| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Hall, C A Adin, S Borin-Crivellenti, A J Rudinsky, P Rajala-Schultz, J Lakritz, C Gilo. Pharmacokinetics and pharmacodynamics of the glucagon-like peptide-1 analog liraglutide in healthy cats. Domestic animal endocrinology. vol 51. 2015-11-24. PMID:25625650. |
glucagon-like peptide-1 (glp-1) is an intestinal hormone that induces glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion. |
2015-11-24 |
2023-08-13 |
Not clear |
| S Marti, M Pérez, A Aris, A Bach, M Devan. Effect of dietary energy density and meal size on growth performance, eating pattern, and carcass and meat quality in Holstein steers fed high-concentrate diets. Journal of animal science. vol 92. issue 8. 2015-11-20. PMID:25006061. |
on d 163, blood samples were collected to determine serum concentrations of leptin, ghrelin, glucagon-like peptide-1 (glp-1), cholecystokinin (cck), glucose, and insulin. |
2015-11-20 |
2023-08-13 |
Not clear |
| S Marti, M Pérez, A Aris, A Bach, M Devan. Effect of dietary energy density and meal size on growth performance, eating pattern, and carcass and meat quality in Holstein steers fed high-concentrate diets. Journal of animal science. vol 92. issue 8. 2015-11-20. PMID:25006061. |
at d 163, serum concentrations of glp-1, cck, and insulin were lower (p < 0.05), and leptin (p = 0.10) and glucose (p = 0.08) concentrations tended to be lower for helm than for ctr or he. |
2015-11-20 |
2023-08-13 |
Not clear |
| Stacey L Dineen, Mikaela L McKenney, Lauren N Bell, Allison M Fullenkamp, Kyle A Schultz, Mouhamad Alloosh, Naga Chalasani, Michael Sture. Metabolic Syndrome Abolishes Glucagon-Like Peptide 1 Receptor Agonist Stimulation of SERCA in Coronary Smooth Muscle. Diabetes. vol 64. issue 9. 2015-11-17. PMID:25845661. |
glucagon-like peptide 1 (glp-1) receptor agonists induce weight loss, increase insulin secretion, and improve glucose tolerance. |
2015-11-17 |
2023-08-13 |
Not clear |
| Katsunori Nonogaki, Tomoe Yamazaki, Mari Murakami, Takao Kaj. Ingestion of eicosapentaenoic acid in the early stage of social isolation reduces a fibroblast growth factor 21 resistant state independently of body weight in KKA(y) mice. Biochemical and biophysical research communications. vol 464. issue 2. 2015-11-17. PMID:26187667. |
here we show that ingestion of eicosapentaenoic acid (epa) for 6 days after individually-housing significantly suppressed the hyperglycemia and hypertriglyceridemia associated with decreases in plasma insulin and fgf21 levels in kka(y) mice while having no effects on food intake, body weight or plasma active glp-1 levels. |
2015-11-17 |
2023-08-13 |
mouse |
| Bingbing Wu, Shunhui Wei, Natalia Petersen, Yusuf Ali, Xiaorui Wang, Taulant Bacaj, Patrik Rorsman, Wanjin Hong, Thomas C Südhof, Weiping Ha. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 32. 2015-11-10. PMID:26216970. |
in type-2 diabetes, insulin secretion is impaired; this impairment is ameliorated by glucagon-like peptide-1 (glp-1) or by glp-1 receptor agonists, which improve glucose homeostasis. |
2015-11-10 |
2023-08-13 |
Not clear |
| Bingbing Wu, Shunhui Wei, Natalia Petersen, Yusuf Ali, Xiaorui Wang, Taulant Bacaj, Patrik Rorsman, Wanjin Hong, Thomas C Südhof, Weiping Ha. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 32. 2015-11-10. PMID:26216970. |
however, the mechanism by which glp-1 receptor agonists boost insulin secretion remains unclear. |
2015-11-10 |
2023-08-13 |
Not clear |
| Bingbing Wu, Shunhui Wei, Natalia Petersen, Yusuf Ali, Xiaorui Wang, Taulant Bacaj, Patrik Rorsman, Wanjin Hong, Thomas C Südhof, Weiping Ha. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 32. 2015-11-10. PMID:26216970. |
here, we report that glp-1 stimulates protein kinase a (pka)-dependent phosphorylation of synaptotagmin-7 at serine-103, which enhances glucose- and ca(2+)-stimulated insulin secretion and accounts for the improvement of glucose homeostasis by glp-1. |
2015-11-10 |
2023-08-13 |
Not clear |
| Bingbing Wu, Shunhui Wei, Natalia Petersen, Yusuf Ali, Xiaorui Wang, Taulant Bacaj, Patrik Rorsman, Wanjin Hong, Thomas C Südhof, Weiping Ha. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 32. 2015-11-10. PMID:26216970. |
a phospho-mimetic synaptotagmin-7 mutant enhances ca(2+)-triggered exocytosis, whereas a phospho-inactive synaptotagmin-7 mutant disrupts glp-1 potentiation of insulin secretion. |
2015-11-10 |
2023-08-13 |
Not clear |
| Bingbing Wu, Shunhui Wei, Natalia Petersen, Yusuf Ali, Xiaorui Wang, Taulant Bacaj, Patrik Rorsman, Wanjin Hong, Thomas C Südhof, Weiping Ha. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 32. 2015-11-10. PMID:26216970. |
our findings thus suggest that synaptotagmin-7 is directly activated by glp-1 signaling and may serve as a drug target for boosting insulin secretion. |
2015-11-10 |
2023-08-13 |
Not clear |
