| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei Huang, Wenqi He, Lakshmi Rajagopal, Andrea Kudwa, Dimitri E Grigoriadis, Herbert Y Meltze. Effects of NBI-98782, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, on neurotransmitter efflux and phencyclidine-induced locomotor activity: Relevance to tardive dyskinesia and antipsychotic action. Pharmacology, biochemistry, and behavior. vol 190. 2021-01-07. PMID:32084491. |
we utilized microdialysis in awake, freely moving mice to determine the effect of nbi-98782, the active metabolite of valbenazine, alone, or in combination with several antipsychotic drugs (apds), to influence neurotransmitter efflux in the medial prefrontal cortex (mpfc), dorsal striatum (dstr), hippocampus and nucleus accumbens (nac); we also compared it with tetrabenazine, the prototypical vmat2 inhibitor. |
2021-01-07 |
2023-08-13 |
mouse |
| Elizabeth S Williams, Claire E Manning, Andrew L Eagle, Ashlyn Swift-Gallant, Natalia Duque-Wilckens, Sadhana Chinnusamy, Adam Moeser, Cynthia Jordan, Gina Leinninger, Alfred Jay Robiso. Androgen-Dependent Excitability of Mouse Ventral Hippocampal Afferents to Nucleus Accumbens Underlies Sex-Specific Susceptibility to Stress. Biological psychiatry. vol 87. issue 6. 2021-01-06. PMID:31601425. |
preclinical studies in male mice suggest that activity of ventral hippocampus (vhpc) neurons projecting to the nucleus accumbens (nac) regulates mood-related behavioral responses to stress. |
2021-01-06 |
2023-08-13 |
mouse |
| Yue Zhang, Wuhuan Lu, Zibin Wang, Ran Zhang, Yuan Xie, Suhan Guo, Li Jiao, Yu Hong, Zizhen Di, Guangji Wang, Jiye A. Reduced Neuronal cAMP in the Nucleus Accumbens Damages Blood-Brain Barrier Integrity and Promotes Stress Vulnerability. Biological psychiatry. vol 87. issue 6. 2021-01-06. PMID:31812254. |
studies have suggested that chronic social stress specifically downregulates endothelial tight junction protein expression in the nucleus accumbens (nac), thus increasing blood-brain barrier (bbb) permeability and promoting depression-like behaviors. |
2021-01-06 |
2023-08-13 |
Not clear |
| Michel Engeln, Swarup Mitra, Ramesh Chandra, Utsav Gyawali, Megan E Fox, David M Dietz, Mary Kay Lob. Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration. Biological psychiatry. vol 87. issue 11. 2021-01-06. PMID:31858986. |
we previously showed that the transcription factor egr3 (early growth response 3) is oppositely regulated in nucleus accumbens (nac) cell subtypes 24 hours following cocaine exposure and bidirectionally mediates cocaine-related behaviors in male rodents. |
2021-01-06 |
2023-08-13 |
Not clear |
| Yao Wang, Zheng Liu, Li Cai, Rong Guo, Yan Dong, Yanhua H Huan. A Critical Role of Basolateral Amygdala-to-Nucleus Accumbens Projection in Sleep Regulation of Reward Seeking. Biological psychiatry. vol 87. issue 11. 2021-01-06. PMID:31924324. |
the nucleus accumbens (nac) is a reward processing hub sensitive to acute sleep deprivation. |
2021-01-06 |
2023-08-13 |
Not clear |
| Dusti A Shay, Rebecca J Welly, Scott A Givan, Nathan Bivens, Jill Kanaley, Brittney L Marshall, Dennis B Lubahn, Cheryl S Rosenfeld, Victoria J Vieira-Potte. Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice. Hormones and behavior. vol 121. 2021-01-06. PMID:32081742. |
the hypothesis tested herein was that whole body aromatase deletion would cause gene expression changes in the nucleus accumbens (nac), a brain regulating motivated behaviors such as physical activity, which is suppressed with loss of estradiol. |
2021-01-06 |
2023-08-13 |
mouse |
| Shinho Cho, Hoon-Ki Min, Myung-Ho In, Hang Joon J. Multivariate pattern classification on BOLD activation pattern induced by deep brain stimulation in motor, associative, and limbic brain networks. Scientific reports. vol 10. issue 1. 2021-01-06. PMID:32372021. |
we report here on the use of a multivariate pattern analysis (mvpa) to demonstrate that stimulation of three dbs targets (stn, subthalamic nucleus; gpi, globus pallidus internus; nac, nucleus accumbens) evoked a sufficiently distinctive blood-oxygen-level-dependent (bold) activation in swine brain. |
