| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanjoy K Paul, Kerenaftali Klein, David Maggs, Jennie H Bes. The association of the treatment with glucagon-like peptide-1 receptor agonist exenatide or insulin with cardiovascular outcomes in patients with type 2 diabetes: a retrospective observational study. Cardiovascular diabetology. vol 14. 2016-01-15. PMID:25616979. |
to evaluate the association of treatment with glucagon-like peptide-1 (glp-1) receptor agonist exenatide and/or insulin on macrovascular outcomes in patients with type 2 diabetes (t2dm). |
2016-01-15 |
2023-08-13 |
Not clear |
| Tianpeng Zheng, Liuxue Yang, Yihong Liu, Hongbo Liu, Jian Yu, Xiaoxi Zhang, Shenghua Qi. Plasma DPP4 Activities Are Associated With Osteoporosis in Postmenopausal Women With Normal Glucose Tolerance. The Journal of clinical endocrinology and metabolism. vol 100. issue 10. 2016-01-13. PMID:26259132. |
inflammation, insulin resistance, dyslipidemia, and glucagon-like peptide-1 (glp-1) are risk factors for osteoporosis. |
2016-01-13 |
2023-08-13 |
Not clear |
| Signe Tellerup Nielsen, Rikke Krogh-Madsen, Kirsten Mølle. Glucose metabolism in critically ill patients: are incretins an important player? Journal of intensive care medicine. vol 30. issue 4. 2016-01-12. PMID:24065782. |
compared to insulin, glp-1 appears to be associated with a lower risk of severe hypoglycemia, probably because the magnitude of its insulinotropic action is dependent on blood glucose (bg). |
2016-01-12 |
2023-08-12 |
Not clear |
| Karen Kleberg, Anne Katrine Jacobsen, Jozelia G Ferreira, Johanne Agerlin Windeløv, Jens F Rehfeld, Jens Juul Holst, Ivan E de Araujo, Harald S Hanse. Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol. The Journal of physiology. vol 593. issue 8. 2016-01-12. PMID:25639597. |
peripheral plasma concentrations of the gut hormones glp-1, gip, pyy, cck and insulin did not offer an explanation of the differing behavioural effects produced by 2-monoacylglycerol and fatty acids. |
2016-01-12 |
2023-08-13 |
mouse |
| Ashraf Ul Kabir, Mehdi Bin Samad, Arif Ahmed, Mohammad Rajib Jahan, Farjana Akhter, Jinat Tasnim, S M Nageeb Hasan, Sania Sarker Sayfe, J M A Hanna. Aqueous fraction of Beta vulgaris ameliorates hyperglycemia in diabetic mice due to enhanced glucose stimulated insulin secretion, mediated by acetylcholine and GLP-1, and elevated glucose uptake via increased membrane bound GLUT4 transporters. PloS one. vol 10. issue 2. 2016-01-12. PMID:25647228. |
aqueous fraction of beta vulgaris ameliorates hyperglycemia in diabetic mice due to enhanced glucose stimulated insulin secretion, mediated by acetylcholine and glp-1, and elevated glucose uptake via increased membrane bound glut4 transporters. |
2016-01-12 |
2023-08-13 |
mouse |
| De-Lin Ma, Fu-Qiong Chen, Wei-Jie Xu, Wen-Zhu Yue, Gang Yuan, Yan Yan. Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26183127. |
the aim of this study was to explore the potential effects of liraglutide (a glp-1 analog), or insulin, on tau phosphorylation in t2d animals. |
2016-01-11 |
2023-08-13 |
mouse |
| De-Lin Ma, Fu-Qiong Chen, Wei-Jie Xu, Wen-Zhu Yue, Gang Yuan, Yan Yan. Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26183127. |
in summary, this study indicates that early glp-1 analog intervention prevented the age-dependent tau hyperphosphorylation in t2d mice brain, probably by facilitating sequential activation in an insulin signaling pathway reflected in increased basal activation of akt and basal suppression of glycogen synthase kinase-3 beta. |
2016-01-11 |
2023-08-13 |
mouse |
| Kirstine Nyvold Bojsen-Mølle. Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass. Danish medical journal. vol 62. issue 4. 2016-01-06. PMID:25872541. |
increased insulin secretion postoperatively was thus linked to the oral and not the iv route of administration highlighting the importance of the changed gastrointestinal anatomy and the exaggerated glp-1 secretion and not supporting major changes in intrinsic beta-cell function after rygb. |
2016-01-06 |
2023-08-13 |
human |
| Kirstine Nyvold Bojsen-Mølle. Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass. Danish medical journal. vol 62. issue 4. 2016-01-06. PMID:25872541. |
changes in alpha-cell function did not seem to contribute substantially to the improved glycaemic control after rygb, as glucagon secretion increased paradoxically after oral glucose, and suppression of glucagon in response to iv infusions of glucose, gip, glp-1 and insulin was largely unchanged postoperatively. |
2016-01-06 |
2023-08-13 |
human |
| Kirstine Nyvold Bojsen-Mølle. Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass. Danish medical journal. vol 62. issue 4. 2016-01-06. PMID:25872541. |
in conclusion, improved glycaemic control after roux-en-y gastric bypass can be explained by early enhancements of hepatic insulin sensitivity and later improvements in peripheral insulin sensitivity in combination with increased postprandial insulin secretion linked to exaggerated postprandial glp-1 secretion. |
2016-01-06 |
2023-08-13 |
human |
| Kirstine Nyvold Bojsen-Mølle. Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass. Danish medical journal. vol 62. issue 4. 2016-01-06. PMID:25872541. |
