| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David H Root, Carlos A Mejias-Aponte, Jia Qi, Marisela Morale. Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 42. 2015-02-06. PMID:25319687. |
we conclude that there is a glutamatergic signal from vta vglut2-mesohabenular neurons that plays a role in aversion by activating lhb glutamatergic receptors. |
2015-02-06 |
2023-08-13 |
mouse |
| Eun-Kyung Hwang, Jun-mo Chun. 5HT(1B) receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula. Neuropharmacology. vol 81. 2014-12-15. PMID:24508708. |
despite the potential importance of glutamatergic excitatory synapses in depression-like behavior, modulation of these lhb synapses by monoamines such as serotonin (5ht) is not fully understood at the cellular and molecular level. |
2014-12-15 |
2023-08-12 |
rat |
| Eun-Kyung Hwang, Jun-mo Chun. 5HT(1B) receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula. Neuropharmacology. vol 81. 2014-12-15. PMID:24508708. |
therefore, we used whole cell voltage-clamp recording to examine the molecular mechanisms by which 5ht modulates glutamatergic transmission in the lhb. |
2014-12-15 |
2023-08-12 |
rat |
| Eun-Kyung Hwang, Jun-mo Chun. 5HT(1B) receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula. Neuropharmacology. vol 81. 2014-12-15. PMID:24508708. |
the present study provides the first evidence that glutamatergic transmission of lhb synapses is inhibited by activation of the 5ht(1b) receptor at the pre-synapse in both acute depression (5ht-ad) and long-term depression (5ht-ltd). |
2014-12-15 |
2023-08-12 |
rat |
| Wolfram C Poller, Vince I Madai, René Bernard, Gregor Laube, Rüdiger W Ve. A glutamatergic projection from the lateral hypothalamus targets VTA-projecting neurons in the lateral habenula of the rat. Brain research. vol 1507. 2014-09-18. PMID:23348378. |
these experiments revealed a mainly glutamatergic projection, probably exerting excitatory effects on the targeted lhb cells. |
2014-09-18 |
2023-08-12 |
rat |
| Wolfram C Poller, Vince I Madai, René Bernard, Gregor Laube, Rüdiger W Ve. A glutamatergic projection from the lateral hypothalamus targets VTA-projecting neurons in the lateral habenula of the rat. Brain research. vol 1507. 2014-09-18. PMID:23348378. |
taken together, the present study describes a strong mainly glutamatergic projection from the lha that targets vta/rmtg-projecting neurons in the lhb. |
2014-09-18 |
2023-08-12 |
rat |
| Cameron H Good, Huikun Wang, Yuan-Hao Chen, Carlos A Mejias-Aponte, Alexander F Hoffman, Carl R Lupic. Dopamine D4 receptor excitation of lateral habenula neurons via multiple cellular mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 43. 2013-12-23. PMID:24155292. |
glutamatergic lateral habenula (lhb) output communicates negative motivational valence to ventral tegmental area (vta) dopamine (da) neurons via activation of the rostromedial tegmental nucleus (rmtg). |
2013-12-23 |
2023-08-12 |
rat |
| Cameron H Good, Huikun Wang, Yuan-Hao Chen, Carlos A Mejias-Aponte, Alexander F Hoffman, Carl R Lupic. Dopamine D4 receptor excitation of lateral habenula neurons via multiple cellular mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 43. 2013-12-23. PMID:24155292. |
these results demonstrate that da can excite glutamatergic lhb output to rmtg via multiple cellular mechanisms. |
2013-12-23 |
2023-08-12 |
rat |
| Hidenori Aizawa, Megumi Kobayashi, Sayaka Tanaka, Tomoki Fukai, Hitoshi Okamot. Molecular characterization of the subnuclei in rat habenula. The Journal of comparative neurology. vol 520. issue 18. 2013-04-18. PMID:22700183. |
in contrast, neurons in the lateral habenula (lhb) were almost uniformly glutamatergic. |
2013-04-18 |
2023-08-12 |
rat |
