| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siddhartha Mondragón-Rodríguez, Anahí Salas-Gallardo, Perla González-Pereyra, Martín Macías, Benito Ordaz, Fernando Peña-Ortega, Azucena Aguilar-Vázquez, Erika Orta-Salazar, Sofía Díaz-Cintra, George Perry, Sylvain William. Phosphorylation of Tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model. The Journal of biological chemistry. vol 293. issue 22. 2019-01-16. PMID:29632073. |
mechanistically, we show that pyramidal neurons and some parvalbumin-positive interneurons in 1-month-old triple-transgenic ad mice accumulate hyperphosphorylated tau protein and that this accumulation correlates with changes in theta oscillations in hippocampal neurons. |
2019-01-16 |
2023-08-13 |
mouse |
| Yuetao Wen, Qingyuan Wu, Quanhong Shi, Yanfeng Xie, Wei Dan, YangMei Chen, Limin M. UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model. Biochemical and biophysical research communications. vol 503. issue 4. 2019-01-14. PMID:29964011. |
our results suggest that uch-l1 may be associated with hippocampal msf followed the epileptogenesis through mediating phosphorylation of tau. |
2019-01-14 |
2023-08-13 |
rat |
| Xinghua Liu, Kuan Zeng, Mengzhu Li, Qun Wang, Rong Liu, Bin Zhang, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wan. Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit. Scientific reports. vol 7. issue 1. 2019-01-11. PMID:28634382. |
interestingly, expression of the mutant tau in mec induces endogenous tau hyperphosphorylation and accumulation in hippocampus and cortex, and inhibits neuronal activity with attenuated pp-dg synapse plasticity, leading to hippocampus-dependent memory deficit with intact olfactory function. |
2019-01-11 |
2023-08-13 |
mouse |
| Elena Lonati, Gessica Sala, Viviana Tresoldi, Silvia Coco, Domenico Salerno, Chiara Milani, Morris Losurdo, Francesca Farina, Laura Botto, Carlo Ferrarese, Paola Palestini, Alessandra Bulbarell. Ischemic Conditions Affect Rerouting of Tau Protein Levels: Evidences for Alteration in Tau Processing and Secretion in Hippocampal Neurons. Journal of molecular neuroscience : MN. vol 66. issue 4. 2019-01-10. PMID:30421280. |
ischemic conditions affect rerouting of tau protein levels: evidences for alteration in tau processing and secretion in hippocampal neurons. |
2019-01-10 |
2023-08-13 |
Not clear |
| Elena Lonati, Gessica Sala, Viviana Tresoldi, Silvia Coco, Domenico Salerno, Chiara Milani, Morris Losurdo, Francesca Farina, Laura Botto, Carlo Ferrarese, Paola Palestini, Alessandra Bulbarell. Ischemic Conditions Affect Rerouting of Tau Protein Levels: Evidences for Alteration in Tau Processing and Secretion in Hippocampal Neurons. Journal of molecular neuroscience : MN. vol 66. issue 4. 2019-01-10. PMID:30421280. |
thus, we investigated the effect of oxygen-glucose deprivation (ogd), an experimental condition mimicking cerebral ischemia, in search of alteration in tau processing and secretion in hippocampal neurons primary cultures. |
2019-01-10 |
2023-08-13 |
Not clear |
| Angélica Maria Sabogal-Guáqueta, Luis Carrillo-Hormaza, Edison Osorio, Gloria Patricia Cardona-Góme. Effects of biflavonoids from Garcinia madruno on a triple transgenic mouse model of Alzheimer's disease. Pharmacological research. vol 129. 2019-01-04. PMID:29229355. |
the bf treatment reduced βa deposition in different regions of the brain (the hippocampus, entorhinal cortex and amygdala), reduced βa1-40 and βa1-42 levels, bace1-mediated cleavage of app (ctfβ), tau pathology, astrogliosis and microgliosis in the brains of aged 3xtg-ad mice. |
2019-01-04 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29040533. |
hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of alzheimer's disease. |
2019-01-02 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29040533. |
the purpose of our study was to understand the toxic effects of hippocampal phosphorylated tau in tau mice. |
2019-01-02 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29040533. |
mwm and rotarod tests revealed that hippocampal learning and memory and motor learning and coordination were impaired in tau mice relative to wild-type (wt) mice. |
2019-01-02 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29040533. |
