| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoqiang Lv, Hui Deng, Cunzhi Li, Wenzhi Gao, Yuhao Zhang, Yongchao Gao, Bin Zhao, Changhong Shi, Junhong Gao, Zhiyong Li. Pad2 Deletion Induces Anxiety‑like Behaviors and Memory Deficits in Mice. Brain research bulletin. 2025-04-04. PMID:40185419. |
furthermore, western blot analysis, immunohistochemistry and proteomics revealed alterations in synaptic-related proteins and dendritic spines in hippocampus of pad2 ko animals. |
2025-04-04 |
2025-04-08 |
mouse |
| Elisa Corti, Carlos B Duart. FMRP Controls Neuronal Architecture and Synaptic Content of NMDA Receptors in Cultured Hippocampal Neurons. Journal of molecular neuroscience : MN. vol 75. issue 2. 2025-04-02. PMID:40172581. |
in this work, we investigated the functional consequences of the absence of fmrp on neuronal morphology and on ionotropic glutamate receptor surface distribution, using primary cultures of mice hippocampal neurons isolated from wild-type (wt) and fmr1 knock-out (ko) pups. |
2025-04-02 |
2025-04-04 |
mouse |
| Elisa Corti, Carlos B Duart. FMRP Controls Neuronal Architecture and Synaptic Content of NMDA Receptors in Cultured Hippocampal Neurons. Journal of molecular neuroscience : MN. vol 75. issue 2. 2025-04-02. PMID:40172581. |
these data support the hypothesis that at the cellular level, fmr1 ko hippocampal neurons are less excitable due to altered input processing, driven by structural defects and altered glun2a expression in the synaptic plasma membrane. |
2025-04-02 |
2025-04-04 |
mouse |
| Patrycja Wardaszka-Pianka, Bozena Kuzniewska, Natalia Guminska, Anna Hojka-Osinska, Monika Puchalska, Jacek Milek, Aleksandra Stawikowska, Pawel Krawczyk, Francois Philippe Pauzin, Tomasz Wojtowicz, Kasia Radwanska, Clive Raymond Bramham, Andrzej Dziembowski, Magdalena Dziembowsk. Terminal nucleotidyltransferase Tent2 microRNA A-tailing enzyme regulates excitatory/inhibitory balance in the hippocampus. RNA (New York, N.Y.). 2025-03-18. PMID:40101932. |
electrophysiological measurements revealed increased excitability in tent2 ko hippocampal neurons, and behavioral analyses showed decreased anxiety and improved fear extinction in these mice. |
2025-03-18 |
2025-03-21 |
mouse |
| Patrycja Wardaszka-Pianka, Bozena Kuzniewska, Natalia Guminska, Anna Hojka-Osinska, Monika Puchalska, Jacek Milek, Aleksandra Stawikowska, Pawel Krawczyk, Francois Philippe Pauzin, Tomasz Wojtowicz, Kasia Radwanska, Clive Raymond Bramham, Andrzej Dziembowski, Magdalena Dziembowsk. Terminal nucleotidyltransferase Tent2 microRNA A-tailing enzyme regulates excitatory/inhibitory balance in the hippocampus. RNA (New York, N.Y.). 2025-03-18. PMID:40101932. |
at the molecular level, we observed changes in mirnas monoadenylation in tent2 ko mouse hippocampus, but found no effect of the tent2 loss on the mrnas total poly(a) tail length, as measured by direct nanopore rna sequencing. |
2025-03-18 |
2025-03-21 |
mouse |
| Anne-Sophie Sack, Esperanza Garcia, Terrance P Snutc. Maturational Stage Dependent Contributions of the Cav3.2 T-type Calcium Channel to Dentate Gyrus Granule Cell Excitability. eNeuro. 2025-03-11. PMID:40068874. |
cav3.2 channels are highly expressed in the dentate gyrus (dg) of the hippocampus, and mice lacking cav3.2 (ko) exhibit impairments in hippocampal dependent learning and memory tasks, as well as attenuated development of pilocarpine induced epilepsy. |
2025-03-11 |