| Luciano Gonçalves, Chemutai Sego, Martin Metzge. Differential projections from the lateral habenula to the rostromedial tegmental nucleus and ventral tegmental area in the rat. The Journal of comparative neurology. vol 520. issue 6. 2012-12-14. PMID:22020635. |
the rmtg receives glutamatergic inputs from the lateral habenula (lhb) and sends substantial gabaergic projections to the vta, which also receives direct projections from the lhb. |
2012-12-14 |
2023-08-12 |
rat |
| Matthieu Maroteaux, Manuel Mamel. Cocaine evokes projection-specific synaptic plasticity of lateral habenula neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 36. 2012-11-16. PMID:22956853. |
recent evidence demonstrates that ampa receptors lacking the glua2 subunit mediate glutamatergic transmission in lhb neurons. |
2012-11-16 |
2023-08-12 |
mouse |
| Steven J Shabel, Christophe D Proulx, Anthony Trias, Ryan T Murphy, Roberto Malino. Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin. Neuron. vol 74. issue 3. 2012-07-12. PMID:22578499. |
although the output of the basal ganglia is thought to be primarily inhibitory, here we show that transmission from the basal ganglia to the lhb is excitatory, glutamatergic, and suppressed by serotonin. |
2012-07-12 |
2023-08-12 |
Not clear |
| W C Poller, R Bernard, C Derst, T Weiss, V I Madai, R W Ve. Lateral habenular neurons projecting to reward-processing monoaminergic nuclei express hyperpolarization-activated cyclic nucleotid-gated cation channels. Neuroscience. vol 193. 2012-01-18. PMID:21798320. |
glutamatergic lhb efferents terminate on gabaergic neurons in the vta, the rostromedial tegmental nucleus (rmtg), and the raphe nuclei, thereby suppressing monoamine release when required by the present behavioral context. |
2012-01-18 |
2023-08-12 |
rat |
| Simon Hong, Thomas C Jhou, Mitchell Smith, Kadharbatcha S Saleem, Okihide Hikosak. Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental nucleus in primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 32. 2011-10-04. PMID:21832176. |
yet lhb neurons are largely glutamatergic, indicating that this inhibition may occur through an intermediate structure. |
2011-10-04 |
2023-08-12 |
rat |
| K Brinschwitz, A Dittgen, V I Madai, R Lommel, S Geisler, R W Ve. Glutamatergic axons from the lateral habenula mainly terminate on GABAergic neurons of the ventral midbrain. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20353812. |
here we show, using in situ hybridization and immunocytochemical double labeling at the light and electron microscopic level, that gabaergic neurons are scarce in the lhb and that glutamatergic axons from the lhb mostly target gabaergic neurons in the vta and the mesopontine rostromedial tegmental nucleus (rmtg), also known as tail of the vta (tvta). |
2010-08-19 |
2023-08-12 |
Not clear |
| Natalia Omelchenko, Roland Bell, Susan R Sesac. Lateral habenula projections to dopamine and GABA neurons in the rat ventral tegmental area. The European journal of neuroscience. vol 30. issue 7. 2010-01-18. PMID:19788571. |
as lhb efferents are reportedly glutamatergic, their ability to inhibit da cells would theoretically require a disynaptic connection involving vta gaba neurons and their local collateral inputs to da cells. |
2010-01-18 |
2023-08-12 |
rat |
| Natalia Omelchenko, Roland Bell, Susan R Sesac. Lateral habenula projections to dopamine and GABA neurons in the rat ventral tegmental area. The European journal of neuroscience. vol 30. issue 7. 2010-01-18. PMID:19788571. |
pre-embedding immunogold labeling for the vesicular glutamate transporter type 2 and post-embedding immunogold staining for gaba confirmed that approximately 85% of lhb terminals were glutamatergic and not gabaergic. |
2010-01-18 |
2023-08-12 |
rat |