| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rao Fu, Qinghua Mei, Wanhong Zuo, Jing Li, Danielle Gregor, Alex Bekker, Jianghong Y. Low-dose ethanol excites lateral habenula neurons projecting to VTA, RMTg, and raphe. International journal of physiology, pathophysiology and pharmacology. vol 9. issue 6. 2020-09-30. PMID:29348799. |
most of the ethanol-activated cfos-ir lhb neurons expressed vglut2 (vesicular glutamate transporters 2, a marker of a glutamatergic phenotype). |
2020-09-30 |
2023-08-13 |
rat |
| Iakovos Lazaridis, Ourania Tzortzi, Moritz Weglage, Antje Märtin, Yang Xuan, Marc Parent, Yvonne Johansson, Janos Fuzik, Daniel Fürth, Lief E Fenno, Charu Ramakrishnan, Gilad Silberberg, Karl Deisseroth, Marie Carlén, Konstantinos Meleti. A hypothalamus-habenula circuit controls aversion. Molecular psychiatry. vol 24. issue 9. 2020-04-27. PMID:30755721. |
we have defined the identity and function of glutamatergic (vglut2) control of the lhb, comparing the role of inputs originating in the globus pallidus internal segment (gpi), and lateral hypothalamic area (lha), respectively. |
2020-04-27 |
2023-08-13 |
Not clear |
| Guang-Wei Zhang, Li Shen, Wen Zhong, Ying Xiong, Li I Zhang, Huizhong W Ta. Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway. Neuron. vol 99. issue 5. 2019-08-01. PMID:30122379. |
cell-type-specific screening reveals that glutamatergic ms projections to the lateral habenula (lhb) are responsible for the induction of aversion, which can be antagonized by gabaergic ms projections to lhb. |
2019-08-01 |
2023-08-13 |
Not clear |
| Yoshikage Muroi, Toshiaki Ishi. Glutamatergic Signals in the Dorsal Raphe Nucleus Regulate Maternal Aggression and Care in an Opposing Manner in Mice. Neuroscience. vol 400. 2019-06-21. PMID:30605702. |
we first examined neuronal activity in the medial prefrontal cortex (mpfc) and lateral habenula (lhb), which send glutamatergic input to the drn, in dams by injecting fluorogold, a retrograde tracer, into the drn. |
2019-06-21 |
2023-08-13 |
mouse |
| Yoshikage Muroi, Toshiaki Ishi. Glutamatergic Signals in the Dorsal Raphe Nucleus Regulate Maternal Aggression and Care in an Opposing Manner in Mice. Neuroscience. vol 400. 2019-06-21. PMID:30605702. |
these results suggest that glutamatergic signals in the drn, which may originate from the mpfc and/or lhb, regulate the preferential display of biting behavior over nurturing behavior in dams. |
2019-06-21 |
2023-08-13 |
mouse |
| Seungwoo Kang, Jing Li, Alex Bekker, Jiang-Hong Y. Rescue of glutamate transport in the lateral habenula alleviates depression- and anxiety-like behaviors in ethanol-withdrawn rats. Neuropharmacology. vol 129. 2018-07-27. PMID:29128307. |
here we show that dihydrokainic acid (dhk), a glt-1 blocker, potentiated glutamatergic transmission to lhb neurons in slices from ethanol naïve rats; this potentiation, though, was not observed in slices from rats withdrawn from repeated in vivo ethanol administration, suggesting reduced glt-1 function. |
2018-07-27 |
2023-08-13 |
human |
| Avi Shah, Wanhong Zuo, Seungwoo Kang, Jing Li, Rao Fu, Haifeng Zhang, Alex Bekker, Jiang-Hong Y. The lateral habenula and alcohol: Role of glutamate and M-type potassium channels. Pharmacology, biochemistry, and behavior. vol 162. 2018-06-18. PMID:28624587. |
multidisciplinary work in animals collectively suggests that lhb function and activity, including m-type potassium channels and glutamatergic transmission are altered by acute and repeated chronic alcohol exposure. |
2018-06-18 |
2023-08-13 |
Not clear |
| Jing Li, Seungwoo Kang, Rao Fu, Liangzhi Wu, Wei Wu, Hongwei Liu, Danielle Gregor, Wanhong Zuo, Alex Bekker, Jiang-Hong Y. Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats. Neuropharmacology. vol 126. 2018-06-12. PMID:28865912. |
glutamatergic synapses in lhb neurons largely express glua1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (ampar) that can be modulated by ca |
2018-06-12 |
2023-08-13 |
rat |
| Salvatore Lecca, Frank Julius Meye, Massimo Trusel, Anna Tchenio, Julia Harris, Martin Karl Schwarz, Denis Burdakov, Francois Georges, Manuel Mamel. Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior. eLife. vol 6. 2018-05-14. PMID:28871962. |
the foot-shock-driven excitation within the lhb requires glutamatergic signaling from the lh, but not from the midbrain. |
2018-05-14 |
2023-08-13 |
mouse |
| Wanhong Zuo, Liwei Wang, Lixin Chen, Krešimir Krnjević, Rao Fu, Xia Feng, Wen He, Seungwoo Kang, Avi Shah, Alex Bekker, Jiang-Hong Y. Ethanol potentiates both GABAergic and glutamatergic signaling in the lateral habenula. Neuropharmacology. vol 113. issue Pt A. 2017-06-30. PMID:27678415. |
we previously showed that ethanol enhances glutamatergic transmission and stimulates lhb neurons. |