2021-01-06 |
2023-08-13 |
Not clear |
| Raghunath Singh, Yashika Bansal, Rupinder Kaur Sodhi, Pragyanshu Khare, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Bikash Medhi, Anurag Kuha. Role of TRPV1/TRPV3 channels in olanzapine-induced metabolic alteration: Possible involvement in hypothalamic energy-sensing, appetite regulation, inflammation and mesolimbic pathway. Toxicology and applied pharmacology. vol 402. 2021-01-06. PMID:32652086. |
furthermore, olanzapine treatment also increased expression of trpv1/trpv3 in nucleus accumbens (nac), trpv3 expression in ventral tegmental area (vta), which were reversed by the respective antagonists. |
2021-01-06 |
2023-08-13 |
mouse |
| Johnathan M Borland, Ellen Kim, Samuel P Swanson, Patrick E Rothwell, Paul G Mermelstein, Robert L Meise. Effect of Aggressive Experience in Female Syrian Hamsters on Glutamate Receptor Expression in the Nucleus Accumbens. Frontiers in behavioral neuroscience. vol 14. 2021-01-06. PMID:33328919. |
in the following study, using syrian hamsters as a well-validated and translational model of female aggression, we investigated the effects of aggressive experience on the expression of markers of postsynaptic structure (psd-95, caskin i) and excitatory synaptic transmission (glua1, glua2, glua4, nr2a, nr2b, mglur1a, and mglur5) in the nucleus accumbens (nac), caudate putamen and prefrontal cortex. |
2021-01-06 |
2023-08-13 |
Not clear |
| Patricia Barra de la Tremblaye, Nicolas Narvaez Linares, Sarah Schock, Hélène Plamondo. Activation of CRHR1 receptors regulates social and depressive-like behaviors and expression of BDNF and TrkB in mesocorticolimbic regions following global cerebral ischemia. Experimental neurology. vol 284. issue Pt A. 2021-01-05. PMID:27498336. |
immunohistochemistry, western blot and rt-pcr were used to assess bdnf and trkb receptor levels in subregions of the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and ventral tegmental area (vta) 30days post-ischemia. |
2021-01-05 |
2023-08-13 |
rat |
| Urszula Skupio, Magdalena Tertil, Wiktor Bilecki, Justyna Barut, Michal Korostynski, Slawomir Golda, Lucja Kudla, Lucja Wiktorowska, Joanna E Sowa, Marcin Siwiec, Bartosz Bobula, Katarzyna Pels, Krzysztof Tokarski, Grzegorz Hess, Blazej Ruszczycki, Grzegorz Wilczynski, Ryszard Przewlock. Astrocytes determine conditioned response to morphine via glucocorticoid receptor-dependent regulation of lactate release. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31254970. |
here, using a spectrum of tools (whole-transcriptome profiling, viral-mediated rna interference in vitro and in vivo, behavioral pharmacology and electrophysiology), we demonstrate that astrocytes in the nucleus accumbens (nac) are an important locus of glucocorticoid receptor (gr)-dependent transcriptional changes that regulate rewarding effects of morphine. |
2020-12-28 |
2023-08-13 |
mouse |
| Ludovica Maddalena Rossi, Ingrid Reverte, Davide Ragozzino, Aldo Badiani, Marco Venniro, Daniele Capriol. Role of nucleus accumbens core but not shell in incubation of methamphetamine craving after voluntary abstinence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31422417. |
here we studied the role of the nucleus accumbens (nac) in this model. |
2020-12-28 |
2023-08-13 |
human |
| Kevin P Uribe, Victor L Correa, Briana E Pinales, Rodolfo J Flores, Bryan Cruz, Zhiying Shan, Adriaan W Bruijnzeel, Arshad M Khan, Laura E O'Del. Overexpression of corticotropin-releasing factor in the nucleus accumbens enhances the reinforcing effects of nicotine in intact female versus male and ovariectomized female rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31614362. |
this study assessed the role of stress systems in the nucleus accumbens (nac) in promoting sex differences in the reinforcing effects of nicotine. |
2020-12-28 |
2023-08-13 |
rat |
