| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chengli Song, Lina Wang, Xiaoyan Wu, Kai Wang, Dan Xie, Qi Xiao, Songyu Li, Kui Jiang, Lujian Liao, John R Yates, Jiing-Dwan Lee, Qingkai Yan. PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent. Cancer research. vol 78. issue 10. 2019-06-12. PMID:29735542. |
this interaction was disrupted by the pml-rara t(15;17) mutation, which stems from chromosomal translocation between dna encoding the c-terminal domain of pml and the retinoic acid receptor alpha (rara) gene. |
2019-06-12 |
2023-08-13 |
Not clear |
| Yulong Li, Hongyan Wang, Xiu Jun Wang, Xiuwen Tan. The short isoform of PML-RARα activates the NRF2/HO-1 pathway through a direct interaction with NRF2. FEBS letters. vol 591. issue 18. 2017-10-11. PMID:28777872. |
in acute promyelocytic leukemia, fusion of the promyelocytic leukemia protein (pml) with retinoic acid receptor alpha (rarα) results in an oncogene, pml-rarα (pr). |
2017-10-11 |
2023-08-13 |
Not clear |
| Nilanjana Das, Neerajana Datta, Uttara Chatterjee, Mrinal Kanti Ghos. Estrogen receptor alpha transcriptionally activates casein kinase 2 alpha: A pivotal regulator of promyelocytic leukaemia protein (PML) and AKT in oncogenesis. Cellular signalling. vol 28. issue 6. 2016-11-10. PMID:27012497. |
estrogen receptor alpha transcriptionally activates casein kinase 2 alpha: a pivotal regulator of promyelocytic leukaemia protein (pml) and akt in oncogenesis. |
2016-11-10 |
2023-08-13 |
mouse |
| Hakan Savlı, Sema Sırma, Melih Aktan, Günçağ Dınçol, Uğur Özbe. Quantification of All-Trans-Retinoic Acid (ATRA) Dependent Expression of CXCR4 Gene in Acute Promyelocytic Leukaemia. Turkish journal of haematology : official journal of Turkish Society of Haematology. vol 20. issue 3. 2016-08-29. PMID:27265573. |
apl is a characteristic disorder with a specific translocation between pml and rar alpha genes on chromosome 15 and 17. |
2016-08-29 |
2023-08-13 |
Not clear |
| R Kolhe, A Mangaonkar, J Mansour, A Clemmons, J Shaw, B Dupont, L Walczak, A Mondal, A Rojiani, A Jillella, V Kot. Utility and impact of early t(15;17) identification by Fluorescence In Situ Hybridization (FISH) in clinical decision making for patients in Acute Promyelocytic Leukemia (APL). International journal of laboratory hematology. vol 37. issue 4. 2016-04-12. PMID:25639817. |
the aim of this project was to validate earlier time frames for the abbott molecular vysis lsi promyelocytic leukemia (pml)/ retinoic acid receptor alpha (rara) fluorescence in situ hybridization (fish) probe (asr 6-16 h). |
2016-04-12 |
2023-08-13 |
Not clear |
| Yinjun Lou, Yafang Ma, Jianai Sun, Xiujin Ye, Hanzhang Pan, Yungui Wang, Wenbin Qian, Haitao Meng, Wenyuan Mai, JingSong He, Hongyan Tong, Jie Ji. Evaluating frequency of PML-RARA mutations and conferring resistance to arsenic trioxide-based therapy in relapsed acute promyelocytic leukemia patients. Annals of hematology. vol 94. issue 11. 2015-12-18. PMID:26294332. |
the frequency and clinical significance of promyelocytic leukemia (pml)-retinoic acid receptor alpha (rara) mutational status using sanger sequencing were evaluated. |
2015-12-18 |
2023-08-13 |
Not clear |
| Ashok K Vaid, Sandeep Batra, Suman S Karanth, Sachin Gupt. Acute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed. Avicenna journal of medicine. vol 5. issue 4. 2015-12-02. PMID:26629469. |
though, complete blood picture revealed only mild hyperleukocytosis, bone marrow biopsy and aspiration revealed 60% blasts and a positive t (15,17)(q22,12) and pml retinoic acid receptor alpha (rara) fusion protein on molecular cytogenetics. |
2015-12-02 |
2023-08-13 |
Not clear |
| C Cameron Yin, Nitin Jain, Meenakshi Mehrotra, Jianhua Zhagn, Alexei Protopopov, Zhuang Zuo, Naveen Pemmaraju, Courtney DiNardo, Cheryl Hirsch-Ginsberg, Sa A Wang, L Jeffrey Medeiros, Lynda Chin, Keyur P Patel, Farhad Ravandi, Andrew Futreal, Carlos E Bueso-Ramo. Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia. Journal of the National Comprehensive Cancer Network : JNCCN. vol 13. issue 1. 2015-09-10. PMID:25583766. |
acute promyelocytic leukemia (apl) is characterized by the fusion of retinoic acid receptor alpha (rara) with promyelocytic leukemia (pml) or, rarely, other gene partners. |
2015-09-10 |
2023-08-13 |
Not clear |
| Wei He, Chuan-Xi Hu, Jia-Kai Hou, Li Fan, Yi-Wei Xu, Man-Hua Liu, Shu-Yang Yan, Guo-Qiang Chen, Ying Huan. Microtubule-associated protein 1 light chain 3 interacts with and contributes to growth inhibiting effect of PML. PloS one. vol 9. issue 11. 2015-07-20. PMID:25419843. |
previously we reported that the expression of promyelocytic leukemia (pml)-retinoic acid receptor alpha (rarα) fusion gene, which is caused by specific translocation (15;17) in acute promyelocytic leukemia, can enhance constitutive autophagic activity in leukemic and nonleukemic cells, and pml overexpression can sequestrate part of microtubule-associated protein light chain 3 (lc3) protein in pml nuclear bodies, suggesting that lc3 protein also distributes into nuclei although it is currently thought to function primarily in the cytoplasm, the site of autophagosomal formation. |
