| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jelena Kolic, Patrick E MacDonal. cAMP-independent effects of GLP-1 on β cells. The Journal of clinical investigation. vol 125. issue 12. 2016-02-05. PMID:26571393. |
in this issue of the jci, shigeto and colleagues demonstrate that physiological glp-1 does indeed amplify the insulin secretory response. |
2016-02-05 |
2023-08-13 |
Not clear |
| Jelena Kolic, Patrick E MacDonal. cAMP-independent effects of GLP-1 on β cells. The Journal of clinical investigation. vol 125. issue 12. 2016-02-05. PMID:26571393. |
intriguingly, while much of this response is pka dependent, as might be expected, the use of picomolar glp-1 reveals a new and important mechanism that contributes to glp-1-induced insulin secretion. |
2016-02-05 |
2023-08-13 |
Not clear |
| Suleiman Al-Sabah, Munya Al-Fulaij, Ghina Shaaban, Hanadi A Ahmed, Rosalind J Mann, Dan Donnelly, Moritz Bünemann, Cornelius Krase. The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively. PloS one. vol 9. issue 9. 2016-02-04. PMID:25191754. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are important regulators of insulin secretion, and their functional loss is an early characteristic of type 2 diabetes mellitus (t2dm). |
2016-02-04 |
2023-08-13 |
Not clear |
| Makoto Shigeto, Reshma Ramracheya, Andrei I Tarasov, Chae Young Cha, Margarita V Chibalina, Benoit Hastoy, Koenraad Philippaert, Thomas Reinbothe, Nils Rorsman, Albert Salehi, William R Sones, Elisa Vergari, Cathryn Weston, Julia Gorelik, Masashi Katsura, Viacheslav O Nikolaev, Rudi Vennekens, Manuela Zaccolo, Antony Galione, Paul R V Johnson, Kohei Kaku, Graham Ladds, Patrik Rorsma. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. The Journal of clinical investigation. vol 125. issue 12. 2016-02-04. PMID:26571400. |
glp-1 stimulates insulin secretion by pkc-dependent trpm4 and trpm5 activation. |
2016-02-04 |
2023-08-13 |
mouse |
| Makoto Shigeto, Reshma Ramracheya, Andrei I Tarasov, Chae Young Cha, Margarita V Chibalina, Benoit Hastoy, Koenraad Philippaert, Thomas Reinbothe, Nils Rorsman, Albert Salehi, William R Sones, Elisa Vergari, Cathryn Weston, Julia Gorelik, Masashi Katsura, Viacheslav O Nikolaev, Rudi Vennekens, Manuela Zaccolo, Antony Galione, Paul R V Johnson, Kohei Kaku, Graham Ladds, Patrik Rorsma. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. The Journal of clinical investigation. vol 125. issue 12. 2016-02-04. PMID:26571400. |
strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (glp-1) therapeutically improve glucose-stimulated insulin secretion (gsis); however, it is not clear whether glp-1 directly drives insulin secretion in pancreatic islets. |
2016-02-04 |
2023-08-13 |
mouse |
| Makoto Shigeto, Reshma Ramracheya, Andrei I Tarasov, Chae Young Cha, Margarita V Chibalina, Benoit Hastoy, Koenraad Philippaert, Thomas Reinbothe, Nils Rorsman, Albert Salehi, William R Sones, Elisa Vergari, Cathryn Weston, Julia Gorelik, Masashi Katsura, Viacheslav O Nikolaev, Rudi Vennekens, Manuela Zaccolo, Antony Galione, Paul R V Johnson, Kohei Kaku, Graham Ladds, Patrik Rorsma. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. The Journal of clinical investigation. vol 125. issue 12. 2016-02-04. PMID:26571400. |
here, we examined the mechanisms by which glp-1 stimulates insulin secretion in mouse and human islets. |
2016-02-04 |
2023-08-13 |
mouse |
| Makoto Shigeto, Reshma Ramracheya, Andrei I Tarasov, Chae Young Cha, Margarita V Chibalina, Benoit Hastoy, Koenraad Philippaert, Thomas Reinbothe, Nils Rorsman, Albert Salehi, William R Sones, Elisa Vergari, Cathryn Weston, Julia Gorelik, Masashi Katsura, Viacheslav O Nikolaev, Rudi Vennekens, Manuela Zaccolo, Antony Galione, Paul R V Johnson, Kohei Kaku, Graham Ladds, Patrik Rorsma. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. The Journal of clinical investigation. vol 125. issue 12. 2016-02-04. PMID:26571400. |