| Catherine F Moore, Michael Z Leonard, Nicholas M Micovic, Klaus A Miczek, Valentina Sabino, Pietro Cotton. Reward sensitivity deficits in a rat model of compulsive eating behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 4. 2020-12-28. PMID:31622973. |
we then quantified da release in the nucleus accumbens (nac) shell after treatment with d-amphetamine using in vivo microdialysis, quantified levels of tyrosine hydroxylase (th) and dopamine transporter (dat) mrna using quantitative polymerase chain reaction (qpcr), and lastly, quantified baseline extracellular da and function of dat in vivo using quantitative "no-net-flux" microdialysis. |
2020-12-28 |
2023-08-13 |
rat |
| Kuisheng Sun, Feng Wang, Lin Ma, Xiaofan Ren, Chun Zhang, Weifang Rong, Tao Su. Genetic knockout of the G protein-coupled estrogen receptor 1 facilitates the acquisition of morphine-induced conditioned place preference and aversion in mice. Biochemical and biophysical research communications. vol 525. issue 4. 2020-12-28. PMID:32184017. |
our study used gper1 knockout (gper1 ko) and wild-type (wt) mice to compare the sensitivity differences of morphine- and sucrose-induced conditioned place preference (cpp) and naloxone-induced conditioned place aversion (cpa), and differences in dopamine (da) content in the nucleus accumbens (nac) were determined by high performance liquid chromatography (hplc). |
2020-12-28 |
2023-08-13 |
mouse |
| Hasan Alhaddad, Woonyen Wong, Adam T Sari, Laura E Crotty Alexander, Youssef Sar. Effects of 3-Month Exposure to E-Cigarette Aerosols on Glutamatergic Receptors and Transporters in Mesolimbic Brain Regions of Female C57BL/6 Mice. Toxics. vol 8. issue 4. 2020-12-26. PMID:33137879. |
in this study, we evaluated the effect of three months' continuous exposure to e-cig vapor (juul pods), containing a high nicotine concentration, on the expression of glutamate receptors and transporters in drug reward brain regions such as the nucleus accumbens (nac) core (nac-core), nac shell (nac-shell) and hippocampus (hip) in female c57bl/6 mice. |
2020-12-26 |
2023-08-13 |
mouse |
| Nan Song, Jun Du, Yan Gao, Shenglian Yan. Epitranscriptome of the ventral tegmental area in a deep brain-stimulated chronic unpredictable mild stress mouse model. Translational neuroscience. vol 11. issue 1. 2020-12-22. PMID:33343932. |
deep brain stimulation (dbs) applied to the nucleus accumbens (nac) alleviates the depressive symptoms of major depressive disorders. |
2020-12-22 |
2023-08-13 |
mouse |
| Hyung W Nam, Caleb A Grant, Ashton N Jorgensen, Carrie J Holtz-Heppelmann, Marjan Trutschl, Urska Cve. Neurogranin Regulates Alcohol Sensitivity through AKT Pathway in the Nucleus Accumbens. Proteomics. vol 20. issue 1. 2020-12-21. PMID:31814311. |
dysfunction of glutamate neurotransmission in the nucleus accumbens (nac) has been implicated in the pathophysiology of alcohol use disorders (aud). |
2020-12-21 |
2023-08-13 |
Not clear |
| Katelyn L Low, Ryan J Tomm, Chunqi Ma, Daniel J Tobiansky, Stan B Floresco, Kiran K Som. Effects of aging on testosterone and androgen receptors in the mesocorticolimbic system of male rats. Hormones and behavior. vol 120. 2020-12-21. PMID:31954104. |
here, we examined young adult (5 months) and aged (22 months) male fischer 344 × brown norway rats, and measured systemic t levels in serum and local t levels in microdissected nodes of the mesocorticolimbic system (ventral tegmental area (vta), nucleus accumbens (nac), medial prefrontal cortex (mpfc), and orbitofrontal cortex (ofc)). |
2020-12-21 |
2023-08-13 |
rat |
| Sabyasachi Dash, Muthukumar Balasubramaniam, Freddyson J Martínez-Rivera, Arthur Godino, Emily G Peck, Srinivas Patnaik, Mrutyunjay Suar, Erin S Calipari, Eric J Nestler, Fernando Villalta, Chandravanu Dash, Jui Pandhar. Cocaine-regulated microRNA miR-124 controls poly (ADP-ribose) polymerase-1 expression in neuronal cells. Scientific reports. vol 10. issue 1. 2020-12-21. PMID:32641757. |
levels of mir-124 were also downregulated upon acute or chronic cocaine exposure in the mouse nucleus accumbens (nac)-a key reward region of brain. |
2020-12-21 |
2023-08-13 |
mouse |