| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Miura, C H. Proton nuclear magnetic resonance investigation of cross-linked asymmetrically modified hemoglobins: influence of the salt bridges on tertiary and quaternary structures of hemoglobin. Biochemistry. vol 23. issue 11. 1984-11-02. PMID:6477880. |
proton nuclear magnetic resonance spectra of these asymmetrically modified hemoglobins together with their parent hemoglobins, des-arg(alpha 141) hb a, des-arg(alpha 141)-tyr(alpha 140) hb a, nes-hb a and nes-des-arg(alpha 141) hb a, have been obtained over the spectral region 5-10 ppm downfield from h2o for the exchangeable proton resonances and 50-80 ppm downfield from h2o for the hyperfine-shifted proximal histidyl n delta h exchangeable proton resonances. |
1984-11-02 |
2023-08-12 |
human |
| T Nakatsuji, K Shimizu, T H Huisma. Hb F-La Grange or alpha 2 gamma 2 101(G3)Glu----Lys; 75Ile; 136Gly: a high oxygen affinity fetal hemoglobin variant observed in a Caucasian newborn. Biochimica et biophysica acta. vol 789. issue 2. 1984-11-01. PMID:6206897. |
hb f-la grange or alpha 2 gamma 2 101(g3)glu----lys; 75ile; 136gly: a high oxygen affinity fetal hemoglobin variant observed in a caucasian newborn. |
1984-11-01 |
2023-08-12 |
Not clear |
| S Matsukawa, Y Itatani, K Mawatari, Y Shimokawa, Y Yoneyam. Quantitative evaluation for the role of beta 146 His and beta 143 His residues in the Bohr effect of human hemoglobin in the presence of 0.1 M chloride ion. The Journal of biological chemistry. vol 259. issue 18. 1984-10-25. PMID:6470009. |
the pk alpha values, which were determined by the deuterium exchange method using 1h nmr, were 8.0 for beta 146 his of deoxy-hb a and 6.5 for that of co hb a, while those of beta 143 his were 5.2 for deoxy-hb a and 6.0 for co hb a. |
1984-10-25 |
2023-08-12 |
human |
| S Matsukawa, Y Itatani, K Mawatari, Y Shimokawa, Y Yoneyam. Quantitative evaluation for the role of beta 146 His and beta 143 His residues in the Bohr effect of human hemoglobin in the presence of 0.1 M chloride ion. The Journal of biological chemistry. vol 259. issue 18. 1984-10-25. PMID:6470009. |
the residual acid bohr effect in the more acidic ph region was presumably contributed by an amino acid residue with pk alpha values of 4.05 and 5.95 for the deoxy- and co hb a, respectively, although the amino acid residue was unspecified. |
1984-10-25 |
2023-08-12 |
human |
| K Harano, T Harano, S Shibata, H Mori, S Ueda, K Imai, Y Ohba, K Irimajir. Hb J Oxford [alpha 15 (A13) Gly----Asp] in Japan. Hemoglobin. vol 8. issue 2. 1984-10-03. PMID:6469697. |
hb j oxford [alpha 15 (a13) gly----asp] in japan. |
1984-10-03 |
2023-08-12 |
Not clear |
| G V Sciarratta, G Ivaldi, G L Molaro, G Sansone, M L Salkie, J B Wilson, A L Reese, T H Huisma. The characterization of hemoglobin Manitoba or alpha (2)102(G9)Ser----Arg beta 2 and hemoglobin Contaldo or alpha (2)103(G10)His----Arg beta 2 by high performance liquid chromatography. Hemoglobin. vol 8. issue 2. 1984-10-03. PMID:6547932. |
hb contaldo with a his----arg substitution at position 103(g10) of the alpha chain is a newly discovered unstable hb variant observed in an italian child. |
1984-10-03 |
2023-08-12 |
Not clear |
