| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z I Randhawa, R T Jones, L E Lie-Inj. Human hemoglobin Portland II (zeta 2 beta 2). Isolation and characterization of Portland hemoglobin components and their constituent globin chains. The Journal of biological chemistry. vol 259. issue 11. 1984-07-16. PMID:6539334. |
the occurrence of hb portland i and hb portland ii in these hydropic neonates is consistent with the hypothesis that, in the absence of normal alpha chain production, zeta chains are continued to be produced at later states of development than normal and form tetramers with each of the beta-like globin chains. |
1984-07-16 |
2023-08-12 |
human |
| G R Honig, M Shamsuddin, L N Vida, M Mompoint, E Valcourt, L J Bowie, E C Jones, P A Powers, R A Spritz, M Gui. Hemoglobin Evanston (alpha 14 Trp----Arg). An unstable alpha-chain variant expressed as alpha-thalassemia. The Journal of clinical investigation. vol 73. issue 6. 1984-07-13. PMID:6725558. |
these observations suggest that two separate mechanisms are contributing to the alpha-thalassemia-like expression of hb evanston : the newly synthesized alpha ev-chains are unstable and are subject to early proteolytic destruction; and the mutant alpha-allele is linked to an alpha-globin gene deletion. |
1984-07-13 |
2023-08-12 |
human |
| T H Huisman, M G Headlee, J B Wilson, H Lam, S E Johnson, B B Webbe. Hb Wayne, the frameshift variant with extended alpha chains observed in a Caucasian family from Alabama. Hemoglobin. vol 8. issue 1. 1984-06-25. PMID:6327575. |
hb wayne, the frameshift variant with extended alpha chains observed in a caucasian family from alabama. |
1984-06-25 |
2023-08-12 |
Not clear |
| T H Huisman, M G Headlee, J B Wilson, H Lam, S E Johnson, B B Webbe. Hb Wayne, the frameshift variant with extended alpha chains observed in a Caucasian family from Alabama. Hemoglobin. vol 8. issue 1. 1984-06-25. PMID:6327575. |
the data include a hematological evaluation of the four heterozygotes, structural characterization of the variant, the use of hplc for the separation of tryptic and chymotryptic peptides, functional analyses of the isolated variant showing high affinity for oxygen and the (near) absence of a bohr effect, and alpha chain gene organization analyses with restriction endonuclease technology suggesting that the hb wayne heterozygote has a full complement of four alpha globin genes. |
1984-06-25 |
2023-08-12 |
Not clear |
| T Nakatsuji, J B Wilson, T H Huisma. Hb Cordele alpha(2)47 (CE5)Asp----Ala beta 2. A mildly unstable variant observed in black twins. Hemoglobin. vol 8. issue 1. 1984-06-25. PMID:6547117. |
hb cordele alpha(2)47 (ce5)asp----ala beta 2. |
1984-06-25 |
2023-08-12 |
Not clear |
| T Nakatsuji, J B Wilson, T H Huisma. Hb Cordele alpha(2)47 (CE5)Asp----Ala beta 2. A mildly unstable variant observed in black twins. Hemoglobin. vol 8. issue 1. 1984-06-25. PMID:6547117. |
hb cordele, which has an asp----ala substitution at position 47 (ce5) of the alpha chain, was discovered in black twins living in cordele, georgia. |
1984-06-25 |
2023-08-12 |
Not clear |
| T Nakatsuji, J B Wilson, T H Huisma. Hb Cordele alpha(2)47 (CE5)Asp----Ala beta 2. A mildly unstable variant observed in black twins. Hemoglobin. vol 8. issue 1. 1984-06-25. PMID:6547117. |
hb cordele has a normal oxygen affinity, but is mildly unstable at 60 degrees c. some of its properties have been compared with those of hb kokura (alpha 47 asp----gly), hb hasharon (alpha 47 asp----his), and hb arya (alpha 47 asp----asn). |
1984-06-25 |
2023-08-12 |
Not clear |
| J W Bender, M P Reilly, T Asakur. Molecular stability and function of hemoglobins Hasharon (alpha(2)47 (CD5)Asp----His beta 2) and Hasharon (alpha(2)47 (CD5)Asp----His delta 2). Hemoglobin. vol 8. issue 1. 1984-06-25. PMID:6724992. |
the molecular stability and function of hemoglobin (hb) hasharon (alpha 2 h beta 2) and hb hasharon2 (alpha 2 h delta 2) were studied and compared to hbs a, a2 and s. hb hasharon and hb hasharon2 had slightly lower p50 values than hb a and hb a2 but had normal responses to organic phosphates. |
1984-06-25 |
2023-08-12 |
Not clear |
| M D Rhoda, Y Blouquit, J Caburi-Martin, N Monplaisir, F Galacteros, M C Garel, J Ros. Effects of the alpha 20 mutation on the polymerization of Hb S. Biochimica et biophysica acta. vol 786. issue 1-2. 1984-06-18. PMID:6712958. |
effects of the alpha 20 mutation on the polymerization of hb s. the contribution of the alpha 20 residues in intermolecular contacts present in hemoglobin s fibers was investigated with mixtures of hb le lamentin alpha 2(20)his----gln beta 2a and of hemoglobin s alpha 2a beta 2(6)glu----val and with artificial hybrids alpha 2(20)his----gln beta 2(6)glu----val. |
