All Relations between ko and hippocampus

Publication Sentence Publish Date Extraction Date Species
Bohan Zhang, Jingbao Zhang, Huan Chen, Dan Qiao, Fangzhen Guo, Xiangting Hu, Chao Qin, Xiaowen Jin, Kaixi Zhang, Chang Wang, Huixian Cui, Sha L. Role of FMRP in AKT/mTOR pathway-mediated hippocampal autophagy in fragile X syndrome. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-06-08. PMID:38823765. to explore the mechanism by which fmrp deficiency inhibits autophagy, we examined the akt/mtor signaling pathway in the hippocampus of fmr1 ko mice, found that fmrp deficiency caused overactivation of the akt/mtor pathway. 2024-06-08 2024-06-11 mouse
Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mab. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. The Journal of biological chemistry. 2024-03-29. PMID:38552740. importantly, arc protein was upregulated in the hippocampus of tau knockout (tau ko) mice and dendrites of tau ko primary hippocampal neurons. 2024-03-29 2024-04-01 mouse
George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. therefore, we employed a multi-level approach to study the behavioral profile and the glutamatergic and gabaergic neurotransmission status in pathophysiology-associated brain structures of fmr1 ko rats, including the recordings of evoked and spontaneous field potentials from hippocampal slices, paralleled with next-generation rna sequencing (rna-seq). 2024-02-20 2024-02-23 mouse
George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. these results are coupled to affected excitability and local inhibitory processes in the hippocampus, along with a specific transcriptional profile, highlighting dysregulated hippocampal network activity in ko rats. 2024-02-20 2024-02-23 mouse
Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. septotemporal variation of information processing in the hippocampus of fmr1 ko rat. 2024-02-18 2024-02-21 rat
Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. method we used a fmr1 knock-out (ko) rat model of fxs and recordings of evoked field potentials from the ca1 field of transverse slices from both the dorsal and the ventral hippocampus of adult rats. 2024-02-18 2024-02-21 rat
Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. results following application of a frequency stimulation protocol consisting of a ten-pulse train and recordings of fepsp, we found that the dorsal but not ventral ko hippocampus shows altered short-term synaptic plasticity. 2024-02-18 2024-02-21 rat
Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. furthermore, applying the frequency stimulation protocol and recordings of population spikes, both segments of the ko hippocampus display altered short-term neuronal dynamics. 2024-02-18 2024-02-21 rat
Sultan Aljuraysi, Mark Platt, Michela Pulix, Harish Poptani, Antonius Plagg. Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in Trappc9 KO mice. Neurobiology of disease. 2024-02-08. PMID:38331351. microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in trappc9 ko mice. 2024-02-08 2024-02-11 mouse
Mario O Caracci, Héctor Pizarro, Carlos Alarcón-Godoy, Luz M Fuentealba, Pamela Farfán, Raffaella De Pace, Natacha Santibañez, Viviana A Cavieres, Tammy P Pástor, Juan S Bonifacino, Gonzalo A Mardones, María-Paz Marzol. The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia. Progress in neurobiology. 2024-01-28. PMID:38281682. ap4e1- knock-out (ko) hela cells and hippocampal neurons from ap4e1-ko mice display increased co-localization of apoer2 with golgi markers. 2024-01-28 2024-01-31 mouse
Mario O Caracci, Héctor Pizarro, Carlos Alarcón-Godoy, Luz M Fuentealba, Pamela Farfán, Raffaella De Pace, Natacha Santibañez, Viviana A Cavieres, Tammy P Pástor, Juan S Bonifacino, Gonzalo A Mardones, María-Paz Marzol. The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia. Progress in neurobiology. 2024-01-28. PMID:38281682. finally, analyses of reelin signaling in mouse hippocampal and human cortical ko neurons show that ap4 deficiency causes no changes in reelin-dependent activation of the akt pathway and only mild changes in reelin-induced dendritic arborization, but reduces reelin-induced erk phosphorylation, creb activation, and golgi deployment. 2024-01-28 2024-01-31 mouse
