| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashley E Smith, James M Kasper, Noelle C Anastasio, Jonathan D Homme. Binge-Type Eating in Rats is Facilitated by Neuromedin U Receptor 2 in the Nucleus Accumbens and Ventral Tegmental Area. Nutrients. vol 11. issue 2. 2019-02-25. PMID:30717427. |
the reinforcing properties of highly palatable foods are mediated by the nucleus accumbens (nac) and the ventral tegmental area (vta), which have been implicated in the overconsumption behavior observed in bed and obesity. |
2019-02-25 |
2023-08-13 |
rat |
| Aman Asif-Malik, Daniel Dautan, Andrew M J Young, Todor V Gerdjiko. Altered cortico-striatal crosstalk underlies object recognition memory deficits in the sub-chronic phencyclidine model of schizophrenia. Brain structure & function. vol 222. issue 7. 2019-02-21. PMID:28293729. |
given that network activity across regions encompassing medial prefrontal cortex (mpfc) and nucleus accumbens (nac) plays a significant role in motivational and cognitive tasks, we measured activity across cortico-striatal pathways in pcp-treated rats to characterize neural enabling and encoding of task performance in a novel object recognition task. |
2019-02-21 |
2023-08-13 |
rat |
| Michelle K Sequeira, Britta S Nelson, Hannah D Fulenwider, Courtney E King, Sadie E Nennig, Jennifer B Bohannon, Kejun Cheng, Kenner C Rice, Markus Heilig, Jesse R Schan. The neurokinin-1 receptor mediates escalated alcohol intake induced by multiple drinking models. Neuropharmacology. vol 137. 2019-02-20. PMID:29758386. |
also, when compared to continuous alcohol access or access to water alone, nk1r expression was increased in the nucleus accumbens (nac) and dorsal striatum, but not the amygdala. |
2019-02-20 |
2023-08-13 |
rat |
| Mengbing Huang, Chen Yan, Xiaoyan Yang, Xiaoshuang Zhou, Wei Lv, Ningning Guo, Ye Li, Jie Ba. Thioredoxin-1 downregulation in the nucleus accumbens promotes methamphetamine-primed reinstatement in mice. Neuropharmacology. vol 139. 2019-02-20. PMID:29981334. |
the nucleus accumbens (nac) is essential for relapse like behavior in reinstatement animal models. |
2019-02-20 |
2023-08-13 |
mouse |
| Michael T Stefanik, Courtney Sakas, Dennis Lee, Marina E Wol. Ionotropic and metabotropic glutamate receptors regulate protein translation in co-cultured nucleus accumbens and prefrontal cortex neurons. Neuropharmacology. vol 140. 2019-02-20. PMID:30077883. |
in contrast, very little is known about glutamatergic regulation of translation in nucleus accumbens (nac) medium spiny neurons (msn), despite their critical role in addiction-related plasticity and recent evidence that protein translation contributes to this plasticity. |
2019-02-20 |
2023-08-13 |
Not clear |
| Ying Zeng, Di Hu, Wei Yang, Emi Hayashinaka, Yasuhiro Wada, Yasuyoshi Watanabe, Qunli Zeng, Yilong Cu. A voxel-based analysis of neurobiological mechanisms in placebo analgesia in rats. NeuroImage. vol 178. 2019-02-19. PMID:29883731. |
we show here that gabapentin-based pavlovian conditioning successfully induced placebo analgesia in neuropathic pain model rats and hierarchical brain regions are involved in placebo analgesia in rats, including the prelimbic cortex (prl) of the medial prefrontal cortex (mpfc), nucleus accumbens (nac), ventrolateral periaqueductal gray matter (vlpag), etc. |
2019-02-19 |
2023-08-13 |
rat |
| Ji-Chun Zhang, Wei Yao, Youge Qu, Mayumi Nakamura, Chao Dong, Chun Yang, Qian Ren, Min Ma, Mei Han, Yukihiko Shirayama, Akiko Hayashi-Takagi, Kenji Hashimot. Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype. Scientific reports. vol 7. issue 1. 2019-02-18. PMID:28769056. |
