| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gozal Bahlakeh, Mehrdad Jahanshahi, Mohsen Saeid. Human chorionic gonadotropin decreases the phosphorylated tau protein level in streptozotocin-Alzheimeric male rats' hippocampus. Folia neuropathologica. vol 56. issue 2. 2019-03-28. PMID:30509034. |
the pharmacological suppression of luteinising hormone or human chorionic gonadotropin (hcg) can reduce aβ plaques in the brains of rats and mice, but the effects of hcg on the phosphorylated tau protein level in the hippocampus have not been studied. |
2019-03-28 |
2023-08-13 |
mouse |
| Gozal Bahlakeh, Mehrdad Jahanshahi, Mohsen Saeid. Human chorionic gonadotropin decreases the phosphorylated tau protein level in streptozotocin-Alzheimeric male rats' hippocampus. Folia neuropathologica. vol 56. issue 2. 2019-03-28. PMID:30509034. |
therefore, we investigated the effects of hcg on the phosphorylated tau protein level and its effect on hcg receptor-immunoreactive neuron density in the hippocampus of alzheimer's disease (ad) model rats (streptozotocin [stz] injected intracerebroventricularly). |
2019-03-28 |
2023-08-13 |
mouse |
| Li Jin, Li Lin, Guo-Yong Li, Sha Liu, Dan-Ju Luo, Qiong Feng, Dong-Sheng Sun, Wei Wang, Jian-Jun Liu, Qun Wang, Dan Ke, Xi-Fei Yang, Gong-Ping Li. Monosodium glutamate exposure during the neonatal period leads to cognitive deficits in adult Sprague-Dawley rats. Neuroscience letters. vol 682. 2019-03-11. PMID:29885453. |
we found that neonatal msg exposure induced hyperglycemia as well as alzheimer-like learning and memory deficits with decreased dendritic spine density and hippocampal synaptic-related protein expression and increased phosphorylated tau levels in ∼3-month-old sd rats. |
2019-03-11 |
2023-08-13 |
rat |
| Isabel Barón-Mendoza, Octavio García, Erika Calvo-Ochoa, Jorge Omar Rebollar-García, Daniel Garzón-Cortés, Reyes Haro, Aliesha González-Arena. Alterations in neuronal cytoskeletal and astrocytic proteins content in the brain of the autistic-like mouse strain C58/J. Neuroscience letters. vol 682. 2019-03-11. PMID:29885454. |
our results show that autistic-like mice present: 1) region-dependent altered expression and phosphorylation patterns of tau isoforms, associated with anomalous microtubule depolymerization; 2) reduced map2 a content in prefrontal cortex; 3) region-dependent changes in cofilin expression and phosphorylation, associated with abnormal actin filament depolymerizing dynamics; 4) diminished synaptopodin levels in the hippocampus; and 5) reduced content of the astrocyte-secreted protein tsp-1 in the prefrontal cortex and hippocampus. |
2019-03-11 |
2023-08-13 |
mouse |
| Cheril Tapia-Rojas, Nibaldo C Inestros. Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice. Journal of neurochemistry. vol 144. issue 4. 2019-03-08. PMID:29240990. |
wnt signaling inhibitors induced severe changes in the hippocampus, including alterations in wnt pathway components and loss of wnt signaling function, severe cognitive deficits, increased tau phosphorylation and aβ |
2019-03-08 |
2023-08-13 |
mouse |
| Yuanyuan Liu, Mengying Wei, Kexin Yue, Mingxin Hu, Shizhe Li, Lihui Men, Zifeng Pi, Zhiqiang Liu, Zhongying Li. Study on Urine Metabolic Profile of Aβ25-35-Induced Alzheimer's Disease Using UHPLC-Q-TOF-MS. Neuroscience. vol 394. 2019-03-01. PMID:30316910. |
the results showed that compared with healthy control rats, ad rats suffered from cognitive dysfunction, hippocampus damage, aβ formation and tau phosphorylation at 8 weeks after surgery, suggesting that the aβ25-35-induced ad model was successfully established. |
