| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lindsay R Clark, Sara E Berman, Derek Norton, Rebecca L Koscik, Erin Jonaitis, Kaj Blennow, Barbara B Bendlin, Sanjay Asthana, Sterling C Johnson, Henrik Zetterberg, Cynthia M Carlsso. Age-accelerated cognitive decline in asymptomatic adults with CSF β-amyloid. Neurology. vol 90. issue 15. 2019-08-07. PMID:29523644. |
compare cognitive and hippocampal volume trajectories in asymptomatic middle-aged and older adults with positive csf markers of β-amyloid (aβ) or tau to adults without an alzheimer disease (ad)-associated biomarker profile. |
2019-08-07 |
2023-08-13 |
Not clear |
| Dawling A Dionisio-Santos, John A Olschowka, M Kerry O'Banio. Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease. Journal of neuroinflammation. vol 16. issue 1. 2019-08-05. PMID:30953557. |
in rodent models, increased neuroinflammation promoted by overexpression of proinflammatory cytokines can cause an increase in hyperphosphorylated tau and a decrease in hippocampal function. |
2019-08-05 |
2023-08-13 |
Not clear |
| Pranav Vemula, Yu Jing, Hu Zhang, Jerry B Hunt, Leslie A Sandusky-Beltran, Daniel C Lee, Ping Li. Altered brain arginine metabolism in a mouse model of tauopathy. Amino acids. vol 51. issue 3. 2019-07-24. PMID:30604097. |
using high-performance liquid chromatographic and mass spectrometric assays, the present study systematically determined the tissue concentrations of l-arginine and its nine downstream metabolites in the frontal cortex, hippocampus, parahippocampal region, striatum, thalamus, and cerebellum in male ps19 mice-bearing human tau p301s mutation at 4, 8, and 12-14 months of age. |
2019-07-24 |
2023-08-13 |
mouse |
| Zhi-Tao Hou, Yu-Sheng Han, Yi-Tian Liu, Yu Xing, Meng Wang, Jing Che. [Effects of Sagacious Confucius' Pillow Elixir on cognitive function in type 2 diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 22. 2019-07-23. PMID:30593246. |
in this study, an experimental model of type 2 diabetes mellitus (t2dm) was established by injecting sprague dawley (sd) rats with streptozocin (stz), so as to compare the learning and memory ability, hippocampal neurons pathological changes, beta amyloid protein (a beta) content, degree of tau protein phosphorylation, blood glucose and insulin level. |
2019-07-23 |
2023-08-13 |
human |
| Zhi-Tao Hou, Yu-Sheng Han, Yi-Tian Liu, Yu Xing, Meng Wang, Jing Che. [Effects of Sagacious Confucius' Pillow Elixir on cognitive function in type 2 diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 22. 2019-07-23. PMID:30593246. |
the results showed that the sagacious confucius' pillow elixir could improve the learning and memory ability of stz injected rats, reduce the level of a beta content both in hippocampus and serum, effectively reduce tau protein phosphorylation degree, and also significantly alleviate hippocampal pathological injury, blood glucose, insulin and other basic indicators. |
2019-07-23 |
2023-08-13 |
human |
| Elisa R Zanier, Ilaria Bertani, Eliana Sammali, Francesca Pischiutta, Maria Antonietta Chiaravalloti, Gloria Vegliante, Antonio Masone, Alessandro Corbelli, Douglas H Smith, David K Menon, Nino Stocchetti, Fabio Fiordaliso, Maria-Grazia De Simoni, William Stewart, Roberto Chies. Induction of a transmissible tau pathology by traumatic brain injury. Brain : a journal of neurology. vol 141. issue 9. 2019-07-17. PMID:30084913. |
brain homogenates from these mice, when inoculated into the hippocampus and overlying cerebral cortex of naïve mice, induced widespread tau pathology, synaptic loss, and persistent memory deficits. |
2019-07-17 |
2023-08-13 |
mouse |
| Ilse Eidhof, Jonathan Baets, Erik-Jan Kamsteeg, Tine Deconinck, Lisa van Ninhuijs, Jean-Jacques Martin, Rebecca Schüle, Stephan Züchner, Peter De Jonghe, Annette Schenck, Bart P van de Warrenbur. GDAP2 mutations implicate susceptibility to cellular stress in a new form of cerebellar ataxia. Brain : a journal of neurology. vol 141. issue 9. 2019-07-17. PMID:30084953. |
neuropathological examination showed degenerative changes in the cerebellum, olive inferior, thalamus, substantia nigra, and pyramidal tracts, as well as tau pathology in the hippocampus and amygdala. |
2019-07-17 |
2023-08-13 |
drosophila_melanogaster |
| Kristen M Craven, William R Kochen, Carlos M Hernandez, Jane M Flin. Zinc Exacerbates Tau Pathology in a Tau Mouse Model. Journal of Alzheimer's disease : JAD. vol 64. issue 2. 2019-07-15. PMID:29914030. |
zinc supplementation in tau mice also increased tangle numbers in the hippocampus while decreasing free-zinc levels, demonstrating that tangles were sequestering zinc. |
2019-07-15 |
2023-08-13 |
mouse |
| Catherine M Roe, Beau M Ances, Denise Head, Ganesh M Babulal, Sarah H Stout, Elizabeth A Grant, Jason Hassenstab, Chengjie Xiong, David M Holtzman, Tammie L S Benzinger, Suzanne E Schindler, Anne M Fagan, John C Morri. Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers. Brain : a journal of neurology. vol 141. issue 11. 2019-07-15. PMID:30304397. |
stepwise cox proportional hazards models tested associations of molecular (pittsburgh compound b; csf amyloid-β42, tau, ptau181, tau/amyloid-β42, ptau181/amyloid-β42), structural (normalized hippocampal volume, normalized whole brain volume), and cognitive (animal naming, trail making a, trail making b, selective reminding test - free recall) biomarkers with time to clinical dementia rating (cdr) > 0. |
