| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander V Matveev, Alexander B Quiambao, J Browning Fitzgerald, Xi-Qin Din. Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- mice. Journal of neurochemistry. vol 106. issue 5. 2008-11-03. PMID:18665891. |
this study investigates the biochemical components of native cone cng channels, using the cone-dominant retina in mice deficient in the transcription factor neural retina leucine zipper (nrl). |
2008-11-03 |
2023-08-12 |
mouse |
| Anne K Hennig, Guang-Hua Peng, Shiming Che. Regulation of photoreceptor gene expression by Crx-associated transcription factor network. Brain research. vol 1192. 2008-06-02. PMID:17662965. |
the cell type (subtype) specificity of this network is governed by factors that are preferentially expressed by rods or cones or both, including the rod-determining factors neural retina leucine zipper protein (nrl) and the orphan nuclear receptor nr2e3; and cone-determining factors, mostly nuclear receptor family members. |
2008-06-02 |
2023-08-12 |
Not clear |
| Lauren L Daniele, Ralf H Adams, Diane E Durante, Edward N Pugh, Nancy J Phil. Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epithelium. The Journal of comparative neurology. vol 505. issue 2. 2008-01-09. PMID:17853450. |
recent studies reported that jam-c mrna was increased threefold in the all-cone retina of the nrl(-/-) mouse, suggesting that jam-c is required for maturation and polarization of cone photoreceptors cells. |
2008-01-09 |
2023-08-12 |
mouse |
| Rafal Farjo, Steven J Fliesler, Muna I Naas. Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrity. The Journal of comparative neurology. vol 504. issue 6. 2008-01-04. PMID:17722028. |
however, cone lamellae assembly, albeit disorganized, concomitantly permits outer limiting membrane association, and this appears to be linked to photoreceptor rosette formation in the rodless (cone-only) nrl(-/-) retina. |
2008-01-04 |
2023-08-12 |
mouse |
| Vera A McIlvain, Barry E Kno. Nr2e3 and Nrl can reprogram retinal precursors to the rod fate in Xenopus retina. Developmental dynamics : an official publication of the American Association of Anatomists. vol 236. issue 7. 2007-10-17. PMID:17377979. |
nr2e3 and nrl can reprogram retinal precursors to the rod fate in xenopus retina. |
2007-10-17 |
2023-08-12 |
human |
| Vera A McIlvain, Barry E Kno. Nr2e3 and Nrl can reprogram retinal precursors to the rod fate in Xenopus retina. Developmental dynamics : an official publication of the American Association of Anatomists. vol 236. issue 7. 2007-10-17. PMID:17377979. |
here, we examined whether neural retina leucine zipper (nrl) and photoreceptor-specific nuclear receptor nr2e3 transcription factors contribute to cell fate determination. |
2007-10-17 |
2023-08-12 |
human |
| Prabodha Swain, Sandeep Kumar, Dharmesh Patel, Sushmita Richong, Pranav Oberoi, Madhumita Ghosh, Anand Swaroo. Mutations associated with retinopathies alter mitogen-activated protein kinase-induced phosphorylation of neural retina leucine-zipper. Molecular vision. vol 13. 2007-09-04. PMID:17653056. |
neural retina leucine-zipper (nrl), a member of the basic motif leucine zipper family of transcription factors, is preferentially expressed in rod photoreceptors of the mammalian retina. |
2007-09-04 |
2023-08-12 |
Not clear |
| Joseph C Corbo, Connie A Myers, Karen A Lawrence, Ashutosh P Jadhav, Constance L Cepk. A typology of photoreceptor gene expression patterns in the mouse. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 29. 2007-08-30. PMID:17620597. |
in this study, we carried out microarray and in situ hybridization analyses of the mouse neural retina leucine zipper gene (nrl) mutant, which shows an en masse conversion of rods into cones, to establish a typology of photoreceptor gene expression and to identify novel cone-specific genes. |
2007-08-30 |
2023-08-12 |
mouse |
| Atsuhiro Kanda, James S Friedman, Koji M Nishiguchi, Anand Swaroo. Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity. Human mutation. vol 28. issue 6. 2007-05-29. PMID:17335001. |
the transcription factor neural retina leucine zipper (nrl) is required for rod photoreceptor differentiation during mammalian retinal development. |
2007-05-29 |
2023-08-12 |
human |
| Yong-Qing Gao, Michael Danciger, Riza Köksal Ozgul, Yekaterina Gribanova, Samuel Jacobson, Debora B Farbe. Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease. Molecular vision. vol 13. 2007-04-30. PMID:17356515. |
we have previously shown that sp4 may be involved in the transcriptional activation of these genes alone or together with other transcription factors such as sp1, neural retina leucine zipper protein (nrl), and cone-rod homeobox gene (crx). |
2007-04-30 |
2023-08-12 |