2025-03-14 |
mouse |
| Jinyi Yao, Keying Li, Zhenli Fu, Jingjing Zheng, Zicong Chen, Jiahao Xu, Guoqing Lai, Yaomin Huang, Jinsheng Huang, Guanying You, Shuangxue Han, Zhijun He, Qiong Liu, Nan L. Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions. The Journal of biological chemistry. 2025-03-07. PMID:40054691. |
of note, with respect to c57 and tau ko mice, the membrane-association of oxidative phosphorylation related proteins were impeded by human tau in the hippocampus. |
2025-03-07 |
2025-03-12 |
mouse |
| Kin Pong U, Lin Gao, Huan Zhang, Zeyuan Ji, Jiacheng Lin, Shenyi Peng, Xiaohu Zhang, Shaolong Xue, Weifeng Qin, Lai Ling Tsang, Yonglun Kong, Yin Xia, Patrick Ming-Kuen Tang, Tao Wang, Wayne Yuk Wai Lee, Gang Li, Xiaohua Jian. KDM3A controls postnatal hippocampal neurogenesis via dual regulation of the Wnt/β-catenin signaling pathway. Cell death and differentiation. 2025-03-03. PMID:40033066. |
however, these effects are diminished in kdm3a ko mice, indicating that quercetin primarily promotes hippocampal neurogenesis through the regulation of kdm3a. |
2025-03-03 |
2025-03-06 |
mouse |
| Bernat González I Llinares, Lydia Danglot, Thierry Galli, Christophe Mull. Properties of Hippocampal Mossy Fibre Synapses in VAMP7 KO Mice. The European journal of neuroscience. vol 61. issue 4. 2025-02-24. PMID:39988820. |
properties of hippocampal mossy fibre synapses in vamp7 ko mice. |
2025-02-24 |
2025-02-26 |
mouse |
| Hee Jeong Kim, Kina Lee, Kiseo Yoo, Jeong Eun Kim, Heeju Kim, Chae-Seok Lim, Young Seok Park, Hyong Kyu Ki. Critical Role of Rho Guanine Nucleotide Exchange Factor 4 in Brain Function. Molecular neurobiology. 2025-02-07. PMID:39920439. |
however, in cultured hippocampal neurons from ko mice, the levels of postsynaptic density protein 95 (psd-95) in the postsynaptic regions were significantly increased from the pre-mature stage to the fully mature stage during neuronal development. |
2025-02-07 |
2025-02-10 |
mouse |
| Hee Jeong Kim, Kina Lee, Kiseo Yoo, Jeong Eun Kim, Heeju Kim, Chae-Seok Lim, Young Seok Park, Hyong Kyu Ki. Critical Role of Rho Guanine Nucleotide Exchange Factor 4 in Brain Function. Molecular neurobiology. 2025-02-07. PMID:39920439. |
electrophysiological recordings of hippocampal neurons from ko mice showed a significant increase in miniature excitatory postsynaptic currents (mepsc) frequency. |
2025-02-07 |
2025-02-10 |
mouse |
| Maria Kuznetsova, Carey Wilson, Lesley Cheng, Terence Pang, Shanshan Li, Blaine Roberts, Larissa C Lago, Harvey Tran, Andrew F Hill, Anthony J Hannan, Thibault Renoi. Serotonergic-dependent effects of exercise and elevated stress hormone on small non-coding RNA transcriptomics and proteomics in a mouse model of affective disorders. Neuropharmacology. 2024-11-29. PMID:39613253. |
using the serotonin transporter (5-htt) knockout (ko) mouse model of depression/anxiety, this study aimed to compare the effects of voluntary exercise (ex) versus chronic treatment with the stress hormone (ct), corticosterone, on hippocampal mirna transcriptome and proteome in five comparison groups: wt-sh vs. ko-sh; wt-sh vs. wt-ex; ko-sh vs. ko-ex; wt-sh vs. wt-ct; ko-sh vs. ko-ct. we hypothesized that treatment with stress hormone will result in mirna and proteomics changes observed in genetic model of depression, while exercise will have beneficial effects similar to antidepressant treatment. |
2024-11-29 |
2024-12-02 |
mouse |
