| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shannon M Conley, Michael W Stuck, Justin L Burnett, Dibyendu Chakraborty, Seifollah Azadi, Steven J Fliesler, Muna I Naas. Insights into the mechanisms of macular degeneration associated with the R172W mutation in RDS. Human molecular genetics. vol 23. issue 12. 2015-01-12. PMID:24463884. |
to facilitate the study of cones in the heavily rod-dominant mouse retina, r172w mice were bred onto an nrl(-/-) background (in which developing rods adopt a cone-like fate). |
2015-01-12 |
2023-08-12 |
mouse |
| Marijana Samardzija, Christian Caprara, Severin R Heynen, Sarah Willcox DeParis, Isabelle Meneau, Ghislaine Traber, Cavit Agca, Johannes von Lintig, Christian Grim. A mouse model for studying cone photoreceptor pathologies. Investigative ophthalmology & visual science. vol 55. issue 8. 2014-10-09. PMID:25034607. |
to develop a model with a functional all-cone retina that is morphologically well structured, we generated r91w;nrl(-/-) double-mutant mice, which express a hypomorphic rpe65 allele (r91w). |
2014-10-09 |
2023-08-13 |
mouse |
| Chunxia Wang, Katsuhiro Hosono, Masafumi Ohtsubo, Kentaro Ohishi, Jie Gao, Nobuo Nakanishi, Akiko Hikoya, Miho Sato, Yoshihiro Hotta, Shinsei Minoshim. Interaction between optineurin and the bZIP transcription factor NRL. Cell biology international. vol 38. issue 1. 2014-07-24. PMID:23956131. |
to study the function of optn in retinal ganglion cells as well as the whole retina, we previously isolated optn-interacting proteins and identified the gene encoding the bzip transcription factor neural retina leucine zipper (nrl), which is a causative gene for retinitis pigmentosa. |
2014-07-24 |
2023-08-12 |
rat |
| Alexander Aslanidis, Marcus Karlstetter, Yana Walczak, Herbert Jägle, Thomas Langman. RETINA-specific expression of Kcnv2 is controlled by cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl). Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664678. |
retina-specific expression of kcnv2 is controlled by cone-rod homeobox (crx) and neural retina leucine zipper (nrl). |
2014-07-24 |
2023-08-12 |
mouse |
| Alexander Aslanidis, Marcus Karlstetter, Yana Walczak, Herbert Jägle, Thomas Langman. RETINA-specific expression of Kcnv2 is controlled by cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl). Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664678. |
reporter electroporation of the wild type promoter region induced strong dsred expression, indicating high regulatory activity, whereas shrna-mediated knockdown of crx and nrl resulted in reduced kcnv2 promoter activity and low endogenous kcnv2 mrna expression in the retina. |
2014-07-24 |
2023-08-12 |
mouse |
| Hong Hao, Janina Gregorski, Haohua Qian, Yichao Li, Chun Y Gao, Sana Idrees, Bin Zhan. In vivo function of the ER-Golgi transport protein LMAN1 in photoreceptor homeostasis. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664723. |
lman1 is a direct target of the transcription factor nrl in mouse retina. |
2014-07-24 |
2023-08-12 |
mouse |
| Marijana Samardzija, Christian Grim. Mouse models for cone degeneration. Advances in experimental medicine and biology. vol 801. 2014-07-24. PMID:24664745. |
recently, however, the sparseness of cones was overcome by the generation of the nrl (- / -) mouse that expresses only cone photoreceptors in the retina. |
2014-07-24 |
2023-08-12 |
mouse |
| Jianhua Xu, Lynsie Morris, Arjun Thapa, Hongwei Ma, Stylianos Michalakis, Martin Biel, Wolfgang Baehr, Igor V Peshenko, Alexander M Dizhoor, Xi-Qin Din. cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 37. 2013-12-02. PMID:24027293. |
the activity and expression levels of cgmp-dependent protein kinase g (pkg) were significantly increased in cnga3(-/-);nrl(-/-) retina compared with nrl(-/-), suggesting an involvement of pkg regulation in cell death. |
2013-12-02 |
2023-08-12 |
mouse |
| Nicholas P Boyer, Peter H Tang, Daniel Higbee, Zsolt Ablonczy, Rosalie K Crouch, Yiannis Koutalo. Lipofuscin and A2E accumulate with age in the retinal pigment epithelium of Nrl-/- mice. Photochemistry and photobiology. vol 88. issue 6. 2013-11-26. PMID:22417141. |
the photoreceptor cells of the nrl(-/-) retina contain only cone-like pigments, and produce cone-like responses to photostimulation. |
2013-11-26 |
2023-08-12 |
mouse |
| Ammaji Rajala, Radhika Dighe, Martin-Paul Agbaga, Robert E Anderson, Raju V S Rajal. Insulin receptor signaling in cones. The Journal of biological chemistry. vol 288. issue 27. 2013-09-13. PMID:23673657. |