| G V Sciarratta, G Ivaldi, G L Molaro, G Sansone, M L Salkie, J B Wilson, A L Reese, T H Huisma. The characterization of hemoglobin Manitoba or alpha (2)102(G9)Ser----Arg beta 2 and hemoglobin Contaldo or alpha (2)103(G10)His----Arg beta 2 by high performance liquid chromatography. Hemoglobin. vol 8. issue 2. 1984-10-03. PMID:6547932. |
similar analyses were made for the alpha x chain of the rare hb manitoba in which alpha 102(g9) ser is replaced by arg. |
1984-10-03 |
2023-08-12 |
Not clear |
| N V Blough, B M Hoffma. Carbon monoxide binding to the ferrous chains of [Mn,Fe(II)] hybrid hemoglobins: pH dependence of the chain affinity constants associated with specific hemoglobin ligation pathways. Biochemistry. vol 23. issue 13. 1984-09-26. PMID:6466622. |
in mixed-metal [mn,fe] hybrid hemoglobins (hb), the two chains of a single type, alpha or beta, are substituted with manganese protoporphyrin ix, which does not bind co in either the mn(ii) or mn(iii) valency states. |
1984-09-26 |
2023-08-12 |
Not clear |
| N V Blough, H Zemel, B M Hoffma. Flash photolytic studies of carbon monoxide binding to the ferrous chains of [Mn(II),Fe(II)] hybrid hemoglobins: kinetic mechanism for the early stages of hemoglobin ligation. Biochemistry. vol 23. issue 13. 1984-09-26. PMID:6466623. |
at low ph (6.6), hb remains predominantly in the t quaternary state for the first two co ligation steps, when binding to either the alpha chains or beta chains. |
1984-09-26 |
2023-08-12 |
Not clear |
| F Galacteros, J D Garin, N Monplaisir, S Namoune, N Arous, Y Blouquit, A Mamalaki, M Tulliez, M Ouka, M Goossen. Two new cases of heterozygosity for hemoglobin Knossos alpha 2 beta 2 27 Ala----Ser detected in the French West Indies and Algeria. Hemoglobin. vol 8. issue 3. 1984-09-24. PMID:6469698. |
hb knossos alpha 2 beta 2 27 ala----ser was first described in a greek family as a silent beta(+) thalassemia variant. |
1984-09-24 |
2023-08-12 |
Not clear |
| J B Wilson, R N Wrightstone, T H Huisma. Hb Oleander, alpha 116(GH4)GLU----GLN, found in a Black female in Georgia. Hemoglobin. vol 8. issue 3. 1984-09-24. PMID:6469700. |
hb oleander, alpha 116(gh4)glu----gln, found in a black female in georgia. |
1984-09-24 |
2023-08-12 |
Not clear |
| K Harano, T Harano, S Shibata, S Ueda, H Mori, M Sek. Hb Okazaki [beta 93(F8) Cys----Arg], a new hemoglobin variant with increased oxygen affinity and instability. FEBS letters. vol 173. issue 1. 1984-09-17. PMID:6745435. |
a new abnormal hemoglobin, hb okazaki [beta 93(f9) cys----arg], with an amino acid substitution at the tyrosine pocket of the beta chain as well as at the alpha 2 beta 1 contact of the quaternary structure of molecule, was discovered in a japanese man. |
1984-09-17 |
2023-08-12 |
Not clear |
| T Jue, G N La Mar, K Han, Y Yamamot. NMR study of the exchange rates of allosterically responsive labile protons in the heme pockets of hemoglobin A. Biophysical journal. vol 46. issue 1. 1984-09-12. PMID:6331541. |
assuming similar exchange mechanisms for the two subunits, the nmr data suggested a more flexible alpha than beta subunit in hb a. |
1984-09-12 |
2023-08-12 |
Not clear |
| A Kutlar, F Kutlar, J B Wilson, M G Headlee, T H Huisma. Quantitation of hemoglobin components by high-performance cation-exchange liquid chromatography: its use in diagnosis and in the assessment of cellular distribution of hemoglobin variants. American journal of hematology. vol 17. issue 1. 1984-08-01. PMID:6741932. |
