| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brice Ayissi Owona, Arnaud Mary, Angelique N Messi, Kishore Aravind Ravichandran, Josephine Ngo Mbing, Emmanuel Pegnyemb, Paul F Moundipa, Michael T Henek. Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation. Molecular neurobiology. 2024-07-16. PMID:39012444. |
neuroinflammation is a common hallmark of alzheimer's disease (ad), with nlrp3 inflammasome proven to be activated in microglia of ad patients' brains. |
2024-07-16 |
2024-07-18 |
human |
| Hui Zhong, Tianshu Liu, You Shang, Chaolin Huang, Shangwen Pa. Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-14. PMID:39004064. |
activation of the nlrp3 inflammasome, situated within microglia, can be triggered by diverse danger signals, leading to cell pyroptosis, apoptosis, and tauopathy. |
2024-07-14 |
2024-07-18 |
Not clear |
| Hui Zhong, Tianshu Liu, You Shang, Chaolin Huang, Shangwen Pa. Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-07-14. PMID:39004064. |
in this review, we focus on elucidating the inhibitory regulatory mechanism of the nlrp3 inflammasome in microglia, which ultimately manifests as suppression of the inflammatory response. |
2024-07-14 |
2024-07-18 |
Not clear |
| Wenjing Ning, Shi Lv, Qian Wang, Yuzhen X. The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage. Neural regeneration research. 2024-07-12. PMID:38993136. |
currently, microglia in subarachnoid hemorrhage are targeted with tlr inhibitors, nuclear factor-κb and stat3 pathway inhibitors, glycine/tyrosine kinases, nlrp3 signaling pathway inhibitors, gasdermin d inhibitors, vincristine receptor α receptor agonists, ferroptosis inhibitors, genetic modification techniques, stem cell therapies, and traditional chinese medicine. |
2024-07-12 |
2024-07-14 |
Not clear |
| Daniel C Shippy, Abigail H Evered, Tyler K Ullan. Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease. Immunological reviews. 2024-07-11. PMID:38989642. |
nlrp3 inflammasome activation in microglia, the primary immune effector cells of the brain, results in caspase-1 activation and secretion of il-1β and il-18. |
2024-07-11 |
2024-07-13 |
Not clear |
| Hilal Cihankaya, Verian Bader, Konstanze F Winklhofer, Matthias Vorgerd, Johann Matschke, Sarah Stahlke, Carsten Theiss, Veronika Matschk. Elevated NLRP3 Inflammasome Activation Is Associated with Motor Neuron Degeneration in ALS. Cells. vol 13. issue 12. 2024-06-26. PMID:38920626. |
additionally, we showed the upregulation of protein levels and the colocalization of nlrp3, c-casp1, and gsdmd in neurons, as well as in microglia and astrocytes. |
2024-06-26 |
2024-06-29 |
mouse |
| FangFang Qian, RenHong He, XiaoHui Du, Yi Wei, Zhou Zhou, JianZhong Fan, YouHua H. Microglia and Astrocytes Responses Contribute to Alleviating Inflammatory Damage by Repetitive Transcranial Magnetic Stimulation in Rats with Traumatic Brain Injury. Neurochemical research. 2024-06-23. PMID:38909329. |
rtms also reduced the levels of pyroptosis within microglia and pyroptosis-related proteins (nlrp3, caspase-1, gsdmd, il-1β and il-18). |
2024-06-23 |
2024-06-25 |
rat |
| Jing-Hao Liang, Heng Yu, Chuan-Peng Xia, Yue-Hui Zheng, Zhe Zhang, Yu Chen, Mazhar Ali Raza, Long Wu, Hede Ya. Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908197. |
in the in vivo study, we adopted the rat chronic constriction injury model, and the results showed that gb(4 mg/kg) treatment effectively reduced pain sensation in rats and decreased the expressions of iba-1 (a microglia marker), nlrp3 inflammasome, and inflammatory factors, such as interleukin (il)-1β, in the spinal cord 7 days post-surgery. |
