| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julie M Brooks, Michelle L Pershing, Morten S Thomsen, Jens D Mikkelsen, Martin Sarter, John P Brun. Transient inactivation of the neonatal ventral hippocampus impairs attentional set-shifting behavior: reversal with an α7 nicotinic agonist. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 11. 2013-02-26. PMID:22781844. |
cognitive deficits represent a core symptom cluster in schizophrenia that are thought to reflect developmental dysregulations within a neural system involving the ventral hippocampus (vh), nucleus accumbens (nac), and prefrontal cortex (pfc). |
2013-02-26 |
2023-08-12 |
rat |
| Karina Possa Abrahao, Maria Lucia Oliveira Souza-Formigon. Behavioral sensitization to ethanol results in cross-sensitization to MK-801 but not to NMDA administered intra-accumbens. Behavioural brain research. vol 235. issue 2. 2013-02-25. PMID:22871257. |
few studies have directly investigated the subsequent neuroadaptations in the nucleus accumbens (nac), the central area of the brain reward system, after chronic ethanol administration. |
2013-02-25 |
2023-08-12 |
mouse |
| Chiung-Chun Huang, Kuei-Sen Hs. Activation of NMDA receptors reduces metabotropic glutamate receptor-induced long-term depression in the nucleus accumbens via a CaMKII-dependent mechanism. Neuropharmacology. vol 63. issue 8. 2013-02-20. PMID:22947307. |
using whole-cell patch-clamp recordings in mouse nucleus accumbens (nac) slices, we found that tetanic stimulation (ts) of excitatory afferents with a naturally occurring frequency (10 min at 13 hz) reliably induces a mglur1/5-dependent long-term depression (mglur1/5-ltd) of excitatory synaptic transmission. |
2013-02-20 |
2023-08-12 |
mouse |
| Carrie R Ferrario, Ivan Goussakov, Grace E Stutzmann, Marina E Wol. Withdrawal from cocaine self-administration alters NMDA receptor-mediated Ca2+ entry in nucleus accumbens dendritic spines. PloS one. vol 7. issue 8. 2013-02-19. PMID:22870207. |
we previously showed that the time-dependent intensification ("incubation") of cue-induced cocaine seeking after withdrawal from extended-access cocaine self-administration is accompanied by accumulation of ca(2+)-permeable ampa receptors (cp-ampars) in the rat nucleus accumbens (nac). |
2013-02-19 |
2023-08-12 |
rat |
| Haosheng Sun, Ian Maze, David M Dietz, Kimberly N Scobie, Pamela J Kennedy, Diane Damez-Werno, Rachael L Neve, Venetia Zachariou, Li Shen, Eric J Nestle. Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 48. 2013-02-19. PMID:23197736. |
here, we show that chronic morphine, like cocaine, decreases g9a expression, and global levels of h3k9me2, in mouse nucleus accumbens (nac), a key brain reward region. |
2013-02-19 |
2023-08-12 |
mouse |
| Addy van Dijk, Andre A Klompmakers, Matthijs G P Feenstra, Damiaan Deny. Deep brain stimulation of the accumbens increases dopamine, serotonin, and noradrenaline in the prefrontal cortex. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23061486. |
deep brain stimulation (dbs) of the nucleus accumbens (nac) is effective in treatment-refractory obsessive-compulsive disorder and major depressive disorder. |
2013-02-14 |
2023-08-12 |
rat |
| Matthew T C Brown, Kelly R Tan, Eoin C O'Connor, Irina Nikonenko, Dominique Muller, Christian Lüsche. Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning. Nature. vol 492. issue 7429. 2013-02-12. PMID:23178810. |
the ventral tegmental area (vta) and nucleus accumbens (nac) are essential for learning about environmental stimuli associated with motivationally relevant outcomes. |
