| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Luo, Fubo Liang, Zhong-Yin Zhan. PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways. Biochemistry. vol 48. issue 8. 2010-06-24. PMID:19199380. |
we find that elevated expression of prl1 increases the levels of the matrix metalloproteinases mmp2 and mmp9. |
2010-06-24 |
2023-08-12 |
Not clear |
| Qing-quan Li, Wen-juan Wang, Guo-ping Xu, Xi-xi Cao, Jing-da Xu, Qi Chen, Feng Tang, Zu-de X. [CD147 and matrix metallo-proteinase (MMP) 2 and MMP9 expression in multidrug resistant breast cancer cells treated with P-glycoprotein substrate drugs]. Zhonghua bing li xue za zhi = Chinese journal of pathology. vol 36. issue 4. 2010-06-22. PMID:17706116. |
[cd147 and matrix metallo-proteinase (mmp) 2 and mmp9 expression in multidrug resistant breast cancer cells treated with p-glycoprotein substrate drugs]. |
2010-06-22 |
2023-08-12 |
Not clear |
| Joseph C Chen, Anne A Wiley, Teh-Yuan Ho, Amy-Lynn Frankshun, Kristin M Hord, Frank F Bartol, Carol A Bagnel. Transient estrogen exposure from birth affects uterine expression of developmental markers in neonatal gilts with lasting consequences in pregnant adults. Reproduction (Cambridge, England). vol 139. issue 3. 2010-06-22. PMID:20032211. |
targets included the relaxin receptor (rxfp1), estrogen receptor-alpha (esr1) and vascular endothelial growth factor (vegfa), morphoregulatory markers hoxa10 and wnt7a, and the matrix metalloproteinases (mmp)2 and mmp9. |
2010-06-22 |
2023-08-12 |
Not clear |
| Siyoung Yang, Jonghwan Kim, Je-Hwang Ryu, Hwanhee Oh, Churl-Hong Chun, Byoung Ju Kim, Byoung Hyun Min, Jang-Soo Chu. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nature medicine. vol 16. issue 6. 2010-06-22. PMID:20495569. |
hif-2alpha directly induces the expression in chondrocytes of genes encoding catabolic factors, including matrix metalloproteinases (mmp1, mmp3, mmp9, mmp12 and mmp13), aggrecanase-1 (adamts4), nitric oxide synthase-2 (nos2) and prostaglandin-endoperoxide synthase-2 (ptgs2). |
2010-06-22 |
2023-08-12 |
mouse |
| Julien H Dey, Fabrizio Bianchi, Johannes Voshol, Debora Bonenfant, Edward J Oakeley, Nancy E Hyne. Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis. Cancer research. vol 70. issue 10. 2010-06-21. PMID:20460524. |
of interest are the downregulated matrix metalloproteases (mmp), in particular mmp9, which is essential for metastatic spread of 4t1 tumors. |
2010-06-21 |
2023-08-12 |
mouse |
| C C van Diemen, D S Postma, Y S Aulchenko, P J L M Snijders, B A Oostra, C M van Duijn, H M Boeze. Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate. The European respiratory journal. vol 35. issue 4. 2010-06-18. PMID:19797132. |
in 91 subjects with global initiative for chronic obstructive lung disease (gold) stage >or=1 copd, who were members of an extended pedigree including 6,175 people from the genetic research in isolated populations study, 32 snps were analysed in 13 candidate genes: a disintegrin and metalloprotease domain 33 gene (adam33), transforming growth factor-beta1 gene ( tgfb1), matrix metalloprotease-1 gene (mmp1), mmp2, mmp9, mmp12, tissue inhibitor of metalloprotease-1 gene (timp1), surfactant protein a1 gene (sftpa1 ), sftpa2, sftpb, sftpd, glutathione s-transferase p1 gene (gstp1), and haem oxygenase 1 gene ( hmox1). |
2010-06-18 |
2023-08-12 |
human |
| Susan E Sweeney, Trevor B Kimbler, Gary S Firestei. Synoviocyte innate immune responses: II. Pivotal role of IFN regulatory factor 3. Journal of immunology (Baltimore, Md. : 1950). vol 184. issue 12. 2010-06-18. PMID:20483755. |