2019-07-15 |
2023-08-13 |
human |
| Eric M Gold, Vitaly Vasilevko, Jonathan Hasselmann, Casey Tiefenthaler, Danny Hoa, Kasuni Ranawaka, David H Cribbs, Brian J Cumming. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral Deficits. ASN neuro. vol 10. 2019-07-11. PMID:29932344. |
in human tau transgenic mice, rmchi induced increases in hyperphosphorylated paired helical filament 1 tau in the hippocampus. |
2019-07-11 |
2023-08-13 |
mouse |
| Robert A Whittington, László Virág, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Mehdi Cheheltanan, Franck Petry, Isabelle Poitras, Françoise Morin, Emmanuel Plane. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of aging. vol 75. 2019-07-11. PMID:30508732. |
in c57bl/6 mice, chronic midazolam administration immediately increased hippocampal tau phosphorylation, and this effect was more pronounced in older mice. |
2019-07-11 |
2023-08-13 |
mouse |
| Robert A Whittington, László Virág, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Mehdi Cheheltanan, Franck Petry, Isabelle Poitras, Françoise Morin, Emmanuel Plane. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of aging. vol 75. 2019-07-11. PMID:30508732. |
interestingly, in young c57bl/6 mice, chronic midazolam administration induced hippocampal tau hyperphosphorylation, which persisted for 1 week. |
2019-07-11 |
2023-08-13 |
mouse |
| Robert A Whittington, László Virág, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Mehdi Cheheltanan, Franck Petry, Isabelle Poitras, Françoise Morin, Emmanuel Plane. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of aging. vol 75. 2019-07-11. PMID:30508732. |
in htau mice, chronic midazolam administration increased hippocampal tau phosphorylation and, although this was not associated with proaggregant changes, this correlated with a decreased capacity of tau to bind to preassembled microtubules. |
2019-07-11 |
2023-08-13 |
mouse |
| Caoyi Chen, Jianlan Gu, Gustavo Basurto-Islas, Nana Jin, Feng Wu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29044200. |
overexpression of ck1ε in the mouse hippocampus increased tau phosphorylation and impaired spontaneous alternation behavior. |
2019-07-01 |
2023-08-13 |
mouse |
| Hugo Botha, William G Mantyh, Melissa E Murray, David S Knopman, Scott A Przybelski, Heather J Wiste, Jonathan Graff-Radford, Keith A Josephs, Christopher G Schwarz, Walter K Kremers, Bradley F Boeve, Ronald C Petersen, Mary M Machulda, Joseph E Parisi, Dennis W Dickson, Val Lowe, Clifford R Jack, David T Jone. FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis. Brain : a journal of neurology. vol 141. issue 4. 2019-06-28. PMID:29538658. |
we evaluated the utility of 18f-fdg-pet to differentiate flortaucipir tau pet negative from flortaucipir positive amnestic mild cognitive impairment and dementia and used an autopsy confirmed cohort to test the hypothesis that hippocampal sclerosis might account for the observed pattern. |
2019-06-28 |
2023-08-13 |
human |
| Michaeline L Hebron, Monica Javidnia, Charbel E-H Mouss. Tau clearance improves astrocytic function and brain glutamate-glutamine cycle. Journal of the neurological sciences. vol 391. 2019-06-27. PMID:30103978. |
to obtain an animal model that expresses tau in the brainstem, we bred hemizygous mice that express p301l tau (taup301l) and detected hyper-phosphorylated tau (p-tau) predominantly in the hippocampus, cortex, brainstem and thalamus. |
2019-06-27 |
2023-08-13 |
mouse |
| Bension Shlomo Tilley, Colin Smith, Nicola Pavese, Johannes Attem. Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration. BMJ case reports. vol 12. issue 3. 2019-06-24. PMID:30850568. |
hyperphosphorylated tau was only found in the entorhinal cortex and hippocampus. |
2019-06-24 |
2023-08-13 |
Not clear |
| Catia M Teixeira, Noemí Pallas-Bazarra, Marta Bolós, Julia Terreros-Roncal, Jesús Ávila, María Llorens-Martí. Untold New Beginnings: Adult Hippocampal Neurogenesis and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29562522. |
importantly, it has been revealed that gsk-3β and tau proteins, which are two of the main players driving ad pathology, are cornerstones of adult hippocampal neurogenesis regulation. |
2019-06-11 |
2023-08-13 |
Not clear |
| Tomas Smolek, Santosh Jadhav, Veronika Brezovakova, Veronika Cubinkova, Bernadeta Valachova, Petr Novak, Norbert Zilk. First-in-Rat Study of Human Alzheimer's Disease Tau Propagation. Molecular neurobiology. vol 56. issue 1. 2019-06-11. PMID:29770957. |
by using specific monoclonal antibodies, we were able to monitor the spreading of tau isolated from human brain directly in the rat hippocampus. |
2019-06-11 |
2023-08-13 |
mouse |
| Yvonne S Davidson, Andrew Robinson, Vee P Prasher, David M A Man. The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29973279. |
tau pathology usually commenced after 35 years of age, initially involving not only entorhinal areas and hippocampus but also subcortical regions such as locus caeruleus (lc) and dorsal raphe nucleus (drn). |
2019-06-04 |
2023-08-13 |
Not clear |