moreover, we determined that glp-1 activates plc, which increases submembrane diacylglycerol and thereby activates pkc, resulting in membrane depolarization and increased action potential firing and subsequent stimulation of insulin secretion. |
2016-02-04 |
2023-08-13 |
mouse |
| Makoto Shigeto, Reshma Ramracheya, Andrei I Tarasov, Chae Young Cha, Margarita V Chibalina, Benoit Hastoy, Koenraad Philippaert, Thomas Reinbothe, Nils Rorsman, Albert Salehi, William R Sones, Elisa Vergari, Cathryn Weston, Julia Gorelik, Masashi Katsura, Viacheslav O Nikolaev, Rudi Vennekens, Manuela Zaccolo, Antony Galione, Paul R V Johnson, Kohei Kaku, Graham Ladds, Patrik Rorsma. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. The Journal of clinical investigation. vol 125. issue 12. 2016-02-04. PMID:26571400. |
these data provide important insight into the therapeutic action of glp-1 and suggest that circulating levels of this hormone directly stimulate insulin secretion by β cells. |
2016-02-04 |
2023-08-13 |
mouse |
| Ghupurjan Gheni, Norihide Yokoi, Masayuki Beppu, Takuro Yamaguchi, Shihomi Hidaka, Ayako Kawabata, Yoshikazu Hoshino, Masayuki Hoshino, Susumu Sein. Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat. Journal of diabetes research. vol 2015. 2016-02-03. PMID:25961052. |
although basal insulin secretion was remarkably high in the isolated pancreatic islets, the responses to both glucose stimulation and the incretin glp-1 were retained. |
2016-02-03 |
2023-08-13 |
rat |
| Morten Asser Karsdal, Bente Juul Riis, Nozer Mehta, William Stern, Ehud Arbit, Claus Christiansen, Kim Henrikse. Lessons learned from the clinical development of oral peptides. British journal of clinical pharmacology. vol 79. issue 5. 2016-02-02. PMID:25408230. |
special interest is given to oral salmon calcitonin (ct), glucagon-like peptide-1 (glp-1), insulin, pyy-(3-36), recombinant human parathyroid hormone (rhpth(1-31)-nh2) and pth(1-34), by different technologies. |
2016-02-02 |
2023-08-13 |
human |
| Sameer Agarwal, Amit Patil, Umesh Aware, Prashant Deshmukh, Brijesh Darji, Santosh Sasane, Kalapatapu V V M Sairam, Priyanka Priyadarsiny, Poonam Giri, Harilal Patel, Suresh Giri, Mukul Jain, Ranjit C Desa. Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist. ACS medicinal chemistry letters. vol 7. issue 1. 2016-01-28. PMID:26819665. |
tgr5 is a g protein-coupled receptor (gpcr), activation of which promotes secretion of glucagon-like peptide-1 (glp-1) and modulates insulin secretion. |
2016-01-28 |
2023-08-13 |
mouse |
| Agnès Marsset-Baglieri, Gilles Fromentin, Françoise Nau, Gheorghe Airinei, Julien Piedcoq, Didier Rémond, Pierre Barbillon, Robert Benamouzig, Daniel Tomé, Claire Gaudicho. The satiating effects of eggs or cottage cheese are similar in healthy subjects despite differences in postprandial kinetics. Appetite. vol 90. 2016-01-27. PMID:25772196. |
gip and insulin secretions increased significantly after the cottage cheese, while glucagon and glp-1 secretions were delayed with the omelette. |
2016-01-27 |
2023-08-13 |
human |
| Dorit Samocha-Bonet, Don J Chisholm, Jens J Holst, Jerry R Greenfiel. L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients. Nutrients. vol 7. issue 4. 2016-01-27. PMID:25811109. |
l-glutamine triggers glucagon-like peptide-1 (glp-1) release from l cells in vitro and when ingested pre-meal, decreases postprandial glycaemia and increases circulating insulin and glp-1 in type 2 diabetes (t2d) patients. |
2016-01-27 |
2023-08-13 |
Not clear |
| Dorit Samocha-Bonet, Don J Chisholm, Jens J Holst, Jerry R Greenfiel. L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients. Nutrients. vol 7. issue 4. 2016-01-27. PMID:25811109. |
