All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Yue Cao, Christian Hölscher, Meng-Ming Hu, Ting Wang, Fang Zhao, Yu Bai, Jun Zhang, Mei-Na Wu, Jin-Shun Q. DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease. European journal of pharmacology. vol 827. 2018-10-09. PMID:29551659. we found that: (1) da5-ch administration effectively improved working-memory and long-term spatial memory of 9-month-old ad mice in y-maze and morris water maze tests; (2) da5-ch also reduced hippocampal amyloid senile plaques and phosphorylated tau protein levels; (3) da5-ch basically reversed the deficits in hippocampal late-phase long-term potentiation; (4) da5-ch up-regulated the levels of p-pi3k and p-akt growth factor kinases and prevented excessive activation of p-gsk3β in the hippocampus of app/ps1 mice. 2018-10-09 2023-08-13 mouse
Chao Wu, Wei-Gang Gong, Yan-Juan Wang, Jun-Jun Sun, Hong Zhou, Zhi-Jun Zhang, Qing-Guo Re. Escitalopram alleviates stress-induced Alzheimer's disease-like tau pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin/GSK-3β signal pathway activity. Neurobiology of aging. vol 67. 2018-10-04. PMID:29656013. the results showed that both depressive and resistant rats displayed spatial memory deficits and an accumulation of tau in the hippocampus. 2018-10-04 2023-08-13 rat
Shuangyue Li, Lijun Yang, Yan Zhang, Cong Zhang, Jing Shao, Xiaohui Liu, Yachen Li, Fengyuan Pia. Taurine Ameliorates Arsenic-Induced Apoptosis in the Hippocampus of Mice Through Intrinsic Pathway. Advances in experimental medicine and biology. vol 975 Pt 1. 2018-10-02. PMID:28849454. the aim of the present study was to clarify the protective capacity of taurine (tau) on as-induced neuronal apoptosis and the related mechanism in mouse hippocampus. 2018-10-02 2023-08-13 mouse
Shuangyue Li, Lijun Yang, Yan Zhang, Cong Zhang, Jing Shao, Xiaohui Liu, Yachen Li, Fengyuan Pia. Taurine Ameliorates Arsenic-Induced Apoptosis in the Hippocampus of Mice Through Intrinsic Pathway. Advances in experimental medicine and biology. vol 975 Pt 1. 2018-10-02. PMID:28849454. the results indicated that tau supplement markedly ameliorates as-induced apoptosis by mitochondria-related pathway in mouse hippocampus. 2018-10-02 2023-08-13 mouse
Satoshi Okuyama, Wakana Shinoka, Kumi Nakamura, Maho Kotani, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Mitsunari Nakajima, Yoshiko Furukaw. Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice. Bioscience, biotechnology, and biochemistry. vol 82. issue 8. 2018-10-02. PMID:29732953. suppressive effects of the peel of citrus kawachiensis (kawachi bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice. 2018-10-02 2023-08-13 mouse
Satoshi Okuyama, Wakana Shinoka, Kumi Nakamura, Maho Kotani, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Mitsunari Nakajima, Yoshiko Furukaw. Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice. Bioscience, biotechnology, and biochemistry. vol 82. issue 8. 2018-10-02. PMID:29732953. moreover, the c. kawachiensis treatment inhibited astroglial activation in the hippocampus and the hyperphosphorylation of tau at 231 of threonine and 396 of serine in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in the db/db mice. 2018-10-02 2023-08-13 mouse
Nadine Ait-Bouziad, Guohua Lv, Anne-Laure Mahul-Mellier, Shifeng Xiao, Gizem Zorludemir, David Eliezer, Thomas Walz, Hilal A Lashue. Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes. Nature communications. vol 8. issue 1. 2018-10-01. PMID:29162800. these complexes are toxic to primary hippocampal cultures and are detected by mc-1, an antibody recognizing pathological tau conformations. 2018-10-01 2023-08-13 Not clear
Elena Anahi Bignante, Nicolás Eric Ponce, Florencia Heredia, Juliana Musso, María C Krawczyk, Julieta Millán, Gustavo F Pigino, Nibaldo C Inestrosa, Mariano M Boccia, Alfredo Lorenz. APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models. Neurobiology of aging. vol 64. 2018-09-27. PMID:29331876. gallein, a selective pharmacological inhibitor of gβγ complex, inhibited aβ-induced dendritic and axonal dystrophy, abnormal tau phosphorylation, synaptic loss, and neuronal cell death in hippocampal neurons expressing endogenous protein levels. 2018-09-27 2023-08-13 mouse
Stergios Tsartsalis, Aikaterini Xekardaki, Patrick R Hof, Enikö Kövari, Constantin Boura. Early Alzheimer-type lesions in cognitively normal subjects. Neurobiology of aging. vol 62. 2018-09-26. PMID:29107845. to define whether amyloid β protein deposits or tau protein lesions appear first during normal brain aging, we performed an immunohistological study on serial sections from 105 autopsy brains (age range: 40-104 years) from patients free of clinical signs of cognitive decline, using anti-tau (at8) and anti-amyloid (4g8) antibodies in the hippocampus, entorhinal cortex, inferior temporal cortex (brodmann area 20), prefrontal cortex (brodmann area 9), occipital cortex (brodmann areas 17 and 18), and in the brainstem. 2018-09-26 2023-08-13 human