2019-03-01 |
2023-08-13 |
rat |
| Yali Zhang, Jiahui Zhang, Enhao Wang, Wei Qian, Yan Fan, Ying Feng, Haimeng Yin, Yang Li, Yuning Wang, Tianli Yua. Microcystin-Leucine-Arginine Induces Tau Pathology Through Bα Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3β Phosphorylation. Toxicological sciences : an official journal of the Society of Toxicology. vol 162. issue 2. 2019-02-25. PMID:29228318. |
the results showed that mc-lr treatment significantly increased demethylation of pp2ac, with a concomitant increase in gsk-3β phosphorylation at ser9 resulting in elevated tau hyperphosphorylation at pp2a-favorable sites in sh-sy5y cells and rat hippocampus. |
2019-02-25 |
2023-08-13 |
rat |
| Chunxia Huang, John Man-Tak Chu, Yan Liu, Raymond Chuen-Chung Chang, Gordon Tin-Chun Won. Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. Neuropharmacology. vol 143. 2019-02-25. PMID:30273594. |
glia activation, aberrant tau phosphorylation (at8) and accumulation of phosphorylated h2ax in the hippocampus were detectable up to postoperative day 14, with neuronal apoptosis seen in the hippocampus. |
2019-02-25 |
2023-08-13 |
mouse |
| Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Diego Botezelli, José Alexandre Curiacos de Almeida Leme, Ricardo José Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology. vol 104. 2019-02-19. PMID:29421605. |
in this context, our study aims to investigate the age-related changes in ptp1b content, insulin signaling, β-amyloid content, and tau phosphorylation in the hippocampus of middle-aged rats. |
2019-02-19 |
2023-08-13 |
rat |
| Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Diego Botezelli, José Alexandre Curiacos de Almeida Leme, Ricardo José Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology. vol 104. 2019-02-19. PMID:29421605. |
also, the aging process increased tau phosphorylation and β-amyloid content in the hippocampus region. |
2019-02-19 |
2023-08-13 |
rat |
| Ercan Babür, Burak Tan, Sumeyra Delibaş, Marwa Yousef, Nurcan Dursun, Cem Süe. Depotentiation of Long-Term Potentiation Is Associated with Epitope-Specific Tau Hyper-/Hypophosphorylation in the Hippocampus of Adult Rats. Journal of molecular neuroscience : MN. vol 67. issue 2. 2019-02-19. PMID:30498986. |
depotentiation of long-term potentiation is associated with epitope-specific tau hyper-/hypophosphorylation in the hippocampus of adult rats. |
2019-02-19 |
2023-08-13 |
rat |
| Ercan Babür, Burak Tan, Sumeyra Delibaş, Marwa Yousef, Nurcan Dursun, Cem Süe. Depotentiation of Long-Term Potentiation Is Associated with Epitope-Specific Tau Hyper-/Hypophosphorylation in the Hippocampus of Adult Rats. Journal of molecular neuroscience : MN. vol 67. issue 2. 2019-02-19. PMID:30498986. |
western blot experiments indicated that tau protein was hyperphosphorylated at ser416 epitope but rather hypophosphorylated at thr231 epitope in the whole hippocampus upon depotentiation of ltp. |
2019-02-19 |
2023-08-13 |
rat |
| Ercan Babür, Burak Tan, Sumeyra Delibaş, Marwa Yousef, Nurcan Dursun, Cem Süe. Depotentiation of Long-Term Potentiation Is Associated with Epitope-Specific Tau Hyper-/Hypophosphorylation in the Hippocampus of Adult Rats. Journal of molecular neuroscience : MN. vol 67. issue 2. 2019-02-19. PMID:30498986. |
these findings indicate that some forms of long-term plastic changes might be related with epitope-specific tau phosphorylation and erk1/2 activation in the hippocampus. |
2019-02-19 |
2023-08-13 |
