| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Kong, Lihong Zhao, Jeremy R Charette, Wanda L Hicks, Lisa Stone, Patsy M Nishina, Jürgen K Nagger. An FRMD4B variant suppresses dysplastic photoreceptor lesions in models of enhanced S-cone syndrome and of Nrl deficiency. Human molecular genetics. vol 27. issue 19. 2019-03-28. PMID:29947801. |
photoreceptor dysplasia, characterized by formation of folds and (pseudo-)rosettes in the outer retina, is associated with loss of functional nuclear receptor subfamily 2 group e member 3 (nr2e3) and neural retina leucine-zipper (nrl) in both humans and mice. |
2019-03-28 |
2023-08-13 |
mouse |
| M Joseph Phillips, Elizabeth E Capowski, Andrew Petersen, Alex D Jansen, Katherine Barlow, Kimberly L Edwards, David M Gam. Generation of a rod-specific NRL reporter line in human pluripotent stem cells. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29402929. |
we created the first human rod reporter line using crispr/cas9 genome editing to replace one allele of the neural retina leucine zipper (nrl) gene with an egfp transgene in the wa09 human embryonic stem cell (hesc) line. |
2018-12-11 |
2023-08-13 |
human |
| Sreekumaran Sreekanth, Vazhanthodi A Rasheed, Lalitha Soundararajan, Jayesh Antony, Minakshi Saikia, Krishnankutty Chandrika Sivakumar, Ani V Da. miR Cluster 143/145 Directly Targets Nrl and Regulates Rod Photoreceptor Development. Molecular neurobiology. vol 54. issue 10. 2018-07-27. PMID:27878762. |
this may be one possible mechanism by which nrl is posttranscriptionally regulated to facilitate the generation of other cell types in retina. |
2018-07-27 |
2023-08-13 |
Not clear |
| Soon Won Choi, Ji-Hee Shin, Jae-Jun Kim, Tae-Hoon Shin, Yoojin Seo, Hyung-Sik Kim, Kyung-Sun Kan. Direct cell fate conversion of human somatic stem cells into cone and rod photoreceptor-like cells by inhibition of microRNA-203. Oncotarget. vol 7. issue 27. 2018-01-15. PMID:27283900. |
this mir-203 is predicted to target multiple retina development-relevant genes, particularly dkk1, crx, rorβ, neurod1, nrl and thrb. |
2018-01-15 |
2023-08-13 |
human |
| Jung-Woong Kim, Hyun-Jin Yang, Adam Phillip Oel, Matthew John Brooks, Li Jia, David Charles Plachetzki, Wei Li, William Ted Allison, Anand Swaroo. Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals. Developmental cell. vol 37. issue 6. 2017-06-13. PMID:27326930. |
our study illuminates several questions regarding the evolution of duplex retina and supports the hypothesis that, in mammals, the s-cone lineage was recruited via the maf-family transcription factor nrl to augment rod photoreceptors. |
2017-06-13 |
2023-08-13 |
mouse |
| Anne Wolf, Alexander Aslanidis, Thomas Langman. Retinal expression and localization of Mef2c support its important role in photoreceptor gene expression. Biochemical and biophysical research communications. vol 483. issue 1. 2017-06-07. PMID:28017720. |
photoreceptor-specific gene expression is controlled by a hierarchical network of transcription factors, including the master regulators cone-rod homeobox (crx) and neural retina leucine zipper (nrl). |
2017-06-07 |
2023-08-13 |
mouse |
| Kollu N Rao, Linjing Li, Wei Zhang, Richard S Brush, Raju V S Rajala, Hemant Khann. Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina. Human molecular genetics. vol 25. issue 7. 2017-01-23. PMID:26908598. |
to assess the effect of the loss of rpgr in the all-cone region of the human retina, we used nrl(-/-) (neural retina leucine zipper) mice, to generate rpgr(ko)::nrl(-/-) double-knock-out (rpgr-dko) mice. |
2017-01-23 |
2023-08-13 |
mouse |
| Kollu N Rao, Linjing Li, Wei Zhang, Richard S Brush, Raju V S Rajala, Hemant Khann. Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina. Human molecular genetics. vol 25. issue 7. 2017-01-23. PMID:26908598. |
transcriptomic analysis revealed predominant up-regulation of retinal pigmented epithelium (rpe)-specific genes associated with visual cycle, whereas fatty acid analysis showed mild decrease in docosahexaenoic acid in the retina of the rpgr-dko mice when compared with the nrl(-/-) mice. |
2017-01-23 |
2023-08-13 |
mouse |
| Diana S Brightman, David Razafsky, Chloe Potter, Didier Hodzic, Shiming Che. Nrl-Cre transgenic mouse mediates loxP recombination in developing rod photoreceptors. Genesis (New York, N.Y. : 2000). vol 54. issue 3. 2016-12-13. PMID:26789558. |
the results showed that nrl-cre expression was specific to the retina where it drives rod-specific recombination with a temporal pattern similar to endogenous nrl expression during retinal development. |
2016-12-13 |
2023-08-13 |
mouse |
| Rossukon Kaewkhaw, Koray Dogan Kaya, Matthew Brooks, Kohei Homma, Jizhong Zou, Vijender Chaitankar, Mahendra Rao, Anand Swaroo. Transcriptome Dynamics of Developing Photoreceptors in Three-Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks. Stem cells (Dayton, Ohio). vol 33. issue 12. 2016-10-27. PMID:26235913. |