Zhihui Gai, Donghong Su, Yawen Wang, Wenlong Li, Bo Cui, Kang Li, Xiaojun She, Rui Wan. Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer's disease-like tau hyperphosphorylation. Environmental health and preventive medicine. vol 22. issue 1. 2018-09-04. PMID:29228900. effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to alzheimer's disease-like tau hyperphosphorylation. 2018-09-04 2023-08-13 rat
Zhihui Gai, Donghong Su, Yawen Wang, Wenlong Li, Bo Cui, Kang Li, Xiaojun She, Rui Wan. Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer's disease-like tau hyperphosphorylation. Environmental health and preventive medicine. vol 22. issue 1. 2018-09-04. PMID:29228900. in this study, we explored the effects of long-term noise exposure on the corticotropin-releasing factor (crf) system in the hippocampus and its role in noise-induced tau phosphorylation. 2018-09-04 2023-08-13 rat
Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland). vol 28. issue 2. 2018-08-30. PMID:28019685. tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. 2018-08-30 2023-08-13 human
Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland). vol 28. issue 2. 2018-08-30. PMID:28019685. common neuropathological features included neuronal loss in the hippocampus and dentate gyrus associated with spherical basophilic pick body-like inclusions showing 4r tau immunoreactivity, which was supported by the detection of predominantly 4r tau species by western blot examination. 2018-08-30 2023-08-13 human
Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland). vol 28. issue 2. 2018-08-30. PMID:28019685. in addition, accumulation of tau immunoreactive argyrophilic astrocytes in the hippocampus and amygdala and oligodendroglial coiled bodies in the hippocampal white matter were observed. 2018-08-30 2023-08-13 human
Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland). vol 28. issue 2. 2018-08-30. PMID:28019685. we suggest that this tauopathy variant with hippocampal 4r tau immunoreactive spherical inclusions might contribute to the cognitive deficits in the patients reported here. 2018-08-30 2023-08-13 human
Anaclara Prada Jardim, Joan Liu, Jack Baber, Zuzanna Michalak, Cheryl Reeves, Matthew Ellis, Jan Novy, Jane de Tisi, Andrew McEvoy, Anna Miserocchi, Elza Marcia Targas Yacubian, Sanjay Sisodiya, Pamela Thompson, Maria Tho. Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit. Brain pathology (Zurich, Switzerland). vol 28. issue 2. 2018-08-30. PMID:28380661. we also evaluated hippocampal regenerative activity (mcm2, nestin, olig2, calbindin), degeneration (at8/phosphorylated tau) and mossy-fiber pathway re-organization (znt3). 2018-08-30 2023-08-13 Not clear
Tong Li, Kerstin E Braunstein, Juhong Zhang, Ashley Lau, Leslie Sibener, Christopher Deeble, Philip C Won. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nature communications. vol 7. 2018-08-27. PMID:27373369. we show that this tau fragment seeds the neuritic plaque-dependent pathological conversion of wild-type tau that spreads from the cortex and hippocampus to the brain stem. 2018-08-27 2023-08-13 mouse
Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi, Toshiki Uchihar. Brainstem tau pathology in Alzheimer's disease is characterized by increase of three repeat tau and independent of amyloid β. Acta neuropathologica communications. vol 6. issue 1. 2018-08-20. PMID:29298724. in the hippocampus, the number of nfts, and the proportion of 3r tau progressively increases. 2018-08-20 2023-08-13 Not clear
Qing-Hua Ma, Liu-Fang Jiang, Jian-Liang Mao, Wen-Xin Xu, Min Huan. Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. Molecular medicine reports. vol 17. issue 3. 2018-08-15. PMID:29257340. these results indicate that vildagliptin administration exerts a protective effect against cognitive deficits by reducing tau phosphorylation and increasing the expression of proteins associated with synaptic plasticity in the hippocampus. 2018-08-15 2023-08-13 rat
Melike Yuksel, Kevser Biberoglu, Seda Onder, K Gonca Akbulut, Ozden Taca. Toluidine blue O modifies hippocampal amyloid pathology in a transgenic mouse model of Alzheimer's disease. Biochimie. vol 146. 2018-08-13. PMID:29248542. similarly, tbo did not recover hyperphosphorylation of tau at residues thr181 and ser202/thr205 significantly in soluble and insoluble hippocampal fractions of 3xtg-ad mice. 2018-08-13 2023-08-13 mouse