2017-06-30 |
2023-08-13 |
rat |
| Guiqin Xie, Wanhong Zuo, Liangzhi Wu, Wenting Li, Wei Wu, Alex Bekker, Jiang-Hong Y. Serotonin modulates glutamatergic transmission to neurons in the lateral habenula. Scientific reports. vol 6. 2017-02-17. PMID:27033153. |
we compared serotonin's effects on glutamatergic transmission across the lhb in rat brains. |
2017-02-17 |
2023-08-13 |
rat |
| Victor Mathis, Brigitte Cosquer, Martino Avallone, Jean-Christophe Cassel, Lucas Lecourtie. Excitatory Transmission to the Lateral Habenula Is Critical for Encoding and Retrieval of Spatial Memory. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 12. 2016-08-02. PMID:25971591. |
in the present study, we used two pharmacological approaches-lhb reversible inactivation with intra-lhb infusion of muscimol, an agonist of the gaba-a receptor, or blockade of excitatory inputs with intra-lhb infusion of 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx), an antagonist of the glutamatergic ampa receptor-to investigate the involvement of the lhb in encoding, consolidation, and retrieval of spatial memory in the water maze (wm) in rats. |
2016-08-02 |
2023-08-13 |
rat |
| Victor Mathis, Brigitte Cosquer, Martino Avallone, Jean-Christophe Cassel, Lucas Lecourtie. Excitatory Transmission to the Lateral Habenula Is Critical for Encoding and Retrieval of Spatial Memory. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 12. 2016-08-02. PMID:25971591. |
they further suggest a dichotomy between the role of glutamatergic and other inputs to the lhb in hippocampus-dependent memory processing, as well as in emotional aspects of goal-directed behaviors. |
2016-08-02 |
2023-08-13 |
rat |
| Hongbin Yang, Junhua Yang, Wang Xi, Sijia Hao, Benyan Luo, Xiaobin He, Liya Zhu, Huifang Lou, Yan-qin Yu, Fuqiang Xu, Shumin Duan, Hao Wan. Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear. Nature neuroscience. vol 19. issue 2. 2016-06-03. PMID:26727549. |
finally, activation of lhb glutamatergic inputs to ldt interneurons was sufficient to generate fear-like responses. |
2016-06-03 |
2023-08-13 |
mouse |
| Alice M Stamatakis, Maaike Van Swieten, Marcus L Basiri, Grace A Blair, Pranish Kantak, Garret D Stube. Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 2. 2016-05-17. PMID:26758824. |
here, we show that lateral hypothalamic area (lha) glutamatergic neurons, and their projections to the lateral habenula (lhb), negatively regulate the consumption of palatable food. |
2016-05-17 |
2023-08-13 |
mouse |
| Alice M Stamatakis, Maaike Van Swieten, Marcus L Basiri, Grace A Blair, Pranish Kantak, Garret D Stube. Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 2. 2016-05-17. PMID:26758824. |
anterior lha glutamatergic neurons send a functional glutamatergic projection to the lhb, a brain region involved in processing aversive stimuli and negative reward prediction outcomes. |
2016-05-17 |
2023-08-13 |
mouse |
| Alice M Stamatakis, Maaike Van Swieten, Marcus L Basiri, Grace A Blair, Pranish Kantak, Garret D Stube. Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 2. 2016-05-17. PMID:26758824. |
pathway-specific, optogenetic stimulation of glutamatergic lha-lhb circuit resulted in detectable glutamate-mediated epscs as well as gaba-mediated ipscs, although the net effect of neurotransmitter release was to increase the firing of most lhb neurons. |
2016-05-17 |
2023-08-13 |
mouse |
| Alice M Stamatakis, Maaike Van Swieten, Marcus L Basiri, Grace A Blair, Pranish Kantak, Garret D Stube. Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 2. 2016-05-17. PMID:26758824. |
collectively, these results demonstrate that lha glutamatergic neurons are well situated to bidirectionally regulate feeding and potentially other behavioral states via their functional circuit connectivity with the lhb and potentially other brain regions. |
2016-05-17 |
2023-08-13 |
mouse |
| Philip Jean-Richard Dit Bressel, Gavan P McNall. The role of the lateral habenula in punishment. PloS one. vol 9. issue 11. 2015-08-18. PMID:25365401. |
the lhb is known to modulate midbrain dopamine (da) neurons, including inhibition of ventral tegmental area (vta) neurons via glutamatergic excitation of the gabaergic rostromedial tegmental nucleus (rmtg). |
2015-08-18 |
2023-08-13 |
rat |
| Frank J Meye, Kristina Valentinova, Salvatore Lecca, Lucile Marion-Poll, Matthieu J Maroteaux, Stefano Musardo, Imane Moutkine, Fabrizio Gardoni, Richard L Huganir, François Georges, Manuel Mamel. Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula. Nature neuroscience. vol 18. issue 3. 2015-04-20. PMID:25643299. |
we found that, in mouse lateral habenula (lhb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced k(+) currents and increased excitability. |
2015-04-20 |
2023-08-13 |
mouse |