| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Chen, Yuyun Hua, Xinshuai Li, Ishfaq Muhammad Arslan, Wei Zhang, Guoliang Men. Distinct Types of Cell Death and the Implication in Diabetic Cardiomyopathy. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32116717. |
dcm has multiple hallmarks, including hyperglycemia, insulin resistance, increased free radical production, lipid peroxidation, mitochondrial dysfunction, endothelial dysfunction, and cell death. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ola M El-Borady, Mohamed S Othman, Heba H Atallah, Ahmed E Abdel Monei. Hypoglycemic potential of selenium nanoparticles capped with polyvinyl-pyrrolidone in streptozotocin-induced experimental diabetes in rats. Heliyon. vol 6. issue 5. 2020-09-28. PMID:32509990. |
plasma glucose and insulin levels, pancreatic insulin expression, the levels of lipid peroxidation (lpo), nitric oxide (no), glutathione peroxidase (gpx) and glutathione (gsh) were evaluated. |
2020-09-28 |
2023-08-13 |
rat |
| Danielle da Silva Dias, Nathalia Bernardes, Filipe Fernandes Stoyell-Conti, Camila Paixão Dos Santos, Amanda Aparecida de Araujo, Susana Llesuy, Maria Cláudia Irigoyen, Kátia De Angeli. Impact of combined exercise training on the development of cardiometabolic and neuroimmune complications induced by fructose consumption in hypertensive rats. PloS one. vol 15. issue 6. 2020-08-18. PMID:32521542. |
fructose consumption (h vs. hf groups) decreased spontaneous baroreflex sensitivity and total variance of pulse interval at day 7 (7 to 60); increased il-6 and tnfα in the heart (at day 15, 30 and 60) and nadph oxidase activity and cardiac lipoperoxidation (lpo) (day 60); increased white adipose tissue weight, reduced insulin sensitivity and increased triglycerides (day 60); induced an additional increase in mean arterial pressure (map) (days 30 and 60). |
2020-08-18 |
2023-08-13 |
rat |
| Mohammad Javad Saeedi Borujeni, Ebrahim Esfandiary, Mustafa Ghanadian, Ali Valiani, Azar Baradaran, Amid Yazdan. Alterations in lipid peroxidation, lipid profile, insulin sensitivity, and hepatic histopathological changes in diabetic rats following the treatment with Salvadora persica. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-17. PMID:30270568. |
alterations in lipid peroxidation, lipid profile, insulin sensitivity, and hepatic histopathological changes in diabetic rats following the treatment with salvadora persica. |
2020-06-17 |
2023-08-13 |
rat |
| Mohammad Javad Saeedi Borujeni, Ebrahim Esfandiary, Mustafa Ghanadian, Ali Valiani, Azar Baradaran, Amid Yazdan. Alterations in lipid peroxidation, lipid profile, insulin sensitivity, and hepatic histopathological changes in diabetic rats following the treatment with Salvadora persica. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-17. PMID:30270568. |
we examined the effects of various partitions of salvadora persica extract on lipid profile (lp), lipid peroxidation, and insulin sensitivity (is) of diabetic rats. |
2020-06-17 |
2023-08-13 |
rat |
| Ting Li, Hua Yan, Yan Geng, Haitao Shi, Hong Li, Shenhao Wang, Yatao Wang, Jingyuan Xu, Gang Zhao, Xiaolan L. Target genes associated with lipid and glucose metabolism in non-alcoholic fatty liver disease. Lipids in health and disease. vol 18. issue 1. 2020-05-04. PMID:31805951. |
insulin resistance (ir) and lipid peroxidation are accepted as 'two-hit' hypothesis of non-alcoholic fatty liver disease (nafld). |
2020-05-04 |
2023-08-13 |
Not clear |
| Ji-Soo Lee, Hyun-Ah Lee, Ji Sook Ha. Sargassum sagamianum extract protects INS-1 pancreatic β cells against high glucose-induced apoptosis. Cytotechnology. vol 71. issue 1. 2020-02-25. PMID:30659444. |
treatment with sse at concentrations of 10-100 μg/ml decreased lipid peroxidation and intracellular reactive oxygen species and nitric oxide levels, and increased cell viability and insulin secretion in high glucose pretreated ins-1 cells in a dose-dependent manner. |
