| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aki Takahashi, Romain Durand-de Cuttoli, Meghan E Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D Blitzer, Michael Lazarus, Kenji F Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J Russ. Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice. Nature communications. vol 13. issue 1. 2022-07-21. PMID:35864121. |
here, we found that glutamatergic projections from the lateral habenula (lhb) to the drn were activated in male mice that experienced pre-exposure to a rival male mouse ("social instigation") resulting in heightened intermale aggression. |
2022-07-21 |
2023-08-14 |
mouse |
| Aki Takahashi, Romain Durand-de Cuttoli, Meghan E Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D Blitzer, Michael Lazarus, Kenji F Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J Russ. Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice. Nature communications. vol 13. issue 1. 2022-07-21. PMID:35864121. |
our results demonstrate that the lhb glutamatergic inputs to the drn promote aggressive arousal induced by social instigation, which contributes to aggressive behavior by activating vta-projecting non-serotonergic drn neurons as one of its potential targets. |
2022-07-21 |
2023-08-14 |
mouse |
| Jian Xu, Andrew Jo, Raina P DeVries, Sercan Deniz, Suraj Cherian, Idris Sunmola, Xingqi Song, John J Marshall, Katherine A Gruner, Tanya L Daigle, Anis Contractor, Talia N Lerner, Hongkui Zeng, Yongling Zh. Intersectional mapping of multi-transmitter neurons and other cell types in the brain. Cell reports. vol 40. issue 1. 2022-07-06. PMID:35793636. |
focusing on the lateral habenula (lhb) as a target, we identified glutamatergic, gabaergic, or co-glutamatergic/gabaergic innervations from ∼40 brain regions. |
2022-07-06 |
2023-08-14 |
mouse |
| Xue Liu, Hongren Huang, Yulin Zhang, Liping Wang, Feng Wan. Sexual Dimorphism of Inputs to the Lateral Habenula in Mice. Neuroscience bulletin. 2022-06-01. PMID:35644002. |
in this study, we used viral tracing combined with in situ hybridization targeting vesicular glutamate transporter 2 (vglut2) and glutamic acid decarboxylase 2 (gad2) to generate a comprehensive whole-brain atlas of inputs to glutamatergic and γ-aminobutyric acid (gaba)ergic neurons in the lhb. |
2022-06-01 |
2023-08-13 |
mouse |
| Xue Liu, Hongren Huang, Yulin Zhang, Liping Wang, Feng Wan. Sexual Dimorphism of Inputs to the Lateral Habenula in Mice. Neuroscience bulletin. 2022-06-01. PMID:35644002. |
our results reveal a comprehensive connectivity atlas of glutamatergic and gabaergic inputs to the lhb in both sexes, which may facilitate a better understanding of sexual dimorphism in physiological and pathological brain functions. |
2022-06-01 |
2023-08-13 |
mouse |
| Marjorie R Levinstein, David J Bergkamp, Zoë K Lewis, Alex Tsobanoudis, Koichi Hashikawa, Garret D Stuber, John F Neumaie. PACAP-expressing neurons in the lateral habenula diminish negative emotional valence. Genes, brain, and behavior. 2022-03-19. PMID:35304804. |
while primarily glutamatergic, lhb neurons express genes coding for many neuropeptides, such as adcyap1 the gene encoding pituitary adenylate cyclase-activating polypeptide (pacap), which itself has been associated with anxiety and stress disorders. |
2022-03-19 |
2023-08-13 |
Not clear |
| Ludovic D Langlois, Rina Y Berman, Ryan D Shepard, Sarah C Simmons, Mumeko C Tsuda, Shawn Gouty, Kwang H Choi, Fereshteh S Nugen. Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats. Addiction biology. 2021-11-26. PMID:34036710. |
md-induced potentiation of glutamatergic synaptic transmission onto lhb neurons shifts the coordination of excitation/inhibition (e/i) balance towards excitation, resulting in an increase in the overall spontaneous neuronal activity with elevation in bursting and tonic firing, and in the intrinsic excitability of lhb neurons in early adolescent male rats. |
2021-11-26 |
2023-08-13 |
rat |
| Ludovic D Langlois, Rina Y Berman, Ryan D Shepard, Sarah C Simmons, Mumeko C Tsuda, Shawn Gouty, Kwang H Choi, Fereshteh S Nugen. Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats. Addiction biology. 2021-11-26. PMID:34036710. |
here, we explored how md affects intravenous morphine self-administration (msa) acquisition and sucrose preference as well as glutamatergic synaptic function in lhb neurons of adult male rats self-administering morphine. |
2021-11-26 |
2023-08-13 |
rat |
| Ludovic D Langlois, Rina Y Berman, Ryan D Shepard, Sarah C Simmons, Mumeko C Tsuda, Shawn Gouty, Kwang H Choi, Fereshteh S Nugen. Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats. Addiction biology. 2021-11-26. PMID:34036710. |
we found that md-induced increases in lhb neuronal and glutamatergic synaptic activity and e/i ratio persisted into adulthood. |
2021-11-26 |
2023-08-13 |
rat |
| Ludovic D Langlois, Rina Y Berman, Ryan D Shepard, Sarah C Simmons, Mumeko C Tsuda, Shawn Gouty, Kwang H Choi, Fereshteh S Nugen. Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats. Addiction biology. 2021-11-26. PMID:34036710. |
