| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Percy Luk Yeung, Natalia G Denissova, Cara Nasello, Zhanna Hakhverdyan, J Don Chen, Mark A Brennema. Promyelocytic leukemia nuclear bodies support a late step in DNA double-strand break repair by homologous recombination. Journal of cellular biochemistry. vol 113. issue 5. 2012-09-17. PMID:22213200. |
in most cases of acute promyelocytic leukemia, the pml and retinoic acid receptor alpha (rara) genes are translocated, resulting in expression of oncogenic pml-rarα fusion proteins. |
2012-09-17 |
2023-08-12 |
Not clear |
| Kyong Eun Kim, Sung Hyun Kim, Jin Yeong Ha. [Acute Monocytic Leukemia with t(11;17)(q23;q21) Involving a Rearrangement of Mixed Lineage Leukemia Gene.]. The Korean journal of laboratory medicine. vol 26. issue 5. 2012-08-23. PMID:18156746. |
fluorescence in situ hybridization (fish) analysis identified a mixed lineage leukemia (mll) gene rearrangement, but not visible disruptions of promyelocytic leukemia (pml) or retinoic acid receptor alpha (rara) genes. |
2012-08-23 |
2023-08-12 |
Not clear |
| Mindy Farris, Astrid Lague, Zara Manuelyan, Jacob Statnekov, Christopher Franckly. Altered nuclear cofactor switching in retinoic-resistant variants of the PML-RARα oncoprotein of acute promyelocytic leukemia. Proteins. vol 80. issue 4. 2012-06-21. PMID:22228505. |
acute promyelocytic leukemia (apl) results from a reciprocal translocation that fuses the gene for the pml tumor suppressor to that encoding the retinoic acid receptor alpha (rarα). |
2012-06-21 |
2023-08-12 |
Not clear |
| Pratibha Kadam Amare, Chanda Baisane, Reena Nair, Hari Menon, Shripad Banavali, Sharayu Kabre, Sumit Gujral, P Subramania. Characterization of cryptic rearrangements, deletion, complex variants of PML, RARA in acute promyelocytic leukemia. Indian journal of human genetics. vol 17. issue 2. 2011-11-23. PMID:22090713. |
acute promyelocytic leukemia (apl) is characterized by a reciprocal translocation t(15;17)(q22;q21) leading to the disruption of promyelocytic leukemia (pml) and retionic acid receptor alpha (rara) followed by reciprocal pml-rara fusion in 90% of the cases. |
2011-11-23 |
2023-08-12 |
Not clear |
| M Occhionorelli, F Santoro, I Pallavicini, A Gruszka, S Moretti, D Bossi, A Viale, D Shing, S Ronzoni, I Muradore, M Soncini, G Pruneri, P Rafaniello, G Viale, P G Pelicci, S Minucc. The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha. Leukemia. vol 25. issue 5. 2011-08-09. PMID:21331069. |
the self-association coiled-coil domain of pml is sufficient for the oncogenic conversion of the retinoic acid receptor (rar) alpha. |
2011-08-09 |
2023-08-12 |
Not clear |
| M Occhionorelli, F Santoro, I Pallavicini, A Gruszka, S Moretti, D Bossi, A Viale, D Shing, S Ronzoni, I Muradore, M Soncini, G Pruneri, P Rafaniello, G Viale, P G Pelicci, S Minucc. The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha. Leukemia. vol 25. issue 5. 2011-08-09. PMID:21331069. |
in acute promyelocytic leukemia (apl) the retinoic acid receptor alpha (rarα) becomes an oncogene through the fusion with several partners, mostly with promyelocytic leukemia protein (pml), all of which have in common the presence of a self-association domain. |
2011-08-09 |
2023-08-12 |
Not clear |
| Syed Khizer Hasan, Francesco Lo-Coc. Utilization of molecular phenotypes to detect relapse and optimize the management of acute promyelocytic leukemia. Clinical lymphoma, myeloma & leukemia. vol 10 Suppl 3. 2011-08-04. PMID:21115433. |