surgical changes in gut anatomy are likely to explain the increased glp-1 secretion and hence the increased postprandial insulin secretion, whereas calorie restriction and subsequent weight loss may be the major cause of improved insulin sensitivity. |
2016-01-06 |
2023-08-13 |
human |
| Babak Behnam Azad, Vanessa Rota, Lihai Yu, Rebecca McGirr, André H St Amant, Ting-Yim Lee, Savita Dhanvantari, Leonard G Luy. Synthesis and evaluation of optical and PET GLP-1 peptide analogues for GLP-1R imaging. Molecular imaging. vol 14. 2016-01-01. PMID:25762192. |
the optical glp-1 probe strongly colocalized with immunofluorescence for insulin and glucagon, and more weakly with amylase (exocrine pancreas) and cytokeratin 19 (ductal cells), confirming its application for in situ glp-1r imaging in various pancreatic cell types. |
2016-01-01 |
2023-08-13 |
mouse |
| Donna Ryan, Andres Acost. GLP-1 receptor agonists: Nonglycemic clinical effects in weight loss and beyond. Obesity (Silver Spring, Md.). vol 23. issue 6. 2015-12-22. PMID:25959380. |
glucagon-like peptide-1 (glp-1) receptor agonists are indicated for treatment of type 2 diabetes since they mimic the actions of native glp-1 on pancreatic islet cells, stimulating insulin release, while inhibiting glucagon release, in a glucose-dependent manner. |
2015-12-22 |
2023-08-13 |
Not clear |
| Hideaki Jinnouchi, Seigo Sugiyama, Akira Yoshida, Kunio Hieshima, Noboru Kurinami, Tomoko Suzuki, Fumio Miyamoto, Keizo Kajiwara, Kunihiko Matsui, Tomio Jinnouch. Liraglutide, a glucagon-like peptide-1 analog, increased insulin sensitivity assessed by hyperinsulinemic-euglycemic clamp examination in patients with uncontrolled type 2 diabetes mellitus. Journal of diabetes research. vol 2015. 2015-12-17. PMID:25922845. |
glucagon-like peptide-1 (glp-1) analog promotes insulin secretion by acting on pancreatic β-cells. |
2015-12-17 |
2023-08-13 |
Not clear |
| Hideaki Jinnouchi, Seigo Sugiyama, Akira Yoshida, Kunio Hieshima, Noboru Kurinami, Tomoko Suzuki, Fumio Miyamoto, Keizo Kajiwara, Kunihiko Matsui, Tomio Jinnouch. Liraglutide, a glucagon-like peptide-1 analog, increased insulin sensitivity assessed by hyperinsulinemic-euglycemic clamp examination in patients with uncontrolled type 2 diabetes mellitus. Journal of diabetes research. vol 2015. 2015-12-17. PMID:25922845. |
we investigated whether liraglutide, a glp-1 analog, could enhance insulin sensitivity as assessed by the hyperinsulinemic-euglycemic clamp in type 2 dm patients. |
2015-12-17 |
2023-08-13 |
Not clear |
| Umar Y Raja, Alison E Eastaugh, Mohammed S Younas, Wasim Hani. Longstanding insulin dependent diabetics may not require insulin after the introduction of GLP-1 analogues. JRSM cardiovascular disease. vol 4. 2015-12-15. PMID:26668738. |
longstanding insulin dependent diabetics may not require insulin after the introduction of glp-1 analogues. |
2015-12-15 |
2023-08-13 |
Not clear |
| Umar Y Raja, Alison E Eastaugh, Mohammed S Younas, Wasim Hani. Longstanding insulin dependent diabetics may not require insulin after the introduction of GLP-1 analogues. JRSM cardiovascular disease. vol 4. 2015-12-15. PMID:26668738. |
although glp-1 analogues have been shown to be more effective in the first few years of diagnosis in type 2 diabetes, we report a case of a patient with longstanding insulin-dependent diabetes started on a glp-1 analogue, liraglutide, who now has controlled blood sugars without the need of insulin. |
2015-12-15 |
2023-08-13 |
Not clear |
| Sergiy V Korol, Zhe Jin, Bryndis Birni. The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABAA Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons. PloS one. vol 10. issue 4. 2015-12-09. PMID:25927918. |
glucagon-like peptide-1 (glp-1) is a metabolic hormone that is secreted in a glucose-dependent manner and enhances insulin secretion. |
2015-12-09 |
2023-08-13 |
rat |
| Joseph F Pierre, Joshua C Neuman, Allison L Brill, Harpreet K Brar, Mary F Thompson, Mark T Cadena, Kelsey M Connors, Rebecca A Busch, Aaron F Heneghan, Candace M Cham, Elaina K Jones, Carly R Kibbe, Dawn B Davis, Guy E Groblewski, Kenneth A Kudsk, Michelle E Kimpl. The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition. American journal of physiology. Gastrointestinal and liver physiology. vol 309. issue 6. 2015-12-08. PMID:26185331. |
while no significant changes in gross endocrine pancreas morphology were observed, pancreatic islets isolated from bbs-treated pn mice showed a significantly enhanced insulin secretion response to the glucagon-like peptide-1 (glp-1) agonist exendin-4, correlating with enhanced glp-1 receptor expression. |
2015-12-08 |
2023-08-13 |
mouse |
| Wakaba Tsuchimochi, Hiroaki Ueno, Eiichiro Yamashita, Chikako Tsubouchi, Hideyuki Sakoda, Shuji Nakamura, Masamitsu Nakazat. Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients. Endocrine journal. vol 62. issue 1. 2015-12-03. PMID:25252844. |
postprandial profiles for glucose, insulin, glucagon, active glucagon-like peptide-1 (glp-1), active glucose-dependent insulinotropic polypeptide (gip), ghrelin, des-acyl ghrelin, and 24 h glycemic fluctuations were measured via continuous glucose monitoring for 4 days. |
2015-12-03 |
2023-08-13 |
Not clear |