surprisingly, irf3 knockdown almost completely blocked expression of additional genes in which the isre is not traditionally considered a dominant promoter site in fibroblast-like synoviocytes, including matrix metalloproteinase (mmp)3, mmp9, il-6, and il-8. |
2010-06-18 |
2023-08-12 |
human |
| Ajanta Chakraborty, Neetu Gupta, Kaushik Ghosh, Partha Ro. In vitro evaluation of the cytotoxic, anti-proliferative and anti-oxidant properties of pterostilbene isolated from Pterocarpus marsupium. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 4. 2010-06-17. PMID:20152895. |
it also inhibited matrix metalloproteinase 9 (mmp9) and alpha-methylacyl-coa recemase (amacr), two very well known metastasis inducers. |
2010-06-17 |
2023-08-12 |
Not clear |
| Mathew Loesch, Hui-Ying Zhi, Song-Wang Hou, Xiao-Mei Qi, Rong-Shan Li, Zainab Basir, Thomas Iftner, Ana Cuenda, Guan Che. p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. The Journal of biological chemistry. vol 285. issue 20. 2010-06-14. PMID:20231272. |
here, we show that the transcription factor c-jun is activated by p38gamma mapk, and the activated c-jun then recruits p38gamma as a cofactor into the matrix metalloproteinase 9 (mmp9) promoter to induce its trans-activation and cell invasion. |
2010-06-14 |
2023-08-12 |
human |
| Zhi-ying Feng, Xiang-lan Mo, Chun-Kui Shao, Zu-lan S. [Expressions of matrix metalloproteinase 9 in mucosal natural killer/T cell and mature T cell lymphomas and its relation to Epstein-Barr virus infection]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 27. issue 9. 2010-06-09. PMID:17884772. |
to investigate the expression of matrix metalloproteinase 9 (mmp9) in mucosal natural killer/t cell and mature t cell lymphomas and its relation to epstein-barr virus (ebv) infection. |
2010-06-09 |
2023-08-12 |
Not clear |
| Kalyan C Nannuru, Mitsuru Futakuchi, Michelle L Varney, Thomas M Vincent, Eric G Marcusson, Rakesh K Sing. Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface. Cancer research. vol 70. issue 9. 2010-05-27. PMID:20406980. |
matrix metalloproteinase (mmp)-13 regulates mammary tumor-induced osteolysis by activating mmp9 and transforming growth factor-beta signaling at the tumor-bone interface. |
2010-05-27 |
2023-08-12 |
mouse |
| Qi-dong Tang, Ping-sheng Wu, Yu-qing Hou, Zheng Huang, Zhong-jiang Zhou, Zhi-gang Guo, Jian-cheng Xiu, Yue-gang Wan. [Plasma matrix metalloproteinases-2 and -9 levels are elevated in patients with acute coronary syndrome and coronary chronic total occlusion]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 29. issue 5. 2010-05-04. PMID:19460733. |
to investigate the changes in plasma matrix metalloproteinases-2 and -9 (mmp2 and mmp9, respectively) levels in patients with different types of coronary heart diseases (chd), and assess the value of mmp2/mmp9 detection in predicting acute coronary syndrome (acs). |
2010-05-04 |
2023-08-12 |
Not clear |
| B Wang, S-H Hsu, S Majumder, H Kutay, W Huang, S T Jacob, K Ghosha. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene. vol 29. issue 12. 2010-04-23. PMID:20023698. |
ectopic expression and depletion of mir-181b showed that mir-181b enhanced matrix metallopeptidases (mmp)2 and mmp9 activity and promoted growth, clonogenic survival, migration and invasion of hepatocellular carcinoma (hcc) cells that could be reversed by modulating timp3 level. |
2010-04-23 |
2023-08-12 |
mouse |
| Mirko Moreno Zaldivar, Katrin Pauels, Philipp von Hundelshausen, Marie-Luise Berres, Petra Schmitz, Jörg Bornemann, M Anna Kowalska, Nikolaus Gassler, Konrad L Streetz, Ralf Weiskirchen, Christian Trautwein, Christian Weber, Hermann E Wasmut. CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis. Hepatology (Baltimore, Md.). vol 51. issue 4. 2010-04-21. PMID:20162727. |
