| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vishvas N Patel, Mehul R Chorawala, Maitri B Shah, Kashvi C Shah, Bhavarth P Dave, Manal P Shah, Tanvi M Pate. Emerging Pathophysiological Mechanisms Linking Diabetes Mellitus and Alzheimer's Disease: An Old Wine in a New Bottle. Journal of Alzheimer's disease reports. vol 6. issue 1. 2022-07-27. PMID:35891636. |
in this review, we have discussed several potential mechanisms underlying diabetes-induced cognitive impairment which include, abnormal insulin signaling, amyloid-β accumulation, oxidative stress, immuno-inflammation, mitochondrial dysfunction, advanced glycation end products, acetylcholinesterase and butyrylcholinesterase, advanced lipid peroxidation products, and apolipoprotein e. all these interconnected mechanisms may act either individually or synergistically which eventually leads to neurodegeneration and ad. |
2022-07-27 |
2023-08-14 |
Not clear |
| Fatima El Zahra M Fathi, Kadry M Sadek, Asmaa F Khafaga, Abdel Wahab Al Senosy, Hanan A Ghoniem, Sahar Fayez, Mohamed F Zewei. Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes. Environmental science and pollution research international. 2022-07-21. PMID:35864405. |
in conclusion, vit d ameliorated the harmful biochemical impact of diabetes mellitus, probably by increasing insulin secretion and sensitivity, ameliorating β-cell function, and decreasing cortisol levels; also, the anti-inflammatory effect of vit d reduces the number of proinflammatory cytokines (e.g., il-6) and increases the activity of the antioxidant system, such as gsh, sod, tac, and catalase while reducing lipid peroxidation enzymes (e.g., mda). |
2022-07-21 |
2023-08-14 |
rat |
| Michelle Berenice Vega Joubert, Paola Ingaramo, María Eugenia Oliva, María Eugenia D'Alessandr. Food & function. 2022-06-21. PMID:35726830. |
the present study showed new aspects of liver damage, lipid peroxidation and oxidative stress in dyslipidemic insulin resistant rats chronically fed with a sucrose-rich diet. |
2022-06-21 |
2023-08-14 |
rat |
| Kehinde Samuel Olaniyi, Chukwubueze L Atuma, Hadiza Mahmud, Azeezat O Saidi, Isaiah Woru Sabinari, Christopher O Akintayo, Isaac O Ajadi, Lawrence A Olatunj. Restoration of cardiac metabolic flexibility by acetate in high fat diet-induced obesity is independent of ANP/BNP modulation. Canadian journal of physiology and pharmacology. 2022-04-08. PMID:35395159. |
it also caused insulin resistance and enhanced β-cell function, increased fasting insulin, lactate, plasma and cardiac triglyceride, total cholesterol, lipid peroxidation, tnf-α, il-6, hdac and cardiac troponin t and γ-glutamyl transferase and decreased plasma and cardiac gsh with unaltered cardiac anp and bnp. |
2022-04-08 |
2023-08-13 |
rat |
| Zydrune Polianskyte-Prause, Tuomas A Tolvanen, Sonja Lindfors, Kanta Kon, Laura C Hautala, Hong Wang, Tsutomu Wada, Hiroshi Tsuneki, Toshiyasu Sasaoka, Sanna Lehtone. Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice. International journal of biological sciences. vol 18. issue 5. 2022-03-28. PMID:35342343. |
ebselen increased insulin-induced akt phosphorylation in cultured myotubes, enhanced insulin sensitivity and protected liver tissue from lipid peroxidation and inflammation in the db/db mice, and improved glucose tolerance more efficiently than metformin in the ship2-tg mice. |
2022-03-28 |
2023-08-13 |
mouse |
| Maksim Khotimchenko, Nicholas E Brunk, Mark S Hixon, Daniel M Walden, Hypatia Hou, Kaushik Chakravarty, Jyotika Varshne. In Silico Development of Combinatorial Therapeutic Approaches Targeting Key Signaling Pathways in Metabolic Syndrome. Pharmaceutical research. 2022-03-21. PMID:35313359. |
hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated lipid peroxidation with further development of atherosclerotic alterations and diabetes. |
2022-03-21 |
2023-08-13 |
Not clear |
| Ambreen Mehmood Awan, Wafa Majeed, Faqir Muhammad, Muhammad Naeem Faisa. Acacia jacquemontii ethyl acetate extract reduces hyperglycemia and pro-inflammatory markers while increasing endogenous antioxidant potential in alloxan-induced diabetic rats. Environmental science and pollution research international. 2022-03-09. PMID:35262888. |
