| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacqueline Maphutha, Danielle Twilley, Namrita Lal. The Role of the PTEN Tumor Suppressor Gene and Its Anti-Angiogenic Activity in Melanoma and Other Cancers. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338464. |
this review discusses the inhibition of angiogenesis through the upregulation of pten and the inhibition of hypoxia-inducible factor 1 alpha (hif-1-α) in human malignant melanoma, as no targeted therapies have been approved by the fda for the inhibition of angiogenesis in human malignant melanoma. |
2024-02-10 |
2024-02-12 |
human |
| Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Peng Cao, Kuo Shen, Hao Gua. PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL. Archives of biochemistry and biophysics. 2024-02-07. PMID:38325773. |
our results demonstrate that the overexpression of pten (adpten) significantly suppressed the expression of type i collagen (col i), type iii collagen (col iii), and alpha smooth muscle actin (α-sma) in hsfs. |
2024-02-07 |
2024-02-10 |
Not clear |
| Elisabetta Albi, Martina Mandarano, Samuela Cataldi, Maria Rachele Ceccarini, Federico Fiorani, Tommaso Beccari, Angelo Sidoni, Michela Codin. The Effect of Cholesterol in MCF7 Human Breast Cancer Cells. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36983016. |
in mcf7 cells, hypocholesterolemia (1) reduced cell growth, and ki67 expression; (2) increased er/pgr expression; (3) stimulated the 3-hydroxy-3-methylglutaryl-coa reductase and neutral sphingomyelinase and; (4) stimulated the expression of cdkn1a gene coding cyclin-dependent kinase inhibitor 1a protein, gadd45a coding growth arrest and dna-damage-inducible alpha protein and, pten gene coding phosphatase and tensin homolog. |
2023-03-29 |
2023-08-14 |
human |
| Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Maryam Shayan, Sadaf Eshraghi, Saeideh Momtaz, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, Amirhossein Sahebka. Spinal Muscular Atrophy Treatment: The MTOR Regulatory Intervention. Current medicinal chemistry. 2023-02-15. PMID:36788689. |
mtor: mammalian/mechanistic target of rapamycin; sma: spinal muscular atrophy; igf-1r: insulin-like growth factor type 1 receptor; foxo3a: forkhead box class o 3a; eif4ebp1: eukaryotic translation initiation factor 4e-binding protein 1; atrogin-1 (fbox32): atrophy gene-1 (f-box only protein 32); traf2: tnf receptor-associated factor 2; p38 (mapk14): p38 (mitogen-activated protein kinase 14); rras2: ras related 2; erk (mapk1): extracellular signal-regulated kinase 1/2 (mitogen-activated protein kinase 1); sbma: spinal and bulbar muscular atrophy; smn: survival motor neuron; akt: protein kinase b; mafbx/atrogin-1: muscle atrophy f-box; murf-1: muscle ring-finger protein-1; wt: wild-type; gc-klf15-bcaa: circadian glucocorticoid-krüppel-like factor 15-branched-chain amino acid; sbma: spinal and bulbar muscular atrophy; pgc1α: proliferator-activated receptor γ coactivator 1 alpha ctrp3: c1q/tnf-related protein 3; smn: survival motor neuron; vegf: vascular endothelial growth factor; pten: phosphatase and tensin homolog. |
2023-02-15 |
2023-08-14 |
Not clear |
| Mai O Kadry, Rehab M Abdel Megee. Ubiquitous toxicity of Mercuric Chloride in target tissues and organs: Impact of Ubidecarenone and liposomal-Ubidecarenone STAT 5A/ PTEN /PI3K/AKT signaling pathways. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 74. 2022-08-11. PMID:35952450. |
