| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cynthia L Montana, Karen A Lawrence, Natecia L Williams, Nicholas M Tran, Guang-Hua Peng, Shiming Chen, Joseph C Corb. Transcriptional regulation of neural retina leucine zipper (Nrl), a photoreceptor cell fate determinant. The Journal of biological chemistry. vol 286. issue 42. 2011-12-07. PMID:21865162. |
the transcription factor neural retina leucine zipper (nrl) is a critical determinant of rod photoreceptor cell fate and a key regulator of rod differentiation. |
2011-12-07 |
2023-08-12 |
mouse |
| Cynthia L Montana, Karen A Lawrence, Natecia L Williams, Nicholas M Tran, Guang-Hua Peng, Shiming Chen, Joseph C Corb. Transcriptional regulation of neural retina leucine zipper (Nrl), a photoreceptor cell fate determinant. The Journal of biological chemistry. vol 286. issue 42. 2011-12-07. PMID:21865162. |
in this study, we sought to define the cis- and trans-acting factors responsible for initiation and maintenance of nrl transcription in the mouse retina. |
2011-12-07 |
2023-08-12 |
mouse |
| Debarshi Mustafi, Brian M Kevany, Christel Genoud, Kiichiro Okano, Artur V Cideciyan, Alexander Sumaroka, Alejandro J Roman, Samuel G Jacobson, Andreas Engel, Mark D Adams, Krzysztof Palczewsk. Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 9. 2011-11-09. PMID:21659555. |
the neural retina leucine zipper transcription factor-knockout (nrl(-/-)) mouse model demonstrates many phenotypic features of human escs, including unstable s-cone-positive photoreceptors. |
2011-11-09 |
2023-08-12 |
mouse |
| Debarshi Mustafi, Brian M Kevany, Christel Genoud, Kiichiro Okano, Artur V Cideciyan, Alexander Sumaroka, Alejandro J Roman, Samuel G Jacobson, Andreas Engel, Mark D Adams, Krzysztof Palczewsk. Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 9. 2011-11-09. PMID:21659555. |
furthermore, lack of phagosomes in the rpe layer of nrl(-/-) retina revealed impairment in phagocytosis. |
2011-11-09 |
2023-08-12 |
mouse |
| Lily Ng, Ailing Lu, Alok Swaroop, David S Sharlin, Anand Swaroop, Douglas Forres. Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 31. 2011-10-11. PMID:21813673. |
mice deleted for thyroid hormone receptor β2 (trβ2) and neural retina leucine zipper factor (nrl) lack m cones and rods, respectively, but gain s cones. |
2011-10-11 |
2023-08-12 |
mouse |
| Lily Ng, Ailing Lu, Alok Swaroop, David S Sharlin, Anand Swaroop, Douglas Forres. Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 31. 2011-10-11. PMID:21813673. |
we also detected precursor cells in normal embryonic retina that transiently coexpressed nrl and trβ2, suggesting that some precursors may originate in a plastic state. |
2011-10-11 |
2023-08-12 |
mouse |
| Emma L West, Rachael A Pearson, Susie E Barker, Ulrich F O Luhmann, Robert E Maclaren, Amanda C Barber, Yanai Duran, Alexander J Smith, Jane C Sowden, Robin R Al. Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation. Stem cells (Dayton, Ohio). vol 28. issue 11. 2011-03-15. PMID:20857496. |
we have previously shown that murine postmitotic rod photoreceptor precursor cells, identified by expression of the rod-specific transcription factor nrl, are able to migrate into and integrate within the adult murine neural retina. |
2011-03-15 |
2023-08-12 |
Not clear |
| Arthur Krigel, Marie-Paule Felder-Schmittbuhl, David Hick. Circadian-clock driven cone-like photoreceptor phagocytosis in the neural retina leucine zipper gene knockout mouse. Molecular vision. vol 16. 2011-02-08. PMID:21203345. |
to characterize the light and circadian control of cone photoreceptor phagocytosis in mice, we capitalized on the blue cone-like phenotype of neural retina leucine zipper gene (nrl) null mice (nrl(-/-)). |
2011-02-08 |
2023-08-12 |
mouse |
| Rosanne M Yetemian, Bruce M Brown, Cheryl M Craf. Neovascularization, enhanced inflammatory response, and age-related cone dystrophy in the Nrl-/-Grk1-/- mouse retina. Investigative ophthalmology & visual science. vol 51. issue 12. 2011-01-13. PMID:20688726. |
the effects of aging and light exposure on cone photoreceptor survival were compared between mouse retinas of neural retina leucine zipper knockout (nrl(-/-)) mice and double-knockout mice lacking g-protein-coupled receptor kinase 1 (nrl(-/-)grk1(-/-)). |
2011-01-13 |
2023-08-12 |
mouse |
| Jung-Woong Kim, Sang-Min Jang, Chul-Hong Kim, Joo-Hee An, Eun-Jin Kang, Kyung-Hee Cho. Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development. The FEBS journal. vol 277. issue 24. 2011-01-13. PMID:21078119. |