the effects of ajeae on fasting plasma glucose, plasma insulin, homa-ir, oral glucose tolerance test, glycated hemoglobin (hba1c), lipid profile, inflammatory cytokines (interleukin-6, tumor necrosis factor-alpha), and oxidative stress markers (lipid peroxidation, nitic oxide, superoxide dismutase, catalase, glutathione peroxidase) were evaluated. |
2022-03-09 |
2023-08-13 |
rat |
| Isabel Hidalgo, Miguel Ortiz-Flores, Francisco Villarreal, Salvador Fonseca-Coronado, Guillermo Ceballos, Eduardo Meaney, Nayelli Nájer. Is it possible to treat nonalcoholic liver disease using a flavanol-based nutraceutical approach? Basic and clinical data. Journal of basic and clinical physiology and pharmacology. 2022-02-04. PMID:35119232. |
the main factors for nafld are closely related to obesity, insulin resistance, intestinal microbiota alterations, hyperinsulinism, low-grade systemic inflammation, nitroxidative stress, lipid peroxidation, and mitochondrial dysfunction. |
2022-02-04 |
2023-08-13 |
Not clear |
| Esra Dandin, Ünsal Veli Üstündağ, İsmail Ünal, Perihan Seda Ateş-Kalkan, Derya Cansız, Merih Beler, Esin Ak, A Ata Alturfan, Ebru Emekli-Alturfa. Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation. Obesity research & clinical practice. 2022-01-15. PMID:35031270. |
after 15 days of overfeeding body weight, and fasting blood glucose, lipid peroxidation and nitric oxide levels and the expressions of fbf21, lepa, ll21, tnfα were elevated, where as there was impaired glucose tolerance and lower superoxide dismutase and glutathione s-transferase activities, dnmt3a expression which is an epigenetic tool of insulin resistance. |
2022-01-15 |
2023-08-13 |
zebrafish |
| Mikhail V Samsonov, Nikita V Podkuychenko, Asker Y Khapchaev, Eugene E Efremov, Elena V Yanushevskaya, Tatiana N Vlasik, Vadim Z Lankin, Iurii S Stafeev, Maxim V Skulachev, Marina V Shestakova, Alexander V Vorotnikov, Vladimir P Shirinsk. AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the Long-Term Palmitate Excess. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008640. |
here, we report that palmitate (pa), a typical ffa, does not impair, by itself, endothelial barrier and insulin signaling in human umbilical vein endothelial cells (huvec), but increases no release, reactive oxygen species (ros) generation, and protein labeling by malondialdehyde (mda) hallmarking oxidative stress and increased lipid peroxidation. |
2022-01-11 |
2023-08-13 |
human |
| Zhixing Cai, Yue Che. Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha-induced inflammation in adipocytes. Bioengineered. vol 12. issue 2. 2021-12-07. PMID:34699329. |
it is widely reported that berberine (bbr) has an anti-inflammatory effect and can reduce glucose and lipid accumulation, whereas ginsenoside rb1 (rb1) has been shown to have a significant inhibitory effect on insulin resistance and lipid peroxidation. |
2021-12-07 |
2023-08-13 |
Not clear |
| Kehinde S Olaniyi, Oluwatobi A Amusa, Isaac O Ajadi, Bolanle Y Alabi, Toluwani B Agunbiade, Mary B Ajad. Repression of HDAC5 by acetate restores hypothalamic-pituitary-ovarian function in type 2 diabetes mellitus. Reproductive toxicology (Elmsford, N.Y.). vol 106. 2021-12-06. PMID:34656705. |
the present data showed that in addition to insulin resistance, increased fasting blood glucose and insulin, t2dm induced elevated plasma, hypothalamic and ovarian triglyceride, lipid peroxidation, tnf-α and glutathione depletion. |
2021-12-06 |
2023-08-13 |
rat |
| Abeer M Abd El-Hamee. Polydatin-loaded chitosan nanoparticles ameliorates early diabetic nephropathy by attenuating oxidative stress and inflammatory responses in streptozotocin-induced diabetic rat. Journal of diabetes and metabolic disorders. vol 19. issue 2. 2021-11-25. PMID:33520856. |
our findings showed that diabetic group presented a significant high level of the blood glucose, blood glycosylated hemoglobin (hba1c), serum insulin, renal function related parameters, renal advanced glycation-end products (ages) and lipid peroxidation level compared to normal control rats, while serum albumin level and the activities of renal antioxidant enzymes were significantly decreased. |