translocation breakpoints are located within the promyelocytic leukemia (pml) locus on chromosome 15 and the retinoic acid receptor alpha (rara) locus on chromosome 17. |
2011-08-04 |
2023-08-12 |
human |
| Marie-Claude Geoffroy, Ellis G Jaffray, Katherine J Walker, Ronald T Ha. Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies. Molecular biology of the cell. vol 21. issue 23. 2011-06-20. PMID:20943951. |
in acute promyelocytic leukemia (apl), the promyelocytic leukemia (pml) protein is fused to the retinoic acid receptor alpha (rar). |
2011-06-20 |
2023-08-12 |
Not clear |
| Stig Ove Bøe, Anne Simonse. Autophagic degradation of an oncoprotein. Autophagy. vol 6. issue 7. 2011-03-01. PMID:20724820. |
acute promyelocytic leukemia (apl) is characterized by a chromosomal t(15;17) translocation that fuses the gene encoding the promyelocytic leukemia protein (pml) to that encoding retinoic acid receptor alpha (rara). |
2011-03-01 |
2023-08-12 |
Not clear |
| Pauline Isakson, Magnar Bjørås, Stig Ove Bøe, Anne Simonse. Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. Blood. vol 116. issue 13. 2010-10-29. PMID:20574048. |
treatment of acute promyelocytic leukemia (apl) with all-trans retinoic acid and/or arsenic trioxide represents a paradigm in targeted cancer therapy because these drugs cause clinical remission by affecting the stability of the fusion oncoprotein promyelocytic leukemia (pml)/retinoic acid receptor alpha (rara). |
2010-10-29 |
2023-08-12 |
Not clear |
| Anuja Chattopadhyay, Robert L Redne. Cryptic insertion of PML-RARA into the 3p25 locus in an acute promyelocytic leukemia with t(3;17)(p25;q21). Cancer genetics and cytogenetics. vol 201. issue 1. 2010-07-29. PMID:20633765. |
fluorescence in situ hybridization failed to show rearrangement of the pml (promyelocytic leukemia protein) locus but did demonstrate relocalization of the retinoic acid receptor alpha (rara) to chromosome 3. |
2010-07-29 |
2023-08-12 |
Not clear |
| P T Sobol, J L Hummel, R M Rodrigues, K L Mossma. PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses. Gene therapy. vol 16. issue 9. 2010-06-29. PMID:19474810. |
disruption of pml signaling through overexpression of the dominant-negative protein pml-retinoic acid receptor alpha in pml-positive cells renders them sensitive to oncolysis by icp0-null herpes simplex virus type-1 and vesicular stomatitis virus m protein mutant viruses, whereas pml overexpression reverses this phenomenon. |
2010-06-29 |
2023-08-12 |
Not clear |
| Xiao-Wei Zhang, Xiao-Jing Yan, Zi-Ren Zhou, Fei-Fei Yang, Zi-Yu Wu, Hong-Bin Sun, Wen-Xue Liang, Ai-Xin Song, Valérie Lallemand-Breitenbach, Marion Jeanne, Qun-Ye Zhang, Huai-Yu Yang, Qiu-Hua Huang, Guang-Biao Zhou, Jian-Hua Tong, Yan Zhang, Ji-Hui Wu, Hong-Yu Hu, Hugues de Thé, Sai-Juan Chen, Zhu Che. Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science (New York, N.Y.). vol 328. issue 5975. 2010-04-26. PMID:20378816. |
arsenic trioxide (as2o3) exerts its therapeutic effect by promoting degradation of an oncogenic protein that drives the growth of apl cells, pml-raralpha (a fusion protein containing sequences from the pml zinc finger protein and retinoic acid receptor alpha). |
2010-04-26 |
2023-08-12 |
Not clear |
| S Careccia, S Mainardi, A Pelosi, A Gurtner, D Diverio, R Riccioni, U Testa, E Pelosi, G Piaggio, A Sacchi, S Lavorgna, F Lo-Coco, G Blandino, M Levrero, M G Rizz. A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes. Oncogene. vol 28. issue 45. 2009-12-04. PMID:19749800. |