1984-06-18 |
2023-08-12 |
Not clear |
| M D Rhoda, Y Blouquit, J Caburi-Martin, N Monplaisir, F Galacteros, M C Garel, J Ros. Effects of the alpha 20 mutation on the polymerization of Hb S. Biochimica et biophysica acta. vol 786. issue 1-2. 1984-06-18. PMID:6712958. |
this study showed an increased solubility and delay time of polymerization of hb s in solution only when the mutation at the alpha 20 residue is cis to the beta 6 val contact. |
1984-06-18 |
2023-08-12 |
Not clear |
| M D Rhoda, Y Blouquit, J Caburi-Martin, N Monplaisir, F Galacteros, M C Garel, J Ros. Effects of the alpha 20 mutation on the polymerization of Hb S. Biochimica et biophysica acta. vol 786. issue 1-2. 1984-06-18. PMID:6712958. |
this result is in agreement with the crystal model of wishner and love, who showed that one of the two alpha 20 residues of the hb s tetramer was involved in an axial contact between hemoglobin s molecules in the crystals of hb s ( wishner , b.c., ward, k.b., lattman , e.e. |
1984-06-18 |
2023-08-12 |
Not clear |
| T Harano, K Harano, S Shibata, S Ueda, H Mori, M Sek. Hemoglobin Aichi [alpha 50(CE8) His----Arg]: a new slightly unstable hemoglobin variant discovered in Japan. FEBS letters. vol 169. issue 2. 1984-06-13. PMID:6714429. |
a new abnormal hemoglobin, hb aichi [alpha 50(ce8) his----arg], was discovered in a young japanese man. |
1984-06-13 |
2023-08-12 |
Not clear |
| R Galanello, L Maccioni, M C Rosatelli, P Ibba, A M Nurchi, A Ca. A genetic combination of silent beta-thalassaemia, high Hb A2 beta-thalassaemia, and single alpha globin gene deletion causing mild thalassaemia intermedia. Journal of medical genetics. vol 21. issue 2. 1984-06-12. PMID:6716419. |
a genetic combination of silent beta-thalassaemia, high hb a2 beta-thalassaemia, and single alpha globin gene deletion causing mild thalassaemia intermedia. |
1984-06-12 |
2023-08-12 |
Not clear |
| R Galanello, L Maccioni, M C Rosatelli, P Ibba, A M Nurchi, A Ca. A genetic combination of silent beta-thalassaemia, high Hb A2 beta-thalassaemia, and single alpha globin gene deletion causing mild thalassaemia intermedia. Journal of medical genetics. vol 21. issue 2. 1984-06-12. PMID:6716419. |
this paper reports a sardinian patient, who was a compound heterozygote for silent beta-thalassaemia and high hb a2 beta o-thalassaemia with the clinical phenotype of mild thalassaemia intermedia; alpha globin gene mapping showed a single alpha globin gene deletion. |
1984-06-12 |
2023-08-12 |
Not clear |
| M Nagai, Y Yoneyam. Enzymatic reduction of hemoglobins M. Biomedica biochimica acta. vol 42. issue 11-12. 1984-06-06. PMID:6675686. |
these three enzymatic reduction systems did not reduce hbs m with an alpha chain anomaly such as hb m iwate and hb m boston. |
1984-06-06 |
2023-08-12 |
human |
| C S Johnson, W A Schroeder, J B Shelton, J R Shelto. The first example of a deletion in the human alpha chain: hemoglobin Boyle Heights or alpha 2 6 (A4) Asp----to O beta 2. Hemoglobin. vol 7. issue 2. 1984-05-14. PMID:6671902. |
like hb sawara (alpha 6 asp leads to ala), hb boyle heights has increased oxygen affinity. |
1984-05-14 |
2023-08-12 |
human |
| C S Johnson, W A Schroeder, J B Shelton, J R Shelto. The first example of a deletion in the human alpha chain: hemoglobin Boyle Heights or alpha 2 6 (A4) Asp----to O beta 2. Hemoglobin. vol 7. issue 2. 1984-05-14. PMID:6671902. |
it is likely that the bohr effect will be altered because the deletion in hb boyle heights should alter the configuration of val alpha 1 and influence its participation in the bohr effect. |
1984-05-14 |
2023-08-12 |
human |
| T Harano, K Harano, S Shibata, S Ueda, K Imai, A Tsuneshige, E Uchida, K Horiuch. Hb Le Lamentin [alpha 20 (B 1) His----Gln] in Japan: structure, function and biosynthesis. Hemoglobin. vol 7. issue 2. 1984-05-14. PMID:6671903. |
hb le lamentin [alpha 20 (b 1) his----gln] in japan: structure, function and biosynthesis. |
1984-05-14 |
2023-08-12 |
Not clear |
| P Bogoevski, G D Efremov, J Kezic, H Lam, J B Wilson, T H Huisma. Hb Sabine or alpha 2 beta 2 91 (F7) Leu----Pro in a Yugoslavian boy. Hemoglobin. vol 7. issue 2. 1984-05-14. PMID:6671906. |
hb sabine or alpha 2 beta 2 91 (f7) leu----pro in a yugoslavian boy. |
1984-05-14 |
2023-08-12 |
Not clear |
| R J Trent, M G Harris, P J Fleming, K Wyatt, W G Hughes, H Kronenber. Haemoglobin D Punjab. Interaction with alpha thalassaemia and diagnosis by gene mapping. Scandinavian journal of haematology. vol 32. issue 3. 1984-04-25. PMID:6322284. |
a family which illustrates the inheritance of hb d punjab (a beta globin chain variant) and alpha thalassaemia is described. |
1984-04-25 |
2023-08-12 |
Not clear |