in a randomized study with a crossover design, t2d patients (n = 10, 6 men) aged 65.1 ± 5.8, with glycosylated hemoglobin (hba1c) 6.6% ± 0.7% (48 ± 8 mmol/mol), received oral l-glutamine (25 g), protein (25 g) or water, followed by an intravenous glucose bolus (0.3 g/kg) and hyperglycemic glucose clamp for 2 h. blood was frequently collected for analyses of glucose, serum insulin and plasma total and active glp-1 and area under the curve of glucose, insulin, total and active glp-1 excursions calculated. |
2016-01-27 |
2023-08-13 |
Not clear |
| Fei Wang, Qing Yang, Sarah Huesman, Min Xu, Xiaoming Li, Danwen Lou, Stephen C Woods, Corina Marziano, Patrick Ts. The role of apolipoprotein A-IV in regulating glucagon-like peptide-1 secretion. American journal of physiology. Gastrointestinal and liver physiology. vol 309. issue 8. 2016-01-27. PMID:26294669. |
both glucagon-like peptide-1 (glp-1) and apolipoprotein a-iv (apoa-iv) are produced from the gut and enhance postprandial insulin secretion. |
2016-01-27 |
2023-08-13 |
mouse |
| Marie Eriksen, David H Jensen, Siri Tribler, Jens J Holst, Sten Madsbad, Thure Kraru. Reduction of insulinotropic properties of GLP-1 and GIP after glucocorticoid-induced insulin resistance. Diabetologia. vol 58. issue 5. 2016-01-20. PMID:25748606. |
reduction of insulinotropic properties of glp-1 and gip after glucocorticoid-induced insulin resistance. |
2016-01-20 |
2023-08-13 |
Not clear |
| Marie Eriksen, David H Jensen, Siri Tribler, Jens J Holst, Sten Madsbad, Thure Kraru. Reduction of insulinotropic properties of GLP-1 and GIP after glucocorticoid-induced insulin resistance. Diabetologia. vol 58. issue 5. 2016-01-20. PMID:25748606. |
we evaluated the insulinotropic properties of glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) in healthy individuals at risk of developing type 2 diabetes before and after glucocorticoid-induced insulin resistance. |
2016-01-20 |
2023-08-13 |
Not clear |
| Agnès Jacquin-Piques, Stéphanie Gaudillat, Thomas Mouillot, Vincent Gigot, Sophie Meillon, Corinne Leloup, Luc Penicaud, Laurent Bronde. Prandial States Modify the Reactivity of the Gustatory Cortex Using Gustatory Evoked Potentials in Humans. Frontiers in neuroscience. vol 9. 2016-01-18. PMID:26778949. |
modifications in the primary taste area activity during the post-prandial period occurred regardless of the nature of the food eaten and could represent the activity of the frontal operculum and insula, which was recently shown to be modulated by gut signals (glp-1, cck, ghrelin, or insulin) through vagal afferent neurons or metabolic changes of the internal milieu after nutrient absorption. |
2016-01-18 |
2023-08-13 |
human |
| Dorit Samocha-Bonet, Donald J Chisholm, Fiona M Gribble, Adelle C F Coster, Kevin H Carpenter, Graham R D Jones, Jens J Holst, Jerry R Greenfiel. Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study. PloS one. vol 9. issue 11. 2016-01-15. PMID:25412338. |
when administered with a meal, glutamine increases glp-1 and insulin excursions and reduces postprandial glycaemia in type 2 diabetes patients. |
2016-01-15 |
2023-08-13 |
Not clear |
| Sho-ichi Yamagishi, Kei Fukami, Takanori Matsu. Crosstalk between advanced glycation end products (AGEs)-receptor RAGE axis and dipeptidyl peptidase-4-incretin system in diabetic vascular complications. Cardiovascular diabetology. vol 14. 2016-01-15. PMID:25582643. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are incretins, gut hormones secreted from the intestine in response to food intake, both of which augment glucose-induced insulin release, suppress glucagon secretion, and slow gastric emptying. |
2016-01-15 |
2023-08-13 |
Not clear |