| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinshi Li, Dan Wu, Yuyang Mu, Yunzhu Wang, Lingling Zhai, Lihong Ji. The combined damage of bisphenol A and high fat diet to learning and memory in young male mice: the regulatory effect of BDNF/TrkB/PI3K/AKT pathway on autophagy. Environmental research. 2025-04-05. PMID:40187395. |
bpa or hfd led to changes in autophagy levels in the hippocampus, manifested by decreased protein levels of mtor and p62, increased level of lc3b, and more significant changes in the combined group. |
2025-04-05 |
2025-04-08 |
mouse |
| Jinshi Li, Dan Wu, Yuyang Mu, Yunzhu Wang, Lingling Zhai, Lihong Ji. The combined damage of bisphenol A and high fat diet to learning and memory in young male mice: the regulatory effect of BDNF/TrkB/PI3K/AKT pathway on autophagy. Environmental research. 2025-04-05. PMID:40187395. |
our results suggested that combined bpa with hfd exposure could impair learning and memory ability, and the combined effect might be related to the bdnf/trkb/pi3k/akt pathway, which regulated mtor mediated autophagy and finally caused hippocampal synaptic damage. |
2025-04-05 |
2025-04-08 |
mouse |
| Amit Kumar, Savita Kumari, Poonam Dhiman, Damanpreet Sing. Medium-Chain Triglycerides Supplementation Protects Epilepsy-Associated Behavioral Impairments in a Mouse Model. Journal of biochemical and molecular toxicology. vol 39. issue 4. 2025-03-21. PMID:40114545. |
in addition, the supplementation attenuated the altered hippocampal lipid peroxidation, and mrna and protein levels of mtor and gsk-3β. |
2025-03-21 |
2025-03-23 |
mouse |
| Cristina Ulecia-Morón, Álvaro G Bris, Karina S MacDowell, Pilar Cerveró-García, José L M Madrigal, Borja García-Bueno, Marta P Pereira, Juan C Leza, Javier R Cas. Chronic mild stress dysregulates autophagy, membrane dynamics, and lysosomal status in frontal cortex and hippocampus of rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 94. 2025-03-08. PMID:40056662. |
among others, we characterized, in frontal cortex (fc) and hippocampus (hp), autophagy markers (upregulations in mtor, atg7, and atg 16l1, and downregulations in ulk1, beclin1, phospho-sqstm1, atg3, atg12, and atg 16l1), effectors of the endosomal sorting complexes required for transport (overexpression in hrs, vps37a, chmp6, and galectin 3, and downregulations in stam2, tsg101, vps28, vps37a, chmp5, vps4b, and galectin 9), and lysosomal proteins (lamp1, lamp2a, mannose receptor, hsc70, hsp70, cathepsin d and b, and cystatin c, whose variations are dependent on lysosomal nature and brain region) of male rats exposed to chronic mild stress, a model of depression, compared to control rats. |
2025-03-08 |
2025-03-11 |
rat |
| Roya Naderi, Rahil Salimi, Abbas Jafari, Nasrin Mehranfar. Age-dependent increase in apoptosis is associated with dysregulation of miR-92a/Akt/mTOR and NF-κB signaling pathways in male rats. Neuroscience letters. 2025-01-12. PMID:39800254. |
herein, we investigated the roles of mir-92a, akt, mtor, and nf-κb in age-associated apoptosis in the hippocampus (a critical structure involved in brain aging) of male rats alone and in combination with prazosin. |
2025-01-12 |
2025-01-16 |
rat |
| Roya Naderi, Rahil Salimi, Abbas Jafari, Nasrin Mehranfar. Age-dependent increase in apoptosis is associated with dysregulation of miR-92a/Akt/mTOR and NF-κB signaling pathways in male rats. Neuroscience letters. 2025-01-12. PMID:39800254. |
we also detected substantial up-regulation of nf-κb as well as substantial down-regulation of phosphorylated-akt and mtor in the aging hippocampus. |
2025-01-12 |
2025-01-16 |
rat |
| Roya Naderi, Rahil Salimi, Abbas Jafari, Nasrin Mehranfar. Age-dependent increase in apoptosis is associated with dysregulation of miR-92a/Akt/mTOR and NF-κB signaling pathways in male rats. Neuroscience letters. 2025-01-12. PMID:39800254. |