2013-02-12 |
2023-08-12 |
mouse |
| Paola Devoto, Roberto Frau, Valentina Bini, Giuliano Pillolla, Pierluigi Saba, Giovanna Flore, Marta Corona, Francesco Marrosu, Marco Bortolat. Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation. Psychoneuroendocrinology. vol 37. issue 10. 2013-02-01. PMID:22029952. |
conversely, apo-induced ppi deficits were countered by fin infusions in the brain ventricles (10μg/1μl) and in the nucleus accumbens (nac) shell and core (0.5μg/0.5μl/side). |
2013-02-01 |
2023-08-12 |
rat |
| Jennifer R St Onge, Soyon Ahn, Anthony G Phillips, Stan B Floresc. Dynamic fluctuations in dopamine efflux in the prefrontal cortex and nucleus accumbens during risk-based decision making. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 47. 2013-02-01. PMID:23175840. |
the prefrontal cortex (pfc) and nucleus accumbens (nac) are two da terminal regions that contribute to decision making in distinct manners. |
2013-02-01 |
2023-08-12 |
rat |
| Andrew F MacAskill, Justin P Little, John M Cassel, Adam G Carte. Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens. Nature neuroscience. vol 15. issue 12. 2013-01-29. PMID:23143514. |
we found that medium spiny neurons (msns) in both the direct and indirect pathways of the mouse nucleus accumbens (nac) receive inputs from the cortex, thalamus and hippocampus. |
2013-01-29 |
2023-08-12 |
mouse |
| G-Q Chang, O Karatayev, S C Liang, J R Barson, S F Leibowit. Prenatal ethanol exposure stimulates neurogenesis in hypothalamic and limbic peptide systems: possible mechanism for offspring ethanol overconsumption. Neuroscience. vol 222. 2013-01-24. PMID:22742906. |
to understand underlying mechanisms, measurements were taken in postnatal offspring of the expression of enk in the hypothalamic paraventricular nucleus (pvn) and nucleus accumbens (nac), gal in the pvn, and ox in the perifornical lateral hypothalamus (pflh) using real-time qpcr and in situ hybridization, and also of the cell proliferation marker, 5-bromo-2-deoxyuridine (brdu), and its double-labeling with either neuronal nuclei (neun), a marker of mature neurons, or the peptides. |
2013-01-24 |
2023-08-12 |
Not clear |
| Jonathan P Britt, Faiza Benaliouad, Ross A McDevitt, Garret D Stuber, Roy A Wise, Antonello Bonc. Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens. Neuron. vol 76. issue 4. 2013-01-24. PMID:23177963. |
excitatory afferents to the nucleus accumbens (nac) are thought to facilitate reward seeking by encoding reward-associated cues. |
2013-01-24 |
2023-08-12 |
Not clear |
| Aneesha Badrinarayan, Seth A Wescott, Caitlin M Vander Weele, Benjamin T Saunders, Brenann E Couturier, Stephen Maren, Brandon J Aragon. Aversive stimuli differentially modulate real-time dopamine transmission dynamics within the nucleus accumbens core and shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 45. 2013-01-23. PMID:23136417. |
specifically, while it is known that dopamine (da) transmission within the nucleus accumbens (nac) is imperative for mediating appetitive motivated behaviors, its role in aversive behavior is controversial. |
2013-01-23 |
2023-08-12 |
rat |
| Sami Ben Hamida, Jeremie Neasta, Amy W Lasek, Viktor Kharazia, Mimi Zou, Sebastien Carnicella, Patricia H Janak, Dorit Ro. The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 45. 2013-01-23. PMID:23136424. |
here, we report that the gtp binding protein, h-ras in the nucleus accumbens (nac) plays a key role in neuroadaptations that underlie excessive alcohol-drinking behaviors. |
