| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William J Flerlage, Sarah C Simmons, Emily H Thomas, Shawn Gouty, Brian M Cox, Fereshteh S Nugen. Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury. Pharmacology, biochemistry, and behavior. 2024-07-27. PMID:39067532. |
following mtbi, while responses to kor activation at lhb glutamatergic synapses remained intact, lhb gabaergic synapses acquired an additional sensitivity to kor-mediated inhibition where we observed a reduction in gaba release probability in response to kor stimulation in lhb neurons of mtbi mice. |
2024-07-27 |
2024-08-02 |
mouse |
| William J Flerlage, Sarah C Simmons, Emily H Thomas, Shawn Gouty, Brian M Cox, Fereshteh S Nugen. Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury. Pharmacology, biochemistry, and behavior. 2024-07-27. PMID:39067532. |
kor activation generally suppressed spontaneous glutamatergic transmission without altering gabaergic transmission, resulting in a significant but sex-similar reduction in net spontaneous e/i and synaptic drive ratios in lhb neurons of sham mice. |
2024-07-27 |
2024-08-02 |
mouse |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
to achieve this, we investigated the proportions of the transmitter machinery in lhb pv neurons, including gabaergic, glutamatergic, serotonergic, cholinergic, and dopaminergic neurotransmitter markers, using transcriptome analysis, mrna in situ hybridization chain reaction, and immunohistochemistry. |
2024-07-03 |
2024-07-10 |
mouse |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
lhb pv neurons comprise three subsets: glutamatergic, gabaergic, and double-positive for glutamatergic and gabaergic machinery. |
2024-07-03 |
2024-07-10 |
mouse |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
by comparing the percentages of the subsets, we found that the lhb was topographically organized anteroposteriorly; the gabaergic and glutamatergic pv neurons were preferentially distributed in the anterior and posterior lhb, respectively, uncovering the anteroposterior topography of the lhb. |
2024-07-03 |
2024-07-10 |
mouse |
| Hiroyuki Ichijo, Nguyen Thi Van Trang, Tomoya Nakamur. Topographic Organization of Glutamatergic and GABAergic Parvalbumin Positive Neurons in the Lateral Habenula. eNeuro. 2024-07-03. PMID:38960707. |
it would be interesting to determine whether their topography is differentially involved in various cognitive and motivational processes associated with the lhb, particularly the involvement of posterior glutamatergic pv neurons. |
2024-07-03 |
2024-07-10 |
mouse |
| Zehui Zhang, Wei Zhang, Yuanyuan Fang, Na Wang, Guoying Liu, Nan Zou, Zhenbo Song, Hanshu Liu, Longshuo Wang, Qin Xiao, Juanjuan Zhao, Yaling Wang, Ting Lei, Cai Zhang, Xiaofeng Liu, Beilin Zhang, Fenlan Luo, Jianxia Xia, Chao He, Zhian Hu, Shuancheng Ren, Hua Zha. A potentiation of REM sleep-active neurons in the lateral habenula may be responsible for the sleep disturbance in depression. Current biology : CB. 2024-06-29. PMID:38944036. |
here, we found that functional manipulations of lhb glutamatergic neurons bidirectionally modulated both non-rem (nrem) sleep and rem sleep. |
2024-06-29 |
2024-07-02 |
mouse |
| Jun Wang, Qian Yang, Xue Liu, Jie Li, Ya-Lan Wen, Yuzheng Hu, Tian-Le Xu, Shumin Duan, Han X. The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation. Nature communications. vol 15. issue 1. 2024-05-13. PMID:38740778. |
at the circuit level, bf glutamatergic neurons make functional contacts with the lateral habenula (lhb) neurons and these connections are potentiated in conditioned mice. |
2024-05-13 |
2024-05-27 |
mouse |
| Jun Wang, Qian Yang, Xue Liu, Jie Li, Ya-Lan Wen, Yuzheng Hu, Tian-Le Xu, Shumin Duan, Han X. The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation. Nature communications. vol 15. issue 1. 2024-05-13. PMID:38740778. |
these data unravel an important function of the bf in fear expression via its glutamatergic projection onto the lhb, and suggest that selective targeting bf-lhb excitatory circuitry could alleviate maladaptive fear in relevant disorders. |
2024-05-13 |
2024-05-27 |
mouse |
| Hongren Huang, Xue Liu, Liping Wang, Feng Wan. Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes. Biology of sex differences. vol 15. issue 1. 2024-04-23. PMID:38654275. |
the cells in the lhb are predominantly glutamatergic and have heterogeneous functions in response to different stimuli. |
