| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Hotsenpiller, M E Wol. Baclofen attenuates conditioned locomotion to cues associated with cocaine administration and stabilizes extracellular glutamate levels in rat nucleus accumbens. Neuroscience. vol 118. issue 1. 2003-08-13. PMID:12676144. |
considering the importance of glutamate transmission in the nucleus accumbens (nac) during associative responses to reward-related stimuli, the effect of baclofen on extracellular levels of glutamate in the nac was tested with microdialysis. |
2003-08-13 |
2023-08-12 |
human |
| Alexander F Hoffman, Murat Oz, Tara Caulder, Carl R Lupic. Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832502. |
the rewarding properties of the psychoactive constituents of marijuana, termed "cannabinoids," may reflect actions on synaptic transmission in the nucleus accumbens (nac). |
2003-08-05 |
2023-08-12 |
rat |
| Ryuichi Takahata, Bita Moghadda. Activation of glutamate neurotransmission in the prefrontal cortex sustains the motoric and dopaminergic effects of phencyclidine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 6. 2003-08-04. PMID:12700703. |
although the major cellular correlate of this behavioral activation is thought to be an increase in dopamine neurotransmission in the nucleus accumbens (nac), recent evidence suggests that nac dopamine is neither necessary nor sufficient to elicit nmda antagonist-induced motor effects. |
2003-08-04 |
2023-08-12 |
Not clear |
| Erkki Tupala, Håkan Hall, Kim Bergström, Tuija Mantere, Pirkko Räsänen, Terttu Särkioja, Jukka Hiltunen, Jari Tiihone. Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics. Synapse (New York, N.Y.). vol 48. issue 4. 2003-07-25. PMID:12687640. |
the role of the mesolimbic da in brain ethanol reinforcement is well established, with nucleus accumbens (nac) serving as a major terminal area of this system, whereas dorsal striatum is more associated with motor control. |
2003-07-25 |
2023-08-12 |
human |
| Erkki Tupala, Håkan Hall, Kim Bergström, Tuija Mantere, Pirkko Räsänen, Terttu Särkioja, Jukka Hiltunen, Jari Tiihone. Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics. Synapse (New York, N.Y.). vol 48. issue 4. 2003-07-25. PMID:12687640. |
we studied the effect of age on dat in caudate (nc), putamen (pu), and nucleus accumbens (nac) of eight type 1 and 2 alcoholics and 10 healthy controls by using [(125)i]pe2i as a radioligand for postmortem human whole hemisphere autoradiography. |
2003-07-25 |
2023-08-12 |
human |
| Jacqueline D Van Hoomissen, Heather O Chambliss, Philip V Holmes, Rod K Dishma. Effects of chronic exercise and imipramine on mRNA for BDNF after olfactory bulbectomy in rat. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742641. |
we examined the effects of chronic activity wheel running and antidepressant treatment on brain-derived neurotrophic factor (bdnf) messenger rna (mrna) in multiple brain regions-hippocampal formation (hf), ventral tegmental area/substantia nigra (vta/sn), nucleus accumbens (nac), and piriform cortex (pfx)-after bilateral olfactory bulbectomy (obx). |
2003-07-22 |
2023-08-12 |
rat |
| Stefan D Schlussman, Yong Zhang, Vadim Yuferov, K Steven LaForge, Ann Ho, Mary Jeanne Kree. Acute 'binge' cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL/6J but not 129/J mice. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742644. |
preprodynorphin mrna was measured in the nucleus accumbens (nac) and caudate putamen (cpu) after 3-day 'binge' pattern cocaine administration in c57bl/6j and 129/j mice, strains which differ in behavior and in dopamine increases in the cpu after 'binge' cocaine. |
2003-07-22 |
2023-08-12 |
mouse |
| Margery C Beinfel. What we know and what we need to know about the role of endogenous CCK in psychostimulant sensitization. Life sciences. vol 73. issue 6. 2003-07-17. PMID:12801586. |
cck microdialysis studies in the nucleus accumbens (nac) have demonstrated that extracellular cck is increased in the nac by psychostimulants, providing neurochemical evidence that cck could be involved in the behavioral response to psychostimulants. |
2003-07-17 |
2023-08-12 |
rat |
| Thomas M Loonam, Pierre A H Noailles, Jing Yu, Judy P Q Zhu, Jesus A Angul. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum. Life sciences. vol 73. issue 6. 2003-07-17. PMID:12801594. |
the mechanism of action of drugs of abuse like cocaine and amphetamines has been studied extensively in the dopamine terminal field areas of the caudate-putamen (cpu) and the nucleus accumbens (nac) of the rodent brain. |
2003-07-17 |
2023-08-12 |
mouse |
| Susan R Sesack, David B Car. Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia. Physiology & behavior. vol 77. issue 4-5. 2003-07-11. PMID:12526992. |
dopamine (da) neurons in the substantia nigra (sn) and ventral tegmental area (vta) form several projection systems with diverse functions, such as motor planning through the striatum, reward seeking via the nucleus accumbens (nac), and cognitive control through the prefrontal cortex (pfc). |
2003-07-11 |
2023-08-12 |
Not clear |