our data highlight that early life stress-induced glutamatergic plasticity in lhb may dampen the positive reinforcing and motivational properties of both natural rewards and opioids, and may contribute to the development of anhedonia and dysphoric states associated with opioids. |
2021-11-26 |
2023-08-13 |
rat |
| b' Marc Fakhoury, Giovanni Hernandez, Daniel L\\xc3\\xa9vesque, Pierre-Paul Rompr\\xc3\\xa. Modulation of brain stimulation reward and locomotor activity by ionotropic glutamate receptors of the tail of the ventral tegmental area. Behavioural brain research. vol 393. 2021-10-25. PMID:32593543.' |
the rostromedial tegmental nucleus also referred to as the tail of the ventral tegmental area (tvta) contains a cluster of gamma-aminobutyric acid (gaba)ergic neurons that receive dense glutamatergic afferents from the lateral habenula (lhb), and project to dopamine (da) neurons of the ventral tegmental area (vta) and substantia nigra pars compacta (snc). |
2021-10-25 |
2023-08-13 |
Not clear |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
interestingly, majority of neurons in lhb were aversion-activated and reward-inhibited neurons, consisting mainly of glutamatergic neurons, while most neurons in vta were reward-activated and aversion-inhibited neurons, which inhibited by glutamatergic neurons in the lhb. |
2021-09-21 |
2023-08-13 |
mouse |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
furthermore, optogenetic activation or inhibition of glutamatergic neurons in lhb and their terminals in vta could induce aversive or reward behaviors. |
2021-09-21 |
2023-08-13 |
mouse |
| Jicheng Li, Renfei Fan, Xiaofeng Liu, Xiangfeng Shen, Xin Liu, Hua Zha. The convergence of aversion and reward signals in individual neurons of the mice lateral habenula. Experimental neurology. vol 339. 2021-09-21. PMID:33549547. |
the aversion behaviors induced by activating lhb glutamatergic neurons may be due to its inhibition on reward-activated neurons in vta. |
2021-09-21 |
2023-08-13 |
mouse |
| Shiyi Zhao, Rui Li, Huiming Li, Sa Wang, Xinxin Zhang, Dan Wang, Juan Guo, Huihui Li, Ao Li, Tingting Tong, Haixing Zhong, Qianzi Yang, Hailong Don. Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice. Neuroscience bulletin. vol 37. issue 7. 2021-08-18. PMID:33847915. |
photostimulation of lha glutamatergic projections to the lateral habenula (lhb) also facilitated the emergence from anesthesia and the transition of anesthesia depth to a lighter level. |
2021-08-18 |
2023-08-13 |
mouse |
| Shiyi Zhao, Rui Li, Huiming Li, Sa Wang, Xinxin Zhang, Dan Wang, Juan Guo, Huihui Li, Ao Li, Tingting Tong, Haixing Zhong, Qianzi Yang, Hailong Don. Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice. Neuroscience bulletin. vol 37. issue 7. 2021-08-18. PMID:33847915. |
collectively, lha glutamatergic neurons and their projections to the lhb regulate anesthetic potency and eeg features. |
2021-08-18 |
2023-08-13 |
mouse |
| Alvaro Nuno-Perez, Massimo Trusel, Arnaud L Lalive, Mauro Congiu, Denise Gastaldo, Anna Tchenio, Salvatore Lecca, Mariano Soiza-Reilly, Claudia Bagni, Manuel Mamel. Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula. Neuron. vol 109. issue 6. 2021-03-26. PMID:33535028. |
accordingly, stressful experiences increased error choices while decreasing glutamatergic neurotransmission onto lhb neurons. |
2021-03-26 |
2023-08-13 |
mouse |
| Dan Wang, Ao Li, Keyi Dong, Huihui Li, Yongxin Guo, Xinxin Zhang, Min Cai, Huiming Li, Guangchao Zhao, Qianzi Yan. Lateral hypothalamus orexinergic inputs to lateral habenula modulate maladaptation after social defeat stress. Neurobiology of stress. vol 14. 2021-02-12. PMID:33569507. |
when mice were defeated during social interaction, both orexinergic neurons in the lha and glutamatergic neurons in the lhb were strongly activated, as indicated by the fostrap strategy. |
2021-02-12 |
2023-08-13 |
mouse |
| Wen-Qiang Cui, Wen-Wen Zhang, Teng Chen, Qian Li, Fei Xu, Qi-Liang Mao-Ying, Wen-Li Mi, Yan-Qing Wang, Yu-Xia Ch. Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. Acta neuropathologica communications. vol 8. issue 1. 2021-01-15. PMID:32264959. |
adeno-associated virus (aav)-mediated expression of hm4d(gi) in glutamatergic neurons of the unilateral lhb followed by clozapine-n-oxide application relieved pt-ion-induced anxiety-like behaviors but not allodynia. |
2021-01-15 |
2023-08-13 |
mouse |
| Wen-Qiang Cui, Wen-Wen Zhang, Teng Chen, Qian Li, Fei Xu, Qi-Liang Mao-Ying, Wen-Li Mi, Yan-Qing Wang, Yu-Xia Ch. Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. Acta neuropathologica communications. vol 8. issue 1. 2021-01-15. PMID:32264959. |
whole-cell patch clamp recording showed that tacr3 overexpression suppressed nerve injury-induced hyperexcitation of lhb neurons, and western blotting showed that the pt-ion-induced upregulation of p-camkii was reversed by aav-mediated tacr3 overexpression or chemicogenetic inhibition of glutamatergic neurons in the lhb. |
2021-01-15 |
2023-08-13 |
mouse |