2015-07-20 |
2023-08-13 |
Not clear |
| Chengwu Zeng, Yan Xu, Ling Xu, Xibao Yu, Jingjing Cheng, Lijian Yang, Shaohua Chen, Yangqiu L. Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells. BMC cancer. vol 14. 2015-05-28. PMID:25245097. |
acute promyelocytic leukemia (apl) is characterized by the reciprocal translocation t(15;17), which fuses pml with retinoic acid receptor alpha (rarα). |
2015-05-28 |
2023-08-13 |
human |
| Katherine J Hands, Delphine Cuchet-Lourenco, Roger D Everett, Ronald T Ha. PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation. Journal of cell science. vol 127. issue Pt 2. 2014-10-14. PMID:24190887. |
arsenic is a clinically effective treatment for acute promyelocytic leukaemia (apl) in which the promyelocytic leukaemia (pml) protein is fused to retinoic receptor alpha (rarα). |
2014-10-14 |
2023-08-12 |
Not clear |
| Kanwal Rehman, Hua Naranmandur. Double-edged effects of arsenic compounds: anticancer and carcinogenic effects. Current drug metabolism. vol 14. issue 10. 2014-08-22. PMID:24164099. |
the basic mechanism through which as2o3 induces molecular remission in apl patients include direct targeting of pml and retinoic acid receptor alpha fusion protein (pml-rarα) by arsenic resulting in oncoprotein degradation leading to partial differentiation. |
2014-08-22 |
2023-08-12 |
Not clear |
| Tao Yang, Le Meng, Xinxing Wang, Longlong Wang, Kui Jia. Direct electrochemical DNA detection originated from the self-redox signal of sulfonated polyaniline enhanced by graphene oxide in neutral solution. ACS applied materials & interfaces. vol 5. issue 21. 2014-06-16. PMID:24088603. |
as an initial application of this system, the pml/rara fusion gene sequence formed from promyelocytic leukemia (pml) and retinoic acid receptor alpha (rara) was successfully detected. |
2014-06-16 |
2023-08-12 |
Not clear |
| W Zhou, S Ba. PML-mediated signaling and its role in cancer stem cells. Oncogene. vol 33. issue 12. 2014-05-07. PMID:23563177. |
the promyelocytic leukemia (pml) protein, initially discovered as a part of the pml/retinoic acid receptor alpha fusion protein, has been found to be a critical player in oncogenesis and tumor progression. |
2014-05-07 |
2023-08-12 |
Not clear |
| W-C Yang, H-M Shi. The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability. Oncogene. vol 32. issue 43. 2013-12-31. PMID:23208507. |
acute promyelocytic leukemia (apl) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (rara) gene and the promyelocytic leukemia (pml) or promyelocytic leukemia zinc finger (plzf) gene. |
2013-12-31 |
2023-08-12 |
mouse |
| Xiwen Cheng, Hung-Ying Ka. Microarray analysis revealing common and distinct functions of promyelocytic leukemia protein (PML) and tumor necrosis factor alpha (TNFα) signaling in endothelial cells. BMC genomics. vol 13. 2013-06-11. PMID:22947142. |
microarray analysis revealing common and distinct functions of promyelocytic leukemia protein (pml) and tumor necrosis factor alpha (tnfα) signaling in endothelial cells. |
2013-06-11 |
2023-08-12 |
human |
| Sébastien Nisole, Mohamed Ali Maroui, Xavier H Mascle, Muriel Aubry, Mounira K Chelbi-Ali. Differential Roles of PML Isoforms. Frontiers in oncology. vol 3. 2013-06-05. PMID:23734343. |
the tumor suppressor promyelocytic leukemia (pml) protein is fused to the retinoic acid receptor alpha in patients suffering from acute promyelocytic leukemia (apl). |
2013-06-05 |
2023-08-12 |
Not clear |
| Sabine Beez, Philipp Demmer, Elena Puccett. Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides. PloS one. vol 7. issue 11. 2013-05-01. PMID:23152790. |
for these two translocations, the retinoic acid receptor alpha (rarα) is fused to the promyelocytic leukemia (pml) gene or the promyelocytic zinc finger (plzf) gene, respectively. |
2013-05-01 |
2023-08-12 |
Not clear |
| Jason Koshy, You-Wen Qian, Gayathri Bhagwath, Maurice Willis, Todd W Kelley, Peter Papenhause. Microarray, gene sequencing, and reverse transcriptase-polymerase chain reaction analyses of a cryptic PML-RARA translocation. Cancer genetics. vol 205. issue 10. 2013-01-10. PMID:22982005. |
the t(15;17) results in the fusion of the promyelocytic leukemia (pml) and retinoic acid receptor alpha (rara) genes. |
2013-01-10 |
2023-08-12 |
Not clear |
| Mangala Gowri, S K Kousar Jahan, Kavitha, Prasannakumari, Madhumathi, L Appaj. Acute promyelocytic leukemia with unusual karyotype. Indian journal of human genetics. vol 17. issue 3. 2012-10-02. PMID:22346000. |
acute myeloid leukemia (aml-m3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (rara) gene on chromosome 17 and the pml gene on chromosome 15. |
2012-10-02 |
2023-08-12 |
Not clear |