here, we report that ppp2r5c (regulatory subunit of protein phosphatase 2a) expression was regulated by the transcription factor neural retina leucine-zipper (nrl) through enhancement of its transcriptional activity on the ppp2r5c promoter. |
2011-01-13 |
2023-08-12 |
mouse |
| Jerome E Roger, Jacob Nellissery, Douglas S Kim, Anand Swaroo. Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation. The Journal of biological chemistry. vol 285. issue 33. 2010-08-30. PMID:20551322. |
development of rod photoreceptors in the mammalian retina is critically dependent on the basic motif-leucine zipper transcription factor nrl (neural retina leucine zipper). |
2010-08-30 |
2023-08-12 |
mouse |
| Jerome E Roger, Jacob Nellissery, Douglas S Kim, Anand Swaroo. Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation. The Journal of biological chemistry. vol 285. issue 33. 2010-08-30. PMID:20551322. |
in the absence of nrl, photoreceptor precursors in mouse retina produce only cones that primarily express s-opsin. |
2010-08-30 |
2023-08-12 |
mouse |
| Jerome E Roger, Jacob Nellissery, Douglas S Kim, Anand Swaroo. Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation. The Journal of biological chemistry. vol 285. issue 33. 2010-08-30. PMID:20551322. |
conversely, ectopic expression of nrl in post-mitotic precursors leads to a rod-only retina. |
2010-08-30 |
2023-08-12 |
mouse |
| Jerome E Roger, Jacob Nellissery, Douglas S Kim, Anand Swaroo. Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation. The Journal of biological chemistry. vol 285. issue 33. 2010-08-30. PMID:20551322. |
consistent with this, in vivo electroporation of the nrl-k20r/k24r mutant into newborn nrl(-/-) mouse retina leads to reduced nr2e3 activation and only a partial rescue of the nrl(-/-) phenotype in contrast to the wild-type nrl that is able to convert cones to rod photoreceptors. |
2010-08-30 |
2023-08-12 |
mouse |
| Li Jia, Edwin C T Oh, Lily Ng, Maya Srinivas, Matthew Brooks, Anand Swaroop, Douglas Forres. Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 41. 2009-11-03. PMID:19805139. |
the phenotype reflects pronounced plasticity between rod and cone lineages and resembles that described for nrl(-/-) mice lacking neural retina leucine zipper factor. |
2009-11-03 |
2023-08-12 |
mouse |
| Kannan Kunchithapautham, Beth Coughlin, Rosalie K Crouch, Bärbel Rohre. Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement. Investigative ophthalmology & visual science. vol 50. issue 10. 2009-10-02. PMID:19407011. |
here, we determine the consequences of 11-cis retinal withdrawal and supplementation on cone development in the all-cone nrl(-/-) retina. |
2009-10-02 |
2023-08-12 |
mouse |
| Edwin C T Oh, Hong Cheng, Hong Hao, Lin Jia, Naheed Wali Khan, Anand Swaroo. Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors. Brain research. vol 1236. 2009-04-16. PMID:18294621. |
the maf-family transcription factor nrl is essential for rod photoreceptor specification in the mammalian retina as its loss of function converts rod precursors to functional cones. |
2009-04-16 |
2023-08-12 |
mouse |
| Edwin C T Oh, Hong Cheng, Hong Hao, Lin Jia, Naheed Wali Khan, Anand Swaroo. Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors. Brain research. vol 1236. 2009-04-16. PMID:18294621. |
given that nrl and nr2e3 have overlapping functions and nr2e3 expression is abolished in the nrl(-/-) retina, we wanted to clarify the distinct roles of nrl and nr2e3 during retinal differentiation. |
2009-04-16 |
2023-08-12 |
mouse |
| Raghuveer S Mali, Guang-Hua Peng, Xiao Zhang, Loan Dang, Shiming Chen, Kenneth P Mitto. FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. BMC molecular biology. vol 9. 2008-11-12. PMID:18854042. |
we reported previously that in the mammalian retina, fiz1 interacts with nrl (neural-retina leucine-zipper), an essential transcriptional activator of rod photoreceptor-specific genes. |
2008-11-12 |
2023-08-12 |
mouse |
| Raghuveer S Mali, Guang-Hua Peng, Xiao Zhang, Loan Dang, Shiming Chen, Kenneth P Mitto. FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. BMC molecular biology. vol 9. 2008-11-12. PMID:18854042. |
the concentration of fiz1 in the retina increases during photoreceptor terminal maturation, when two key transcription factors nrl and crx (cone-rod homeobox) become detectable on the promoters of photoreceptor-specific genes (i.e. |
2008-11-12 |
2023-08-12 |
mouse |