to date there are no studies on the insulin receptor signaling in cones; however, mrna levels of ir signaling proteins are significantly higher in cone-dominant neural retina leucine zipper (nrl) knock-out mouse retinas compared with wild type rod-dominant retinas. |
2013-09-13 |
2023-08-12 |
mouse |
| I Hernan, M J Gamundi, E Borràs, M Maseras, B García-Sandoval, F Blanco-Kelly, C Ayuso, M Carball. Novel p.M96T variant of NRL and shRNA-based suppression and replacement of NRL mutants associated with autosomal dominant retinitis pigmentosa. Clinical genetics. vol 82. issue 5. 2013-03-21. PMID:21981118. |
mutations in the gene encoding the transcription factor neural retina leucine zipper (nrl) are known to cause autosomal dominant (adrp) or recessive (arrp) retinitis pigmentosa (rp). |
2013-03-21 |
2023-08-12 |
human |
| Hari Jayaram, Peng-Tee Khaw, Robert E MacLaren, G Astrid Lim. Focus on molecules: neural retina leucine zipper (NRL). Experimental eye research. vol 104. 2013-01-25. PMID:22445942. |
focus on molecules: neural retina leucine zipper (nrl). |
2013-01-25 |
2023-08-12 |
Not clear |
| Hong Hao, Douglas S Kim, Bernward Klocke, Kory R Johnson, Kairong Cui, Norimoto Gotoh, Chongzhi Zang, Janina Gregorski, Linn Gieser, Weiqun Peng, Yang Fann, Martin Seifert, Keji Zhao, Anand Swaroo. Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysis. PLoS genetics. vol 8. issue 4. 2012-09-26. PMID:22511886. |
in the mammalian retina, the basic motif leucine zipper transcription factor nrl determines rod versus cone photoreceptor cell fate and activates the expression of many rod-specific genes. |
2012-09-26 |
2023-08-12 |
human |
| Michael W Stuck, Shannon M Conley, Muna I Naas. Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina. PloS one. vol 7. issue 3. 2012-08-20. PMID:22427845. |
in the nrl(-/-) retina, rods are converted into functional cone-like cells. |
2012-08-20 |
2023-08-12 |
mouse |
| Michael W Stuck, Shannon M Conley, Muna I Naas. Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina. PloS one. vol 7. issue 3. 2012-08-20. PMID:22427845. |
the nrl(-/-) retina is characterized by large undulations of the outer nuclear layer (onl) commonly known as rosettes. |
2012-08-20 |
2023-08-12 |
mouse |
| Michael W Stuck, Shannon M Conley, Muna I Naas. Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina. PloS one. vol 7. issue 3. 2012-08-20. PMID:22427845. |
here we explore the mechanism of rosette development in the nrl(-/-) retina. |
2012-08-20 |
2023-08-12 |
mouse |
| Michael W Stuck, Shannon M Conley, Muna I Naas. Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina. PloS one. vol 7. issue 3. 2012-08-20. PMID:22427845. |
we show that the adherens junctions between photoreceptors and müller glia which comprise the retinal outer limiting membrane (olm) are not uniformly formed in the nrl(-/-) retina and thus allow protrusion of a population of developing photoreceptors into the subretinal space where their maturation becomes delayed. |
2012-08-20 |
2023-08-12 |
mouse |
| Michael W Stuck, Shannon M Conley, Muna I Naas. Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina. PloS one. vol 7. issue 3. 2012-08-20. PMID:22427845. |
these data suggest that the rosettes of the nrl(-/-) retina arise due to defects in the olm and delayed maturation of a subset of photoreceptors, and that rods may play an important role in the proper formation of the olm. |
2012-08-20 |
2023-08-12 |
mouse |
| Jung-Woong Kim, Sang-Min Jang, Chul-Hong Kim, Joo-Hee An, Kyung-Hee Cho. Transcriptional activity of neural retina leucine zipper (Nrl) is regulated by c-Jun N-terminal kinase and Tip60 during retina development. Molecular and cellular biology. vol 32. issue 9. 2012-06-25. PMID:22354990. |
transcriptional activity of neural retina leucine zipper (nrl) is regulated by c-jun n-terminal kinase and tip60 during retina development. |
2012-06-25 |
2023-08-12 |
mouse |
| Jung-Woong Kim, Sang-Min Jang, Chul-Hong Kim, Joo-Hee An, Kyung-Hee Cho. Transcriptional activity of neural retina leucine zipper (Nrl) is regulated by c-Jun N-terminal kinase and Tip60 during retina development. Molecular and cellular biology. vol 32. issue 9. 2012-06-25. PMID:22354990. |
neural retina leucine zipper (nrl), a key basic motif leucine zipper (bzip) transcription factor, modulates rod photoreceptor differentiation by activating rod-specific target genes. |
2012-06-25 |
2023-08-12 |
mouse |