nevertheless, liposomal drug delivery system is a promising era in the field of nano-medicine and have the advantageous of increasing drug bioavailability and retention phenomena in addition to targeting organ for all mentioned the present study was designed to investigate the hypothesis that messenger rna gene expression of signal transducer and activator of transcription- 5 a (stat-5a), phosphatase and tensin homolog (pten), phosphoinositol kinase (pi3k) and alpha serine/threonine-protein kinase (akt) can trigger hgcl3 induced nephrotoxicity post ubidecarenone and liposomal ubidecarenone therapy. |
2022-08-11 |
2023-08-14 |
Not clear |
| Xin Yang, Heling Zhang, Tong Qu, Yi Wang, Yongxian Zhong, Yuchen Yan, Xuefei Ji, Tiayan Chi, Peng Liu, Libo Zo. Tolfenamic acid inhibits ROS-generating oxidase Nox1-regulated p53 activity in intrastriatal injection of malonic acid rats. The journal of physiological sciences : JPS. vol 72. issue 1. 2022-07-19. PMID:35850611. |
tolfenamic acid reduced mouse double minute 2 (mdm2), phosphatase and tensin homologue (pten), p53-upregulated modulator of apoptosis (puma) and bcl2-associated x (bax) at the mrna level to inhibit apoptosis and downregulated sestrin 2 (sesn2) and hypoxia inducible factor 1, alpha subunit (hif-1α) mrna levels to exert antioxidative stress effects. |
2022-07-19 |
2023-08-14 |
mouse |
| Chao Li, Hui Wang, Song Meng, Jian Hong, Libin Yao, Yong Shao, Xiaocheng Zh. lncRNA GAS8-AS1 regulates cancer cell proliferation and predicts poor survival of patients with gastric cancer. Oncology letters. vol 23. issue 2. 2022-01-07. PMID:34992681. |
the expression levels of gas8-as1, microrna (mir)-21-3p, pten and pyruvate dehydrogenase (e1) alpha subunit gene (pdha1) in gastric cancer and non-cancerous tissues, as well as in gastric cancer cell lines, were detected using reverse transcription-quantitative pcr. |
2022-01-07 |
2023-08-13 |
Not clear |
| Sathiya Sekar, Wendie N Marks, Venkat Gopalakrishnan, Quentin Greba, Terrance P Snutch, John G Howland, Changiz Taghibiglo. Evidence for altered insulin signalling in the brains of genetic absence epilepsy rats from Strasbourg. Clinical and experimental pharmacology & physiology. vol 47. issue 9. 2021-11-17. PMID:32304254. |
for the brain samples, the nuclear fraction (nf) and total homogenate (th) were isolated and investigated for insulin signalling markers including insulin receptor beta (irβ), ir substrate-1 and 2 (irs1 & 2), phosphatase and tensin homologue (pten), phosphoinositide 3-kinase phospho-85 alpha (pi3k p85α), phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol (3,4,5)-trisphosphate, protein kinase b (pkb/akt1/2/3), glucose transporter-1 and 4 (glut1 & 4) and glycogen synthase kinase-3β (gsk3β) using western blotting. |
2021-11-17 |
2023-08-13 |
rat |
| Weiyu Wang, Jinghua Tang, Min Zhong, Jie Chen, Tingyu Li, Ying Da. HIF-1 α may play a role in late pregnancy hypoxia-induced autism-like behaviors in offspring rats. Behavioural brain research. vol 411. 2021-10-18. PMID:34048873. |
western blotting analysis showed increased levels of hypoxia inducible factor 1 alpha (hif-1α) and decreased levels of phosphatase and tensin homolog (pten) in the hypoxic-induced autism group. |
2021-10-18 |
2023-08-13 |
rat |
| Yasuto Kunii, Junya Matsumoto, Ryuta Izumi, Atsuko Nagaoka, Mizuki Hino, Risa Shishido, Makoto Sainouchi, Hiroyasu Akatsu, Yoshio Hashizume, Akiyoshi Kakita, Hirooki Yab. Evidence for Altered Phosphoinositide Signaling-Associated Molecules in the Postmortem Prefrontal Cortex of Patients with Schizophrenia. International journal of molecular sciences. vol 22. issue 15. 2021-09-08. PMID:34361045. |
