| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingzhen Tian, Meysam Keshavarz, Ali Anil Demircali, Bing Han, Guang-Zhong Yan. Localized Microrobotic Delivery of Enzyme-Responsive Hydrogel-Immobilized Therapeutics to Suppress Triple-Negative Breast Cancer. Small (Weinheim an der Bergstrasse, Germany). 2024-12-18. PMID:39692188. |
crucially, the drug release mechanism is engineered to be responsive to the tumor microenvironment and is regulated by the overexpression of the enzymatic activity of matrix metalloproteinases (mmp2 and mmp9) in tnbc tumors, triggering the degradation of the hydrogel matrix, leading to controlled release of the immobilized therapeutic drug. |
2024-12-18 |
2024-12-21 |
Not clear |
| Xianjie Ai, Xinyu Wang, Taotao Ren, Zhong Li, Bo Wu, Ming L. MMP9 in pan-cancer and computational study to screen for MMP9 inhibitors. American journal of translational research. vol 16. issue 11. 2024-12-16. PMID:39678601. |
the stromal cell protein metalloproteinase 9 (mmp9), associated with extracellular matrix degradation and remodeling, promotes tumor invasion and metastasis and regulates cell adhesion molecule and cytokine activity. |
2024-12-16 |
2024-12-21 |
Not clear |
| Amira M Kamel, Mona Moaness, Abeer Salama, Manar M Ahmed, Hanan H Beherei, Mostafa Mabrou. Smart hydrogels for rapid wound repair: Chitosan-PVP matrices empowered by bimetallic MOF nanocages. International journal of biological macromolecules. 2024-12-13. PMID:39672442. |
this rapid healing occurred due to the reduction of inflammation and il-1 content in the dermis; the downregulation of mmp9 halted the breakdown of the extracellular matrix (ecm); the upregulation of tgf accelerated cell growth and raised the levels of collagen 1 and -sma in the ecm. |
2024-12-13 |
2024-12-21 |
Not clear |
| Cynthia Rosa Regalado, Mihály Balog. MMP9: Link between neuropathy and colorectal cancer? Frontiers in molecular biosciences. vol 11. 2024-12-12. PMID:39664453. |
this review investigates the role of matrix metalloproteinase 9 (mmp9) in linking crc to neuropathy, aiming to uncover shared mechanisms that could offer new therapeutic targets. |
2024-12-12 |
2024-12-14 |
Not clear |
| Jianhui Xie, Shiyan Chen, Yangli Chen, Junlu Tong, Huijie Huang, Jingwen Liao, Jixin Sun, Li Cong, Yingjuan Zen. FFA intervention on LO2 cells mediates SNX-10 synthesis and regulates MMP9 secretion in LX2 cells via TGF-β1. Archives of biochemistry and biophysics. 2024-12-11. PMID:39662717. |
transforming growth factor-β1(tgf-β1) plays an important regulatory role in multiple mafld stages, as it can promote the expression of matrix metalloproteinase-9 (mmp9) and promote liver fibrosis. |
2024-12-11 |
2024-12-14 |
Not clear |
| Yao Wang, Jinjin Zhang, Yunsong Wang, Feng Wu, Baoshen Song, Jiatian Li, Qiuyue Lin, Yunpeng Xie, Yunlong Xia, Xiangbo An, Jiawei Lia. Ubiquitin-like modifier-activating enzyme 1 as a potential therapeutic target for aortic dissection. International immunopharmacology. vol 145. 2024-12-05. PMID:39637577. |
treatment of tak-243, a specific uba1 inhibitor, prevented bapn-induced ad formation in mice and attenuated aortic medial degeneration, as evidenced by decreased elastin fragmentation (evaluated by evg scoring), reduced vascular smooth muscle cell loss (visualized by α-sma immunohistochemistry), and less extracellular matrix degradation (indicated by diminished mmp2 and mmp9 expression in immunohistochemistry and rt-qpcr). |
2024-12-05 |
2024-12-08 |
mouse |
| Gengfan Ye, Zhigang Wang, Pandi Chen, Junyi Ye, Shiwei Li, Maosong Chen, Jiugeng Feng, Hongcai Wang, Wei Che. Serpina3n in neonatal microglia mediates its protective role for damaged adult microglia by alleviating extracellular matrix remodeling-induced tunneling nanotubes degradation in a cell model of traumatic brain injury. Neuroscience. 2024-11-29. PMID:39613247. |
