| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M I Tussié-Luna, L Rozo, A L Ro. Pro-proliferative function of the long isoform of PML-RARalpha involved in acute promyelocytic leukemia. Oncogene. vol 25. issue 24. 2006-07-24. PMID:16434964. |
the translocation results in a fusion gene product, pml-raralpha, in which the pml gene fuses to the retinoic acid receptor alpha (raralpha) gene. |
2006-07-24 |
2023-08-12 |
Not clear |
| E M Rego, D Ruggero, C Tribioli, G Cattoretti, S Kogan, R L Redner, P P Pandolf. Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. Oncogene. vol 25. issue 13. 2006-05-04. PMID:16331271. |
the rar alpha gene fuses to variable partners (pml, plzf, npm, numa and stat5b: x genes) leading to the expression of apl-specific fusion proteins with identical rar alpha moieties. |
2006-05-04 |
2023-08-12 |
mouse |
| Cleo L Bishop, Michal Ramalho, Nachiket Nadkarni, Wing May Kong, Christopher F Higgins, Nina Krauzewic. Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA. Molecular and cellular biology. vol 26. issue 7. 2006-04-24. PMID:16537904. |
this association did not play a role in regulating transgene expression, but pml protein was necessary for the inhibition of transgene expression with alpha interferon (ifn-alpha). |
2006-04-24 |
2023-08-12 |
Not clear |
| Mohtashim Naeem, Kathleen Harrison, Kevin Barton, Sucha Nand, Serhan Alka. A unique case of acute promyelocytic leukemia showing monocytic differentiation after ATRA (all-trans retinoic acid) therapy. European journal of haematology. vol 76. issue 2. 2006-03-28. PMID:16405439. |
acute promyelocytic leukemia (pml) is characterized by a reciprocal translocation between chromosomes 15 and 17 resulting in a chimeric pml and retinoic acid receptor alpha (rara) oncogene. |
2006-03-28 |
2023-08-12 |
Not clear |
| Y-L Yao, W-M Yan. Nuclear proteins: promising targets for cancer drugs. Current cancer drug targets. vol 5. issue 8. 2006-01-25. PMID:16375665. |
in acute promyelocytic leukemia (apl), pml forms a fusion protein with the retinoic acid receptor (rar) alpha as a result of chromosomal translocation. |
2006-01-25 |
2023-08-12 |
Not clear |
| Elena Puccetti, Xiaomin Zheng, Daria Brambilla, Anita Seshire, Tim Beissert, Simone Boehrer, Heike Nürnberger, Dieter Hoelzer, Oliver Gerhard Ottmann, Clara Nervi, Martin Ruthard. The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha. Cancer research. vol 65. issue 14. 2005-09-14. PMID:16024608. |
this phenotype is induced by specific acute myeloid leukemia-associated translocations, such as t(15;17) and t(11;17), which involve an identical portion of the retinoic acid receptor alpha (raralpha) and either the promyelocytic leukemia (pml) or promyelocytic zinc finger (plzf) genes, respectively. |
2005-09-14 |
2023-08-12 |
Not clear |
| Francesco Fazi, Lorena Travaglini, Daniela Carotti, Franco Palitti, Daniela Diverio, Myriam Alcalay, Suzan McNamara, Wilson H Miller, Francesco Lo Coco, Pier Giuseppe Pelicci, Clara Nerv. Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo. Oncogene. vol 24. issue 11. 2005-04-14. PMID:15688037. |
the acute promyelocytic leukemia (pml)-retinoic acid receptor alpha (raralpha) fusion product recruits histone deacetylase (hdac) and dna methyltransferase (dnmt) activities on retinoic acid (ra)-target promoters causing their silencing and differentiation block. |
2005-04-14 |
2023-08-12 |
Not clear |
| Lucia Altucci, Emmanuelle Wilhelm, Hinrich Gronemeye. Leukemia: beneficial actions of retinoids and rexinoids. The international journal of biochemistry & cell biology. vol 36. issue 2. 2004-08-05. PMID:14643883. |
acute promyelocytic leukemia is caused by chromosomal translocations, which in the large majority of cases generate the prototypic promyelocytic leukemia-retinoic-acid receptor alpha (pml-raralpha) an oncogenic fusion protein formed from the retinoic-acid receptor alpha and the so-called pml protein. |
2004-08-05 |
2023-08-12 |
Not clear |
| Veronika P Pozharskaya, Laura L Weakland, James C Zimring, Laurie T Krug, Elizabeth R Unger, Andrew Neisch, Harish Joshi, Naoki Inoue, Margaret K Offerman. Short duration of elevated vIRF-1 expression during lytic replication of human herpesvirus 8 limits its ability to block antiviral responses induced by alpha interferon in BCBL-1 cells. Journal of virology. vol 78. issue 12. 2004-06-29. PMID:15163753. |
the low levels of virf-1 that were associated with pml bodies were insufficient to block alpha ifn (ifn-alpha)-induced alterations in gene expression, whereas cells that expressed high levels of virf-1 were resistant to some changes induced by ifn-alpha, including the expression of the double-stranded-rna-activated protein kinase. |
2004-06-29 |
2023-08-12 |
human |
| Shuo Dong, David L Stenoien, Jihui Qiu, Michael A Mancini, David J Tweard. Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha. Molecular and cellular biology. vol 24. issue 10. 2004-06-17. PMID:15121864. |