analyses of the hemoglobin in cells from hb s and hb c heterozygotes with different numbers of alpha chain genes (alpha alpha/alpha alpha; -alpha/alpha alpha; -alpha/-alpha) after separation by a dextran density centrifugation technique failed to show significant changes in the relative quantitation of the variant hemoglobin types. |
1984-08-01 |
2023-08-12 |
human |
| L J Parkhurst, D J Gos. Ligand binding kinetic studies on the hybrid hemoglobin alpha (human):beta (carp): a hemoglobin with mixed conformations and sequential conformational changes. Biochemistry. vol 23. issue 10. 1984-07-30. PMID:6733081. |
oxygen and co ligand binding kinetics have been studied for the hybrid hemoglobin (hb) alpha (human):beta (carp), hybrid ii. |
1984-07-30 |
2023-08-12 |
human |
| Z I Randhawa, R T Jones, L E Lie-Inj. Human hemoglobin Portland II (zeta 2 beta 2). Isolation and characterization of Portland hemoglobin components and their constituent globin chains. The Journal of biological chemistry. vol 259. issue 11. 1984-07-16. PMID:6539334. |
the occurrence of hb portland i and hb portland ii in these hydropic neonates is consistent with the hypothesis that, in the absence of normal alpha chain production, zeta chains are continued to be produced at later states of development than normal and form tetramers with each of the beta-like globin chains. |
1984-07-16 |
2023-08-12 |
human |
| G R Honig, M Shamsuddin, L N Vida, M Mompoint, E Valcourt, L J Bowie, E C Jones, P A Powers, R A Spritz, M Gui. Hemoglobin Evanston (alpha 14 Trp----Arg). An unstable alpha-chain variant expressed as alpha-thalassemia. The Journal of clinical investigation. vol 73. issue 6. 1984-07-13. PMID:6725558. |
these observations suggest that two separate mechanisms are contributing to the alpha-thalassemia-like expression of hb evanston : the newly synthesized alpha ev-chains are unstable and are subject to early proteolytic destruction; and the mutant alpha-allele is linked to an alpha-globin gene deletion. |
1984-07-13 |
2023-08-12 |
human |
| T H Huisman, M G Headlee, J B Wilson, H Lam, S E Johnson, B B Webbe. Hb Wayne, the frameshift variant with extended alpha chains observed in a Caucasian family from Alabama. Hemoglobin. vol 8. issue 1. 1984-06-25. PMID:6327575. |
hb wayne, the frameshift variant with extended alpha chains observed in a caucasian family from alabama. |
1984-06-25 |
2023-08-12 |
Not clear |
| T H Huisman, M G Headlee, J B Wilson, H Lam, S E Johnson, B B Webbe. Hb Wayne, the frameshift variant with extended alpha chains observed in a Caucasian family from Alabama. Hemoglobin. vol 8. issue 1. 1984-06-25. PMID:6327575. |
the data include a hematological evaluation of the four heterozygotes, structural characterization of the variant, the use of hplc for the separation of tryptic and chymotryptic peptides, functional analyses of the isolated variant showing high affinity for oxygen and the (near) absence of a bohr effect, and alpha chain gene organization analyses with restriction endonuclease technology suggesting that the hb wayne heterozygote has a full complement of four alpha globin genes. |
1984-06-25 |
2023-08-12 |
Not clear |
| T Nakatsuji, J B Wilson, T H Huisma. Hb Cordele alpha(2)47 (CE5)Asp----Ala beta 2. A mildly unstable variant observed in black twins. Hemoglobin. vol 8. issue 1. 1984-06-25. PMID:6547117. |
hb cordele alpha(2)47 (ce5)asp----ala beta 2. |
1984-06-25 |
2023-08-12 |
Not clear |