Not clear |
| Edwin C T Oh, Naheed Khan, Elena Novelli, Hemant Khanna, Enrica Strettoi, Anand Swaroo. Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 5. 2007-03-09. PMID:17242361. |
to examine the role of nrl in cell fate determination, we generated transgenic mice that express nrl under the control of crx promoter in postmitotic photoreceptor precursors of wt and nrl-/- retina. |
2007-03-09 |
2023-08-12 |
mouse |
| Edwin C T Oh, Naheed Khan, Elena Novelli, Hemant Khanna, Enrica Strettoi, Anand Swaroo. Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 5. 2007-03-09. PMID:17242361. |
we show that nrl expression, in both genetic backgrounds, leads to a functional retina with only rod photoreceptors. |
2007-03-09 |
2023-08-12 |
mouse |
| Andreas Wenzel, Johannes von Lintig, Vitus Oberhauser, Naoyuki Tanimoto, Christian Grimm, Mathias W Seelige. RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice. Investigative ophthalmology & visual science. vol 48. issue 2. 2007-03-01. PMID:17251447. |
in the current study, neural retina leucine zipper-deficient (nrl(-/-)) and rod opsin (rho(-/-))-deficient mice were used, two mouse models that have been described as having a "cone-only" retina, to analyze the retinoid metabolism of cones. |
2007-03-01 |
2023-08-12 |
mouse |
| Raghuveer S Mali, Xiao Zhang, Widmann Hoerauf, Danielle Doyle, Jeffrey Devitt, Janice Loffreda-Wren, Kenneth P Mitto. FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro. Experimental eye research. vol 84. issue 2. 2007-02-20. PMID:17141759. |
fiz1 (flt-3 interacting zinc-finger) interacts and co-purifies with the rod-specific transcription factor nrl (neural retina leucine zipper). |
2007-02-20 |
2023-08-12 |
mouse |
| Hemant Khanna, Masayuki Akimoto, Sandrine Siffroi-Fernandez, James S Friedman, David Hicks, Anand Swaroo. Retinoic acid regulates the expression of photoreceptor transcription factor NRL. The Journal of biological chemistry. vol 281. issue 37. 2006-10-31. PMID:16854989. |
nrl (neural retina leucine zipper) is a key basic motif-leucine zipper (bzip) transcription factor, which orchestrates rod photoreceptor differentiation by activating the expression of rod-specific genes. |
2006-10-31 |
2023-08-12 |
mouse |
| Xavier Le Guezennec, Michiel Vermeulen, Hendrik G Stunnenber. Molecular characterization of Sin3 PAH-domain interactor specificity and identification of PAH partners. Nucleic acids research. vol 34. issue 14. 2006-09-13. PMID:16914451. |
in addition, a tandem affinity purification (tap)-tagging approach of sin3b resulted in the isolation of known and novel interactors amongst which neural retina leucine (nrl) zipper. |
2006-09-13 |
2023-08-12 |
Not clear |
| Lyudmyla G Glushakova, Adrian M Timmers, Tawfik M Issa, Nenita G Cortez, Jijing Pang, Jacqueline T Teusner, William W Hauswirt. Does recombinant adeno-associated virus-vectored proximal region of mouse rhodopsin promoter support only rod-type specific expression in vivo? Molecular vision. vol 12. 2006-05-04. PMID:16617297. |
here, we evaluated whether the presence of certain cis-elements in this proximal promoter, such as the rod-specific, neural retina leucine zipper protein (nrl) response element (nre), can render it a driver of rod-specific expression. |
2006-05-04 |
2023-08-12 |
mouse |
| Shigeo Yoshida, Alan J Mears, James S Friedman, Todd Carter, Shirley He, Edwin Oh, Yuezhou Jing, Rafal Farjo, Gilles Fleury, Carrolee Barlow, Alfred O Hero, Anand Swaroo. Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Human molecular genetics. vol 13. issue 14. 2005-12-19. PMID:15163632. |
expression profiling of the developing and mature nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of nrl. |
2005-12-19 |
2023-08-12 |
mouse |
| Shigeo Yoshida, Alan J Mears, James S Friedman, Todd Carter, Shirley He, Edwin Oh, Yuezhou Jing, Rafal Farjo, Gilles Fleury, Carrolee Barlow, Alfred O Hero, Anand Swaroo. Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Human molecular genetics. vol 13. issue 14. 2005-12-19. PMID:15163632. |
the rod photoreceptor-specific neural retina leucine zipper protein nrl is essential for rod differentiation and plays a critical role in regulating gene expression. |
2005-12-19 |
2023-08-12 |
mouse |
| Shigeo Yoshida, Alan J Mears, James S Friedman, Todd Carter, Shirley He, Edwin Oh, Yuezhou Jing, Rafal Farjo, Gilles Fleury, Carrolee Barlow, Alfred O Hero, Anand Swaroo. Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Human molecular genetics. vol 13. issue 14. 2005-12-19. PMID:15163632. |
in the mouse retina, rods account for 97% of the photoreceptors; however, in the absence of nrl (nrl-/-), no rods are present and a concomitant increase in cones is observed. |
2005-12-19 |
2023-08-12 |
mouse |