| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuge Shu, Xinting Chen, Jiawen Ren, Xiangyu Yu, Hao Zhang, Yongquan Y. Glyphosate Induces Anxiety-Like Behaviors in Mice via Activating NLRP3-Mediated Hippocampal Microglia Pyroptosis. Journal of applied toxicology : JAT. 2025-04-20. PMID:40254291. |
as a result, glyphosate directly compromised the morphological structure of neurons, increased the number of iba-1 microglia, and activated the expression of nlrp3-mediated pyroptosis pathway (nlrp3, caspase-1, gsdmd, and il-18) in the hippocampus of mice. |
2025-04-20 |
2025-04-23 |
mouse |
| Shuge Shu, Xinting Chen, Jiawen Ren, Xiangyu Yu, Hao Zhang, Yongquan Y. Glyphosate Induces Anxiety-Like Behaviors in Mice via Activating NLRP3-Mediated Hippocampal Microglia Pyroptosis. Journal of applied toxicology : JAT. 2025-04-20. PMID:40254291. |
moreover, the glyphosate-induced activation of nlrp3 pathway in microglia was markedly reversed by nlrp3 inhibitor mcc950. |
2025-04-20 |
2025-04-23 |
mouse |
| Bowen Li, Ying Gao, Huiyue Han, Zhu Wang, Yang Zhang, Li Yu, Yunzhi Lin. Pharmacological inhibition of Kv1.3 channel reduces sevoflurane-induced cognitive impairment through NLRP3-dependent microglial modulation. Brain research bulletin. 2025-04-19. PMID:40252702. |
pap-1 treatment also promoted the transition of microglia from a pro-inflammatory m1 phenotype to an anti-inflammatory m2 phenotype and suppressed nlrp3 inflammasome activation. |
2025-04-19 |
2025-04-22 |
mouse |
| Ranika Maurya, Abha Sharma, Saba Naqv. Decoding NLRP3 Inflammasome Activation in Alzheimer's Disease: A Focus on Receptor Dynamics. Molecular neurobiology. 2025-04-15. PMID:40232645. |
in ad, amyloid-beta (aβ) plaques and tau aggregates act as damps, triggering nlrp3 inflammasome activation in microglia and astrocytes. |
2025-04-15 |
2025-04-17 |
Not clear |
| Huina Liu, Weitao Chen, Meiyuan He, Linlin Nie, Yaru Pan, Danni Guan, Yongyi Li, Ting Wan, Lining Duan, Cong Yang, Weirong Li, Qi Wang, Lixing Zhuang, Yifan Zhan. Methyl isoeugenol suppresses NLRP3 inflammasome-mediated pyroptosis via activation of Nrf2/NQO1/HO-1 signaling in cerebral ischemia-reperfusion injury. Biochemical pharmacology. 2025-04-14. PMID:40228641. |
the results showed that methyl isoeugenol reduced cerebral infarct volume, modulated microglia m1/m2 phenotypes, and protected against nlrp3 inflammasome-primed pyroptosis. |
2025-04-14 |
2025-04-17 |
Not clear |
| Li Wan, Haiyue Guo, Fan Hu, Yinbing Pan, Shuo Yang, Chun-Yi Jiang, Wentao Liu, Xuefeng Wu, Xudong W. EZH2-mediated suppression of TIMP1 in spinal GABAergic interneurons drives microglial activation via MMP-9-TLR2/4-NLRP3 signaling in neuropathic pain. Brain, behavior, and immunity. 2025-04-10. PMID:40209863. |
the imbalance between timp1 and mmp-9 leads to nlrp3 activation in spinal microglia and increases il-1β maturation via tlr2/4 pathway. |
2025-04-10 |
2025-04-14 |
mouse |
| Yu-Xiao Xue, Yi-Jun Chen, Mei-Zhen Qin, Fan-Fan Shang, Yi-Ting Lu, Yu-Hao Sun, Liu-Guan Bian, Ao Zhang, Yang Yu, Chun-Yong Din. Microglial STING activation promotes neuroinflammation and pathological changes in experimental mice with intracerebral haemorrhage. Acta pharmacologica Sinica. 2025-04-08. PMID:40200123. |
