17510313. |
mdm4, a p53-stabilizing protein, was repressed by g alpha(12) deficiency and to a lesser extent by g alpha(13) deficiency, whereas mdm2, pten, beta-catenin, atm, and chk2 were unaffected. |
2007-06-29 |
2023-08-12 |
Not clear |
| Tomohiro Kawaguchi, Yoji Yamashita, Masayuki Kanamori, Raelene Endersby, Krystof S Bankiewicz, Suzanne J Baker, Gabriele Bergers, Russell O Piepe. The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer research. vol 66. issue 23. 2007-01-10. PMID:17145879. |
consistent with this idea, several integrin alpha(v)beta(3)-expressing glioma cell lines with pten mutations and high levels of phospho-akt (pakt) were unaffected by exposure to an active fragment of tumstatin (t3), whereas alpha(v)beta(3)-expressing glioma cell lines with a functional pten/low levels of pakt exhibited t3-induced growth suppression that could be bypassed by small interfering rna-mediated suppression of pten, introduction of a constitutively expressed akt, or introduction of the akt and mtor target eukaryotic translation initiation factor 4e. |
2007-01-10 |
2023-08-12 |
mouse |
| Anabel Gil, Amparo Andrés-Pons, Elena Fernández, Miguel Valiente, Josema Torres, Javier Cervera, Rafael Pulid. Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Molecular biology of the cell. vol 17. issue 9. 2006-10-17. PMID:16807353. |
coexpression of a dominant negative ran gtpase protein blocked pten accumulation in the nucleus, which was also affected by coexpression of importin alpha proteins. |
2006-10-17 |
2023-08-12 |
Not clear |
| Zenglin Lian, Pasquale De Luca, Antonio Di Cristofan. Gene expression analysis reveals a signature of estrogen receptor activation upon loss of Pten in a mouse model of endometrial cancer. Journal of cellular physiology. vol 208. issue 2. 2006-08-11. PMID:16688764. |
strikingly, we found that the expression levels of over 100 genes known to be regulated by estrogen receptor alpha (eralpha) are also altered in the neoplastic uterus from pten(+/-) mice, thus mimicking a hyperestrogenic environment. |
2006-08-11 |
2023-08-12 |
mouse |
| Anna Vilgelm, Zenglin Lian, Hong Wang, Stephen L Beauparlant, Andres Klein-Szanto, Lora Hedrick Ellenson, Antonio Di Cristofan. Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice. Cancer research. vol 66. issue 7. 2006-05-22. PMID:16585156. |
here, we show that loss of pten in the mouse endometrium activates akt and results in increased phosphorylation of estrogen receptor alpha (eralpha) on ser(167). |
2006-05-22 |
2023-08-12 |
mouse |
| Katsutoshi Oda, David Stokoe, Yuji Taketani, Frank McCormic. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer research. vol 65. issue 23. 2006-01-25. PMID:16322209. |
in addition to inactivation of the pten tumor suppressor gene, mutations or amplifications of the catalytic subunit alpha of pi3k (pik3ca) have been reported. |
2006-01-25 |
2023-08-12 |
human |
| Lao H Saal, Karolina Holm, Matthew Maurer, Lorenzo Memeo, Tao Su, Xiaomei Wang, Jennifer S Yu, Per-Olof Malmström, Mahesh Mansukhani, Jens Enoksson, Hanina Hibshoosh, Ake Borg, Ramon Parson. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer research. vol 65. issue 7. 2005-05-26. PMID:15805248. |
deregulation of the phosphatidylinositol 3-kinase (pi3k) pathway either through loss of pten or mutation of the catalytic subunit alpha of pi3k (pik3ca) occurs frequently in human cancer. |
2005-05-26 |
2023-08-12 |
human |
| Anju Agarwal, Kingshuk Das, Natalia Lerner, Swati Sathe, Muzaffer Cicek, Graham Casey, Nywana Sizemor. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592509. |
the constitutive activation of nf kappa b- and beta-catenin-dependent transcription is inhibited by transiently transfecting either kinase dead (kd) ikk alpha, which blocks ikk alpha kinase activity, kd akt, which blocks akt activity, or wildtype (wt) pten, which inhibits pi3k and akt activity. |
2005-03-02 |
2023-08-12 |
Not clear |
| Anju Agarwal, Kingshuk Das, Natalia Lerner, Swati Sathe, Muzaffer Cicek, Graham Casey, Nywana Sizemor. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592509. |
the ability of kd ikk alpha, kd akt or wt pten to decrease beta-catenin-dependent transcription is independent of their effects on nf kappa b. inducible expression of either kd ikk alpha or wt pten strongly inhibits both the constitutive nf kappa b- and beta-catenin-dependent promoter and endogenous gene activation. |
2005-03-02 |
2023-08-12 |
Not clear |
| Michael V G Latronico, Stefan Costinean, Maria Luisa Lavitrano, Cesare Peschle, Gianluigi Condorell. Regulation of cell size and contractile function by AKT in cardiomyocytes. Annals of the New York Academy of Sciences. vol 1015. 2004-07-28. PMID:15201165. |
in these cells, akt is activated by upstream molecules such as beta-adrenergic receptor, insulin-like growth factor-1 or insulin receptor, through pi3k alpha; whereas its activation is inhibited by the pten molecule. |
2004-07-28 |
2023-08-12 |
mouse |