2020-02-25 |
2023-08-13 |
Not clear |
| Zwe-Ling Kong, Sabri Sudirman, Yu-Chun Hsu, Chieh-Yu Su, Hsiang-Ping Ku. Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model. International journal of molecular sciences. vol 20. issue 18. 2020-01-30. PMID:31514311. |
in the animal study, fucoxanthin administration improved insulin resistance, restored sperm motility, decreased abnormal sperm number, and inhibited lipid peroxidation. |
2020-01-30 |
2023-08-13 |
rat |
| Ramavat Ravindhar Naik, Praveen Kumar Munipally, Turlapati Nagaraj. Andrographolide reorganise hyperglycaemia and distorted antioxidant profile in streptozotocin-induced diabetic rats. Cardiovascular & hematological agents in medicinal chemistry. 2019-11-20. PMID:29076435. |
andrographolide (2.5 mg/kg b.w) was administered orally to diabetic rats and glibenclamide (25mg/kg b.w) as control for 30 days to assess its effects on blood glucose, insulin, insulin resistance and antioxidant profiles such as superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation in various regions of brain namely hypothalamus, cerebellum, hippocampus and brain cerebral cortex. |
2019-11-20 |
2023-08-13 |
rat |
| Carolina B Ribeiro, Fernanda M Ramos, John A Manthey, Thais B Cesa. Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study. Phytotherapy research : PTR. vol 33. issue 7. 2019-10-28. PMID:31183921. |
treatment with all doses of eriomin (200, 400, and 800 mg) had similar effects and altered significantly the following variables: blood glucose (-5%), insulin resistance (-7%), glucose intolerance (-7%), glycated hemoglobin (-2%), glucagon (-6.5%), c-peptide (-5%), hscrp (-12%), interleukin-6 (-13%), tnfα (-11%), lipid peroxidation (-17%), systolic blood pressure (-8%), glp-1 (+15%), adiponectin (+19%), and antioxidant capacity (+6%). |
2019-10-28 |
2023-08-13 |
Not clear |
| Nafiseh Sokri Mashhadi, Mehrnoosh Zakerkish, Javad Mohammadiasl, Mehdi Zarei, Majid Mohammadshahi, Mohammad Hossein Haghighizade. Astaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitus. Asia Pacific journal of clinical nutrition. vol 27. issue 2. 2019-09-11. PMID:29384321. |
this randomized, placebo-controlled trial was performed for 8 weeks to investigate the potential effects of astaxanthin (ast) supplementation on the adiponectin concentration, lipid peroxidation, glycemic control, insulin sensitivity, and anthropometric indices in participants with type 2 diabetes mellitus. |
2019-09-11 |
2023-08-13 |
human |
| Basiru O Ajiboye, Oluwafemi A Ojo, Oluwatosin Adeyonu, Oluwatosin D Imiere, Adewale O Fadaka, Adetutu O Osukoy. Ameliorative Activity of Ethanol Extract of Artocarpus heterophyllus Stem Bark on Pancreatic β-Cell Dysfunction in Alloxan-Induced Diabetic Rats. Journal of evidence-based complementary & alternative medicine. vol 22. issue 4. 2019-08-16. PMID:29279019. |
assays determined were serum insulin, lipid peroxidation, and antioxidant enzyme activities. |
2019-08-16 |
2023-08-13 |
rat |
| Basiru O Ajiboye, Oluwafemi A Ojo, Oluwatosin Adeyonu, Oluwatosin D Imiere, Adewale O Fadaka, Adetutu O Osukoy. Ameliorative Activity of Ethanol Extract of Artocarpus heterophyllus Stem Bark on Pancreatic β-Cell Dysfunction in Alloxan-Induced Diabetic Rats. Journal of evidence-based complementary & alternative medicine. vol 22. issue 4. 2019-08-16. PMID:29279019. |
eah stem bark reduced fasting blood glucose and lipid peroxidation levels and increased serum insulin levels and activities of antioxidant enzymes. |
2019-08-16 |
2023-08-13 |
rat |
| Bárbara Maiztegui, Carolina Lisi Román, Juan José Gagliardino, Luis Emilio Flore. Impaired endocrine-metabolic homeostasis: underlying mechanism of its induction by unbalanced diet. Clinical science (London, England : 1979). vol 132. issue 8. 2019-07-01. PMID:29626110. |
we measured plasma glucose, insulin, triglyceride, leptin, and lipid peroxidation levels; homeostasis model assessment (homa)-insulin resistance (homa-ir) and homa for β-cell function (homa-β) indexes were also determined. |
