| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Galanello, L Maccioni, R Ruggeri, L Perseu, A Ca. Alpha thalassaemia in Sardinian newborns. British journal of haematology. vol 58. issue 2. 1984-11-09. PMID:6548148. |
infants with two alpha-globin genes deleted (- alpha/- alpha and --/ alpha alpha genotypes) had microcytosis, low mch and hb bart's in the 2.0-7.1% range. |
1984-11-09 |
2023-08-12 |
Not clear |
| R Galanello, L Maccioni, R Ruggeri, L Perseu, A Ca. Alpha thalassaemia in Sardinian newborns. British journal of haematology. vol 58. issue 2. 1984-11-09. PMID:6548148. |
a minority (38.9%) of infants with the (- alpha/ alpha alpha) globin genotype had detectable hb bart's, in the 0.78-2.5% range, frequently associated with minimal microcytosis while the remainder (61.1%) were completely silent. |
1984-11-09 |
2023-08-12 |
Not clear |
| R Galanello, L Maccioni, R Ruggeri, L Perseu, A Ca. Alpha thalassaemia in Sardinian newborns. British journal of haematology. vol 58. issue 2. 1984-11-09. PMID:6548148. |
infants carriers of a non-deletion type of alpha-thalassaemia showed hb bart's levels within the range found in the (- alpha / alpha alpha) genotype. |
1984-11-09 |
2023-08-12 |
Not clear |
| H J Li, D X Liu, Z G Liu, P Li, L Li, J Chen, S Z Ho. A new fast-moving hemoglobin variant, Hb J-Tashikuergan alpha 19(AB1) Ala----Glu. Hemoglobin. vol 8. issue 4. 1984-11-09. PMID:6548207. |
a new fast-moving hemoglobin variant, hb j-tashikuergan alpha 19(ab1) ala----glu. |
1984-11-09 |
2023-08-12 |
Not clear |
| S Miura, C H. Proton nuclear magnetic resonance investigation of cross-linked asymmetrically modified hemoglobins: influence of the salt bridges on tertiary and quaternary structures of hemoglobin. Biochemistry. vol 23. issue 11. 1984-11-02. PMID:6477880. |
asymmetrically modified hemoglobins, [alpha(des-arg)beta]a[alpha beta]cxl, [alpha(des-arg-tyr)beta]a[alpha beta]cxl, [alpha(des-arg)beta(nes)]a[alpha beta]cxl, and [alpha(des-arg)beta]a[alpha beta(nes)]cxl, have been prepared from chemically modified human normal adult hemoglobin (hb a) and mutant hemoglobin c (beta 6glu----lys), where the subscript a or c denotes that the alpha beta dimer is from either hb a or hb c, respectively, and xl symbolizes a cross-linked hemoglobin prepared by reaction with a bifunctional cross-linking reagent, bis(3,5-dibromosalicyl) fumarate. |
1984-11-02 |
2023-08-12 |
human |
| S Miura, C H. Proton nuclear magnetic resonance investigation of cross-linked asymmetrically modified hemoglobins: influence of the salt bridges on tertiary and quaternary structures of hemoglobin. Biochemistry. vol 23. issue 11. 1984-11-02. PMID:6477880. |
proton nuclear magnetic resonance spectra of these asymmetrically modified hemoglobins together with their parent hemoglobins, des-arg(alpha 141) hb a, des-arg(alpha 141)-tyr(alpha 140) hb a, nes-hb a and nes-des-arg(alpha 141) hb a, have been obtained over the spectral region 5-10 ppm downfield from h2o for the exchangeable proton resonances and 50-80 ppm downfield from h2o for the hyperfine-shifted proximal histidyl n delta h exchangeable proton resonances. |
1984-11-02 |
2023-08-12 |
human |