protein expression levels of phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (pip5k1c), phosphatidylinositol 4-kinase alpha (pik4ca, also known as pik4a), phosphatase and tensin homolog deleted from chromosome 10 (pten), protein kinase b (akt), and glycogen synthase kinase 3β (gsk3β) were measured using enzyme-linked immunosorbent assays and multiplex fluorescent bead-based immunoassays of the prefrontal cortex (pfc) of postmortem samples from 23 schizophrenia patients and 47 normal controls. |
2021-09-08 |
2023-08-13 |
Not clear |
| Huiying Wan, Dingding Zhang, Weimin Hu, Zhen Xie, Qiu Du, Qiongrong Xia, Taishen Wen, Haiping Ji. Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma. Medicine. vol 100. issue 30. 2021-08-20. PMID:34397726. |
this study aimed to investigate the expression of phosphatase and tensin homolog (pten), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), phosphorylated mitogen-activated kinase-like protein (pmapk), and tumor protein p53 (tp53) in scalp and face angiosarcoma and to assess tumor tissue apoptosis.the expression and intracellular distribution of pten, pik3ca, pmapk, and tp53 proteins in 21 specimens of human scalp and face angiosarcoma and 16 specimens of human benign hemangioma were evaluated using immunohistochemistry. |
2021-08-20 |
2023-08-13 |
human |
| Wei-Pang Chung, Wei-Lun Huang, Wei-An Liao, Wan-Ling Huang, You-Yu Liu, Wu-Chou S. Development of the CK-MB-1 trastuzumab-resistant HER2-positive breast cancer cell line and xenograft animal models. Cancer medicine. vol 10. issue 7. 2021-07-19. PMID:33665980. |
most trastuzumab-resistant breast cancer cell lines available from biobanks feature either phosphoinositide-3-kinase, catalytic, alpha (pik3ca) mutation or the loss of phosphatase and tensin homolog (pten). |
2021-07-19 |
2023-08-13 |
human |
| Bjoern C Froehlich, Robert Popp, Constance A Sobsey, Sahar Ibrahim, Andre M LeBlanc, Yassene Mohammed, Adriana Aguilar-Mahecha, Oliver Poetz, Michael X Chen, Alan Spatz, Mark Basik, Gerald Batist, René P Zahedi, Christoph H Borcher. Systematic Optimization of the iMALDI Workflow for the Robust and Straightforward Quantification of Signaling Proteins in Cancer Cells. Proteomics. Clinical applications. vol 14. issue 5. 2021-07-05. PMID:32643306. |
imaldi assays are optimized for the pi3-kinase signaling pathway members phosphatase and tensin homolog (pten) and pi3-kinase catalytic subunit alpha (p110α), with regard to sensitivity, robustness, and throughput. |
2021-07-05 |
2023-08-13 |
Not clear |
| Xue Yang, Yang Xia, Liyan Xu, Li Liang, Minglei Zhuo, Meina Wu, Tongtong An, Ziping Wang, Yuyan Wang, Jianjie Li, Jia Zhong, Hanxiao Chen, Bo Jia, Jingjing Wang, Jun Zha. Efficacy and Safety of Combination Treatment With Apatinib and Osimertinib After Osimertinib Resistance in Epidermal Growth Factor Receptor-Mutant Non-small Cell Lung Carcinoma-A Retrospective Analysis of a Multicenter Clinical Study. Frontiers in molecular biosciences. vol 8. 2021-05-26. PMID:34026823. |
the spectrum of resistance to osimertinib mechanisms included c-mesenchymal-epithelial transition factor (c-met) amplification, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) gain-of-function mutation, phosphatase and tensin homolog (pten) loss-of-function mutation, erb-b2 receptor tyrosine kinase 2 (erbb2) amplification, and insulin-like growth factor 1 receptor (igf1r) mutation. |