both the reduced baseline mobility of x-rar alpha and the ligand-induced slowing of x-rar alpha could be attributed to the protein interaction domain contained within x. rxr alpha aberrantly colocalized within each x-rar alpha; colocalization of rxr alpha with promyelocytic leukemia (pml)-rar alpha resulted in reduced mobility of rxr alpha. |
2004-06-17 |
2023-08-12 |
Not clear |
| Ian Pitha-Rowe, Bret A Hassel, Ethan Dmitrovsk. Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. The Journal of biological chemistry. vol 279. issue 18. 2004-06-10. PMID:14976209. |
acute promyelocytic leukemia (apl) cases expressing the t(15,17) product, promyelocytic leukemia (pml)/retinoic acid receptor alpha (raralpha), have clinical remissions through leukemic cell differentiation after all-trans-retinoic acid (ra) treatment. |
2004-06-10 |
2023-08-12 |
human |
| Masataka Okuno, Soichi Kojima, Rie Matsushima-Nishiwaki, Hisashi Tsurumi, Yasutoshi Muto, Scott L Friedman, Hisataka Moriwak. Retinoids in cancer chemoprevention. Current cancer drug targets. vol 4. issue 3. 2004-06-10. PMID:15134535. |
in apl, a chromosomal translocation produces a chimeric protein between rar alpha and a protein called promyelocyte leukemia protein (pml). |
2004-06-10 |
2023-08-12 |
human |
| Masataka Okuno, Soichi Kojima, Rie Matsushima-Nishiwaki, Hisashi Tsurumi, Yasutoshi Muto, Scott L Friedman, Hisataka Moriwak. Retinoids in cancer chemoprevention. Current cancer drug targets. vol 4. issue 3. 2004-06-10. PMID:15134535. |
pml-rar alpha works as a dominant negative receptor in the leukemic cells, interfering with the normal function of rar alpha and/or pml, which in turn results in the arrest of cell maturation at the stage of promyelocytes. |
2004-06-10 |
2023-08-12 |
human |
| Dorothy J Park, Peter T Vuong, Sven de Vos, Dan Douer, H Phillip Koeffle. Comparative analysis of genes regulated by PML/RAR alpha and PLZF/RAR alpha in response to retinoic acid using oligonucleotide arrays. Blood. vol 102. issue 10. 2004-01-05. PMID:12893766. |
acute promyelocytic leukemia (apl) is associated with chromosomal translocations involving retinoic acid receptor alpha (rar alpha) and its fusion partners including promyelocytic leukemia (pml) and promyelocytic leukemia zinc finger (plzf). |
2004-01-05 |
2023-08-12 |
human |
| Simona Segalla, Laura Rinaldi, Charlotte Kilstrup-Nielsen, Gianfranco Badaracco, Saverio Minucci, Pier Giuseppe Pelicci, Nicoletta Landsberge. Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties. Molecular and cellular biology. vol 23. issue 23. 2003-12-16. PMID:14612419. |
retinoic acid receptor alpha fusion to pml affects its transcriptional and chromatin-remodeling properties. |
2003-12-16 |
2023-08-12 |
xenopus_laevis |
| Anita R Mistry, Eva W Pedersen, Ellen Solomon, David Grimwad. The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease. Blood reviews. vol 17. issue 2. 2003-11-12. PMID:12642121. |
acute promyelocytic leukaemia (apl) is characterised by chromosomal rearrangements of 17q21, leading to fusion of the gene encoding retinoic acid receptor alpha (raralpha) to a number of alternative partner genes (x), the most frequent of which are pml (>95%), plzf (0.8%) and npm (0.5%). |
2003-11-12 |
2023-08-12 |
Not clear |
| Kazuhiro Fujita, Remi Oba, Hiroshi Harada, Hiraku Mori, Haruo Niikura, Keiichi Isoyama, Mitsuhiro Omin. Cytogenetics, FISH and RT-PCR analysis of acute promyelocytic leukemia: structure of the fusion point in a case lacking classic t(15;17) translocation. Leukemia & lymphoma. vol 44. issue 1. 2003-10-02. PMID:12691149. |
metaphase fish of the patient with normal karyotype revealed a juxtaposed pml-rar alpha fusion signal on one chromosome 17 homologue, an rar alpha signal on the other chromosome 17 homologue, and one pml signal on each chromosome 15 homologue. |
2003-10-02 |
2023-08-12 |
Not clear |
| Ana V Chee, Pascal Lopez, Pier Paolo Pandolfi, Bernard Roizma. Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects. Journal of virology. vol 77. issue 12. 2003-07-03. PMID:12768029. |
pml has been reported to mediate the effects of interferon (ifn) and viral mutants lacking icp0 (delta alpha 0 mutants). |
2003-07-03 |
2023-08-12 |
Not clear |
| Ana V Chee, Pascal Lopez, Pier Paolo Pandolfi, Bernard Roizma. Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects. Journal of virology. vol 77. issue 12. 2003-07-03. PMID:12768029. |
to test the hypothesis that hsv disaggregates nd10 structures and disperses pml to preclude ifn-mediated antiviral effects, we tested the accumulation of viral proteins and virus yields from murine pml(+/+) and pml(-/-) cells mock treated or exposed to ifn-alpha, ifn-gamma, or both and infected with the wild-type or delta alpha 0 mutant virus. |
2003-07-03 |
2023-08-12 |
Not clear |
| Ana V Chee, Pascal Lopez, Pier Paolo Pandolfi, Bernard Roizma. Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects. Journal of virology. vol 77. issue 12. 2003-07-03. PMID:12768029. |
(ii) major effects of ifn-alpha and -gamma were observed in pml(+/+) cells infected with the delta alpha 0 mutant virus, and more minor effects were observed in cells infected with the wild-type virus. |
2003-07-03 |
2023-08-12 |
Not clear |