rat |
| Philip Regan, Daniel J Whitcomb, Kwangwook Ch. Physiological and Pathophysiological Implications of Synaptic Tau. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 23. issue 2. 2019-02-18. PMID:26908138. |
in particular, long-term depression, a form of synaptic weakening, is dependent on the presence of tau in hippocampal neurons. |
2019-02-18 |
2023-08-13 |
Not clear |
| Edna Maria Camelo Chaves, Jose Eduardo Ribeiro Honório-Júnior, Caren Nádia Soares Sousa, Valdécio Silveira Monteiro, Dayanne Terra Tenório Nonato, Leonardo Pimentel Dantas, Ana Silvia Suassuna Carneiro Lúcio, José Maria Barbosa-Filho, Manoel Cláudio Azevedo Patrocínio, Glauce Socorro Barros Viana, Silvânia Maria Mendes Vasconcelo. The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29086102. |
after behavioral tests, these animals were sacrificed and had their prefrontal cortex (pfc), hippocampus (hc) and striatum (st) dissected for assaying amino acids (aspartate- asp, glutamate- glu, glycine- gly, taurine- tau and gamma-aminobutyric acid- gaba). |
2019-01-31 |
2023-08-13 |
mouse |
| Suvi R K Hokkanen, Sally Hunter, Tuomo M Polvikoski, Hannah A D Keage, Thais Minett, Fiona E Matthews, Carol Brayn. Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. Brain pathology (Zurich, Switzerland). vol 28. issue 4. 2019-01-23. PMID:28833898. |
we developed a semi-quantitative protocol, which captures various hippocampal neuron loss patterns, and compared their occurrence in the context of hs-aging, tdp-43, vascular and tau pathology in 672 brains (tdp-43 staining n = 642/672, 96%) donated for the population-based cambridge city over-75s cohort and the cognitive function and ageing study. |
2019-01-23 |
2023-08-13 |
Not clear |
| Kristen R Montgomery, A S C Louis Sam Titus, Lulu Wang, Santosh R D'Mell. Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome. Molecular neurobiology. vol 55. issue 12. 2019-01-18. PMID:29637441. |
mecp2-tg mice display elevated gfap and tau expression within the hippocampus and cortex followed by neuronal loss in these brain regions. |
2019-01-18 |
2023-08-13 |
mouse |
| Andrew Arner, Edward Rockenstein, Michael Mante, Jazmin Florio, Deborah Masliah, Bahar Salehi, Anthony Adame, Cassia Overk, Eliezer Masliah, Robert A Rissma. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. Journal of Alzheimer's disease : JAD. vol 61. issue 3. 2019-01-17. PMID:29332037. |
increased vulnerability of the hippocampus in transgenic mice overexpressing app and triple repeat tau. |
2019-01-17 |
2023-08-13 |
mouse |
| Andrew Arner, Edward Rockenstein, Michael Mante, Jazmin Florio, Deborah Masliah, Bahar Salehi, Anthony Adame, Cassia Overk, Eliezer Masliah, Robert A Rissma. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. Journal of Alzheimer's disease : JAD. vol 61. issue 3. 2019-01-17. PMID:29332037. |
we found that even in young animals we found that the presence of app/aβ increased the accumulation of 3r tau in the neocortex and hippocampus. |
2019-01-17 |
2023-08-13 |
mouse |
| Siddhartha Mondragón-Rodríguez, Anahí Salas-Gallardo, Perla González-Pereyra, Martín Macías, Benito Ordaz, Fernando Peña-Ortega, Azucena Aguilar-Vázquez, Erika Orta-Salazar, Sofía Díaz-Cintra, George Perry, Sylvain William. Phosphorylation of Tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model. The Journal of biological chemistry. vol 293. issue 22. 2019-01-16. PMID:29632073. |
phosphorylation of tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in alzheimer's model. |
2019-01-16 |
2023-08-13 |
mouse |