| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia Corongiu, Christian Dessì, Cristina Cadon. Adolescence versus adulthood: Differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse. Addiction biology. vol 25. issue 1. 2021-02-10. PMID:30779271. |
although no significant difference between adolescents and adults was observed in dopamine basal levels in the nucleus accumbens (nac)shell and core, reduced da levels were found in the dorsolateral striatum (dls) of early and mid-adolescent rats. |
2021-02-10 |
2023-08-13 |
rat |
| Mengnan Li, Xiaomin Zhang, Chongyang Li, Yanan Liu, Shuang Yang, Shilian X. Galanin Receptor 2 Is Involved in Galanin-Induced Analgesic Effect by Activating PKC and CaMKII in the Nucleus Accumbens of Inflammatory Pain Rats. Frontiers in neuroscience. vol 14. 2021-02-10. PMID:33551722. |
this study focused on the involvement of galr2 in the galanin-induced analgesic effect and its signaling mechanism in the nucleus accumbens (nac) of inflammatory rats. |
2021-02-10 |
2023-08-13 |
rat |
| Qingxiao Hong, Wenjin Xu, Zi Lin, Jing Liu, Weisheng Chen, Huaqiang Zhu, Miaojun Lai, Dingding Zhuang, Zemin Xu, Dan Fu, Wenhua Zhou, Huifen Li. Role of GABRD Gene Methylation in the Nucleus Accumbens in Heroin-Seeking Behavior in Rats. Frontiers in pharmacology. vol 11. 2021-02-10. PMID:33551813. |
using a sprague-dawley rat model, we show that heroin self-administration resulted in gamma-aminobutyric acid type a receptor subunit delta (gabrd) gene hypomethylation, which was associated with transcriptional upregulation of gabrd in the nucleus accumbens (nac). |
2021-02-10 |
2023-08-13 |
rat |
| Edita Navratilova, Kelsey Nation, Bethany Remeniuk, Volker Neugebauer, Kirsty Bannister, Anthony H Dickenson, Frank Porrec. Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex. Pain. vol 161. issue 3. 2021-02-08. PMID:31725062. |
as opioid receptors are found in both the central (cea) and basolateral (bla) nuclei of the amygdala, we investigated the effects of morphine microinjection on evoked pain responses, pain-motivated behaviors, dopamine release in the nucleus accumbens (nac), and descending modulation in rats with left-side spinal nerve ligation (snl). |
2021-02-08 |
2023-08-13 |
rat |
| H Z Rosa, H J Segat, R C S Barcelos, Kr Roversi, D R Rossato, G F de Brum, M E Burge. Involvement of the endogenous opioid system in the beneficial influence of physical exercise on amphetamine-induced addiction parameters. Pharmacology, biochemistry, and behavior. vol 197. 2021-02-08. PMID:32702398. |
after amph-cpp re-exposure, our outcomes showed that physical exercise, in addition to minimizing the relapse behavior in the cpp, it increased d1r, d2r and dat in the ventral tegmental area (vta), but not in the nucleus accumbens (nac). |
2021-02-08 |
2023-08-13 |
rat |
| Eric Vornholt, John Drake, Mohammed Mamdani, Gowon McMichael, Zachary N Taylor, Silviu-Alin Bacanu, Michael F Miles, Vladimir I Vladimiro. Network preservation reveals shared and unique biological processes associated with chronic alcohol abuse in NAc and PFC. PloS one. vol 15. issue 12. 2021-02-03. PMID:33332381. |
here, we analyzed genome-wide mrna and mirna expression from matched cases with alcohol dependence (ad) and controls (n = 35) via gene network analysis to identify unique and shared biological processes dysregulated in the prefrontal cortex (pfc) and nucleus accumbens (nac). |
2021-02-03 |
2023-08-13 |
Not clear |
| Shervin Assar. Stronger Association between Nucleus Accumbens Density and Body Mass Index in Low-Income and African American Children. Research in health science. vol 5. issue 2. 2021-02-02. PMID:33294757. |