| T Nakatsuji, K Shimizu, T H Huisma. Hb F-La Grange or alpha 2 gamma 2 101(G3)Glu----Lys; 75Ile; 136Gly: a high oxygen affinity fetal hemoglobin variant observed in a Caucasian newborn. Biochimica et biophysica acta. vol 789. issue 2. 1984-11-01. PMID:6206897. |
hb f-la grange or alpha 2 gamma 2 101(g3)glu----lys; 75ile; 136gly: a high oxygen affinity fetal hemoglobin variant observed in a caucasian newborn. |
1984-11-01 |
2023-08-12 |
Not clear |
| S Matsukawa, Y Itatani, K Mawatari, Y Shimokawa, Y Yoneyam. Quantitative evaluation for the role of beta 146 His and beta 143 His residues in the Bohr effect of human hemoglobin in the presence of 0.1 M chloride ion. The Journal of biological chemistry. vol 259. issue 18. 1984-10-25. PMID:6470009. |
the pk alpha values, which were determined by the deuterium exchange method using 1h nmr, were 8.0 for beta 146 his of deoxy-hb a and 6.5 for that of co hb a, while those of beta 143 his were 5.2 for deoxy-hb a and 6.0 for co hb a. |
1984-10-25 |
2023-08-12 |
human |
| S Matsukawa, Y Itatani, K Mawatari, Y Shimokawa, Y Yoneyam. Quantitative evaluation for the role of beta 146 His and beta 143 His residues in the Bohr effect of human hemoglobin in the presence of 0.1 M chloride ion. The Journal of biological chemistry. vol 259. issue 18. 1984-10-25. PMID:6470009. |
the residual acid bohr effect in the more acidic ph region was presumably contributed by an amino acid residue with pk alpha values of 4.05 and 5.95 for the deoxy- and co hb a, respectively, although the amino acid residue was unspecified. |
1984-10-25 |
2023-08-12 |
human |
| K Harano, T Harano, S Shibata, H Mori, S Ueda, K Imai, Y Ohba, K Irimajir. Hb J Oxford [alpha 15 (A13) Gly----Asp] in Japan. Hemoglobin. vol 8. issue 2. 1984-10-03. PMID:6469697. |
hb j oxford [alpha 15 (a13) gly----asp] in japan. |
1984-10-03 |
2023-08-12 |
Not clear |
| G V Sciarratta, G Ivaldi, G L Molaro, G Sansone, M L Salkie, J B Wilson, A L Reese, T H Huisma. The characterization of hemoglobin Manitoba or alpha (2)102(G9)Ser----Arg beta 2 and hemoglobin Contaldo or alpha (2)103(G10)His----Arg beta 2 by high performance liquid chromatography. Hemoglobin. vol 8. issue 2. 1984-10-03. PMID:6547932. |
hb contaldo with a his----arg substitution at position 103(g10) of the alpha chain is a newly discovered unstable hb variant observed in an italian child. |
1984-10-03 |
2023-08-12 |
Not clear |
| G V Sciarratta, G Ivaldi, G L Molaro, G Sansone, M L Salkie, J B Wilson, A L Reese, T H Huisma. The characterization of hemoglobin Manitoba or alpha (2)102(G9)Ser----Arg beta 2 and hemoglobin Contaldo or alpha (2)103(G10)His----Arg beta 2 by high performance liquid chromatography. Hemoglobin. vol 8. issue 2. 1984-10-03. PMID:6547932. |
similar analyses were made for the alpha x chain of the rare hb manitoba in which alpha 102(g9) ser is replaced by arg. |
1984-10-03 |
2023-08-12 |
Not clear |
| N V Blough, B M Hoffma. Carbon monoxide binding to the ferrous chains of [Mn,Fe(II)] hybrid hemoglobins: pH dependence of the chain affinity constants associated with specific hemoglobin ligation pathways. Biochemistry. vol 23. issue 13. 1984-09-26. PMID:6466622. |
in mixed-metal [mn,fe] hybrid hemoglobins (hb), the two chains of a single type, alpha or beta, are substituted with manganese protoporphyrin ix, which does not bind co in either the mn(ii) or mn(iii) valency states. |
