| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrica Strettoi, Alan J Mears, Anand Swaroo. Recruitment of the rod pathway by cones in the absence of rods. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 34. 2005-01-26. PMID:15329405. |
in the retina of nrl (neural retina leucine zipper) knock-out mice, in which rods fail to form and all photoreceptors are cones, rod bipolar cells have normal morphology, pattern of staining, and lamination, but they form synaptic connections with cones. |
2005-01-26 |
2023-08-12 |
mouse |
| Hong Cheng, Hemant Khanna, Edwin C T Oh, David Hicks, Kenneth P Mitton, Anand Swaroo. Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors. Human molecular genetics. vol 13. issue 15. 2005-01-11. PMID:15190009. |
in transient transfection studies using hek 293 cells, both nr2e3 and nr1d1 activated the promoters of rod phototransduction genes synergistically with neural retina leucine zipper (nrl) and cone-rod homeobox (crx). |
2005-01-11 |
2023-08-12 |
mouse |
| Jindan Yu, Shirley He, James S Friedman, Masayuki Akimoto, Debashis Ghosh, Alan J Mears, David Hicks, Anand Swaroo. Altered expression of genes of the Bmp/Smad and Wnt/calcium signaling pathways in the cone-only Nrl-/- mouse retina, revealed by gene profiling using custom cDNA microarrays. The Journal of biological chemistry. vol 279. issue 40. 2004-11-15. PMID:15292180. |
to gain insights into the molecular differences between rods and cones, we compared the gene expression profile of the rod-dominated retina of wild type mouse with that of the cone-only retina of nrl(-/-) (neural retina leucine zipper knockout) mouse. |
2004-11-15 |
2023-08-12 |
mouse |
| Jindan Yu, Shirley He, James S Friedman, Masayuki Akimoto, Debashis Ghosh, Alan J Mears, David Hicks, Anand Swaroo. Altered expression of genes of the Bmp/Smad and Wnt/calcium signaling pathways in the cone-only Nrl-/- mouse retina, revealed by gene profiling using custom cDNA microarrays. The Journal of biological chemistry. vol 279. issue 40. 2004-11-15. PMID:15292180. |
our analysis, using custom microarrays of eye-expressed genes, provided equivalent data using either direct or reference-based experimental designs, confirmed differential expression of rod- and cone-specific genes in the nrl(-/-) retina and identified novel genes that could serve as candidates for retinopathies or for functional studies. |
2004-11-15 |
2023-08-12 |
mouse |
| Jindan Yu, Shirley He, James S Friedman, Masayuki Akimoto, Debashis Ghosh, Alan J Mears, David Hicks, Anand Swaroo. Altered expression of genes of the Bmp/Smad and Wnt/calcium signaling pathways in the cone-only Nrl-/- mouse retina, revealed by gene profiling using custom cDNA microarrays. The Journal of biological chemistry. vol 279. issue 40. 2004-11-15. PMID:15292180. |
prompted by these findings, additional real-time pcr analysis revealed that genes belonging to the bmp/smad and wnt/ca(2+) signaling pathways are expressed in the mature wild type retina and that their expression is significantly altered in the nrl(-/-) retina. |
2004-11-15 |
2023-08-12 |
mouse |
| Jindan Yu, Shirley He, James S Friedman, Masayuki Akimoto, Debashis Ghosh, Alan J Mears, David Hicks, Anand Swaroo. Altered expression of genes of the Bmp/Smad and Wnt/calcium signaling pathways in the cone-only Nrl-/- mouse retina, revealed by gene profiling using custom cDNA microarrays. The Journal of biological chemistry. vol 279. issue 40. 2004-11-15. PMID:15292180. |
chromatin immunoprecipitation analysis of adult retina identified bmp4 and smad4, which are down-regulated in the nrl(-/-) retina, as possible direct transcriptional targets of nrl. |
2004-11-15 |
2023-08-12 |
mouse |
| Jindan Yu, Shirley He, James S Friedman, Masayuki Akimoto, Debashis Ghosh, Alan J Mears, David Hicks, Anand Swaroo. Altered expression of genes of the Bmp/Smad and Wnt/calcium signaling pathways in the cone-only Nrl-/- mouse retina, revealed by gene profiling using custom cDNA microarrays. The Journal of biological chemistry. vol 279. issue 40. 2004-11-15. PMID:15292180. |
we hypothesize that bmp/smad and wnt/ca(2+) pathways participate in cell-cell communication in the mature retina, and expression changes observed in the nrl(-/-) retina reflect their biased utilization in rod versus cone homeostasis. |
2004-11-15 |
2023-08-12 |
mouse |
| Keely M Bumsted O'Brien, Hong Cheng, Yibin Jiang, Dorothea Schulte, Anand Swaroop, Anita E Hendrickso. Expression of photoreceptor-specific nuclear receptor NR2E3 in rod photoreceptors of fetal human retina. Investigative ophthalmology & visual science. vol 45. issue 8. 2004-08-31. PMID:15277507. |
to study the physiological function of nr2e3 and possible molecular mechanisms underlying enhanced short-wavelength cone syndrome (escs) pathogenesis in developing human retina, and to compare its expression to that of neural retina leucine zipper (nrl), a transcription factor essential for rod differentiation. |
2004-08-31 |
2023-08-12 |
human |
| Steven J Pittler, Youwen Zhang, Shiming Chen, Alan J Mears, Donald J Zack, Zhiyong Ren, Prabodh K Swain, Suxia Yao, Anand Swaroop, J Brandon Whit. Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity. The Journal of biological chemistry. vol 279. issue 19. 2004-06-15. PMID:15001570. |
