| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karel Pacak, Olga Tjurmina, Milkós Palkovits, David S Goldstein, Christian A Koch, Thomas Hoff, George P Chrouso. Chronic hypercortisolemia inhibits dopamine synthesis and turnover in the nucleus accumbens: an in vivo microdialysis study. Neuroendocrinology. vol 76. issue 3. 2002-10-09. PMID:12218347. |
concentrations of dihydroxyphenylalanine (dopa) in interstitial fluid in the nucleus accumbens (nac) and perifrontal cortex (pfc) were measured before and after local perfusion with nsd-1015, an irreversible inhibitor of l-aromatic amino acid decarboxylase, to assess local dopamine (da) biosynthesis. |
2002-10-09 |
2023-08-12 |
rat |
| Xiu-Ti Hu, Timothy E Koeltzow, Donald C Cooper, George S Robertson, Francis J White, Paul Vezin. Repeated ventral tegmental area amphetamine administration alters dopamine D1 receptor signaling in the nucleus accumbens. Synapse (New York, N.Y.). vol 45. issue 3. 2002-10-01. PMID:12112395. |
in the nucleus accumbens (nac), such neuroadaptations include enhanced da overflow in response to a subsequent amph challenge as well as increased sensitivity to the inhibitory effects of d1 da receptor (d1r) activation and an altered profile of d1r-dependent induction of immediate early genes (iegs). |
2002-10-01 |
2023-08-12 |
rat |
| Jilla Sabeti, Greg A Gerhardt, Nancy R Zahnise. Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183681. |
the role of the dopamine transporter (dat) in mediating the behavioral differences in cocaine responsiveness in lcrs and hcrs was investigated by high-speed chronoamperometric recording of exogenous dopamine (da) clearance signals in nucleus accumbens (nac) and dorsal striatum (dstr). |
2002-09-18 |
2023-08-12 |
rat |
| Nicole L Schramm, Regula E Egli, Danny G Winde. LTP in the mouse nucleus accumbens is developmentally regulated. Synapse (New York, N.Y.). vol 45. issue 4. 2002-09-13. PMID:12125042. |
glutamatergic transmission in the nucleus accumbens (nac) has been shown to be important for behavioral adaptations in response to drugs of abuse. |
2002-09-13 |
2023-08-12 |
mouse |
| Yan Zhou, Rudolph Spangler, Stefan D Schlussman, Vadim P Yuferov, Ichiro Sora, Ann Ho, George R Uhl, Mary Jeanne Kree. Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the striatum and hypothalamic-pituitary-adrenal axis of mu-opioid receptor knockout mice. Synapse (New York, N.Y.). vol 45. issue 4. 2002-09-13. PMID:12125043. |
mice were sacrificed 30 min after the last injection and mrnas for ppdyn and preproenkephalin (ppenk) in the cpu and nucleus accumbens (nac), and for type i corticotropin-releasing hormone receptor (crh(1) receptor) and pro-opiomelanocortin (pomc) in the hypothalamus and pituitary, were measured by solution hybridization rnase protection assays. |
2002-09-13 |
2023-08-12 |
mouse |
| Malgorzata Filip, Kathryn A Cunningha. Serotonin 5-HT(2C) receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888566. |
the serotonin 5-ht(2c) receptor (5-ht(2c)r) is abundant in the nucleus accumbens (nac) shell and is considered an important target for 5-ht to modulate the dopamine (da) mesoaccumbens circuit, which plays a prominent role in the behavioral effects of cocaine. |
2002-09-11 |
2023-08-12 |
rat |
| M A Pezze, J Feldon, C A Murph. Increased conditioned fear response and altered balance of dopamine in the shell and core of the nucleus accumbens during amphetamine withdrawal. Neuropharmacology. vol 42. issue 5. 2002-09-10. PMID:11985821. |
it has been suggested that neuroadaptations within the nucleus accumbens (nac) dopaminergic (da) projection contribute to the negative affect associated with psychostimulant withdrawal. |
2002-09-10 |
2023-08-12 |
Not clear |
| Marco Pistis, Anna Lisa Muntoni, Giuliano Pillolla, Gian Luigi Gess. Cannabinoids inhibit excitatory inputs to neurons in the shell of the nucleus accumbens: an in vivo electrophysiological study. The European journal of neuroscience. vol 15. issue 11. 2002-09-04. PMID:12081659. |
the nucleus accumbens (nac) represents a critical site for the rewarding properties of diverse classes of drugs of abuse. |
2002-09-04 |
2023-08-12 |
rat |
| Bernard Le Foll, Henriette Francès, Jorge Diaz, Jean-Charles Schwartz, Pierre Sokolof. Role of the dopamine D3 receptor in reactivity to cocaine-associated cues in mice. The European journal of neuroscience. vol 15. issue 12. 2002-09-04. PMID:12099907. |
cocaine-conditioned mice had increased levels of d3r mrna and binding in the nucleus accumbens (nac), and transcripts of brain-derived neurotrophic factor (bdnf), a factor controlling d3r expression, in the ventral tegmental area (vta). |
2002-09-04 |
2023-08-12 |
mouse |
| W Lu, M Marinelli, D Xu, P F Worley, M E Wol. Amphetamine and cocaine do not increase Narp expression in rat ventral tegmental area, nucleus accumbens or prefrontal cortex, but Narp may contribute to individual differences in responding to a novel environment. The European journal of neuroscience. vol 15. issue 12. 2002-09-04. PMID:12099908. |
immunohistochemical studies demonstrated the existence of narp-positive cells in hippocampus, prefrontal cortex (pfc) and nucleus accumbens (nac), with lower levels of staining in the ventral tegmental area (vta). |