we found increased ratios of p-epha4/epha4 and p-ephexin1/ephexin1 in the prefrontal cortex (pfc) and hippocampus but not in the nucleus accumbens (nac), of susceptible mice after social defeat stress. |
2019-02-18 |
2023-08-13 |
mouse |
| Kolter B Grigsby, Cathleen M Kovarik, George E Rottinghaus, Frank W Boot. High and low nightly running behavior associates with nucleus accumbens N-Methyl-d-aspartate receptor (NMDAR) NR1 subunit expression and NMDAR functional differences. Neuroscience letters. vol 671. 2019-02-18. PMID:29425730. |
in so, we utilized female wistar rats selectively bred to voluntarily run high (hvr) and low (lvr) nightly distances in order to examine if endogenous differences in nucleus accumbens (nac) nmda receptor expression and function underlies the propensity for high or low motivation to voluntarily wheel-run. |
2019-02-18 |
2023-08-13 |
rat |
| R Chen, S McIntosh, S E Hemby, H Sun, T Sexton, T J Martin, S R Childer. High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. Neuroscience letters. vol 671. 2019-02-18. PMID:29454035. |
dopamine d2 receptors (d2rs) in the ventral tegmental area (vta) and the nucleus accumbens (nac) are associated with vulnerability to addiction; however, whether d2rs in these two brain regions play differential roles in regulation of drug intake is unknown. |
2019-02-18 |
2023-08-13 |
rat |
| R M Bastle, R J Oliver, A S Gardiner, N S Pentkowski, F Bolognani, A M Allan, T Chaudhury, M St Peter, N Galles, C Smith, J L Neisewander, N I Perrone-Bizzozer. In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens. Molecular psychiatry. vol 23. issue 2. 2019-02-15. PMID:28044061. |
this small non-coding rna is also highly expressed within the nucleus accumbens (nac), a pivotal brain region underlying reward and motivation. |
2019-02-15 |
2023-08-13 |
mouse |
| Amy R Johnson, Matthew L Banks, Dana E Selley, S Stevens Negu. Amphetamine maintenance differentially modulates effects of cocaine, methylenedioxypyrovalerone (MDPV), and methamphetamine on intracranial self-stimulation and nucleus accumbens dopamine in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 8. 2019-02-14. PMID:29703999. |
in neurochemical studies, nucleus accumbens (nac) levels of dopamine (da) and serotonin (5-ht) were monitored by in vivo microdialysis. |
2019-02-14 |
2023-08-13 |
rat |
| Jia Zhan, Chloe J Jordan, Guo-Hua Bi, Xiang-Hu He, Eliot L Gardner, Yan-Lin Wang, Zheng-Xiong X. Genetic deletion of the dopamine D3 receptor increases vulnerability to heroin in mice. Neuropharmacology. vol 141. 2019-02-13. PMID:30138692. |
in addition, deletion of the d3r induced higher baseline levels of extracellular dopamine (da) in the nucleus accumbens (nac), higher basal levels of locomotion, and reduced nac da and locomotor responses to lower doses of heroin. |
2019-02-13 |
2023-08-13 |
mouse |
| Julie Corre, Ruud van Zessen, Michaël Loureiro, Tommaso Patriarchi, Lin Tian, Vincent Pascoli, Christian Lüsche. Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement. eLife. vol 7. 2019-02-12. PMID:30373717. |
here, we monitor genetically encoded da and calcium indicators as well as cfos in mice to reveal that heroin activates da neurons located in the medial part of the vta, preferentially projecting to the medial shell of the nucleus accumbens (nac). |
2019-02-12 |
2023-08-13 |
mouse |