| Hong-Beom Park, Hyeyoon Kim, Dohyun Ha. In-Depth Proteome Profiling of the Hippocampus of LDLR Knockout Mice Reveals Alternation in Synaptic Signaling Pathway. Proteomics. 2024-11-16. PMID:39548955. |
in this study, we conducted first-time proteomic profiling of hippocampus tissue from ldlr ko mice using tandem mass tag (tmt)-based ms analysis. |
2024-11-16 |
2024-11-20 |
mouse |
| John M Andraka, Naveen Sharma, Yannick Marchalan. New Insights on the Effects of Krill Oil Supplementation, a High-Fat Diet, and Aging on Hippocampal-Dependent Memory, Neuroinflammation, Synaptic Density, and Neurogenesis. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519107. |
we thus hypothesized that dietary ko supplementation could counteract the effects of cognitive aging and an hfd on spatial learning, neuroinflammation, neurogenesis, and synaptic density in the cortex and hippocampus of aged rats. |
2024-11-09 |
2024-11-17 |
rat |
| John M Andraka, Naveen Sharma, Yannick Marchalan. New Insights on the Effects of Krill Oil Supplementation, a High-Fat Diet, and Aging on Hippocampal-Dependent Memory, Neuroinflammation, Synaptic Density, and Neurogenesis. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519107. |
our results demonstrate that the dietary ko dose provided in the current study does not benefit hippocampal or cortical functions in an aging model. |
2024-11-09 |
2024-11-17 |
rat |
| Daniel S Scott, Muthumeenakshi Subramanian, Jun Yamamoto, Carol A Tamming. Schizophrenia pathology reverse-translated into mouse shows hippocampal hyperactivity, psychosis behaviors and hyper-synchronous events. Molecular psychiatry. 2024-10-15. PMID:39407000. |
we had previously studied a dentate gyrus (dg)-specific glun1 ko, which displays hippocampal hyperactivity and a psychosis-relevant behavioral phenotype. |
2024-10-15 |
2024-10-18 |
mouse |
| Matthew Napier, Ashish Kumar, Natasha Szulist, Dale Martin, Angela L Scot. P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus. Hippocampus. 2024-09-13. PMID:39269925. |
using the fmr1 ko mouse model of fxs, much work has been done to understand fxs hippocampus dysfunction. |
2024-09-13 |
2024-09-16 |
mouse |
| Matthew Napier, Ashish Kumar, Natasha Szulist, Dale Martin, Angela L Scot. P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus. Hippocampus. 2024-09-13. PMID:39269925. |
purinergic signaling, where atp and its metabolites are used as signaling molecules, participates in hippocampus development, but it is unknown if purinergic signaling is affected in the developing fmr1 ko hippocampus. |
2024-09-13 |
2024-09-16 |
mouse |
| Matthew Napier, Ashish Kumar, Natasha Szulist, Dale Martin, Angela L Scot. P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus. Hippocampus. 2024-09-13. PMID:39269925. |
we first found that p2x7 was reduced in fmr1 ko whole hippocampus tissue at p14 and p21, corresponding to the periods of neurite outgrowth and synaptic refinement in the hippocampus. |
2024-09-13 |
2024-09-16 |
mouse |
| Matthew Napier, Ashish Kumar, Natasha Szulist, Dale Martin, Angela L Scot. P2X7 expression patterns in the developing Fmr1-knockout mouse hippocampus. Hippocampus. 2024-09-13. PMID:39269925. |
we then evaluated the cell-specific expression of p2x7 with immunofluorescence and found differences between wt and fmr1 ko mice in p2x7 colocalization with hippocampal microglia and neurons. |
2024-09-13 |
2024-09-16 |
mouse |