we further investigated whether the apl-associated oncogene, promyelocytic leukemia gene (pml)/retinoic acid receptor alpha (raralpha), might be involved in the transcriptional repression of mir-107, -342 and let-7c. |
2009-12-04 |
2023-08-12 |
Not clear |
| Jacqueline E Payton, Nicole R Grieselhuber, Li-Wei Chang, Mark Murakami, Gary K Geiss, Daniel C Link, Rakesh Nagarajan, Mark A Watson, Timothy J Le. High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. The Journal of clinical investigation. vol 119. issue 6. 2009-07-24. PMID:19451695. |
acute promyelocytic leukemia (apl) is characterized by the t(15;17) chromosomal translocation, which results in fusion of the retinoic acid receptor alpha (rara) gene to another gene, most commonly promyelocytic leukemia (pml). |
2009-07-24 |
2023-08-12 |
mouse |
| A Choughule, S Polampalli, P Amre, S Shinde, S Banavali, K Prabhash, R Nair, P G Subramanian, S Gujral, P M Parik. Identification of PML/RARalpha fusion gene transcripts that showed no t(15;17) with conventional karyotyping and fluorescent in situ hybridization. Genetics and molecular research : GMR. vol 8. issue 1. 2009-06-05. PMID:19224461. |
acute promyelocytic leukemia (apl) is characterized by a reciprocal translocation, t(15;17)(q22;q11-21), resulting in the fusion of the promyelocytic leukemia (pml) and retinoic acid receptor alpha (raralpha) genes. |
2009-06-05 |
2023-08-12 |
Not clear |
| Nicola J M Brown, Michal Ramalho, Eva W Pedersen, Eva Moravcsik, Ellen Solomon, David Grimwad. PML nuclear bodies in the pathogenesis of acute promyelocytic leukemia: active players or innocent bystanders? Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273155. |
strikingly, over a decade ago, pml-nbs were found to be disrupted in acute promyelocytic leukemia (apl) in which pml is fused to the gene encoding retinoic acid receptor alpha (rara) due to the t(15;17) chromosomal translocation, generating the pml-rara chimeric protein. |
2009-04-07 |
2023-08-12 |
Not clear |
| Maria Kalamvoki, Bernard Roizma. Nuclear retention of ICP0 in cells exposed to HDAC inhibitor or transfected with DNA before infection with herpes simplex virus 1. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 51. 2009-01-27. PMID:19073918. |
the retention of icp0 in the nucleus is concordant with failure to degrade pml and disperse nd10 structures, and delays in the transition to post alpha genes expression, translocation of components of the corest/rest/hdac1 complex and histone relocation in the infected cell. |
2009-01-27 |
2023-08-12 |
rabbit |
| Z Diaz, K K Mann, S Marcoux, M Kourelis, M Colombo, P B Komarnitsky, W H Mille. A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines. Leukemia. vol 22. issue 10. 2008-11-07. PMID:18633430. |
however, darinaparsin does not induce promyelocytic leukemia/retinoic acid receptor alpha (pml/rar alpha) degradation or rearrange pml nuclear bodies in apl cells, nor is its toxicity increased by glutathione depletion. |
2008-11-07 |
2023-08-12 |
Not clear |
| Beth A McNally, Joanne Trgovcich, Gerd G Maul, Yang Liu, Pan Zhen. A role for cytoplasmic PML in cellular resistance to viral infection. PloS one. vol 3. issue 5. 2008-09-02. PMID:18509536. |
pml gene was discovered as a fusion partner with retinoic acid receptor (rar) alpha in the t(15:17) chromosomal translocation associated with acute promyelocytic leukemia (apl). |
2008-09-02 |
2023-08-12 |
Not clear |