| Toshihide Kuroki, Herbert Y Meltzer, Junji Ichikaw. 5-HT 2A receptor stimulation by DOI, a 5-HT 2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Brain research. vol 972. issue 1-2. 2003-07-11. PMID:12711095. |
(+/-)-([1-(2,5-dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (doi) (2.5 mg/kg), a 5-ht(2a/2c) agonist, significantly potentiated d-amphetamine (amph) (1 mg/kg)-induced dopamine (da) release in rat medial prefrontal cortex (mpfc) and nucleus accumbens (nac). |
2003-07-11 |
2023-08-12 |
rat |
| M-C Peakman, C Colby, L I Perrotti, P Tekumalla, T Carle, P Ulery, J Chao, C Duman, C Steffen, L Monteggia, M R Allen, J L Stock, R S Duman, J D McNeish, M Barrot, D W Self, E J Nestler, E Schaeffe. Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain research. vol 970. issue 1-2. 2003-07-08. PMID:12706249. |
administration of cocaine induces the fos family of transcription factors in the striatum, including the nucleus accumbens (nac), a brain region important for the rewarding effects of addictive drugs. |
2003-07-08 |
2023-08-12 |
mouse |
| Gregory O Hjelmstad, Howard L Field. Kappa opioid receptor activation in the nucleus accumbens inhibits glutamate and GABA release through different mechanisms. Journal of neurophysiology. vol 89. issue 5. 2003-07-02. PMID:12740400. |
through their actions in the nucleus accumbens (nac), kappa opioid (kop) receptors and their endogenous ligand, dynorphin, modify behaviors associated with the administration of drugs of abuse and are regulated by exposure to such drugs. |
2003-07-02 |
2023-08-12 |
Not clear |
| Takatoshi Hikida, Yasuji Kitabatake, Ira Pastan, Shigetada Nakanish. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 10. 2003-07-01. PMID:12721372. |
cocaine and morphine elevate dopamine levels in the nucleus accumbens (nac), and the overwhelming actions of dopamine are implicated in reinforcement and addiction of abusive drugs. |
2003-07-01 |
2023-08-12 |
Not clear |
| C W Stevenson, A Gratto. Basolateral amygdala modulation of the nucleus accumbens dopamine response to stress: role of the medial prefrontal cortex. The European journal of neuroscience. vol 17. issue 6. 2003-06-27. PMID:12670317. |
the basolateral amygdala (bla) is involved in modulating affective responses to stress and, along with the nucleus accumbens (nac) and medial prefrontal cortex (mpfc), receives a stress-responsive dopamine (da) projection from the ventral tegmental area. |
2003-06-27 |
2023-08-12 |
rat |
| C P Müller, R J Carey, J B Salloum, J P Husto. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668045. |
the hippocampus and the nucleus accumbens (nac) are important structures for the modulation of spontaneous locomotor activity. |
2003-06-23 |
2023-08-12 |
rat |
| Ilona Vathy, Romana Slamberová, Agnes Rimanóczy, Michelle A Riley, Noffar Ba. Autoradiographic evidence that prenatal morphine exposure sex-dependently alters mu-opioid receptor densities in brain regions that are involved in the control of drug abuse and other motivated behaviors. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 3. 2003-06-23. PMID:12691773. |
the present study examined the effects of prenatal morphine exposure on mu-opioid receptor density in young adult male and female rats to assess the long-term alterations in several brain areas including the nucleus accumbens (nac), bed nucleus of stria terminalis (bnst), and the basolateral (bla), lateral (la), central (cea), and posteromedial cortical (pmcoa) amygdaloid nuclei. |
2003-06-23 |
2023-08-12 |
rat |
| Mark J Thomas, Robert C Malenk. Synaptic plasticity in the mesolimbic dopamine system. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 358. issue 1432. 2003-06-20. PMID:12740128. |
to address these potential functional roles of ltp and ltd, we have taken advantage of the powerful in vivo effects of drugs of abuse that exert their behavioural effects in large part by acting in the nucleus accumbens (nac) and ventral tegmental area (vta); the two major components of the mesolimbic dopamine system. |
2003-06-20 |
2023-08-12 |
Not clear |
| Roberto I Melendez, Zachary A Rodd-Henricks, William J McBride, James M Murph. Alcohol stimulates the release of dopamine in the ventral pallidum but not in the globus pallidus: a dual-probe microdialysis study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 5. 2003-06-11. PMID:12637946. |
rats were bilaterally implanted with microdialysis probes aimed at the vp and gp or nucleus accumbens (nac) and dorsal striatum (dstr). |
2003-06-11 |
2023-08-12 |
rat |
| M R Bauter, B J Brockel, D E Pankevich, M B Virgolini, D A Cory-Slecht. Glutamate and dopamine in nucleus accumbens core and shell: sequence learning versus performance. Neurotoxicology. vol 24. issue 2. 2003-05-07. PMID:12606295. |
this study sought to determine whether neurochemical changes associated with chronic postweaning lead (pb) exposure, namely, enhanced dopamine (da) activity and/or blockade of nmda function in nucleus accumbens (nac), underlie the learning impairments also associated with this pb regimen, and whether core or shell subregions of nucleus accumbens would be more important to such effects. |
2003-05-07 |
2023-08-12 |
rat |