| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martijn Figee, Judy Luigjes, Ruud Smolders, Carlos-Eduardo Valencia-Alfonso, Guido van Wingen, Bart de Kwaasteniet, Mariska Mantione, Pieter Ooms, Pelle de Koning, Nienke Vulink, Nina Levar, Lukas Droge, Pepijn van den Munckhof, P Richard Schuurman, Aart Nederveen, Wim van den Brink, Ali Mazaheri, Matthijs Vink, Damiaan Deny. Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nature neuroscience. vol 16. issue 4. 2013-05-21. PMID:23434914. |
we found that dbs targeted at the nucleus accumbens (nac) normalized nac activity, reduced excessive connectivity between the nac and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. |
2013-05-21 |
2023-08-12 |
Not clear |
| Pamela J Kennedy, Jian Feng, A J Robison, Ian Maze, Ana Badimon, Ezekiell Mouzon, Dipesh Chaudhury, Diane M Damez-Werno, Stephen J Haggarty, Ming-Hu Han, Rhonda Bassel-Duby, Eric N Olson, Eric J Nestle. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nature neuroscience. vol 16. issue 4. 2013-05-21. PMID:23475113. |
induction of histone acetylation in the nucleus accumbens (nac), a key brain reward region, promotes cocaine-induced alterations in gene expression. |
2013-05-21 |
2023-08-12 |
mouse |
| Devesh Mishra, Xiaoqun Zhang, Karima Chergu. Ethanol disrupts the mechanisms of induction of long-term potentiation in the mouse nucleus accumbens. Alcoholism, clinical and experimental research. vol 36. issue 12. 2013-05-17. PMID:22551245. |
long-term changes in the efficacy of glutamatergic synaptic transmission in reward-related brain regions such as the nucleus accumbens (nac) are proposed to contribute to neuroadaptations that lead to drug addiction. |
2013-05-17 |
2023-08-12 |
mouse |
| B Á Nic Dhonnchadha, A Lin, K A Leite-Morris, G B Kaplan, H Y Man, K M Kanta. Alterations in expression and phosphorylation of GluA1 receptors following cocaine-cue extinction learning. Behavioural brain research. vol 238. 2013-05-17. PMID:23085477. |
phosphorylation of glua1 at ser(845) was increased in the vmpfc and nucleus accumbens (nac). |
2013-05-17 |
2023-08-12 |
rat |
| A Jean, L Laurent, J Bockaert, Y Charnay, N Dusticier, A Nieoullon, M Barrot, R Neve, V Compa. The nucleus accumbens 5-HTR₄-CART pathway ties anorexia to hyperactivity. Translational psychiatry. vol 2. 2013-05-17. PMID:23233022. |
we previously discovered an addictive molecular facet of anorexia, involving production, in the nucleus accumbens (nac), of the same transcripts stimulated in response to cocaine and amphetamine (cart) upon stimulation of the 5-ht(4) receptors (5-htr(4)) or mdma (ecstasy). |
2013-05-17 |
2023-08-12 |
mouse |
| Daniela I Beiderbeck, Stefan O Reber, Andrea Havasi, Remco Bredewold, Alexa H Veenema, Inga D Neuman. High and abnormal forms of aggression in rats with extremes in trait anxiety--involvement of the dopamine system in the nucleus accumbens. Psychoneuroendocrinology. vol 37. issue 12. 2013-05-16. PMID:22608548. |
also, only in lab rats, the nucleus accumbens (nac) was found to be strongly activated in response to the ri test as reflected by increased c-fos and zif268 mrna expression, and higher local dopamine release compared with nab males, without differences in local dopamine receptor binding. |
2013-05-16 |
2023-08-12 |
rat |
| Daniel García-Pérez, M Luisa Laorden, M Victoria Milanés, Cristina Núñe. Glucocorticoids regulation of FosB/ΔFosB expression induced by chronic opiate exposure in the brain stress system. PloS one. vol 7. issue 11. 2013-05-13. PMID:23185589. |
in sham-operated rats, fosb/Δfosb was induced after chronic morphine administration in all the brain stress areas investigated: nucleus accumbens(shell) (nac), bed nucleus of the stria terminalis (bnst), central amygdala (cea), hypothalamic paraventricular nucleus (pvn) and nucleus of the solitary tract noradrenergic cell group (nts-a(2)). |
2013-05-13 |
2023-08-12 |
rat |
| Florence R M Theberge, Charles L Pickens, Evan Goldart, Sanya Fanous, Bruce T Hope, Qing-Rong Liu, Yavin Shaha. Association of time-dependent changes in mu opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving. Psychopharmacology. vol 224. issue 4. 2013-05-10. PMID:22790874. |
we investigated whether this incubation is associated with time-dependent changes in brain-derived neurotrophic factor (bdnf) and methyl-cpg binding protein 2 (mecp2) signaling and mu opioid receptor (mor) expression in nucleus accumbens (nac), dorsal striatum (ds), and medial prefrontal cortex (mpfc). |
2013-05-10 |
2023-08-12 |
rat |
| Sam A Golden, Daniel J Christoffel, Mitra Heshmati, Georgia E Hodes, Jane Magida, Keithara Davis, Michael E Cahill, Caroline Dias, Efrain Ribeiro, Jessica L Ables, Pamela J Kennedy, Alfred J Robison, Javier Gonzalez-Maeso, Rachael L Neve, Gustavo Turecki, Subroto Ghose, Carol A Tamminga, Scott J Russ. Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression. Nature medicine. vol 19. issue 3. 2013-05-09. PMID:23416703. |
transcriptional profiling of the nucleus accumbens (nac) for rho gtpase-related genes, which are known regulators of synaptic structure, revealed a sustained reduction in ras-related c3 botulinum toxin substrate 1 (rac1) expression after chronic social defeat stress. |
2013-05-09 |
2023-08-12 |
mouse |