2021-11-25 |
2023-08-13 |
rat |
| Jinendra Satiya, Heather S Snyder, Shivaram Prasad Singh, Sanjaya K Satapath. Narrative review of current and emerging pharmacological therapies for nonalcoholic steatohepatitis. Translational gastroenterology and hepatology. vol 6. 2021-11-23. PMID:34805582. |
the pharmacologic therapies which are being developed target the various components believed to be involved in the pathogenesis of nonalcoholic fatty liver disease (nafld)/nash which includes insulin resistance, lipid metabolism oxidative stress, lipid peroxidation, inflammatory and cell death pathways, and fibrosis. |
2021-11-23 |
2023-08-13 |
Not clear |
| Tolulope Eniola Adegoke, Isaiah Woru Sabinari, Emmanuel Damilare Areola, Folasade Ajao, Olayinka Olawale Asafa, Talha Kolade Soluoku, Abdullahi Bello, Adejoke Mosunmade Adesanmi, Shukurat Olaide Yusuf, AyokunleOlusuyi Omoleye, Mariam Tayo Ayinla, Lawrence Aderemi Olatunj. Inhibition of dipeptidyl peptidase-4 averts free fatty acids deposition in the hearts of oral estrogen-progestin contraceptive-induced hyperinsulinemic female rats. Canadian journal of physiology and pharmacology. vol 99. issue 12. 2021-11-22. PMID:34310895. |
from our data, estrogen-progestin oc exposure in female rats led to elevated plasma insulin, cardiac dpp-4 activity, ffa and triglyceride (tg) accumulation, tg/high-density lipoprotein cholesterol (tg/hdl-c) ratio, adenosine deaminase/xanthine oxidase/uric acid pathway (ada/xo/ua), lipid peroxidation, glycogen synthase activity, and alanine phosphatase; whereas cardiac glucose-6-phosphate dehydrogenase, na |
2021-11-22 |
2023-08-13 |
rat |
| Qifang Wu, Xueting Du, Xucong Feng, Huimin Cheng, Yingjun Chen, Chenying Lu, Mingjiang Wu, Haibin Ton. Chlordane exposure causes developmental delay and metabolic disorders in Drosophila melanogaster. Ecotoxicology and environmental safety. vol 225. 2021-10-05. PMID:34481351. |
collectively, chlordane causes lipid peroxidation and disrupts redox homeostasis, which may be a potential mechanism leading to impaired insulin signaling and the metabolism of glucose and lipid, ultimately affects drosophila development. |
2021-10-05 |
2023-08-13 |
drosophila_melanogaster |
| Malak M Aljumaiah, Mona A Alonazi, Abeer M Al-Dbass, Ahmad T Almnaizel, Mohammed Alahmed, Dina A Soliman, Afaf El-Ansar. Association of Maternal Diabetes and Autism Spectrum Disorders in Offspring: a Study in a Rodent Model of Autism. Journal of molecular neuroscience : MN. 2021-09-25. PMID:34562183. |
maternal t1d without insulin therapy increased lipid peroxidation levels, reduced gst activity, and lower offspring' vitamin c and gsh levels. |
2021-09-25 |
2023-08-13 |
rat |
| Gökçe Kuzgun, Rahman Başaran, Ebru Arıoğlu İnan, Benay Can Ek. Effects of insulin treatment on hepatic CYP1A1 and CYP2E1 activities and lipid peroxidation levels in streptozotocin-induced diabetic rats. Journal of diabetes and metabolic disorders. vol 19. issue 2. 2021-08-25. PMID:33520832. |
effects of insulin treatment on hepatic cyp1a1 and cyp2e1 activities and lipid peroxidation levels in streptozotocin-induced diabetic rats. |
2021-08-25 |
2023-08-13 |
rat |
| Gökçe Kuzgun, Rahman Başaran, Ebru Arıoğlu İnan, Benay Can Ek. Effects of insulin treatment on hepatic CYP1A1 and CYP2E1 activities and lipid peroxidation levels in streptozotocin-induced diabetic rats. Journal of diabetes and metabolic disorders. vol 19. issue 2. 2021-08-25. PMID:33520832. |
this study is aimed to investigate the effects of streptozotocin-induced diabetes and insulin treatment on hepatic cytochrome p450 1a1 (cyp1a1) and cytochrome p450 2e1 (cyp2e1) activities and lpo levels. |
2021-08-25 |
2023-08-13 |
rat |
| Mingzhu Xu, Ruifang Wang, Hui Fan, Ziyuan N. Nobiletin ameliorates streptozotocin-cadmium-induced diabetic nephropathy Archives of physiology and biochemistry. 2021-08-04. PMID:34346259. |
the stz/cd-induced dn leads to a significantly increased of the glucose levels, glycosylated haemoglobin, hepatic and kidney function markers, lipid peroxidation levels, and reduction of insulin levels, total haemoglobin, body weight, and antioxidant status markers. |
2021-08-04 |
2023-08-13 |
rat |