consistent with a requirement for crx and nrl in pde6a promoter activity, pde6a mrna is reduced by 87% in the retina of crx(-/-) mice and is undetectable in nrl(-/-) mice at postnatal day 10. |
2004-06-15 |
2023-08-12 |
mouse |
| Kenneth P Mitton, Prabodh K Swain, Hemant Khanna, Mary Dowd, Ingrid J Apel, Anand Swaroo. Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. Human molecular genetics. vol 12. issue 4. 2003-09-12. PMID:12566383. |
nrl (neural retina leucine zipper) is a basic motif leucine zipper transcription factor of the maf-subfamily. |
2003-09-12 |
2023-08-12 |
mouse |
| Kenneth P Mitton, Prabodh K Swain, Hemant Khanna, Mary Dowd, Ingrid J Apel, Anand Swaroo. Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. Human molecular genetics. vol 12. issue 4. 2003-09-12. PMID:12566383. |
missense mutations in the human nrl gene are associated with autosomal dominant retinitis pigmentosa, whereas the loss of its function leads to rodless retina in nrl-knockout mice that exhibit enhanced s-cone function. |
2003-09-12 |
2023-08-12 |
mouse |
| Kenneth P Mitton, Prabodh K Swain, Hemant Khanna, Mary Dowd, Ingrid J Apel, Anand Swaroo. Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. Human molecular genetics. vol 12. issue 4. 2003-09-12. PMID:12566383. |
our results indicate potential cross-talk among signaling pathways in the retina and suggest that the function of nrl is modulated by its interaction with specific repressor proteins. |
2003-09-12 |
2023-08-12 |
mouse |
| Xuemei Zhu, Bruce Brown, Aimin Li, Alan J Mears, Anand Swaroop, Cheryl M Craf. GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 14. 2003-08-07. PMID:12853434. |
using the "pure-cone" retinas of the neural retina leucine zipper (nrl) knock-out (ko, -/-) mice (mears et al., 2001), we have demonstrated the light-dependent, multi-site phosphorylation of both s and m cone opsins by in situ phosphorylation and isoelectric focusing. |
2003-08-07 |
2023-08-12 |
mouse |
| Margaret M DeAngelis, Jonna L Grimsby, Michael A Sandberg, Eliot L Berson, Thaddeus P Dryj. Novel mutations in the NRL gene and associated clinical findings in patients with dominant retinitis pigmentosa. Archives of ophthalmology (Chicago, Ill. : 1960). vol 120. issue 3. 2002-04-02. PMID:11879142. |
to search for mutations in the neural retina leucine zipper (nrl) gene in patients with dominant retinitis pigmentosa and to compare the severity of disease in these patients with that observed previously in patients with dominant rhodopsin mutations. |
2002-04-02 |
2023-08-12 |
Not clear |
| A J Mears, M Kondo, P K Swain, Y Takada, R A Bush, T L Saunders, P A Sieving, A Swaroo. Nrl is required for rod photoreceptor development. Nature genetics. vol 29. issue 4. 2001-12-20. PMID:11694879. |
the protein neural retina leucine zipper (nrl) is a basic motif-leucine zipper transcription factor that is preferentially expressed in rod photoreceptors. |
2001-12-20 |
2023-08-12 |
mouse |
| P K Swain, D Hicks, A J Mears, I J Apel, J E Smith, S K John, A Hendrickson, A H Milam, A Swaroo. Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors. The Journal of biological chemistry. vol 276. issue 39. 2001-11-01. PMID:11477108. |
here we report that six isoforms of nrl (29-35 kda) are generated by phosphorylation and expressed specifically in the mammalian retina. |
2001-11-01 |
2023-08-12 |
human |
| P K Swain, D Hicks, A J Mears, I J Apel, J E Smith, S K John, A Hendrickson, A H Milam, A Swaroo. Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors. The Journal of biological chemistry. vol 276. issue 39. 2001-11-01. PMID:11477108. |
in both human retinal cell cultures and sections of fetal and adult human retina, nrl is present in the nuclei of developing and mature rods but not cones. |
2001-11-01 |
2023-08-12 |
human |
| S Gerber, I Perrault, S Hanein, F Barbet, D Ducroq, I Ghazi, D Martin-Coignard, C Leowski, T Homfray, J L Dufier, A Munnich, J Kaplan, J M Roze. Complete exon-intron structure of the RPGR-interacting protein (RPGRIP1) gene allows the identification of mutations underlying Leber congenital amaurosis. European journal of human genetics : EJHG. vol 9. issue 8. 2001-09-20. PMID:11528500. |
two retinal specific candidate genes were known to map to this region, namely the neural retina leucine zipper (nrl) and the retinitis pigmentosa gtpase regulator interacting protein (rpgrip1). |
2001-09-20 |
2023-08-12 |
Not clear |
| K P Mitton, P K Swain, S Chen, S Xu, D J Zack, A Swaroo. The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation. The Journal of biological chemistry. vol 275. issue 38. 2000-11-03. PMID:10887186. |
nrl (neural retina leucine zipper) and crx (cone rod homeobox) proteins bind to the adjacent nre and ret-4 sites, respectively, within this region. |
2000-11-03 |
2023-08-12 |
Not clear |
| B Z Ring, S P Cordes, P A Overbeek, G S Bars. Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development (Cambridge, England). vol 127. issue 2. 2000-02-16. PMID:10603348. |
maf and the closely related family members neural retina leucine zipper (nrl), l-maf, and krml1/mafb have been implicated in a wide variety of developmental and physiologic roles; however, mutations in vivo have been described only for krml1/mafb, in which a loss-of-function causes abnormalities in hindbrain development due to failure to activate the hoxa3 and hoxb3 genes. |
2000-02-16 |
2023-08-12 |
mouse |