cone gene expression is concomitant with crx, whereas rod differentiation factor neural retina leucine zipper protein (nrl) is first observed at day 67. |
2016-10-27 |
2023-08-13 |
human |
| P Geiger, M Barben, C Grimm, M Samardzij. Blue light-induced retinal lesions, intraretinal vascular leakage and edema formation in the all-cone mouse retina. Cell death & disease. vol 6. 2016-09-28. PMID:26583326. |
recently, we generated r91w;nrl(-/-) double-mutant mice, which display a well-ordered all-cone retina with normal retinal vasculature and a strong photopic function that generates useful vision. |
2016-09-28 |
2023-08-13 |
mouse |
| P Geiger, M Barben, C Grimm, M Samardzij. Blue light-induced retinal lesions, intraretinal vascular leakage and edema formation in the all-cone mouse retina. Cell death & disease. vol 6. 2016-09-28. PMID:26583326. |
microglia/macrophage infiltration at the site of injury was more pronounced in the all-cone retina of r91w;nrl(-/-) than in wt mice. |
2016-09-28 |
2023-08-13 |
mouse |
| P Geiger, M Barben, C Grimm, M Samardzij. Blue light-induced retinal lesions, intraretinal vascular leakage and edema formation in the all-cone mouse retina. Cell death & disease. vol 6. 2016-09-28. PMID:26583326. |
similarly, vascular leakage was abundant in the inner and outer retina in r91w;nrl(-/-) mice, whereas it was mild and restricted to the subretinal space in wt mice. |
2016-09-28 |
2023-08-13 |
mouse |
| Marijana Samardzija, Maya Barben, Philipp Geiger, Christian Grim. The Consequences of Hypomorphic RPE65 for Rod and Cone Photoreceptors. Advances in experimental medicine and biology. vol 854. 2016-04-18. PMID:26427430. |
to study the impact on cones, we combined the r91w with the nrl (-/-) mouse that develops an all-cone retina. |
2016-04-18 |
2023-08-13 |
mouse |
| Hong Hao, Shobi Veleri, Bo Sun, Douglas S Kim, Patrick W Keeley, Jung-Woong Kim, Hyun-Jin Yang, Sharda P Yadav, Souparnika H Manjunath, Raman Sood, Paul Liu, Benjamin E Reese, Anand Swaroo. Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL. Human molecular genetics. vol 23. issue 16. 2016-03-22. PMID:24691551. |
the maf-family leucine zipper transcription factor nrl is essential for rod photoreceptor development and functional maintenance in the mammalian retina. |
2016-03-22 |
2023-08-13 |
mouse |
| Hong Hao, Shobi Veleri, Bo Sun, Douglas S Kim, Patrick W Keeley, Jung-Woong Kim, Hyun-Jin Yang, Sharda P Yadav, Souparnika H Manjunath, Raman Sood, Paul Liu, Benjamin E Reese, Anand Swaroo. Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL. Human molecular genetics. vol 23. issue 16. 2016-03-22. PMID:24691551. |
mutations in nrl are associated with human retinopathies, and loss of nrl in mice leads to a cone-only retina with the complete absence of rods. |
2016-03-22 |
2023-08-13 |
mouse |
| Hong Hao, Shobi Veleri, Bo Sun, Douglas S Kim, Patrick W Keeley, Jung-Woong Kim, Hyun-Jin Yang, Sharda P Yadav, Souparnika H Manjunath, Raman Sood, Paul Liu, Benjamin E Reese, Anand Swaroo. Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL. Human molecular genetics. vol 23. issue 16. 2016-03-22. PMID:24691551. |
among the highly down-regulated genes in the nrl(-/-) retina, we identified receptor expression enhancing protein 6 (reep6), which encodes a member of a family of proteins involved in shaping of membrane tubules and transport of g-protein coupled receptors. |
2016-03-22 |
2023-08-13 |
mouse |
| Tiago Santos-Ferreira, Kai Postel, Henrike Stutzki, Thomas Kurth, Günther Zeck, Marius Ade. Daylight vision repair by cell transplantation. Stem cells (Dayton, Ohio). vol 33. issue 1. 2015-09-16. PMID:25183393. |
thus, an abundant and traceable source for donor cone-like photoreceptors was generated by crossing neural retina leucine zipper-deficient (nrl(-/-) ) mice with an ubiquitous green fluorescent protein (gfp) reporter line resulting in double transgenic tg(nrl(-/-); agfp) mice. |
2015-09-16 |
2023-08-13 |
mouse |
| Tiago Santos-Ferreira, Kai Postel, Henrike Stutzki, Thomas Kurth, Günther Zeck, Marius Ade. Daylight vision repair by cell transplantation. Stem cells (Dayton, Ohio). vol 33. issue 1. 2015-09-16. PMID:25183393. |
donor cells correctly integrated into host retinas, acquired mature photoreceptor morphology, expressed cone-specific markers, and survived for up to 6 months, with significantly increased integration rates in the cone-only nrl(-/-) retina. |
2015-09-16 |
2023-08-13 |
mouse |
| Yulong Fu, Hong Liu, Lily Ng, Jung-Woong Kim, Hong Hao, Anand Swaroop, Douglas Forres. Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL. The Journal of biological chemistry. vol 289. issue 47. 2015-02-12. PMID:25296752. |
the neural retina leucine zipper factor (nrl) transcription factor critically controls photoreceptor fates as it stimulates rod differentiation and suppresses cone differentiation. |
2015-02-12 |
2023-08-13 |
mouse |