treatment with prazosin significantly suppressed apoptosis and reversed mir-92a gene expression, as well as akt, mtor, and nf-κb protein expressions in the aging hippocampus. |
2025-01-12 |
2025-01-16 |
rat |
| Lazari Kambli, Dezaree Raut, Lokesh Kumar Bhat. Sulfamethizole Attenuates Pentylenetetrazole-Induced Seizures in Mice via mTOR Inhibition. Drug development research. vol 86. issue 1. 2024-12-26. PMID:39723688. |
mtor and il-6 levels were also increased in the brain, along with neuronal degeneration and a decreased layer of neuronal cells in the hippocampus. |
2024-12-26 |
2024-12-29 |
mouse |
| Jingzhi Wang, Zhongyu Huang, Yiwen Li, Qian Li, Xi Li, Li Che. Electroacupuncture improves cognitive function in high-fat diet/streptozocin-induced type 2 diabetic mice by inhibiting autophagy-related ferroptosis. Experimental animals. 2024-12-08. PMID:39647901. |
meanwhile, electroacupuncture intervention increased the levels of beclin1 and lc3ii/lc3i, as well as decreased the levels of p62 and phosphorylated-mtor in the hippocampus of t2dm mice, suggesting that electroacupuncture facilitated autophagy activation by inhibiting mtor activity. |
2024-12-08 |
2024-12-11 |
mouse |
| Max Kowalczyk, Yu-Ju Lee, Wei-Hsiang Huan. TSC2-mTORC1 axis regulates morphogenesis and neurological function of Gli1 Molecular biology of the cell. 2024-11-27. PMID:39602293. |
tsc2-mtorc1 axis regulates morphogenesis and neurological function of gli1 aberrant adult hippocampal neurogenesis is implicated in neurological and mood disorders associated with dysregulation of the mechanistic target of rapamycin (mtor). |
2024-11-27 |
2024-11-30 |
Not clear |
| Max Kowalczyk, Yu-Ju Lee, Wei-Hsiang Huan. TSC2-mTORC1 axis regulates morphogenesis and neurological function of Gli1 Molecular biology of the cell. 2024-11-27. PMID:39602293. |
understanding how the mtor pathway shapes the functional development of different subpopulations of adult-born hippocampal neural stem cells will enable insight into potential therapeutic pathways for these disorders. |
2024-11-27 |
2024-11-30 |
Not clear |
| Maheedhar Kodali, Leelavathi N Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny J Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok K Shett. Residual microglia following short-term PLX5622 treatment in 5xFAD mice exhibit diminished NLRP3 inflammasome and mTOR signaling, and enhanced autophagy. Aging cell. 2024-11-21. PMID:39571180. |
additionally, phosphorylated s6 ribosomal protein and the protein sequestosome 1 analysis suggested reduced mechanistic targets of rapamycin (mtor) signaling and autophagy in microglia and neurons within the hippocampus and cerebral cortex. |
2024-11-21 |
2024-11-24 |
mouse |
| Maheedhar Kodali, Leelavathi N Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny J Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok K Shett. Residual microglia following short-term PLX5622 treatment in 5xFAD mice exhibit diminished NLRP3 inflammasome and mTOR signaling, and enhanced autophagy. Aging cell. 2024-11-21. PMID:39571180. |
biochemical assays validated the inhibition of nlrp3 inflammasome activation, decreased mtor signaling in the hippocampus and cerebral cortex, and enhanced autophagy in the hippocampus. |
2024-11-21 |
2024-11-24 |
mouse |
| Yan Zhang, Chu-Ke Wei, Ping Wang, Liu-Cheng Zheng, Yang Cheng, Zhen-Hua Ren, Yu-Hong Jin, Yu-You Yao, Huan-Zhong Li. S-ketamine alleviates depression-like behavior and hippocampal neuroplasticity in the offspring of mice that experience prenatal stress. Scientific reports. vol 14. issue 1. 2024-11-06. PMID:39505897. |