significantly decreased cell apoptosis, alleviated hematoma growth, and improved motor impairments in ich mice, accompanied by inhibiting the sting pathway in microglia, reducing production/release of the cgas-sting pathway downstream inflammatory factors, nlrp3 inflammasome activation and gasdermin d (gsdmd)-induced microglial pyroptosis. |
2025-04-08 |
2025-04-11 |
mouse |
| Renqing Zhao, Xin Tian, Haocheng Xu, Yuanxin Wang, Junjie Lin, Bin Wan. Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway. Aging cell. 2025-04-07. PMID:40192010. |
in cultured microglia, fibril α-synuclein reduced fndc5/irisin protein levels and induced nlrp3 inflammasome formation and il-1β production, which could be diminished by recombinant irisin treatment. |
2025-04-07 |
2025-04-09 |
mouse |
| Renqing Zhao, Xin Tian, Haocheng Xu, Yuanxin Wang, Junjie Lin, Bin Wan. Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway. Aging cell. 2025-04-07. PMID:40192010. |
interestingly, "runner serum" isolated from exercising rodents enhanced fndc5/irisin expression and reduced nlrp3 inflammasome components and il-1β secretion in α-synuclein-treated microglia. |
2025-04-07 |
2025-04-09 |
mouse |
| Qi-Ming Pang, Cui Wang, Bang-Tao Li, Su-Li Zhang, Jiao-Yang Li, Shuo G. LINC00665/miR-132-5p Reduces Inflammation in Epileptic Cells by Targeting MAPK3. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2025-04-04. PMID:40183143. |
epilepsy cell models were constructed with microglia, transfected with mir-132-5p inhibitor and nc, and the expression of linc00665 and mir-132-5p was detected by q-pcr, the expression of tnf-α, il-1β, and il-6 in the cell supernatant was detected by elisa, and the protein levels of nlrp3 and mapk3 were detected by wb. |
2025-04-04 |
2025-04-06 |
Not clear |
| Li Yang, Yao Yao, Weidong Zheng, Xuedong Zheng, Maosong Xie, Libin Huan. Nitric Oxide Mediates Negative Feedback on the TXNIP/NLRP3 Inflammasome Pathway to Prevent Retinal Neurovascular Unit Dysfunction in Early Diabetic Retinopathy. Free radical biology & medicine. 2025-04-03. PMID:40180022. |
in an in vitro co-culture system, silencing txnip or nlrp3 in retinal microglia (rmg) significantly upregulated glial cell-derived neurotrophic factor (gdnf) and downregulated inducible nitric oxide synthase (inos) expression in retinal ganglion cells (rgc). |
2025-04-03 |
2025-04-06 |
rat |
| Hebatallah M Saad, Esraa Atef, Abeer E Elsaye. New Insights on the Potential Role of Pyroptosis in Parkinson's Neuropathology and Therapeutic Targeting of NLRP3 Inflammasome with Recent Advances in Nanoparticle-Based miRNA Therapeutics. Molecular neurobiology. 2025-03-18. PMID:40100493. |
microglia possess an inflammatory complex pathway termed the nucleotide-binding oligomerization domain-, leucine-rich repeat, and pyrin domain-containing 3 (nlrp3) inflammasome. |
2025-03-18 |
2025-03-21 |
mouse |
| Kai-Long He, Xian Yu, Lei Xia, Yan-Dong Xie, En-Bo Qi, Liang Wan, Xu-Ming Hua, Chao-Hui Jin. A new perspective on the regulation of neuroinflammation in intracerebral hemorrhage: mechanisms of NLRP3 inflammasome activation and therapeutic strategies. Frontiers in immunology. vol 16. 2025-03-14. PMID:40083546. |
targeting nlrp3 inflammasomes in microglia or astrocytes may provide an effective approach to mitigate neuroinflammation following ich. |
2025-03-14 |
2025-03-16 |
Not clear |
| Xuheng Tang, Lin Huang, Weiquan Ma, Mingxin Huang, Zhenhua Zeng, Yiqin Yu, Na Qin, Fei Zhou, Fen Li, Shenhai Gong, Hong Yan. Intestinal 8 gingerol attenuates TBI-induced neuroinflammation by inhibiting microglia NLRP3 inflammasome activation in a PINK1/Parkin-dependent manner. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 140. 2025-03-09. PMID:40058316. |