2002-09-04 |
2023-08-12 |
rat |
| Marcello Solinas, Sergi Ferré, Zhi-Bing You, Marzena Karcz-Kubicha, Patrizia Popoli, Steven R Goldber. Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 15. 2002-09-03. PMID:12151508. |
an increase in the extracellular concentration of dopamine in the nucleus accumbens (nac) is believed to be one of the main mechanisms involved in the rewarding and motor-activating properties of psychostimulants such as amphetamines and cocaine. |
2002-09-03 |
2023-08-12 |
rat |
| Junji Ichikawa, Jin Dai, Herbert Y Meltze. 5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex. Brain research. vol 939. issue 1-2. 2002-08-28. PMID:12020849. |
atypical apds also increase acetylcholine (ach) release in the mpfc, but not the nucleus accumbens (nac) or striatum (str), whereas typical apds such as haloperidol, s(-)-sulpiride and thioridazine do not produce either effect in the mpfc. |
2002-08-28 |
2023-08-12 |
rat |
| Christian P Müller, Robert J Carey, Maria A De Souza Silva, Gerhard Jocham, Joseph P Husto. Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5-HT1a-receptor antagonism blocks behavioral but potentiates serotonergic activation. Synapse (New York, N.Y.). vol 45. issue 2. 2002-08-08. PMID:12112399. |
neuronal activity in the hippocampus and the nucleus accumbens (nac) depend on serotonergic (5-ht) transmission. |
2002-08-08 |
2023-08-12 |
rat |
| Corinne Beurrier, Robert C Malenk. Enhanced inhibition of synaptic transmission by dopamine in the nucleus accumbens during behavioral sensitization to cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 14. 2002-08-06. PMID:12122043. |
neural adaptations in the nucleus accumbens (nac), a key component of the mesolimbic dopamine (da) system, are thought to mediate several of the long-term behavioral sequelas of chronic in vivo exposure to drugs of abuse. |
2002-08-06 |
2023-08-12 |
mouse |
| Jianhua Zhang, Dongsheng Zhang, Ming X. Identification of chronic cocaine-induced gene expression through dopamine d1 receptors by using cDNA microarrays. Annals of the New York Academy of Sciences. vol 965. 2002-08-02. PMID:12105080. |
our initial experiments focused on a target of the mesocorticolimbic da pathway, the nucleus accumbens (nac), which is the primary neural substrate for mediating the long-term effects of cocaine. |
2002-08-02 |
2023-08-12 |
mouse |
| Roberto I Melendez, Zachary A Rodd-Henricks, Eric A Engleman, Ting-Kai Li, William J McBride, James M Murph. Microdialysis of dopamine in the nucleus accumbens of alcohol-preferring (P) rats during anticipation and operant self-administration of ethanol. Alcoholism, clinical and experimental research. vol 26. issue 3. 2002-07-25. PMID:11923583. |
the present study was designed to test directly whether a contextual stimulus for access to ethanol would acquire the ability to enhance locomotor activity and dopamine efflux in the nucleus accumbens (nac) of alcohol-preferring (p) rats. |
2002-07-25 |
2023-08-12 |
rat |
| Anh Hai Tran, Ryoi Tamura, Teruko Uwano, Tsuneyuki Kobayashi, Motoya Katsuki, Gen Matsumoto, Taketoshi On. Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 13. 2002-07-19. PMID:12084937. |
the nucleus accumbens (nac) plays an important role in the integration of reward with motor function, and it receives dense dopamine innervation and extensive limbic and cortical afferents. |
2002-07-19 |
2023-08-12 |
mouse |
| Margery C Beinfeld, Kelly J Connolly, R Christopher Pierc. Cocaine treatment increases extracellular cholecystokinin (CCK) in the nucleus accumbens shell of awake, freely moving rats, an effect that is enhanced in rats that are behaviorally sensitized to cocaine. Journal of neurochemistry. vol 81. issue 5. 2002-07-09. PMID:12065614. |
to better understand its role, cck was measured by microdialysis in the nucleus accumbens (nac) shell in response to cocaine in drug-naive rats and in rats that are behaviorally sensitized to cocaine. |
2002-07-09 |
2023-08-12 |
rat |
| David Robbe, Gerard Alonso, Severine Chaumont, Joel Bockaert, Olivier J Manzon. Role of p/q-Ca2+ channels in metabotropic glutamate receptor 2/3-dependent presynaptic long-term depression at nucleus accumbens synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 11. 2002-07-05. PMID:12040040. |
the nucleus accumbens (nac) is an important cerebral area involved in reward and spatial memory (pennartz et al., 1994), but little is known about synaptic plasticity in this region. |
2002-07-05 |
2023-08-12 |
Not clear |
| Valentina Bassareo, Maria Antonietta De Luca, Gaetano Di Chiar. Differential Expression of Motivational Stimulus Properties by Dopamine in Nucleus Accumbens Shell versus Core and Prefrontal Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 11. 2002-07-05. PMID:12040078. |
the response of extracellular dopamine (da) and its relationship to motivational valence (positive or negative) and novelty of motivational stimuli was investigated by brain microdialysis in the nucleus accumbens (nac) shell and core and prefrontal cortex (pfcx) of rats. |
2002-07-05 |
2023-08-12 |
rat |