| Linzy M Hendrickson, Melissa J Guildford, Andrew R Tappe. Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. Frontiers in psychiatry. vol 4. 2013-05-06. PMID:23641218. |
like nicotine, ethanol activates daergic neurons of the ventral tegmental area (vta) which project to the nucleus accumbens (nac). |
2013-05-06 |
2023-08-12 |
human |
| Brad A Grueter, Alfred J Robison, Rachael L Neve, Eric J Nestler, Robert C Malenk. ∆FosB differentially modulates nucleus accumbens direct and indirect pathway function. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 5. 2013-05-03. PMID:23319622. |
synaptic modifications in nucleus accumbens (nac) medium spiny neurons (msns) play a key role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction. |
2013-05-03 |
2023-08-12 |
Not clear |
| Pilar Almela, Javier Navarro-Zaragoza, Juan-Antonio García-Carmona, Lucía Mora, Juana Hidalgo, María-Victoria Milanés, María-Luisa Laorde. Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc). PloS one. vol 7. issue 10. 2013-05-01. PMID:23071721. |
role of corticotropin-releasing factor (crf) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (nac). |
2013-05-01 |
2023-08-12 |
rat |
| Pilar Almela, Javier Navarro-Zaragoza, Juan-Antonio García-Carmona, Lucía Mora, Juana Hidalgo, María-Victoria Milanés, María-Luisa Laorde. Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc). PloS one. vol 7. issue 10. 2013-05-01. PMID:23071721. |
the effects of naloxone-precipitated morphine withdrawal on signs of withdrawal, hypothalamo-pituitary-adrenocortical (hpa) axis activity, dopamine (da) and noradrenaline (na) turnover in the nucleus accumbens (nac) and activation of vta dopaminergic neurons, were investigated in rats pretreated with vehicle or cp-154,526 (selective crf1r antagonist). |
2013-05-01 |
2023-08-12 |
rat |
| Xiao Han, Nanxin Li, Xiaofang Xue, Feng Shao, Weiwen Wan. Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats. Brain research. vol 1447. 2013-04-30. PMID:22341870. |
in the present study, we investigated the effects of peri-adolescent social isolation on latent inhibition (li) and dopamine d2 receptor expression in the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) of young adult rats. |
2013-04-30 |
2023-08-12 |
rat |
| Neal R Swerdlow, Paul D Shilling, Michelle Breier, Ryan S Trim, Gregory A Light, Richard Saint Mari. Fronto-temporal-mesolimbic gene expression and heritable differences in amphetamine-disrupted sensorimotor gating in rats. Psychopharmacology. vol 224. issue 3. 2013-04-29. PMID:22700037. |
differences in sensitivity to the prepulse inhibition (ppi)-disruptive effects of d2-family agonists in sprague-dawley (sd) vs. long evans (le) rats are heritable, reflect differential activation of da signaling in the nucleus accumbens (nac), and are associated with differences in expression of specific nac genes. |
2013-04-29 |
2023-08-12 |
rat |
| Andrey Sequeira-Cordero, Marianela Masís-Calvo, Andrea Mora-Gallegos, Jaime Fornaguera-Tría. Maternal behavior as an early modulator of neurobehavioral offspring responses by Sprague-Dawley rats. Behavioural brain research. vol 237. 2013-04-26. PMID:23018125. |
this effect seems to be associated with the serotonergic systems in both nucleus accumbens (nac) and hippocampus (hpc), since offspring of low lg mothers showed decreased 5-ht neurotransmission in those brain regions compared with animals of high lg mothers. |
2013-04-26 |
2023-08-12 |
rat |
| Rodrigo Pedroza-Llinás, Mónica Méndez-Díaz, Alejandra E Ruiz-Contreras, Óscar Prospéro-Garcí. CB1 receptor activation in the nucleus accumbens core impairs contextual fear learning. Behavioural brain research. vol 237. 2013-04-26. PMID:23018128. |
there is evidence suggesting an important role for both the nucleus accumbens (nac) and the endocannabinoid system in contextual fear conditioning formation. |
2013-04-26 |
2023-08-12 |
human |
| Alfred J Robison, Vincent Vialou, Michelle Mazei-Robison, Jian Feng, Saïd Kourrich, Miles Collins, Sunmee Wee, George Koob, Gustavo Turecki, Rachael Neve, Mark Thomas, Eric J Nestle. Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 10. 2013-04-26. PMID:23467346. |
the transcription factor Δfosb and the brain-enriched calcium/calmodulin-dependent protein kinase ii (camkiiα) are induced in the nucleus accumbens (nac) by chronic exposure to cocaine or other psychostimulant drugs of abuse, in which the two proteins mediate sensitized drug responses. |
2013-04-26 |
2023-08-12 |
human |
| Kyle K Pitchers, Vincent Vialou, Eric J Nestler, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 8. 2013-04-24. PMID:23426671. |
drugs of abuse induce neuroplasticity in the natural reward pathway, specifically the nucleus accumbens (nac), thereby causing development and expression of addictive behavior. |
2013-04-24 |
2023-08-12 |
rat |
| S Puig, F Noble, N Benturqui. Short- and long-lasting behavioral and neurochemical adaptations: relationship with patterns of cocaine administration and expectation of drug effects in rats. Translational psychiatry. vol 2. 2013-04-23. PMID:23092979. |
we compared the effects of intermittent (once daily) and binge (three times a day) cocaine treatments for 1 (wd1) and 14 (wd14) days after the last cocaine injection on spontaneous locomotor activity and dopamine (da) levels in the nucleus accumbens (nac). |
2013-04-23 |
2023-08-12 |
rat |