2013-01-23 |
2023-08-12 |
mouse |
| Shui-Bing Liu, Lan Ma, Hong-Ju Guo, Bin Feng, Yan-Yan Guo, Xiao-Qiang Li, Wen-Ji Sun, Lian-He Zheng, Ming-Gao Zha. Gentiopicroside attenuates morphine rewarding effect through downregulation of GluN2B receptors in nucleus accumbens. CNS neuroscience & therapeutics. vol 18. issue 8. 2013-01-22. PMID:22621711. |
nucleus accumbens (nac) is a forebrain structure known for its role in drug addiction. |
2013-01-22 |
2023-08-12 |
mouse |
| Iván Gómez-Milanés, Pilar Almela, Juan-Antonio García-Carmona, M Salud García-Gutiérrez, Auxiliadora Aracil-Fernández, Jorge Manzanares, María Victoria Milanés Maquilón, M Luisa Laorde. Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice. Neurochemistry international. vol 61. issue 3. 2013-01-22. PMID:22713675. |
the purpose of the present study was to evaluate: (i) the turnover of da, na and 5-ht in the nucleus accumbens (nac), one of the most important substrates for aversive states, (ii) the changes in tyrosine hydroxylase (th) gene expression in the ventral tegmental area, and (iii) total th protein levels and th phosphorylation in the nac after naloxone-induced morphine withdrawal. |
2013-01-22 |
2023-08-12 |
mouse |
| Debra K Cozzoli, Justin Courson, Amanda L Caruana, Bailey W Miller, Daniel I Greentree, Andrew B Thompson, Melissa G Wroten, Ping-Wu Zhang, Bo Xiao, Jia-Hua Hu, Matthias Klugmann, Pamela Metten, Paul F Worley, John C Crabbe, Karen K Szumlinsk. Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Alcoholism, clinical and experimental research. vol 36. issue 9. 2013-01-21. PMID:22432643. |
alcohol increases the expression of group 1 metabotropic glutamate receptors (mglurs) and their associated scaffolding protein homer2 and stimulates phosphatidylinositol 3-kinase (pi3k) within the nucleus accumbens (nac). |
2013-01-21 |
2023-08-12 |
Not clear |
| Amber Asher, Daniel J Lodg. Distinct prefrontal cortical regions negatively regulate evoked activity in nucleus accumbens subregions. The international journal of neuropsychopharmacology. vol 15. issue 9. 2013-01-17. PMID:22008178. |
information from the prefrontal cortex is integrated in the nucleus accumbens (nac) to guide goal-directed behaviour. |
2013-01-17 |
2023-08-12 |
Not clear |
| Abbas Haghparast, Mohadeseh Ghalandari-Shamami, Majid Hassanpour-Ezatt. Blockade of D1/D2 dopamine receptors within the nucleus accumbens attenuated the antinociceptive effect of cannabinoid receptor agonist in the basolateral amygdala. Brain research. vol 1471. 2013-01-16. PMID:22765910. |
furthermore, the nucleus accumbens (nac) plays an important role in mediating the suppression of pain in animal models. |
2013-01-16 |
2023-08-12 |
rat |
| Qiang Li, Yarong Wang, Yi Zhang, Wei Li, Weichuan Yang, Jia Zhu, Ning Wu, Haifeng Chang, Ying Zheng, Wei Qin, Liyan Zhao, Kai Yuan, Jixin Liu, Wei Wang, Jie Tia. Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: an event-related fMRI study. Brain research. vol 1469. 2013-01-14. PMID:22759909. |
direct comparison between the two groups showed that brain activation to heroin-related minus neutral cues was significantly greater for the heroin-dependent group in the bilateral nucleus accumbens (nac), caudate, putamen, amygdala, hippocampus/parahippocampus, midcingulate cortex, dorsolateral prefrontal cortex (dlpfc), orbitofrontal cortex (ofc), medial frontal gyrus (mefg), midbrain, thalamus, left anterior cingulate cortex (acc), posterior cingulate cortex (pcc), and subcallosal gyrus. |
2013-01-14 |
2023-08-12 |
human |