2019-07-01 |
2023-08-13 |
human |
| Bárbara Maiztegui, Carolina Lisi Román, Juan José Gagliardino, Luis Emilio Flore. Impaired endocrine-metabolic homeostasis: underlying mechanism of its induction by unbalanced diet. Clinical science (London, England : 1979). vol 132. issue 8. 2019-07-01. PMID:29626110. |
hs rats had increased plasma triglyceride, insulin, leptin, and lipid peroxidation (os marker) levels associated with an insulin-resistant state. |
2019-07-01 |
2023-08-13 |
human |
| Vânia Ortega Gutierres, Renata Pires Assis, Carlos Alberto Arcaro, Juliana Oriel Oliveira, Tayra Ferreira Oliveira Lima, Ana Laura Remédio Zeni Beretta, Paulo Inácio Costa, Amanda Martins Baviera, Iguatemy Lourenço Brunett. Curcumin improves the effect of a reduced insulin dose on glycemic control and oxidative stress in streptozotocin-diabetic rats. Phytotherapy research : PTR. vol 33. issue 4. 2019-06-10. PMID:30656757. |
isolated treatments using curcumin or insulin in a reduced dose (1 u/day) decreased glycemia, dyslipidemia, and biomarkers of liver and kidney damage and increased the activity of hepatic antioxidants (superoxide dismutase and glutathione peroxidase), however, only to a lesser extent than 4-u/day insulin, without improvements in catalase activity or plasma lipid peroxidation. |
2019-06-10 |
2023-08-13 |
rat |
| Ying Zhao, Hanchen Sun, Xiaosai Li, Yumei Zha, Weikai Ho. Hydroxysafflor yellow A attenuates high glucose-induced pancreatic β-cells oxidative damage via inhibiting JNK/c-jun signaling pathway. Biochemical and biophysical research communications. vol 505. issue 2. 2019-05-21. PMID:30249395. |
after 72 h of cultivation, the related indexes of oxidative stress (reactive oxygen species, catalase, glutathione peroxidase, lipid peroxidation, and superoxide dismutase), apoptosis (caspase3, parp) and the function of glucose stimulated insulin secretion were determined. |
2019-05-21 |
2023-08-13 |
rat |
| Kathiroli Sujithra, Subramani Srinivasan, Dhananjayan Indumathi, Veerasamy Vinothkuma. Allyl methyl sulfide, a garlic active component mitigates hyperglycemia by restoration of circulatory antioxidant status and attenuating glycoprotein components in streptozotocin-induced experimental rats. Toxicology mechanisms and methods. vol 29. issue 3. 2019-05-03. PMID:30318971. |
stz treated diabetic rats showed significant augment in plasma glucose level, lipidperoxidative (lpo) markers, glycoprotein components (hexose, hexosamine, sialic acid, and fucose), and significant decline in plasma insulin level, nonenzymatic antioxidants and activities of antioxidant enzymes in the circulatory system and tissues. |
2019-05-03 |
2023-08-13 |
rat |
| Salah O Bashi. Concomitant administration of resveratrol and insulin protects against diabetes mellitus type-1-induced renal damage and impaired function via an antioxidant-mediated mechanism and up-regulation of Na Archives of physiology and biochemistry. vol 125. issue 2. 2019-04-22. PMID:29436859. |
mechanism of actions revealed a synergist effect of both drugs due to hypoglycaemic effect of insulin and the ability of both drugs to increase renal cortex antioxidant enzymes activities, inhibit lipid peroxidation, and up-regulate na |
2019-04-22 |
2023-08-13 |
rat |
| Elizabeth O Dangana, Olugbenga S Michael, Tolulope E Omolekulo, Emmanuel D Areola, Lawrence A Olatunj. Enhanced hepatic glycogen synthesis and suppressed adenosine deaminase activity by lithium attenuates hepatic triglyceride accumulation in nicotine-exposed rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-26. PMID:30551393. |
along with increased insulin resistance (ir), fasting plasma glucose, lactate, plasma and hepatic ada, xo, ua, and triglyceride (tg), total cholesterol (tc), free fatty acid, lipid peroxidation and liver injury markers. |
2019-03-26 |
2023-08-13 |
rat |