the nucleus accumbens' (nac) size, function, and density influence individuals' body mass index (bmi). |
2021-02-02 |
2023-08-13 |
Not clear |
| Xiao-Yang Zhang, Shi-Yu Peng, Li-Ping Shen, Qian-Xing Zhuang, Bin Li, Shu-Tao Xie, Qian-Xiao Li, Ming-Run Shi, Tian-Yu Ma, Qipeng Zhang, Jian-Jun Wang, Jing-Ning Zh. Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 50. 2021-02-01. PMID:33257584. |
here we report an amelioration of both anxiety and ocd via the histamine presynaptic h3 heteroreceptor on glutamatergic afferent terminals from the prelimbic prefrontal cortex (prl) to the nucleus accumbens (nac) core, a vital node in the limbic loop. |
2021-02-01 |
2023-08-13 |
Not clear |
| Aimilia Lydia Kalafateli, Cajsa Aranäs, Elisabet Jerlha. Effects of sub-chronic amylin receptor activation on alcohol-induced locomotor stimulation and monoamine levels in mice. Psychopharmacology. vol 237. issue 11. 2021-01-27. PMID:32651639. |
the identification of amylin receptors in areas processing reward, namely laterodorsal tegmental area (ldtg), ventral tegmental area (vta), and nucleus accumbens (nac), has attributed them a role as reward regulators. |
2021-01-27 |
2023-08-13 |
mouse |
| Prasanna N de Silv. Are sweetened drinks a gateway to alcohol, opiate and stimulant addiction? Summary of evidence and therapeutic strategies. Medical hypotheses. vol 135. 2021-01-25. PMID:31733533. |
drinks sweetened with both sugar and artificial additives lead to dopamine release at the nucleus accumbens (nac) in rat models; the basis of experiences of pleasure in humans, resulting in impulsive binging behaviour at times. |
2021-01-25 |
2023-08-13 |
rat |
| Luciana Marangni Nolli, Danilo Gustavo Rodrigues de Oliveira, Stefany Sousa Alves, Marcus Vinicius von Zuben, Aline Pic-Taylor, Marcia Renata Mortari, Eloisa Dutra Calda. Effects of the hallucinogenic beverage ayahuasca on voluntary ethanol intake by rats and on cFos expression in brain areas relevant to drug addiction. Alcohol (Fayetteville, N.Y.). vol 84. 2021-01-22. PMID:31698029. |
ethanol intake was estimated throughout the experiment, and cfos expression was evaluated in medial orbital cortex (mo), ventral orbital cortex (vo), lateral orbital cortex (lo), nucleus accumbens (nac), and striatum. |
2021-01-22 |
2023-08-13 |
rat |
| Di Wen, Rongji Hui, Yi Liu, Yixiao Luo, Jian Wang, Xi Shen, Bing Xie, Feng Yu, Bin Cong, Chunling M. Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-ΔFosB signaling in the mouse nucleus accumbens. Progress in neuro-psychopharmacology & biological psychiatry. vol 97. 2021-01-18. PMID:31629777. |
in the present study, we investigated the roles of molecular hydrogen on the acquisition and transfer of meth-induced behavioral sensitization and the accompanying changes in erk phosphorylation and Δfosb activation in the nucleus accumbens (nac) of mice. |
2021-01-18 |
2023-08-13 |
mouse |
| Giulia Costa, Marcello Serra, Jacopo Marongiu, Micaela Morelli, Nicola Simol. Influence of dopamine transmission in the medial prefrontal cortex and dorsal striatum on the emission of 50-kHz ultrasonic vocalizations in rats treated with amphetamine: Effects on drug-stimulated and conditioned calls. Progress in neuro-psychopharmacology & biological psychiatry. vol 97. 2021-01-18. PMID:31669508. |
studies in amphetamine-treated rats have shown that activation of dopamine transmission in the nucleus accumbens (nac) initiates the emission of 50-khz usvs, but little is known on how dopamine transmission in other brain regions modulates the effects of drugs on calling behavior. |
2021-01-18 |