2024-06-22 |
2024-06-25 |
rat |
| Jing-Hao Liang, Heng Yu, Chuan-Peng Xia, Yue-Hui Zheng, Zhe Zhang, Yu Chen, Mazhar Ali Raza, Long Wu, Hede Ya. Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908197. |
moreover, it lowered the expression of inflammation-related proteins, such as caspase-1, il-1β, and nlrp3 in microglia. |
2024-06-22 |
2024-06-25 |
rat |
| Ryan Gober, Julian Dallmeier, David Davis, Daniel Brzostowicki, Juan Pablo de Rivero Vaccari, Brianna Cyr, Ayled Barreda, Xiaoyan Sun, Sakir Humayun Gultekin, Susanna Garamszegi, William Scott, Regina Vontel. Increased inflammasome protein expression identified in microglia from postmortem brains with schizophrenia. Journal of neuropathology and experimental neurology. 2024-06-21. PMID:38904417. |
to assess changes in the cell populations that express key inflammasome proteins, we performed ihc analyses of apoptosis-associated speck-like protein containing a card (asc), nod-like receptor protein 3 (nlrp3), and interleukin (il)-18 to determine if these proteins are expressed in microglia, astrocytes, oligodendrocytes, or neurons. |
2024-06-21 |
2024-06-23 |
Not clear |
| Ryan Gober, Julian Dallmeier, David Davis, Daniel Brzostowicki, Juan Pablo de Rivero Vaccari, Brianna Cyr, Ayled Barreda, Xiaoyan Sun, Sakir Humayun Gultekin, Susanna Garamszegi, William Scott, Regina Vontel. Increased inflammasome protein expression identified in microglia from postmortem brains with schizophrenia. Journal of neuropathology and experimental neurology. 2024-06-21. PMID:38904417. |
increased numbers of microglia were present in the sfc of scz brains and exhibited higher inflammasome protein expression of asc, nlrp3, and il-18 compared to nps. |
2024-06-21 |
2024-06-23 |
Not clear |
| Jia-Rui Zhang, Shi-Yu Shen, Meng-Ying Zhai, Zu-Qi Shen, Wei Li, Ling-Feng Liang, Shu-Yuan Yin, Qiu-Qin Han, Bing Li, Yu-Qiu Zhang, Jin Y. Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress. Nature communications. vol 15. issue 1. 2024-06-18. PMID:38890305. |
extracellular atp (eatp) signaling through the p2x7 receptor pathway is widely believed to trigger nlrp3 inflammasome assembly in microglia, potentially contributing to depression. |
2024-06-18 |
2024-06-21 |
mouse |
| Abudurousuli Adili, Aerken Dilihumaer, Huhu Zhu, Huifang Tan. Research progress on phosphodiesterase 4 inhibitors in central nervous system diseases. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2024-06-11. PMID:38860393. |
pde4 inhibitors play a role in depression; autism spectrum and huntington's disease by inhibiting the advanced glycation end product receptor (rage), tlr4 and nlrp3 pathways in the hippocampus, reducing the activation of microglia and the production of interleukin-1β, down-regulating hmgb1/rage signaling pathway and inhibiting inflammatory factors and increase the nociception threshold. |
2024-06-11 |
2024-06-14 |
Not clear |
| Shuai Feng, Juanji Li, Tingting Liu, Shiqi Huang, Xiangliang Chen, Shen Liu, Junshan Zhou, Hongdong Zhao, Ye Hon. Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke. Neural regeneration research. vol 20. issue 2. 2024-06-06. PMID:38819062. |
low-density lipoprotein receptor, a classic cholesterol regulatory receptor, has been found to inhibit nlr family pyrin domain containing protein 3 (nlrp3) inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with alzheimer's disease. |