nmg expressed higher levels of serpina3n, which played a crucial role in reducing granzyme b, matrix metalloproteinase (mmp) 2 and mmp9 expression, thereby mitigating ecm remodeling. |
2024-11-29 |
2024-12-02 |
Not clear |
| Choong-Jae Lee, Tae-Young Jang, So-El Jeon, Hyeon-Ji Yun, Yeong-Hoon Cho, Da-Ye Lim, Jeong-Seok Na. The dysadherin/MMP9 axis modifies the extracellular matrix to accelerate colorectal cancer progression. Nature communications. vol 15. issue 1. 2024-11-29. PMID:39613801. |
in this study, we find that the membrane glycoprotein dysadherin directly targets matrix metalloprotease 9 (mmp9), initiating ecm remodeling within the tme and amplifying cancer progression. |
2024-11-29 |
2024-12-02 |
mouse |
| Yanting Su, Xin Ao, Yunfeng Long, Zhengrong Zhang, Mingzhu Zhang, Zhenwang Zhang, Mingjie Wei, Shigang Shan, Surui Lu, You Yu, Bo X. C1GALT1 high expression enhances the progression of glioblastoma through the EGFR-AKT/ERK cascade. Cellular signalling. 2024-11-19. PMID:39561885. |
and c1galt1 knockdown decreased the expression of cyclind1, matrix metalloproteinase 9 (mmp9) through the akt/erk signaling pathway furthermore, transcription factor sp1 which the expression was found to be associated the c1galt1 expression could bind to the promoter of c1galt1 gene and regulated its expression. |
2024-11-19 |
2024-11-23 |
mouse |
| YouLin Tuo, YiFeng Y. Sterile Alpha Motif Domain-Containing 5 Suppresses Malignant Phenotypes and Tumor Growth in Breast Cancer: Regulation of Polo-Like Kinase 1 and c-Myc Signaling in a Xenograft Model. Cureus. vol 16. issue 11. 2024-11-14. PMID:39524172. |
this study further assessed the expression levels of proliferation and invasion markers, including ki67 (a marker for cell proliferation), matrix metalloproteinase-2 (mmp2), and matrix metalloproteinase-9 (mmp9). |
2024-11-14 |
2024-11-17 |
mouse |
| Cheng Huang, Jiaxing Lin, Lan Chen, Wenzhe Sun, Jinjun Xia, Min W. Upregulation of C1QC as a Mediator of Blood-Brain Barrier Damage in Type 2 Diabetes Mellitus. Molecular neurobiology. 2024-11-12. PMID:39531193. |
the presence of a high level of c1qc, through its binding to discoidin domain receptor 2 (ddr2), may trigger the activation of its downstream mmp9, a calcium-dependent enzyme that is capable of degrading protein components in the extracellular matrix, consequently leading to the structural and functional disruption of bbb. |
2024-11-12 |
2024-11-17 |
Not clear |
| Tellez-Jimenez Olivia, Trejo-Jasso Christian, Ramos-Ramirez Patricia, Chapela Rocío, Miguel-Reyes José Luis, López-Estrada Erika Del Carmen, Bazán-Perkins Blanc. Serum integrin accumulation during asthma exacerbation: The role of matrix metalloproteinases. Scandinavian journal of immunology. 2024-11-08. PMID:39511761. |
the activity of matrix metalloproteinase 9 (mmp9) increased during exacerbation, while mmp2 remained unchanged. |
2024-11-08 |
2024-11-16 |
Not clear |
| Zhen Yuan, Li Shu, Peipei Yang, Jie Sun, Mengsha Zheng, Jiantao Fu, Yidong Wang, Shen Song, Zhenjie Liu, Zhejun Ca. Inhibitory interferon regulatory factor 5 binding peptide suppresses abdominal aortic aneurysm expansion in vivo. Journal of molecular and cellular cardiology. 2024-11-03. PMID:39490644. |
additionally, the ibp group showed decreased macrophage infiltration and reduced matrix metalloproteinase-9 (mmp9) activity. |
2024-11-03 |
2024-11-06 |
mouse |
| Mücahit Varlı, Kyungha Lee, Kyo Bin Kang, Hangun Ki. Unveiling the anti-metastatic activity of monoterpene indole alkaloids targeting MMP9 in cancer cells, with a focus on pharmacokinetic and cellular insights. Molecules and cells. 2024-10-31. PMID:39481856. |