2024-04-23 |
2024-04-26 |
mouse |
| Hongren Huang, Xue Liu, Liping Wang, Feng Wan. Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes. Biology of sex differences. vol 15. issue 1. 2024-04-23. PMID:38654275. |
the circuitry connections of the lhb glutamatergic neurons play a crucial role in integrating a wide range of events. |
2024-04-23 |
2024-04-26 |
mouse |
| Hongren Huang, Xue Liu, Liping Wang, Feng Wan. Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes. Biology of sex differences. vol 15. issue 1. 2024-04-23. PMID:38654275. |
however, the circuitry connections of lhb glutamatergic neurons in both sexes have not been thoroughly investigated. |
2024-04-23 |
2024-04-26 |
mouse |
| Kang Zhou, Lin-Chen Zhang, He Zhu, Bei Wen, Jia-Li Tang, Ping-Chuan Yuan, A-Fang Zhu, Yu-Guang Huan. A Common Neuronal Ensemble in the Lateral Habenula Regulates Ciprofol Anesthesia in Mice. Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543149. |
recent studies have revealed that the glutamatergic neurons of the lateral habenula (lhb) play a crucial role in modulating the loc induced by propofol and sevoflurane. |
2024-03-28 |
2024-03-30 |
mouse |
| Sarah C Simmons, William J Flerlage, Ludovic D Langlois, Ryan D Shepard, Christopher Bouslog, Emily H Thomas, Kaitlyn M Gouty, Jennifer L Sanderson, Shawn Gouty, Brian M Cox, Mark L Dell'Acqua, Fereshteh S Nugen. AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula. Communications biology. vol 7. issue 1. 2024-03-21. PMID:38509283. |
using whole cell patch clamp recordings in lhb of male wildtype and Δpka knockin mice (with deficiency in akap-anchoring of pka), here we show that the genetic disruption of pka anchoring to akap150 significantly reduces ampa receptor-mediated glutamatergic transmission and prevents the induction of presynaptic endocannabinoid-mediated long-term depression in lhb neurons. |
2024-03-21 |
2024-03-23 |
mouse |
| Xiaowei Chen, Xiaofeng Liu, Shuxin Luan, Xuxin Wang, Ying Zhang, Yulei Hao, Qiang Zhang, Jiaming Zhang, Hua Zha. Optogenetic activation of the lateral habenula European archives of psychiatry and clinical neuroscience. 2024-01-18. PMID:38236282. |
optogenetic activation of the lateral habenula a number of different receptors are distributed in glutamatergic neurons of the lateral habenula (lhb). |
2024-01-18 |
2024-01-20 |
Not clear |
| Xiaowei Chen, Xiaofeng Liu, Shuxin Luan, Xuxin Wang, Ying Zhang, Yulei Hao, Qiang Zhang, Jiaming Zhang, Hua Zha. Optogenetic activation of the lateral habenula European archives of psychiatry and clinical neuroscience. 2024-01-18. PMID:38236282. |
these glutamatergic neurons are involved in different neural pathways, which may identify how the lhb regulates various physiological functions. |
2024-01-18 |
2024-01-20 |
Not clear |
| S C Simmons, W J Flerlage, L D Langlois, R D Shepard, C Bouslog, E H Thomas, K M Gouty, J L Sanderson, S Gouty, B M Cox, M L Dell'Acqua, F S Nugen. AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenula. bioRxiv : the preprint server for biology. 2023-12-18. PMID:38106086. |
using whole cell patch clamp recordings in lhb of male wildtype (wt) and Δpka knockin mice (with deficiency in akap-anchoring of pka), we found that the genetic disruption of pka anchoring to akap150 significantly reduced ampa receptor (ampar)-mediated glutamatergic transmission and prevented the induction of presynaptic endocannabinoid (ecb)-mediated long-term depression (ltd) in lhb neurons. |
2023-12-18 |
2023-12-21 |
mouse |
| Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Ki. A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017642. |
in vivo extracellular recording found that the lh sent a glutamatergic projection to the lhb. |
2023-11-30 |
2023-12-07 |
Not clear |
| Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Ki. A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017642. |
these findings suggest that the lh glutamatergic projection to the lhb plays an active role in the modulation of cocaine-induced psychomotor responses. |
2023-11-30 |
2023-12-07 |
Not clear |
| Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Ki. A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017642. |
in vivo extracellular recording found that the lh sent a glutamatergic projection to the lhb. |
2023-11-29 |
2023-12-07 |
Not clear |