these findings suggest that hippocampal accumulation of phosphorylated tau is responsible for abnormal mitochondrial dynamics and reducing dendritic protein map2 and dendritic spines and hippocampal based learning and memory impairments, and mitochondrial structural and functional changes in tau mice. |
2019-01-02 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29040533. |
based on these observations, we propose that reduced hippocampal phosphorylated tau is an important therapeutic strategy for ad and other tauopathies. |
2019-01-02 |
2023-08-13 |
mouse |
| An Phu Tran Nguyen, Guillaume Daniel, Pamela Valdés, Md Shariful Islam, Bernard L Schneider, Darren J Moor. G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29088368. |
p301s-tau expression induces hippocampal tau pathology and marked degeneration of ca1 pyramidal neurons in mice, however, this occurs independently of endogenous or pathogenic lrrk2 expression. |
2019-01-02 |
2023-08-13 |
mouse |
| An Phu Tran Nguyen, Guillaume Daniel, Pamela Valdés, Md Shariful Islam, Bernard L Schneider, Darren J Moor. G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29088368. |
we further developed new aav2/6 vectors co-expressing human wt-tau and gfp to monitor the neuron-to-neuron transmission of tau within defined hippocampal neuronal circuits. |
2019-01-02 |
2023-08-13 |
mouse |
| Nan Zhang, Marc L Gordo. Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients. Clinical interventions in aging. vol 13. 2018-12-20. PMID:30349215. |
based on these studies, donepezil has been shown to be effective and safe in chinese ad patients and may impact ad biomarkers, such as hippocampal atrophy, aβ, and tau. |
2018-12-20 |
2023-08-13 |
human |
| Caterina Scuderi, Maria Rosanna Bronzuoli, Roberta Facchinetti, Lorenzo Pace, Luca Ferraro, Kevin Donald Broad, Gaetano Serviddio, Francesco Bellanti, Gianmauro Palombelli, Giulia Carpinelli, Rossella Canese, Silvana Gaetani, Luca Steardo, Luca Steardo, Tommaso Cassan. Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease by exerting anti-inflammatory and neuroprotective effects. Translational psychiatry. vol 8. issue 1. 2018-12-12. PMID:29382825. |
moreover, it reduces aβ formation, the phosphorylation of tau proteins, and promotes neuronal survival in the ca1 subregion of the hippocampus. |
2018-12-12 |
2023-08-13 |
mouse |
| Hai-Hong Wang, Yan Li, Ang Li, Fang Yan, Zhen-Lin Li, Zhong-Ying Liu, Lei Zhang, Jian Zhang, Wei-Ren Dong, Lin Zhan. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27995573. |
forskolin induces hyperphosphorylation of tau accompanied by cell cycle reactivation in primary hippocampal neurons. |
2018-12-11 |
2023-08-13 |
Not clear |
| Hai-Hong Wang, Yan Li, Ang Li, Fang Yan, Zhen-Lin Li, Zhong-Ying Liu, Lei Zhang, Jian Zhang, Wei-Ren Dong, Lin Zhan. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27995573. |
the aim of the present study was to investigate cell cycle reactivation during tau hyperphosphorylation in primary hippocampal neurons. |
2018-12-11 |
2023-08-13 |
Not clear |
| Hai-Hong Wang, Yan Li, Ang Li, Fang Yan, Zhen-Lin Li, Zhong-Ying Liu, Lei Zhang, Jian Zhang, Wei-Ren Dong, Lin Zhan. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27995573. |
we used forskolin, a specific activator of pka, to induce tau hyperphosphorylation in cultured primary hippocampal neurons, and then measured levels of cyclin d1 and cyclin b1. |
2018-12-11 |
2023-08-13 |
Not clear |
| Hai-Hong Wang, Yan Li, Ang Li, Fang Yan, Zhen-Lin Li, Zhong-Ying Liu, Lei Zhang, Jian Zhang, Wei-Ren Dong, Lin Zhan. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27995573. |
the tau hyperphosphorylation was accompanied by increases in cyclin d1 and cyclin b1 levels; immunostaining showed overlapping distribution of hyperphosphorylated tau and cyclin d1 and cyclin b1 in primary hippocampal neurons. |
2018-12-11 |
2023-08-13 |
Not clear |
| Lin-Na Ning, Teng Zhang, Jiang Chu, Na Qu, Li Lin, Ying-Yan Fang, Yan Shi, Peng Zeng, Er-Li Cai, Xiao-Ming Wang, Qun Wang, You-Ming Lu, Xin-Wen Zhou, Qi Zhang, Qing Tia. Gender-Related Hippocampal Proteomics Study from Young Rats After Chronic Unpredicted Mild Stress Exposure. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:28064424. |
further, the synapse-related proteins, cytoskeleton protein tau, and stress-related kinases in hippocampus were assayed by western blotting. |
2018-12-11 |
2023-08-13 |
rat |