at the molecular level, by western blot and rt-pcr we detected that s-ketamine significantly upregulated the expression of bdnf and psd95 and activated akt and mtor in the hippocampus. |
2024-11-06 |
2024-11-09 |
mouse |
| Nisha, Vijay Paramani. Neuroprotective Roles of Daidzein Through Extracellular Signal-Regulated Kinases Dependent Pathway In Chronic Unpredictable Mild Stress Mouse Model. Molecular neurobiology. 2024-11-04. PMID:39495229. |
further, immunofluorescence results showed daidzein improved erk1/2, perk1/2 and mtor expressions in the cortex, hippocampus and medulla of stressed mice. |
2024-11-04 |
2024-11-06 |
mouse |
| Yu-Yuan Peng, Can Tang, Hai-Yan Wang, Yang Ding, Huan Yang, Xin-Mei Ma, Jie Gao, Sen Li, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wan. p75NTR mediated chronic restraint stress-induced depression-like behaviors in mice via hippocampal mTOR pathway. Life sciences. 2024-10-30. PMID:39477145. |
p75ntr mediated chronic restraint stress-induced depression-like behaviors in mice via hippocampal mtor pathway. |
2024-10-30 |
2024-11-02 |
mouse |
| Rongchen Zhu, Xuewen Tong, Yuhan Du, Jiahua Liu, Xuefei Xu, Yang He, Liankui Wen, Zhitong Wan. Improvement of chlorpyrifos-induced cognitive impairment by mountain grape anthocyanins based on PI3K/Akt signaling pathway. Pesticide biochemistry and physiology. vol 205. 2024-10-30. PMID:39477625. |
morris water maze, histopathological, elisa and western blot analyses showed that anthocyanins effectively ameliorated cpf-induced spatial learning memory impairment in mice by ameliorating cpf-induced ache inhibition, oxidative stress, and neuroinflammation and by modulating the levels of apoptosis (caspase-3, caspase-9) and autophagy (lc3ii/ lc3i, beclin1, p62, mtor) biomarkers, in order to restore damaged hippocampal tissue morphology, neuron and synapse structures. |
2024-10-30 |
2024-11-02 |
mouse |
| Karine Ramires Lima, Ana Carolina de Souza da Rosa, Gabriela Cristiane Mendes Gomes, Gabriela Jaques Sigaran, Anna Cecilia Perreto Vieira de Souza, Pâmela Billig Mello-Carpe. Acute exercise performed during the late consolidation phase improves memory persistence by hippocampal protein synthesis and catecholamine modulation. Pharmacology, biochemistry, and behavior. 2024-10-17. PMID:39419355. |
the inhibition of hippocampal protein synthesis immediately after acute pe using anisomycin (a ribosomal inhibitor) or rapamycin (an mtor pathway inhibitor) impaired the effect of pe on memory persistence. |
2024-10-17 |
2024-10-20 |
rat |
| David A Narvaiz, Katherine J Blandin, D Gregory Sullens, Paige D Womble, Jacob B Pilcher, Grace O'Neill, Taylor A Wiley, Eliesse M Kwok, Srikhar V Chilukuri, Joaquin N Lug. NS-Pten knockout mice exhibit sex and hippocampal subregion-specific increases in microglia/macrophage density. Epilepsy research. vol 206. 2024-08-30. PMID:39213710. |
as a model of hyperactive mtor induced epilepsy, neuronal subset specific phosphatase and tensin homolog (ns-pten) knockout (ko) mice exhibit hyperactive mtor signaling in the hippocampus, seizures that progress with age, and enhanced hippocampal microglia/macrophage activation. |
2024-08-30 |
2024-09-04 |
mouse |
| J Krummeich, L Nardi, C Caliendo, D Aschauer, V Engelhardt, A Arlt, J Maier, F Bicker, M D Kwiatkowski, K Rolski, K Vincze, R Schneider, S Rumpel, S Gerber, M J Schmeisser, S Schweige. Premature cognitive decline in a mouse model of tuberous sclerosis. Aging cell. 2024-08-28. PMID:39192595. |
while we did not detect any morphological changes of hippocampal projections and synaptic contacts, molecular markers of neurodegeneration were increased and the mtor signaling cascade was downregulated in hippocampal synaptosomes. |
2024-08-28 |
2024-08-30 |
mouse |