| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sai-Juan Chen, Li-Juan Chen, Guang-Biao Zho. [Basic and clinical studies of the gene product-targeting therapy based on leukemogenesis--editorial]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 1. 2008-08-18. PMID:15748426. |
as(2)o(3) binds ubiquitin like sumo-1 through the lysine 160 of pml, resulting in the degradation of pml-rar alpha. |
2008-08-18 |
2023-08-12 |
mouse |
| Sai-Juan Chen, Li-Juan Chen, Guang-Biao Zho. [Basic and clinical studies of the gene product-targeting therapy based on leukemogenesis--editorial]. Zhongguo shi yan xue ye xue za zhi. vol 13. issue 1. 2008-08-18. PMID:15748426. |
taken together, atra and as(2)o(3) target the transcription factor pml-rar alpha, the former by retinoic acid receptor and the latter by pml sumolization, both induce pml-rar alpha degradation and apl cells differentiation and apoptosis. |
2008-08-18 |
2023-08-12 |
mouse |
| P Salomoni, B J Ferguson, A H Wyllie, T Ric. New insights into the role of PML in tumour suppression. Cell research. vol 18. issue 6. 2008-08-11. PMID:18504460. |
the pml gene is involved in the t(15;17) translocation of acute promyelocytic leukaemia (apl), which generates the oncogenic fusion protein pml (promyelocytic leukaemia protein)-retinoic acid receptor alpha. |
2008-08-11 |
2023-08-12 |
human |
| Shori Abe, Idumi Ishikawa, Hideo Harigae, Tomohiro Sugawar. A new complex translocation t(5;17;15)(q11;q21;q22) in acute promyelocytic leukemia. Cancer genetics and cytogenetics. vol 184. issue 1. 2008-08-07. PMID:18558288. |
acute promyelocytic leukemia (apl) is associated with the t(15;17)(q22;q21) translocation which causes the fusion of the retinoic acid alpha gene (rara) on 17q21 to the promyelocytic leukemia gene (pml) on 15q22. |
2008-08-07 |
2023-08-12 |
Not clear |
| Sumit J Shah, Steven Blumen, Ian Pitha-Rowe, Sutisak Kitareewan, Sarah J Freemantle, Qing Feng, Ethan Dmitrovsk. UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation. Molecular cancer therapeutics. vol 7. issue 4. 2008-07-18. PMID:18413804. |
ube1l represses pml/rar{alpha} by targeting the pml domain for isg15ylation. |
2008-07-18 |
2023-08-12 |
Not clear |
| Sumit J Shah, Steven Blumen, Ian Pitha-Rowe, Sutisak Kitareewan, Sarah J Freemantle, Qing Feng, Ethan Dmitrovsk. UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation. Molecular cancer therapeutics. vol 7. issue 4. 2008-07-18. PMID:18413804. |
acute promyelocytic leukemia (apl) is characterized by expression of promyelocytic leukemia (pml)/retinoic acid (ra) receptor alpha (raralpha) protein and all-trans-ra-mediated clinical remissions. |
2008-07-18 |
2023-08-12 |
Not clear |
| Michael H Tatham, Marie-Claude Geoffroy, Linnan Shen, Anna Plechanovova, Neil Hattersley, Ellis G Jaffray, Jorma J Palvimo, Ronald T Ha. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nature cell biology. vol 10. issue 5. 2008-06-19. PMID:18408734. |
in acute promyelocytic leukaemia (apl), the promyelocytic leukaemia (pml) protein is fused to the retinoic acid receptor alpha (rar). |
2008-06-19 |
2023-08-12 |
Not clear |
| Karen Yao, Susan Gagnon, Nahid Akhyani, Elizabeth Williams, Julie Fotheringham, Elliot Frohman, Olaf Stuve, Nancy Monson, Michael K Racke, Steven Jacobso. Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients. PloS one. vol 3. issue 4. 2008-05-28. PMID:18446218. |
the alpha(4) integrin antagonist natalizumab was shown to be effective in patients with immune-mediated disorders but was unexpectedly associated with jc polyomavirus associated progressive multifocal leukoencephalopathy (pml) in two multiple sclerosis (ms) and one crohn's disease patients. |
2008-05-28 |
2023-08-12 |
human |
| Lan Wang, Guang-Biao Zhou, Ping Liu, Jun-Hong Song, Yang Liang, Xiao-Jing Yan, Fang Xu, Bing-Shun Wang, Jian-Hua Mao, Zhi-Xiang Shen, Sai-Juan Chen, Zhu Che. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 12. 2008-04-22. PMID:18344322. |
ati causes intensified ubiquitination/degradation of promyelocytic leukemia (pml)-retinoic acid receptor alpha (raralpha) oncoprotein, stronger reprogramming of myeloid differentiation regulators, and enhanced g(1)/g(0) arrest in apl cells through hitting multiple targets compared with the effects of mono- or biagents. |
2008-04-22 |
2023-08-12 |
human |
| Zhen-Yi Wang, Zhu Che. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood. vol 111. issue 5. 2008-04-15. PMID:18299451. |
morphologically, it is identified as the m3 subtype of acute myeloid leukemia by the french-american-british classification and cytogenetically is characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion between promyelocytic leukemia (pml) gene and retinoic acid receptor alpha (raralpha). |
2008-04-15 |
2023-08-12 |
Not clear |
| Jihui Qiu, Ying Huang, Guoqiang Chen, Zhu Chen, David J Tweardy, Shuo Don. Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Molecular biology of the cell. vol 18. issue 10. 2007-11-27. PMID:17671166. |
