| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alok Sharma, Geetanjali Paliwal, Nisha Upadhyay, Archana Tiwar. Therapeutic stimulation of GLP-1 and GIP protein with DPP-4 inhibitors for type-2 diabetes treatment. Journal of diabetes and metabolic disorders. vol 14. 2015-10-16. PMID:26473146. |
glp-1 enhances insulin secretion and diminishes glucagon secretion, in this manner reducing glucose concentrations in blood. |
2015-10-16 |
2023-08-13 |
Not clear |
| Nils Wierup, Andreas Lindqvist, Peter Spégel, Leif Groop, Jan Hedenbro, Mikael Ekelun. Short- and long-term hormonal and metabolic consequences of reversing gastric bypass to normal anatomy in a type 2 diabetes patient. Obesity surgery. vol 25. issue 1. 2015-10-14. PMID:25330869. |
homeostasis model assessment (homa)-β was higher at mmt2-m, but reduced at mmt12-m. matsuda index revealed slightly reduced insulin sensitivity at mmt2-m, which deteriorated further at mmt12-m. markers for metabolic stress and insulin resistance were elevated at mmt12-m. gastric inhibitory polypeptide (gip) levels were increased at mmt2-m and decreased at mmt12-m. glucagon-like peptide-1 (glp-1) decreased at mmt2-m and further decreased at mmt12-m. |
2015-10-14 |
2023-08-13 |
Not clear |
| Noora Al-Rasheid, Rosaire Gray, Pratik Sufi, Nephtali Marina-Gonzalez, Mohammed Al-Sayrafi, Elizabeth Atherton, Vidya Mohamed-Al. Chronic elevation of systemic glucagon-like peptide-1 following surgical weight loss: association with nausea and vomiting and effects on adipokines. Obesity surgery. vol 25. issue 2. 2015-10-14. PMID:25411121. |
weight loss, glycaemia, insulin and post-prandial glp-1 levels were similar in all post-operative subjects. |
2015-10-14 |
2023-08-13 |
human |
| Floriane Baraille, Sami Ayari, Véronique Carrière, Céline Osinski, Kevin Garbin, Bertrand Blondeau, Ghislaine Guillemain, Patricia Serradas, Monique Rousset, Michel Lacasa, Philippe Cardot, Agnès Ribeir. Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4γ: A Critical Role for Enteroendocrine Cell Lineage. Diabetes. vol 64. issue 8. 2015-10-09. PMID:25829452. |
moreover, the enteroendocrine l-type cell lineage is modified, as assessed by the increased expression of transcription factors isl1, foxa1/2, and hnf4a, leading to an increase of both glp-1-positive cell number and basal and stimulated glp-1 plasma levels potentiating the glucose-stimulated insulin secretion. |
2015-10-09 |
2023-08-13 |
mouse |
| Charlotte C Ronveaux, Guillaume de Lartigue, Helen E Rayboul. Ability of GLP-1 to decrease food intake is dependent on nutritional status. Physiology & behavior. vol 135. 2015-10-07. PMID:24955496. |
gut-derived glucagon like peptide-1 (glp-1) acts in the postprandial period to stimulate insulin secretion and inhibit gastrointestinal motor and secretory function; whether endogenous peripheral glp-1 inhibits food intake is less clear. |
2015-10-07 |
2023-08-13 |
Not clear |
| Srividya Vasu, R Charlotte Moffett, Bernard Thorens, Peter R Flat. Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress. PloS one. vol 9. issue 6. 2015-10-07. PMID:24967820. |
role of endogenous glp-1 and gip in beta cell compensatory responses to insulin resistance and cellular stress. |
2015-10-07 |
2023-08-13 |
mouse |
| Srividya Vasu, R Charlotte Moffett, Bernard Thorens, Peter R Flat. Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress. PloS one. vol 9. issue 6. 2015-10-07. PMID:24967820. |
role of glp-1 and gip in beta cell compensatory responses to beta cell attack and insulin resistance were examined in c57bl/6 mice lacking functional receptors for glp-1 and gip. |
2015-10-07 |
2023-08-13 |
mouse |
| Srividya Vasu, R Charlotte Moffett, Bernard Thorens, Peter R Flat. Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress. PloS one. vol 9. issue 6. 2015-10-07. PMID:24967820. |
in contrast, hydrocortisone treatment and induction of insulin resistance increased islet numbers and area, with enhanced beta cell replication, elevated mass of beta and alpha cells, together with co-expression of glp-1 and gip with glucagon in islets. |
2015-10-07 |
2023-08-13 |
mouse |
| Srividya Vasu, R Charlotte Moffett, Bernard Thorens, Peter R Flat. Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress. PloS one. vol 9. issue 6. 2015-10-07. PMID:24967820. |
our observations cannot be explained by simple changes in circulating incretin concentrations, suggesting that intra-islet glp-1 and gip make a significant contribution to islet adaptation, particularly expansion of beta cell mass and compensatory islet compensation to hydrocortisone and insulin resistance. |
2015-10-07 |
2023-08-13 |
mouse |
| Mary K Caffre. Can early use of insulin, GLP-1 halt diabetes progression? The American journal of managed care. vol 20. issue 10 Spec No. 2015-10-06. PMID:25830193. |
can early use of insulin, glp-1 halt diabetes progression? |
2015-10-06 |
2023-08-13 |
Not clear |
| Julio Rosenstock, Vivian A Fonseca, Jorge L Gross, Robert E Ratner, Bo Ahrén, Francis C C Chow, Fred Yang, Diane Miller, Susan L Johnson, Murray W Stewart, Lawrence A Leite. Advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: a comparison of adding albiglutide, a weekly GLP-1 receptor agonist, versus thrice-daily prandial insulin lispro. Diabetes care. vol 37. issue 8. 2015-10-01. PMID:24898300. |
advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: a comparison of adding albiglutide, a weekly glp-1 receptor agonist, versus thrice-daily prandial insulin lispro. |
2015-10-01 |
2023-08-13 |
Not clear |
| Julio Rosenstock, Vivian A Fonseca, Jorge L Gross, Robert E Ratner, Bo Ahrén, Francis C C Chow, Fred Yang, Diane Miller, Susan L Johnson, Murray W Stewart, Lawrence A Leite. Advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: a comparison of adding albiglutide, a weekly GLP-1 receptor agonist, versus thrice-daily prandial insulin lispro. Diabetes care. vol 37. issue 8. 2015-10-01. PMID:24898300. |
glp-1 receptor agonists may provide an alternative to prandial insulin for advancing basal insulin therapy. |
2015-10-01 |
2023-08-13 |
Not clear |
| Christina Daousi, Jonathan H Pinkney, Jacqueline Cleator, John P Wilding, L R Ranganat. Acute peripheral administration of synthetic human GLP-1 (7-36 amide) decreases circulating IL-6 in obese patients with type 2 diabetes mellitus: a potential role for GLP-1 in modulation of the diabetic pro-inflammatory state? Regulatory peptides. vol 183. 2015-09-30. PMID:23499806. |
to explore the effects of acute administration of glp-1 and gip on circulating levels of key adipocyte-derived hormones and gut-brain peptides with established roles in energy and appetite regulation, modulation of insulin sensitivity and inflammation. |
2015-09-30 |
2023-08-12 |
human |
| Giulia Cantini, Alessandra Di Franco, Jinous Samavat, Gianni Forti, Edoardo Mannucci, Michaela Lucon. Effect of liraglutide on proliferation and differentiation of human adipose stem cells. Molecular and cellular endocrinology. vol 402. 2015-09-30. PMID:25575456. |
these effects could contribute to the actions of glp-1 receptor agonists on body weight and insulin sensitivity. |
2015-09-30 |
2023-08-13 |
human |
| Yusuke Seino, Hidetada Ogata, Ryuya Maekawa, Takako Izumoto, Atsushi Iida, Norio Harada, Takashi Miki, Susumu Seino, Nobuya Inagaki, Shin Tsunekawa, Yutaka Oiso, Yoji Hamad. Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K(+) channels. Journal of diabetes investigation. vol 6. issue 5. 2015-09-29. PMID:26417408. |
in the present study, we investigated the involvement of the katp channel in fructose-induced gip, glp-1 and insulin secretion in mice. |
2015-09-29 |
2023-08-13 |
mouse |
| Yusuke Seino, Hidetada Ogata, Ryuya Maekawa, Takako Izumoto, Atsushi Iida, Norio Harada, Takashi Miki, Susumu Seino, Nobuya Inagaki, Shin Tsunekawa, Yutaka Oiso, Yoji Hamad. Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K(+) channels. Journal of diabetes investigation. vol 6. issue 5. 2015-09-29. PMID:26417408. |
fructose significantly stimulated insulin secretion in kir6.2 (+/+) mice, but not in mice lacking katp channels (kir6.2 (-/-) ), and fructose stimulated glp-1 secretion in both kir6.2 (+/+) mice and kir6.2 (-/-) mice under the normoglycemic condition. |
2015-09-29 |
2023-08-13 |
mouse |
| Yusuke Seino, Hidetada Ogata, Ryuya Maekawa, Takako Izumoto, Atsushi Iida, Norio Harada, Takashi Miki, Susumu Seino, Nobuya Inagaki, Shin Tsunekawa, Yutaka Oiso, Yoji Hamad. Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K(+) channels. Journal of diabetes investigation. vol 6. issue 5. 2015-09-29. PMID:26417408. |
these results show that fructose-induced gip and glp-1 secretion is katp channel-independent and that fructose-induced insulin secretion is katp channel-dependent. |
2015-09-29 |
2023-08-13 |
mouse |
| S Temizkan, O Deyneli, M Yasar, M Arpa, M Gunes, D Yazici, O Sirikci, G Haklar, N Imeryuz, D G Yavu. Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in patients with type 2 diabetes. European journal of clinical nutrition. vol 69. issue 2. 2015-09-28. PMID:25271009. |
the objective of this study was to determine the effect of artificial sweeteners (aspartame and sucralose) on blood glucose, insulin, c-peptide and glucagon-like peptide-1 (glp-1) levels. |
2015-09-28 |
2023-08-13 |
human |
| Amanda R Ves. Incretin-related drug therapy in heart failure. Current heart failure reports. vol 12. issue 1. 2015-09-21. PMID:25323108. |
thus, glp-1 agonists, which stimulate glucose-dependent insulin release and enhance myocardial glucose uptake, have become a focus of investigation in both animal models and humans with heart failure. |
2015-09-21 |
2023-08-13 |
Not clear |
| Zeynep Kusku-Kiraz, Sema Genc, Seldag Bekpinar, Yesim Unlucerci, Vakur Olgac, Mujdat Uysal, Figen Gurdo. Circulating levels of apelin, glucagon-like peptide and visfatin in hypercholesterolemic-hyperhomocysteinemic guinea-pigs: their relation with NO metabolism. Molecular and cellular biochemistry. vol 400. issue 1-2. 2015-09-21. PMID:25380625. |
serum insulin, glp-1, apelin, visfatin, and nitrotyrosine concentrations were measured by the manufacturer's kits based on elisa; asymmetric dimethylarginine (adma) and arginine levels were measured by the high performance liquid chromatography. |
2015-09-21 |
2023-08-13 |
Not clear |