2021-05-26 |
2023-08-13 |
Not clear |
| Philippe Jamme, Marie Fernandes, Marie-Christine Copin, Clotilde Descarpentries, Fabienne Escande, Angela Morabito, Valérie Grégoire, Matthieu Jamme, Simon Baldacci, David Tulasne, Zoulika Kherrouche, Alexis B Corto. Alterations in the PI3K Pathway Drive Resistance to MET Inhibitors in NSCLC Harboring MET Exon 14 Skipping Mutations. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 15. issue 5. 2021-01-06. PMID:32169477. |
we found a phosphatidylinositol 3-kinase catalytic subunit alpha (pik3ca) mutation in two of 65 samples (3%) and loss of pten in six of 26 samples (23%). |
2021-01-06 |
2023-08-13 |
Not clear |
| Lili Wang, Shasha Hu, Fangjie Xin, Han Zhao, Guangqi Li, Wenwen Ran, Xiaoming Xing, Jigang Wan. MED12 exon 2 mutation is uncommon in intravenous leiomyomatosis: clinicopathologic features and molecular study. Human pathology. vol 99. 2020-10-26. PMID:32240666. |
the immunohistochemical expressions of p16, phosphatase and tensin homolog deleted on chromosome 10 (pten), alpha thalassemia/mental retardation syndrome x-linked (atrx), retinoblastoma 1 (rb1), fumarate hydratase (fh), and p53, were evaluated. |
2020-10-26 |
2023-08-13 |
Not clear |
| Kayla A Lewis, Harrison R Jordan, Trygve O Tollefsbo. Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells. Cancers. vol 11. issue 1. 2020-10-01. PMID:30591655. |
the compounds affected the expression of oncogenic mir-221/222 and tumor suppressors, p27 and pten, in addition to estrogen receptor alpha (erα). |
2020-10-01 |
2023-08-13 |
Not clear |
| Ying Cheng, Xin Dai, Ti Yang, Nan Zhang, Zhenzhong Liu, Yiguo Jian. Low Long Noncoding RNA Growth Arrest-Specific Transcript 5 Expression in the Exosomes of Lung Cancer Cells Promotes Tumor Angiogenesis. Journal of oncology. vol 2019. 2020-10-01. PMID:31186629. |
in addition, we found that gas5 competitively bound mirna-29-3p with phosphatase and tensin homolog (pten), upregulating pten mrna and protein expression, and inhibited level of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pi3k) and serine/threonine kinase 1 (akt) phosphorylation in huvecs. |
2020-10-01 |
2023-08-13 |
mouse |
| Franziska E Marquard, Manfred Jücke. PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer. Biochemical pharmacology. vol 172. 2020-07-20. PMID:31785230. |
pi3k/akt/mtor signaling is active in over 90% of hnscc, as a result of egfr activation (47%), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) mutations (8.6%), pik3ca amplifications (14.2%), phosphatidylinositol 3-kinase (pi3k) overexpression (27.2%) and phosphatase and tensin homolog (pten) mutation (10-15%). |
2020-07-20 |
2023-08-13 |
mouse |
| Sreenivasulu Kilari, Chuanqi Cai, Chenglei Zhao, Amit Sharma, Ekaterina Chernogubova, Michael Simeon, Chin-Cheng Wu, Hsiang-Lin Song, Lars Maegdefessel, Sanjay Misr. The Role of MicroRNA-21 in Venous Neointimal Hyperplasia: Implications for Targeting miR-21 for VNH Treatment. Molecular therapy : the journal of the American Society of Gene Therapy. vol 27. issue 9. 2020-06-16. PMID:31326400. |
immunohistochemistry demonstrated a significant decrease in myofibroblasts and proliferation with an increase in terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel) staining in mir-21-knockdown vessels, along with a decrease in hypoxia-inducible factor-1 alpha (hif-1α) and phospho-smad2 (psmad-2) and phospho-smad3 (psmad-3) and an increase in phosphatase and tensin homolog (pten) staining. |
2020-06-16 |
2023-08-13 |
Not clear |