| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Ki. A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017642. |
these findings suggest that the lh glutamatergic projection to the lhb plays an active role in the modulation of cocaine-induced psychomotor responses. |
2023-11-29 |
2023-12-07 |
Not clear |
| Lei Zhang, Yuan Guo, Jian Liu, Libo Li, Yixuan Wang, Xiang Wu, Yihua Bai, Jing Li, Qiaojun Zhang, Yanping Hu. Transcranial direct current stimulation of the prefrontal cortex improves depression-like behaviors in rats with Parkinson's disease. Brain research. 2023-11-03. PMID:37923003. |
meanwhile, tdcs decreased the expression of c-fos protein (n = 8-11 rats/group) and the excitation of glutamatergic neurons (n = 6-8 rats/group) in the prl and lhb of pd model rats. |
2023-11-03 |
2023-11-08 |
rat |
| Matthew V Green, David A Gallegos, Jane-Valeriane Boua, Luke C Bartelt, Arthy Narayanan, Anne E Wes. Single-Nucleus Transcriptional Profiling of GAD2-Positive Neurons From Mouse Lateral Habenula Reveals Distinct Expression of Neurotransmission- and Depression-Related Genes. Biological psychiatry global open science. vol 3. issue 4. 2023-10-26. PMID:37881543. |
glutamatergic projection neurons of the lateral habenula (lhb) drive behavioral state modulation by regulating the activity of midbrain monoaminergic neurons. |
2023-10-26 |
2023-11-08 |
mouse |
| Jamie C Moffa, India N Bland, Jessica R Tooley, Vani Kalyanaraman, Monique Heitmeier, Meaghan C Creed, Bryan A Copit. Cell specific single viral vector CRISPR/Cas9 editing and genetically encoded tool delivery in the central and peripheral nervous systems. bioRxiv : the preprint server for biology. 2023-10-24. PMID:37873336. |
we tested these tools in multiple brain regions and cell types, including gabaergic neurons in the nucleus accumbens (nac), glutamatergic neurons projecting from the ventral pallidum (vp) to the lateral habenula (lhb), dopaminergic neurons in the ventral tegmental area (vta), and parvalbumin (pv)-positive proprioceptive neurons in the periphery. |
2023-10-24 |
2023-11-08 |
mouse |
| Chun-Kui Zhang, Pan Wang, Yuan-Yuan Ji, Jian-Shuai Zhao, Jun-Xiang Gu, Xian-Xia Yan, Hong-Wei Fan, Ming-Ming Zhang, Yu Qiao, Xiao-Die Liu, Bao-Juan Li, Ming-Hui Wang, Hai-Long Dong, Hao-Hong Li, Peng-Cheng Huang, Yun-Qing Li, Wu-Gang Hou, Jin-Lian Li, Tao Che. Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain. Science China. Life sciences. 2023-10-20. PMID:37864083. |
we determined that the spike discharges of the ventral tegmental area (vta)-projecting lateral habenula (lhb) glutamatergic (glu) neurons were sequentially increased in sham, resilient and susceptible mice, which consequently inhibited vta dopaminergic (da) neurons through a lhb |
2023-10-20 |
2023-11-08 |
mouse |
| Suchan Chang, Hyung Kyu Kim, Yeonhee Ryu, Han Byeol Jang, DanBi Ahn, Bong Hyo Lee, Dong-Ho Youn, Bae Hwan Lee, Hee Young Ki. Mediation of mPFC-LHb pathway in acupuncture inhibition of cocaine psychomotor activity. Addiction biology. vol 28. issue 10. 2023-09-27. PMID:37753567. |
optopatch experiment proved glutamatergic projections from mpfc to lhb. |
2023-09-27 |
2023-10-07 |
rat |
| Xingyun Xu, Hang Zhou, Hainan Wu, Zhigang Miao, Bo Wan, Haigang Ren, Wei Ge, Guanghui Wang, Xingshun X. Tet2 acts in the lateral habenula to regulate social preference in mice. Cell reports. vol 42. issue 7. 2023-07-04. PMID:37402169. |
further, tet2 knockdown in the glutamatergic neurons of lhb causes impaired social behaviors, but the inhibition of glutamatergic excitability restores social preference. |