intestinal 8 gingerol attenuates tbi-induced neuroinflammation by inhibiting microglia nlrp3 inflammasome activation in a pink1/parkin-dependent manner. |
2025-03-09 |
2025-03-12 |
Not clear |
| Xiaolin Pang, Zhun Wang, Mengxue Zhang, Jinpeng Dong, Zhonglan Dong, Yiqing Yi. SP3-Mediated Transcriptional Activation of GRIK1 is Involved in Alzheimer's Disease-Induced Cognitive Decline by Inducing Inflammasome Activation in Microglia. Neuromolecular medicine. vol 27. issue 1. 2025-03-07. PMID:40055261. |
app-ps1 mice with grik1 knockdown were constructed using adeno-associated virus, and the effects of grik1 knockdown on the nlrp3 inflammasome activation in microglia of brain tissues of app-ps1 mice were analyzed. |
2025-03-07 |
2025-03-12 |
mouse |
| Xiaolin Pang, Zhun Wang, Mengxue Zhang, Jinpeng Dong, Zhonglan Dong, Yiqing Yi. SP3-Mediated Transcriptional Activation of GRIK1 is Involved in Alzheimer's Disease-Induced Cognitive Decline by Inducing Inflammasome Activation in Microglia. Neuromolecular medicine. vol 27. issue 1. 2025-03-07. PMID:40055261. |
overall, our results revealed that sp3-induced grik1 transcription potentiates nlrp3 inflammasome activation in microglia, leading to cognitive dysfunction in ad. |
2025-03-07 |
2025-03-12 |
mouse |
| Zhifei Cheng, Wei Shao, Chaoqi Wei, Yaru Zhang, Ru Xiao, Shuai Zhang, Jingyi Zhang, Yunfei She, Chenglin Pan, Qi Liu, Qi Wan. Cascade-Type Microglial Pyroptosis Inhibitors for Enhanced Treatment of Cerebral Ischemia-Reperfusion Injury. ACS nano. 2025-03-06. PMID:40047143. |
excessive generation of reactive oxygen species (ros) by overactivated microglia is considered to serve as the signal molecule that triggers nlrp3 inflammasome-mediated pyroptosis. |
2025-03-06 |
2025-03-08 |
rat |
| Paige E Anton, Shannon Twardy, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCulloug. Suppression of NF-κB/NLRP3 by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. Journal of leukocyte biology. 2025-03-04. PMID:40036603. |
studies utilizing rodent models of neurodegenerative disease reveal heightened activation of nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) and nod like receptor 3 (nlrp3) mediate microglia activation and associated neuronal injury. |
2025-03-04 |
2025-03-07 |
mouse |
| Paige E Anton, Shannon Twardy, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCulloug. Suppression of NF-κB/NLRP3 by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. Journal of leukocyte biology. 2025-03-04. PMID:40036603. |
in primary microglia, ethanol-induced expression of reactivity markers and nlrp3 inflammasome activation were more pronounced in microglia from aged mice compared to young. |
2025-03-04 |
2025-03-07 |
mouse |
| Paige E Anton, Shannon Twardy, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCulloug. Suppression of NF-κB/NLRP3 by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. Journal of leukocyte biology. 2025-03-04. PMID:40036603. |
using a nlrp3-specific inhibitor (olt1177) and a novel brain-penetrant nanoligomer that inhibits nf-κb and nlrp3 translation (sb_ni_112), we find ethanol-induced microglial reactivity can be attenuated by olt1177 and sb_ni_112 in microglia from aged mice. |
2025-03-04 |
2025-03-07 |
mouse |