| Camilla Kappe, Liselotte Fransson, Petra Wolbert, Henrik Ortsäte. Glucocorticoids suppress GLP-1 secretion: possible contribution to their diabetogenic effects. Clinical science (London, England : 1979). vol 129. issue 5. 2015-11-09. PMID:25853863. |
however, although defective glp-1 secretion has been correlated with insulin resistance, potential direct effects of gcs on glp-1-producing l-cell function in terms of glp-1 secretion and apoptosis have not been studied in any greater detail. |
2015-11-09 |
2023-08-13 |
rat |
| Camilla Kappe, Liselotte Fransson, Petra Wolbert, Henrik Ortsäte. Glucocorticoids suppress GLP-1 secretion: possible contribution to their diabetogenic effects. Clinical science (London, England : 1979). vol 129. issue 5. 2015-11-09. PMID:25853863. |
furthermore, in vivo administration of dexamethasone to rats reduced the circulating levels of glp-1 concurrent with induction of insulin resistance and glucose intolerance. |
2015-11-09 |
2023-08-13 |
rat |
| Kristiina R Juvonen, Adam Macierzanka, Martina E Lille, David E Laaksonen, Hannu M Mykkänen, Leo K Niskanen, Jussi Pihlajamäki, Kari A Mäkelä, Clare E N Mills, Alan R Mackie, Paul Malcolm, Karl-Heinz Herzig, Kaisa S Poutanen, Leila J Karhune. Cross-linking of sodium caseinate-structured emulsion with transglutaminase alters postprandial metabolic and appetite responses in healthy young individuals. The British journal of nutrition. vol 114. issue 3. 2015-10-30. PMID:26159899. |
blood samples were collected from the individuals at baseline and for 6 h postprandially for the determination of serum tag and plasma nefa, cholecystokinin (cck), glucagon-like peptide 1 (glp-1), glucose and insulin responses. |
2015-10-30 |
2023-08-13 |
Not clear |
| Ming Zhang, Mélanie Robitaille, Aaron D Showalter, Xinyi Huang, Ying Liu, Alpana Bhattacharjee, Francis S Willard, Junfeng Han, Sean Froese, Li Wei, Herbert Y Gaisano, Stéphane Angers, Kyle W Sloop, Feihan F Dai, Michael B Wheele. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Molecular & cellular proteomics : MCP. vol 13. issue 11. 2015-10-23. PMID:25044020. |
because of their direct stimulation of insulin secretion from pancreatic β cells, glp-1 receptor (glp-1r) agonists are now important therapeutic options for the treatment of type 2 diabetes. |
2015-10-23 |
2023-08-13 |
human |
| R Charlotte Moffett, Srividya Vasu, Bernard Thorens, Daniel J Drucker, Peter R Flat. Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy. PloS one. vol 9. issue 6. 2015-10-22. PMID:24927416. |
knockout of glp-1r abolished these islet adaptations and paradoxically decreased pancreatic insulin, glp-1 and gip. |
2015-10-22 |
2023-08-13 |
mouse |
| Debbie A Hinne. Therapeutic Options for the Management of Postprandial Glucose in Patients With Type 2 Diabetes on Basal Insulin. Clinical diabetes : a publication of the American Diabetes Association. vol 33. issue 4. 2015-10-21. PMID:26487791. |
in brief for patients with type 2 diabetes who require add-on therapy to metformin plus basal insulin, glp-1 receptor agonists may be a favorable option because they effectively manage postprandial glucose, reduce body weight, and have an overall favorable safety profile compared to other agents. |
2015-10-21 |
2023-08-13 |
Not clear |
| Sarah Farr, Jennifer Taher, Khosrow Adel. Glucagon-like peptide-1 as a key regulator of lipid and lipoprotein metabolism in fasting and postprandial states. Cardiovascular & hematological disorders drug targets. vol 14. issue 2. 2015-10-19. PMID:24801723. |
recently, the insulin secretagogue glucagon-like peptide-1 (glp-1) has received attention not only as an anti-diabetic therapy for regulating glycaemia, but also as a regulator of lipid and lipoprotein metabolism. |
2015-10-19 |
2023-08-13 |
Not clear |
| Agus Lastya, Made Ratna Saraswati, Ketut Suastik. The low level of glucagon-like peptide-1 (glp-1) is a risk factor of type 2 diabetes mellitus. BMC research notes. vol 7. 2015-10-19. PMID:25427660. |
glucagon like peptide-1 (glp-1), an incretin hormone, regulates glucose metabolism by inducing insulin secretion and suppressing glucagon secretion. |
2015-10-19 |
2023-08-13 |
human |
| M Rendel. First fixed-ratio combination of insulin degludec and liraglutide for the treatment of type 2 diabetes. Drugs of today (Barcelona, Spain : 1998). vol 51. issue 3. 2015-10-16. PMID:25876562. |
insulin therapy is associated with hypoglycemia and weight gain while glp-1 receptor agonists promote weight loss. |
2015-10-16 |
2023-08-13 |
Not clear |
| M Rendel. First fixed-ratio combination of insulin degludec and liraglutide for the treatment of type 2 diabetes. Drugs of today (Barcelona, Spain : 1998). vol 51. issue 3. 2015-10-16. PMID:25876562. |
the combined use of basal insulin and glp-1 receptor agonists results in improved glycemic control and mitigates weight gain. |
2015-10-16 |
2023-08-13 |
Not clear |