2023-07-04 |
2023-08-14 |
mouse |
| Saida Oubraim, Roh-Yu Shen, Samir Haj-Dahman. Oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses. iScience. vol 26. issue 5. 2023-05-30. PMID:37250336. |
neuronal mapping demonstrates that oxt preferentially potentiates glutamate synapses of 5-ht neurons projecting to medial prefrontal cortex (mpfc) and depresses glutamatergic inputs to 5-ht neurons projecting to lateral habenula (lhb) and central amygdala (cea). |
2023-05-30 |
2023-08-14 |
Not clear |
| Han-Wen Gu, Guang-Fen Zhang, Pan-Miao Liu, Wei-Tong Pan, Yuan-Xiang Tao, Zhi-Qiang Zhou, Jian-Jun Yan. Contribution of activating lateral hypothalamus-lateral habenula circuit to nerve trauma-induced neuropathic pain in mice. Neurobiology of disease. 2023-05-14. PMID:37182721. |
here, we report that a projection from the lateral hypothalamus (lh) glutamatergic neurons to the lateral habenula (lhb), an excitatory lh-lhb neuronal circuit, participates in nerve injury-induced nociceptive hypersensitivity. |
2023-05-14 |
2023-08-14 |
mouse |
| Sukanya G Gakare, Rajesh R Ugal. Pharmacological evaluation of lateral habenula and rostromedial tegmental nucleus in the expression of ethanol-induced place preference. Behavioural pharmacology. vol 34. issue 4. 2023-05-12. PMID:37171461. |
we found that activation of lhb glutamatergic system by intra-lhb administration of l-trans-2,4-pyrrolidine dicarboxylate (pdc) (glutamate transporter inhibitor) significantly decreased cpp score; on the contrary, lamotrigine (inhibits glutamate release) significantly increased cpp score and showed a rewarding effect in cpp. |
2023-05-12 |
2023-08-14 |
Not clear |
| Mobina Alemi, Ana Raquel Pereira, Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cru. Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979799. |
signaling in the lhb-vta pathway can be exacerbated during pain conditions by a hyperactivity of lhb glutamatergic neurons to inhibit local vta daergic cells. |
2023-03-29 |
2023-08-14 |
rat |
| Wen-Wen Zhang, Teng Chen, Shi-Yi Li, Xin-Yue Wang, Wen-Bo Liu, Yu-Quan Wang, Wen-Li Mi, Qi-Liang Mao-Ying, Yan-Qing Wang, Yu-Xia Ch. Tachykinin receptor 3 in the lateral habenula alleviates pain and anxiety comorbidity in mice. Frontiers in immunology. vol 14. 2023-02-09. PMID:36756128. |
chemicogenetic activation of bilateral lhb glutamatergic neurons in naive mice induced orofacial allodynia and anxiety-like behaviors, and pharmacological activation of nk3r in the lhb attenuated allodynia and anxiety-like behaviors induced by pt-ion. |
2023-02-09 |
2023-08-14 |
mouse |
| Matthew V Green, David A Gallegos, Jane-Valeriane Boua, Luke C Bartelt, Arthy Narayanan, Anne E Wes. Single-nucleus transcriptional profiling of GAD2-positive neurons from mouse lateral habenula reveals distinct expression of neurotransmission- and depression-related genes. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711842. |
glutamatergic projection neurons of the lateral habenula (lhb) drive behavioral state modulation by regulating the activity of midbrain monoaminergic neurons. |
2023-01-30 |
2023-08-14 |
mouse |
| Matthew V Green, David A Gallegos, Jane-Valeriane Boua, Luke C Bartelt, Arthy Narayanan, Anne E Wes. Single-nucleus transcriptional profiling of GAD2-positive neurons from mouse lateral habenula reveals distinct expression of neurotransmission- and depression-related genes. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711842. |