2023-08-13 |
rat |
| Nadi F Salaya-Velazquez, Luis A López-Muciño, Sara Mejía-Chávez, Pedro Sánchez-Aparicio, Andrés A Domínguez-Guadarrama, Arturo Venebra-Muño. Anandamide and sucralose change ΔFosB expression in the reward system. Neuroreport. vol 31. issue 3. 2021-01-15. PMID:31923023. |
our results show that the chronic administration of aea and sucralose intake induces an overexpression of Δfosb in the infralimbic cortex (cx), nucleus accumbens (nac) core, shell, and central nucleus of amygdala (amy). |
2021-01-15 |
2023-08-13 |
Not clear |
| Wanpeng Cui, Tomomi Aida, Hikaru Ito, Kenta Kobayashi, Yusaku Wada, Shigeki Kato, Takashi Nakano, Meina Zhu, Kaoru Isa, Kazuto Kobayashi, Tadashi Isa, Kohichi Tanaka, Hidenori Aizaw. Dopaminergic Signaling in the Nucleus Accumbens Modulates Stress-Coping Strategies during Inescapable Stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 38. 2021-01-15. PMID:32847967. |
dopamine signaling in the nucleus accumbens (nac) has been shown to modulate behavior by reinforcing learning and evading aversive stimuli, which are important for the survival of animals under environmental challenges such as stress. |
2021-01-15 |
2023-08-13 |
mouse |
| Elena Molokotos, Alyssa L Peechatka, Kainan S Wang, Diego A Pizzagalli, Amy C Jane. Caudate reactivity to smoking cues is associated with increased responding to monetary reward in nicotine-dependent individuals. Drug and alcohol dependence. vol 209. 2021-01-12. PMID:32145666. |
neurobiological responses to smoking cues are often observed in reward-related brain regions such as the caudate and nucleus accumbens (nac). |
2021-01-12 |
2023-08-13 |
Not clear |
| Yangyang Li, Lei Wang, Guotao Zhang, Xueli Qiao, Mingxing Zhan. SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway. Pain research & management. vol 2020. 2021-01-12. PMID:32922581. |
mounting evidence has shown that sirtuin 1 (sirt1), a class iii histone deacetylase, alleviated several types of neuropathic pain in the spinal cord and dorsal root ganglion and regulated some aberrant behaviors in the ventral tegmental area (vta) and the nucleus accumbens (nac). |
2021-01-12 |
2023-08-13 |
Not clear |
| Nuria Daviu, Michael R Bruchas, Bita Moghaddam, Carmen Sandi, Anna Beyele. Neurobiological links between stress and anxiety. Neurobiology of stress. vol 11. 2021-01-11. PMID:31467945. |
we then describe recent studies revealing a new role for mitochondrial function within the nucleus accumbens (nac), defining individual trait anxiety in rodents, and participating in the link between stress and anxiety. |
2021-01-11 |
2023-08-13 |
Not clear |
| Aurélie Papilloud, Meltem Weger, Alexandre Bacq, Ioannis Zalachoras, Fiona Hollis, Thomas Larrieu, Dorian Battivelli, Jocelyn Grosse, Olivia Zanoletti, Sébastien Parnaudeau, François Tronche, Carmen Sand. The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents. Psychoneuroendocrinology. vol 112. 2021-01-11. PMID:31841985. |
previous studies have highlighted the nucleus accumbens (nac) as a key brain region in the attainment of social hierarchies in rodents. |
2021-01-11 |
2023-08-13 |
mouse |
| Ainhoa Bilbao, Daniela Neuhofer, Marja Sepers, Shou-Peng Wei, Manuela Eisenhardt, Sarah Hertle, Olivier Lassalle, Almudena Ramos-Uriarte, Nagore Puente, Raissa Lerner, Aurore Thomazeau, Pedro Grandes, Beat Lutz, Olivier J Manzoni, Rainer Spanage. Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior. iScience. vol 23. issue 3. 2021-01-10. PMID:32179475. |
the nucleus accumbens (nac) plays a key role in drug-related behavior and natural reward learning. |
2021-01-10 |
2023-08-13 |
Not clear |