matrix metalloproteinase 9 (mmp9) is widely known for its ability to break down the extracellular matrix and it also modulates the motility of cancer cells. |
2024-10-31 |
2024-11-03 |
Not clear |
| Ana Paula DA S Alves, Roberta Jenniffer M Teixeira, Raissa M DA Silva, Renata DE A Canevari, Luciana B Sant'ann. Amniotic membrane modulates MMP9 and MMP12 gene and protein expression in experimental model of the hepatic fibrosis. Anais da Academia Brasileira de Ciencias. vol 96. issue 4. 2024-10-30. PMID:39475998. |
the aim of this study was to investigate the effects of am on the matrix metalloproteinase 9 (mmp9) and matrix metalloproteinase 12 (mmp12) genes and proteins expression by real time quantitative pcr and immunohistochemistry, respectively, as well as image analysis on biliary fibrosis induced in rats by the bile duct ligation (bdl).two weeks after the bdl, an am fragment was applied onto the liver, and four weeks later, the liver samples were collected. |
2024-10-30 |
2024-11-02 |
human |
| Elham Bazargan, Fatemeh Ashrafi, Elham Siasi Torbat. Niosome-loaded Tet-Amp against S. aureus, K. pneumoniae, and P. aeruginosa. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. 2024-10-23. PMID:39441517. |
in addition, (tet/amp)-nio can upregulate the expression level of matrix metallopeptidase 2 (mmp2) and matrix metallopeptidase 9 (mmp9) genes, which shows their great activity in the wound healing process. |
2024-10-23 |
2024-10-25 |
human |
| Varda Lev-Ram, Sakina Palida Lemieux, Thomas J Deerinck, Eric A Bushong, Alex J Perez, Denise R Pritchard, Brandon H Toyama, Sung Kyu R Park, Daniel B McClatchy, Jeffrey N Savas, Michael Whitney, Stephen R Adams, Mark H Ellisman, John Yates, Roger Y Tsie. Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit? Cells. vol 13. issue 19. 2024-10-15. PMID:39404392. |
preventing pnn erosion by using pharmacological inhibition of pnn-modifying proteases or matrix metalloproteases 9 (mmp9) knockout mice allowed normal fear memory acquisition but diminished long-term memory stabilization, supporting the above hypothesis. |
2024-10-15 |
2024-10-17 |
mouse |
| Peiqiang Liu, Xiaomin Wu, Hao Lv, Jingyu Huang, Tian Gu, Duo Liu, Yu X. Oridonin alleviates cigarette smoke-induced nasal polyp formation by promoting autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 180. 2024-10-15. PMID:39405900. |
following treatment with oridonin, the levels of ova-specific ige, il-6, ifn-γ, il-5, il-13 and il-17a in serum were observed to decrease; the levels of tgf-β1, matrix metalloproteinase 2 (mmp2), mmp7, mmp9 and mmp12 levels in nasal lavage fluid were reduced, while tissue inhibitor of metalloproteinase-1 (timp-1) levels were increased. |
2024-10-15 |
2024-10-18 |
mouse |
| Zhengyuan Li, Lin Hao, Shenghong Chen, Wenhan Fu, Hui Zhang, Zongsheng Yin, Yin Wang, Jun Wan. Forkhead box C1 promotes the pathology of osteoarthritis in subchondral bone osteoblasts via the Piezo1/YAP axis. Cellular signalling. 2024-10-13. PMID:39396563. |
mechanistically, the overexpression of foxc1 through piezo1 activation, in combination with downstream yap signaling, led to increased levels of alkaline phosphatase (alp), collagen type 1 (col1) a1, runx2, osteocalcin, matrix metalloproteinase (mmp) 3, and mmp9 expression. |
2024-10-13 |
2024-10-16 |
mouse |
| Olga V Stepanenko, Maksim I Sulatsky, Ekaterina V Mikhailova, Olesya V Stepanenko, Anna I Sulatskay. Degradation of pathogenic amyloids induced by matrix metalloproteinase-9. International journal of biological macromolecules. 2024-10-12. PMID:39395518. |
this study examines poorly understood effects of an immune enzyme, extracellular matrix metalloproteinase-9 (mmp9), on amyloids associated with alzheimer's and parkinson's diseases, lysozyme, insulin, and dialysis-related amyloidoses. |
2024-10-12 |
2024-10-15 |
Not clear |