2024-06-06 |
2024-06-08 |
mouse |
| Fa Yuan, Rong Zhang, Jiani Li, Qiannan Lei, Shuyi Wang, Fanying Jiang, Yanan Guo, Mengqing Xian. CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis. Journal of neuroinflammation. vol 21. issue 1. 2024-05-28. PMID:38802924. |
accordingly, overexpression of ccr5, a ccl5 receptor, in mesenchymal stem cells (mscs) enhances their homing capacity and improves their immunomodulatory outcomes in preventing eau, by reducing infiltrating t cells and activated microglia and suppressing nlrp3 inflammasome activation. |
2024-05-28 |
2024-06-03 |
mouse |
| Federica Mannino, Valentina Urzì Brancati, Rita Lauro, Igor Pirrotta, Michelangelo Rottura, Natasha Irrera, Gian Maria Cavallini, Giovanni Pallio, Eloisa Gitto, Sara Mant. Levosimendan and Dobutamin Attenuate LPS-Induced Inflammation in Microglia by Inhibiting the NF-κB Pathway and NLRP3 Inflammasome Activation via Nrf2/HO-1 Signalling. Biomedicines. vol 12. issue 5. 2024-05-25. PMID:38790971. |
levosimendan and dobutamin attenuate lps-induced inflammation in microglia by inhibiting the nf-κb pathway and nlrp3 inflammasome activation via nrf2/ho-1 signalling. |
2024-05-25 |
2024-05-27 |
human |
| Blake W Dieckmann, Marcell E Paguaga, Gary W McCollum, John S Penn, Md Imam Uddi. Role of NLRP3 Inflammasomes in Monocyte and Microglial Recruitments in Choroidal Neovascularization. ImmunoHorizons. vol 8. issue 5. 2024-05-22. PMID:38775688. |
inhibition of nlrp3 inflammasomes, using mcc950, caused an increased ccr2rfp-positive macrophages, cx3cr1gfp-positive microglia, and other cells, resulting in an increase in total lesion size. |
2024-05-22 |
2024-05-27 |
mouse |
| Wentao Hu, Menghan Wang, Guifang Sun, Limin Zhang, Hong L. RND3 modulates microglial polarization and alleviates neuroinflammation in Parkinson's disease by suppressing NLRP3 inflammasome activation. Experimental cell research. vol 439. issue 1. 2024-05-22. PMID:38744409. |
in vivo experiments confirmed that rnd3 overexpression could modulate microglia phenotype and ameliorate mptp-induced neuroinflammation through inhibiting activation of the nlrp3 inflammasome in substantia nigra pars compacta (snpc). |
2024-05-22 |
2024-05-27 |
mouse |
| Ting-Bin Chen, Cheng-Chia Yang, I-Ju Tsai, Hao-Wen Yang, Yung-Chu Hsu, Ching-Mao Chang, Chun-Pai Yan. Neuroimmunological effects of omega-3 fatty acids on migraine: a review. Frontiers in neurology. vol 15. 2024-05-21. PMID:38770523. |
this interplay is partially mediated by neuropeptides such as calcitonin gene receptor peptide (cgrp), pituitary adenylate cyclase activating polypeptide (pacap) and/or cortical spreading depression (csd) and involves oxidative stress, mitochondrial dysfunction, nucleotide-binding domain-like receptor family pyrin domain containing-3 (nlrp3) inflammasome formation, activated microglia, and reactive astrocytes. |
2024-05-21 |
2024-05-27 |
Not clear |
| Fernanda da Silva Rodrigues, William Robert Newton, Isadora D'Ávila Tassinari, Felipe Henrique da Cunha Xavier, Adél Marx, Luciano Stürmer de Fraga, Karen Wright, Renata Padilha Guedes, Victorio Bambini-J. Cannabidiol prevents LPS-induced inflammation by inhibiting the NLRP3 inflammasome and iNOS activity in BV2 microglia cells via CB2 receptors and PPARγ. Neurochemistry international. 2024-05-18. PMID:38761855. |
cannabidiol prevents lps-induced inflammation by inhibiting the nlrp3 inflammasome and inos activity in bv2 microglia cells via cb2 receptors and pparγ. |
2024-05-18 |
2024-05-27 |
Not clear |