our data confirm that gad2+/vglut2+ neurons intrinsic to the lhb co-express markers of both glutamatergic and gabaergic transmission and that they are transcriptionally distinct from either gabaergic interneurons or habenular glutamatergic neurons. |
2023-01-30 |
2023-08-14 |
mouse |
| Lucas Lecourtier, Laura Durieux, Victor Mathi. Alteration of LHb function prevents the proper exploration of a novel environment. Neuroscience. 2023-01-30. PMID:36716915. |
in the present study, we used two pharmacological approaches altering lhb activity, intra-lhb infusion of either the gaba-a receptor agonist, muscimol, or the glutamatergic ampa receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx) and exposed rats to three consecutive open field (of) sessions. |
2023-01-30 |
2023-08-14 |
rat |
| Fang Wang, Juen Zhang, Yuan Yuan, Ming Chen, Zilong Gao, Shulu Zhan, Chengyu Fan, Wenzhi Sun, Ji H. Salience processing by glutamatergic neurons in the ventral pallidum. Science bulletin. vol 65. issue 5. 2023-01-20. PMID:36659230. |
besides, vp glutamatergic neurons project to both the lateral habenula (lhb) and the ventral tegmental area (vta). |
2023-01-20 |
2023-08-14 |
Not clear |
| Jessica L Swanson, Joshua Ortiz-Guzman, Snigdha Srivastava, Pey-Shyuan Chin, Sean W Dooling, Elizabeth Hanson Moss, Mikhail Y Kochukov, Patrick J Hunt, Jay M Patel, Brandon T Pekarek, Qingchun Tong, Benjamin R Arenkie. Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior. Scientific reports. vol 12. issue 1. 2022-12-21. PMID:36543829. |
using viral-mediated circuit mapping, we identified a population of glutamatergic neurons within the bf that project to the lhb, which responds to diverse sensory cues, including aversive and food-related odors. |
2022-12-21 |
2023-08-14 |
Not clear |
| Jack F Webster, Sanne Beerens, Christian Wozn. Effects of early life stress and subsequent re-exposure to stress on neuronal activity in the lateral habenula. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-11-13. PMID:36371544. |
however, while we find the lhb to be less active at rest, we report that the neurons reside in a sensitised state where they are more responsive to re-exposure to stress in adulthood in the form of acute restraint, thus priming them to respond to aversive events with an increase in neuronal activity mediated by changes in glutamatergic transmission. |
2022-11-13 |
2023-08-14 |
mouse |
| William J Flerlage, Ludovic D Langlois, Milan Rusnak, Sarah C Simmons, Shawn Gouty, Regina C Armstrong, Brian M Cox, Aviva Symes, Mumeko C Tsuda, Fereshteh Nugen. Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury-Induced Motivational Deficits. Journal of neurotrauma. 2022-08-16. PMID:35972745. |
additionally, mtbi diminished spontaneous glutamatergic and gabaergic synaptic activity onto lhb neurons, while synaptic excitation and inhibition (e/i) balance was shifted toward excitation through a greater suppression of gabaergic transmission. |
2022-08-16 |
2023-08-14 |
Not clear |
| William J Flerlage, Ludovic D Langlois, Milan Rusnak, Sarah C Simmons, Shawn Gouty, Regina C Armstrong, Brian M Cox, Aviva Symes, Mumeko C Tsuda, Fereshteh Nugen. Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury-Induced Motivational Deficits. Journal of neurotrauma. 2022-08-16. PMID:35972745. |
we found that chemogenetic inhibition of lhb glutamatergic neurons was sufficient to reverse mtbi-induced delays in grooming behavior. |
2022-08-16 |
2023-08-14 |
Not clear |