| Seonil Kim, Jiayi Shou, Sinedu Abera, Edward B Zif. Sucrose withdrawal induces depression and anxiety-like behavior by Kir2.1 upregulation in the nucleus accumbens. Neuropharmacology. vol 130. 2019-02-11. PMID:29191750. |
in the nucleus accumbens (nac) of sucrose withdrawal animals, dopamine levels and camp response element binding protein (creb) activity were significantly reduced, while the inwardly rectifying k |
2019-02-11 |
2023-08-13 |
Not clear |
| Ken T Wakabayashi, Malte Feja, Ajay N Baindur, Michael J Bruno, Rohan V Bhimani, Jinwoo Park, Kathryn Hausknecht, Roh-Yu Shen, Samir Haj-Dahmane, Caroline E Bas. Chemogenetic activation of ventral tegmental area GABA neurons, but not mesoaccumbal GABA terminals, disrupts responding to reward-predictive cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 2. 2019-02-11. PMID:29875446. |
dopamine projections from the ventral tegmental area (vta) to the nucleus accumbens (nac) are critical in regulating cue-motivated responding. |
2019-02-11 |
2023-08-13 |
rat |
| Taku Nagai, Kiyofumi Yamada, Kozo Kaibuch. Reward signals downstream of dopamine D1 receptors. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 51. issue 6. 2019-02-11. PMID:30461245. |
the principal target of dopamine is medium spiny neurons (msns), which are a special type of gabaergic inhibitory cell that represents,90% of the neurons within the striatum, including the nucleus accumbens (nac). |
2019-02-11 |
2023-08-13 |
Not clear |
| Xiaoting Wang, David A Gallegos, Vladimir M Pogorelov, Justin K O'Hare, Nicole Calakos, William C Wetsel, Anne E Wes. Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 5. 2019-02-06. PMID:28840858. |
to determine the requirement for parvalbumin (pv) expressing gabaergic interneurons of the nucleus accumbens (nac) in the behavioral adaptations induced by amphetamine (amph), we blocked synaptic vesicle release from these neurons using cre-inducible viral expression of the tetanus toxin light chain in male and female pv-cre mice. |
2019-02-06 |
2023-08-13 |
mouse |
| S E Nennig, H D Fulenwider, S H Chimberoff, B M Smith, J E Eskew, M K Sequeira, C Karlsson, C Liang, J F Chen, M Heilig, J R Schan. Selective Lesioning of Nuclear Factor-κB Activated Cells in the Nucleus Accumbens Shell Attenuates Alcohol Place Preference. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 5. 2019-02-06. PMID:28901327. |
after alcohol place conditioning, we observed increased β-gal staining in the nucleus accumbens (nac) shell and dorsal raphe nucleus, and found that disruption of nf-κb-expressing cells using daun02 attenuated the development of alcohol place preference when infused into the nac shell following conditioning sessions. |
2019-02-06 |
2023-08-13 |
mouse |
| Karine Guillem, Serge H Ahme. Incubation of Accumbal Neuronal Reactivity to Cocaine Cues During Abstinence Predicts Individual Vulnerability to Relapse. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 5. 2019-02-06. PMID:28920590. |
we recorded nucleus accumbens (nac) neuronal responses to drug conditioned stimuli (cs) 1 day before and after 1 month of abstinence from cocaine intake escalation. |
2019-02-06 |
2023-08-13 |
rat |
| Suchan Chang, Yeonhee Ryu, Young Seob Gwak, Nam Jun Kim, Jin Mook Kim, Jun Yeon Lee, Seol Ah Kim, Bong Hyo Lee, Scott C Steffensen, Eun Young Jang, Chae Ha Yang, Hee Young Ki. Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28706288. |
lesions of dorsal column or lateral habenula (lhb) prevented the inhibitory effects of peripheral stimulation on cocaine-induced neuronal activation in the nucleus accumbens (nac). |
2019-02-04 |
2023-08-13 |
Not clear |