acute promyelocytic leukemia (apl) is characterized by specific chromosomal translocations, which generate fusion proteins such as promyelocytic leukemia (pml)-retinoic acid receptor (rar)alpha and promyelocytic leukemia zinc finger (plzf)-raralpha (x-raralpha). |
2007-11-27 |
2023-08-12 |
Not clear |
| Jin-Yeong Han, Kyong-Eun Kim, Kyeong-Hee Kim, Joo-In Park, Jae-Seok Ki. Identification of PML-RARA rearrangement by RT-PCR and sequencing in an acute promyelocytic leukemia without t(15;17) on G-banding and FISH. Leukemia research. vol 31. issue 2. 2007-10-12. PMID:16797070. |
acute promyelocytic leukemia (apl) is characterized by a reciprocal translocation, t(15;17) (q22;q12), resulting in fusion of the genes promyelocytic leukemia (pml) and retinoic acid receptor alpha (rara). |
2007-10-12 |
2023-08-12 |
Not clear |
| A Marinelli, D Bossi, P G Pelicci, S Minucc. A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia. Leukemia. vol 21. issue 4. 2007-09-28. PMID:17252005. |
alterations of the retinoic acid receptor (rar)alpha locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (pml)-raralpha chimeric protein. |
2007-09-28 |
2023-08-12 |
Not clear |
| Hitoshi Yoshida, Hitoshi Ichikawa, Yusuke Tagata, Takuo Katsumoto, Kazunori Ohnishi, Yukihiro Akao, Tomoki Naoe, Pier Paolo Pandolfi, Issay Kitabayash. PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation. Molecular and cellular biology. vol 27. issue 16. 2007-09-06. PMID:17562868. |
pml-retinoic acid receptor alpha inhibits pml iv enhancement of pu.1-induced c/ebpepsilon expression in myeloid differentiation. |
2007-09-06 |
2023-08-12 |
mouse |
| Hitoshi Yoshida, Hitoshi Ichikawa, Yusuke Tagata, Takuo Katsumoto, Kazunori Ohnishi, Yukihiro Akao, Tomoki Naoe, Pier Paolo Pandolfi, Issay Kitabayash. PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation. Molecular and cellular biology. vol 27. issue 16. 2007-09-06. PMID:17562868. |
in contrast to pml iv, the leukemia-associated pml-retinoic acid receptor alpha fusion protein dissociated the pu.1/pml iv/p300 complex and inhibited pu.1-induced transcription. |
2007-09-06 |
2023-08-12 |
mouse |
| Guang-Biao Zhou, Ji Zhang, Zhen-Yi Wang, Sai-Juan Chen, Zhu Che. Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 362. issue 1482. 2007-07-06. PMID:17317642. |
of note, both atra and ato trigger catabolism of the pml-raralpha fusion protein which is the key player in apl leukaemogenesis generated from t(15;17), targeting the raralpha (retinoic acid receptor alpha) or promyelocytic leukaemia (pml) moieties, respectively. |
2007-07-06 |
2023-08-12 |
Not clear |
| Jun-O Jin, Hae-Young Park, Ja-Woong Kim, Joo-In Park, Young-Seoub Hong, Do Sik Min, Jong-Young Kwa. Phosphatidic acid induces the differentiation of human acute promyelocytic leukemic cells into dendritic cell-like. Journal of cellular biochemistry. vol 100. issue 1. 2007-02-28. PMID:16924673. |
we investigated whether phosphatidic acid (pa) can differentiate the promyelocytic leukemia (pml)-retinoic acid receptor alpha (rar alpha)-expressing acute promyelocytic leukemic cell line, nb4, to dendritic cell (dc)-like cells. |
2007-02-28 |
2023-08-12 |
human |
| B A A Santana, M C Pintão, R S Abreu e Lima, P S Scheucher, G A S Santos, A B Garcia, R P Falcão, E M Reg. Asynchronous expression of myeloid antigens in leukemic cells in a PML/RARalpha transgenic mouse model. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 39. issue 5. 2007-02-16. PMID:16648899. |
acute promyelocytic leukemia (apl) is characterized by the expansion of blasts that resemble morphologically promyelocytes and harbor a chromosomal translocation involving the retinoic acid receptor alpha (raralpha) and the promyelocytic leukemia (pml) genes on chromosomes 17 and 15, respectively. |
2007-02-16 |
2023-08-12 |
mouse |
| Cristian Bellodi, Karin Kindle, Francesca Bernassola, Andrea Cossarizza, David Dinsdale, Gerry Melino, David Heery, Paolo Salomon. A cytoplasmic PML mutant inhibits p53 function. Cell cycle (Georgetown, Tex.). vol 5. issue 22. 2007-02-12. PMID:17172828. |
the promyelocytic leukaemia gene (pml) is a tumor suppressor identified in acute promyelocytic leukaemia (apl), where it is fused to rar alpha gene as a result of the chromosomal translocation t(15;17). |
2007-02-12 |
2023-08-12 |
Not clear |
| Sara Caprodossi, Marika Pedinotti, Consuelo Amantini, Giorgio Santoni, Saverio Minucci, Pier Giuseppe Pelicci, Mirco Fanell. Differentiation response of acute promyelocytic leukemia cells and PML/RARa leukemogenic activity studies by real-time RT-PCR. Molecular biotechnology. vol 30. issue 3. 2006-09-19. PMID:15988048. |
acute promyelocytic leukemia (apl) is a human cancer generated by a chromosomal translocation t(15;17) involving the promyelocytic leukemia (pml) and retinoic acid receptor alpha (raralpha) genes. |
2006-09-19 |
2023-08-12 |
human |