Heleen M Van't Spijker, Joel D Richte. FMRP regulation of aggrecan mRNA translation controls perineuronal net development. Journal of neurochemistry. 2024-01-15. PMID:38225196. examination of pnns by wfa staining at p14 and p42 in the hippocampus, somatosensory cortex, and retrosplenial cortex shows that they were reduced in these brain regions at p14 but mostly less so at p42 in fmr1 ko mice. 2024-01-15 2024-01-18 mouse
Kara Snyder, C Edward Dixon, Jeremy Henchir, Kiersten Gorse, Vincent A Vagni, Keri Janesko-Feldman, Patrick M Kochanek, Travis C Jackso. Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice. Experimental neurology. 2024-01-13. PMID:38218585. immunoprecipitation and western blot confirmed protein expression of a novel ~170 kda rims2 variant in the cerebellum, and in the hippocampus, it was significantly increased in ko vs wt (p < 0.0001), and in a sex-dependent manner (p = 0.0390). 2024-01-13 2024-01-16 mouse
Nicola Forte, Alessandro Nicois, Brenda Marfella, Isabella Mavaro, Livia D'Angelo, Fabiana Piscitelli, Anna Scandurra, Paolo De Girolamo, Pietro Baldelli, Fabio Benfenati, Vincenzo Di Marzo, Luigia Cristin. Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-12. PMID:38214769. however, the involvement of the endocannabinoid system, known to regulate seizure development and propagation, in the modulation of the excitatory/inhibitory balance in the epileptic hippocampal network of synii ko mice has not been explored. 2024-01-12 2024-01-14 mouse
Nicola Forte, Alessandro Nicois, Brenda Marfella, Isabella Mavaro, Livia D'Angelo, Fabiana Piscitelli, Anna Scandurra, Paolo De Girolamo, Pietro Baldelli, Fabio Benfenati, Vincenzo Di Marzo, Luigia Cristin. Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-12. PMID:38214769. in this study, we investigated the impact of endocannabinoids on glutamatergic and gabaergic synapses at hippocampal dentate gyrus granule cells in young pre-symptomatic (1-2 months old) and adult symptomatic (5-8 months old) synii ko mice. 2024-01-12 2024-01-14 mouse
Zicheng Ling, Sirui Zhou, Yancheng Zhou, Wanyu Zhong, Zhonghao Su, Zhenxia Qi. Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration. Neuropharmacology. 2024-01-05. PMID:38181970. aside from abnormal accumulation of l-isoasp, pimt knockout (ko) mice mirrors some neuropathological hallmarks such as anxiety-like behaviors, impaired spatial memory and aberrant synaptic plasticity in the hippocampus of neurodegenerative diseases (nds), including alzheimer's disease (ad) and related dementias, and parkinson's disease (pd). 2024-01-05 2024-01-08 mouse
Yun-Chieh Tsai, Sheng-Min Huang, Hsu-Hsia Peng, Shu-Wha Lin, Shu-Rung Lin, Ting-Yu Chin, Shih-Ming Huan. Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice. Neurobiology of aging. vol 135. 2024-01-04. PMID:38176125. additionally, increasing levels of extrasynaptic nmda receptors and phosphorylation of tau were observed in middle-aged crmp1 ko mice, leading to synaptic and neuronal loss in the ca3 regions of hippocampus. 2024-01-04 2024-01-07 mouse
Meng Wang, Tao Wei, Chaoji Yu, Ruiyang Li, Yunsi Yin, Hanchen Yang, Run Di, Xinyi Xia, Qi Qin, Yi Tan. Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer's Disease. Molecular neurobiology. 2023-12-08. PMID:38066402. metabolomic analysis of hippocampal tissue from app/ps1 and app/ps1-trem2 knockout (ko) mice found that trem2 ko was associated with abnormalities in several metabolism pathways, and the effect was particularly pronounced in lipid metabolism and glucose metabolism pathways. 2023-12-08 2023-12-17 mouse
Leonidas J Leontiadis, George Trompoukis, Panagiotis Felemegkas, Giota Tsotsokou, Athina Miliou, Costas Papatheodoropoulo. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Brain sciences. vol 13. issue 11. 2023-11-25. PMID:38002556. using a fmr1 knock-out (ko) rat model of fxs, we found increased neuronal excitability in both the dorsal and ventral ko hippocampus and increased excitatory synaptic transmission in the dorsal hippocampus. 2023-11-25 2023-11-28 rat
Leonidas J Leontiadis, George Trompoukis, Panagiotis Felemegkas, Giota Tsotsokou, Athina Miliou, Costas Papatheodoropoulo. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Brain sciences. vol 13. issue 11. 2023-11-25. PMID:38002556. interestingly, synaptic inhibition is significantly increased in the ventral but not the dorsal ko hippocampus. 2023-11-25 2023-11-28 rat