accordingly, genetic deletion of cxcl4 in mice significantly reduced histological and biochemical liver damage in vivo, which was accompanied by changes in the expression of fibrosis-related genes (timp-1 [tissue inhibitor of matrix metalloproteinase 1], mmp9 [matrix metalloproteinase 9], tgf-beta [transforming growth factor beta], il10 [interleukin 10]). |
2010-04-21 |
2023-08-12 |
mouse |
| Morris Schweitzer, Benjamin Mitmaker, Daniel Obrand, Nathan Sheiner, Cherrie Abraham, Stevan Dostanic, Melissa Meilleur, Tomoko Sugahara, Lorraine E Chalifou. Atorvastatin modulates matrix metalloproteinase expression, activity, and signaling in abdominal aortic aneurysms. Vascular and endovascular surgery. vol 44. issue 2. 2010-04-01. PMID:20034937. |
matrix metalloproteinase 1, mmp2, mmp3, mmp9, tissue inhibitor of metalloproteinase (timp2), timp3, timp4, or total sma mothers against decapentaplegia (smad2) expression did not differ with treatment. |
2010-04-01 |
2023-08-12 |
human |
| Fei Han, Hong-Guang Zh. Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells. The Journal of surgical research. vol 159. issue 1. 2010-03-23. PMID:20031158. |
the gelatinases b (mmp9) and a (mmp2) are two members of the matrix metalloproteinase (mmps) family that are expressed in human cancer, and play a critical role in tumor cell invasion and metastasis. |
2010-03-23 |
2023-08-12 |
human |
| Camila F Nascimento, Letícia N Gama-De-Souza, Vanessa M Freitas, Ruy G Jaege. Role of MMP9 on invadopodia formation in cells from adenoid cystic carcinoma. Study by laser scanning confocal microscopy. Microscopy research and technique. vol 73. issue 2. 2010-03-17. PMID:19658178. |
after 1 h in fluorescent substrate, cells with silenced mmp9 showed clear decrease in matrix digestion compared with controls. |
2010-03-17 |
2023-08-12 |
human |
| Zhi-jie He, Zi-tong Huang, Xiao-tong Chen, Zi-jun Zo. Effects of matrix metalloproteinase 9 inhibition on the blood brain barrier and inflammation in rats following cardiopulmonary resuscitation. Chinese medical journal. vol 122. issue 19. 2010-03-17. PMID:20079138. |
matrix metalloproteinases (mmps), especially mmp9 attracted much attention because of its function in focal brain ischemia/reperfusion injury. |
2010-03-17 |
2023-08-12 |
rat |
| Geraldine Gueron, Adriana De Siervi, Mercedes Ferrando, Marcelo Salierno, Paola De Luca, Belen Elguero, Roberto Meiss, Nora Navone, Elba S Vazque. Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells. Molecular cancer research : MCR. vol 7. issue 11. 2010-03-04. PMID:19903769. |
using reverse transcription-quantitative pcr-generated gene array, a set of inflammatory and angiogenic genes were upregulated or downregulated in response to ho-1 overexpression identifying matrix metalloprotease 9 (mmp9) as a novel downstream target of ho-1. |
2010-03-04 |
2023-08-12 |
mouse |
| Silvia Barbaresi, Marc S Cortese, Jean Quinn, G Hossein Ashrafi, Sheila V Graham, M Saveria Camp. Effects of human papillomavirus type 16 E5 deletion mutants on epithelial morphology: functional characterization of each transmembrane domain. The Journal of general virology. vol 91. issue Pt 2. 2010-02-09. PMID:19812262. |
using deletion mutants which encompass the three hydrophobic domains of e5, we have assigned the ability to promote invasion of the matrix to the first hydrophobic domain, and the capacity to induce mmp9 to the c-terminal four amino acids. |
2010-02-09 |
2023-08-12 |
human |