1984-09-26 |
2023-08-12 |
Not clear |
| N V Blough, H Zemel, B M Hoffma. Flash photolytic studies of carbon monoxide binding to the ferrous chains of [Mn(II),Fe(II)] hybrid hemoglobins: kinetic mechanism for the early stages of hemoglobin ligation. Biochemistry. vol 23. issue 13. 1984-09-26. PMID:6466623. |
at low ph (6.6), hb remains predominantly in the t quaternary state for the first two co ligation steps, when binding to either the alpha chains or beta chains. |
1984-09-26 |
2023-08-12 |
Not clear |
| F Galacteros, J D Garin, N Monplaisir, S Namoune, N Arous, Y Blouquit, A Mamalaki, M Tulliez, M Ouka, M Goossen. Two new cases of heterozygosity for hemoglobin Knossos alpha 2 beta 2 27 Ala----Ser detected in the French West Indies and Algeria. Hemoglobin. vol 8. issue 3. 1984-09-24. PMID:6469698. |
hb knossos alpha 2 beta 2 27 ala----ser was first described in a greek family as a silent beta(+) thalassemia variant. |
1984-09-24 |
2023-08-12 |
Not clear |
| J B Wilson, R N Wrightstone, T H Huisma. Hb Oleander, alpha 116(GH4)GLU----GLN, found in a Black female in Georgia. Hemoglobin. vol 8. issue 3. 1984-09-24. PMID:6469700. |
hb oleander, alpha 116(gh4)glu----gln, found in a black female in georgia. |
1984-09-24 |
2023-08-12 |
Not clear |
| K Harano, T Harano, S Shibata, S Ueda, H Mori, M Sek. Hb Okazaki [beta 93(F8) Cys----Arg], a new hemoglobin variant with increased oxygen affinity and instability. FEBS letters. vol 173. issue 1. 1984-09-17. PMID:6745435. |
a new abnormal hemoglobin, hb okazaki [beta 93(f9) cys----arg], with an amino acid substitution at the tyrosine pocket of the beta chain as well as at the alpha 2 beta 1 contact of the quaternary structure of molecule, was discovered in a japanese man. |
1984-09-17 |
2023-08-12 |
Not clear |
| T Jue, G N La Mar, K Han, Y Yamamot. NMR study of the exchange rates of allosterically responsive labile protons in the heme pockets of hemoglobin A. Biophysical journal. vol 46. issue 1. 1984-09-12. PMID:6331541. |
assuming similar exchange mechanisms for the two subunits, the nmr data suggested a more flexible alpha than beta subunit in hb a. |
1984-09-12 |
2023-08-12 |
Not clear |
| A Kutlar, F Kutlar, J B Wilson, M G Headlee, T H Huisma. Quantitation of hemoglobin components by high-performance cation-exchange liquid chromatography: its use in diagnosis and in the assessment of cellular distribution of hemoglobin variants. American journal of hematology. vol 17. issue 1. 1984-08-01. PMID:6741932. |
analyses of the hemoglobin in cells from hb s and hb c heterozygotes with different numbers of alpha chain genes (alpha alpha/alpha alpha; -alpha/alpha alpha; -alpha/-alpha) after separation by a dextran density centrifugation technique failed to show significant changes in the relative quantitation of the variant hemoglobin types. |
1984-08-01 |
2023-08-12 |
human |
| L J Parkhurst, D J Gos. Ligand binding kinetic studies on the hybrid hemoglobin alpha (human):beta (carp): a hemoglobin with mixed conformations and sequential conformational changes. Biochemistry. vol 23. issue 10. 1984-07-30. PMID:6733081. |
oxygen and co ligand binding kinetics have been studied for the hybrid hemoglobin (hb) alpha (human):beta (carp), hybrid ii. |
1984-07-30 |
2023-08-12 |
human |